Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    It explains what algorithms do, how they are used, the risks associated with using them, and why governments should be concerned. Important areas arehighlighted, such as Stream Ciphers, block ciphers, public key algorithms, digital signatures, and applications such as e-commerce. This book highlights the explosive impact of cryptography on modern society, with, for example, the evolution of the internet and the introduction of more sophisticatedbanking methods.

    Only now, with the hindsight of the half-century since his death, can we assess his true legacy to current thought. As an experienced psychiatrist himself, Anthony Storr offers a lucid and objective look at Freud's major theories, evaluating whether they have stood the test of time, and in the process examines Freud himself in light of his own ideas. An excellent introduction to Freud's work, this book will appeal to all those broadly curious about psychoanalysis, psychology, and sociology. About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Explaining the nature of genetic variation in the human population, how hereditary factors were identified as molecules of DNA, and how certain specific mutations can lead to disease, Slack highlights how DNA variants are used to trace human ancestry and migration, and can also be used by forensic scientists to identify individuals in crime. Slack also explores issues such as the role of genetic heritability and IQ as well as the changes that occur in the genes of populations during evolution. An ideal guide for anyone curious about what genes are and how genetics can be put to use, this Very Short Introduction demonstrates the ways in which the gene concept has been understood and used by molecular biologists, population biologists, and social scientists around the world. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

    However, their impact has not been limited to debates about geology and evolution: attempts to explain their existence has shaken religion at its very roots, and they have remained a subject of ceaseless fascination for people of all ages and backgrounds. In this readable and wide-ranging book, Keith Thomson provides a remarkably all-encompassing explanation of fossils as a phenomenon. How did Darwin use fossils to support his theory of evolution? What are living fossils? What fossils will we leave behind for future generations to examine? Beyond the scientific aspects, Thomson highlights the impact of fossils on philosophy and mythology, our concept of time, and today's popular culture. From the black market to the Piltdown Man, and from mythological dragons to living dinosaurs, fossils hold a permanent place in the popular imagination.

    They changed the course of history, but the myth theyestablished was even stranger than their real achievements. This Very Short Introduction deploys the latest scholarship to shatter and replace the traditional narrative. Chapters explore New World civilizations prior to the invasions, the genesis of conquistador culture on both sides of theAtlantic, the roles black Africans and Native Americans played, and the consequences of the invasions. The book reveals who the conquistadors were and what made their adventures possible.

    In this accessible and stimulating Very Short Introduction, Martin Bunton illuminates the history of the problem, reducing it to its very essence. Adopting a fresh and original approach, Bunton explores the Palestinian-Israeli dispute in twenty-year segments, to highlight the historical complexity of the conflict throughout successive decades. Each chapter starts with an examination of the relationships among people and events that marked particular years as historical stepping stones in the evolution of the conflict, including the 1897 Basle Congress, the 1917 Balfour Declaration and British occupation of Palestine, and the 1947 UN Partition Plan and the war for Palestine.Providing a clear and fair exploration of the main issues, Bunton explores not only the historical basis of the conflict, but also looks at how and why partition has been so difficult and how efforts to restore peace continue today.About the Series:Oxford's Very Short Introductions series offers concise and original introductions to a wide range of subjects--from Islam to Sociology, Politics to Classics, Literary Theory to History, and Archaeology to the Bible. Not simply a textbook of definitions, each volume in this series provides trenchant and provocative--yet always balanced and complete--discussions of the central issues in a given discipline or field. Every Very Short Introduction gives a readable evolution of the subject in question, demonstrating how the subject has developed and how it has influenced society. Eventually, the series will encompass every major academic discipline, offering all students an accessible and abundant reference library. Whatever the area of study that one deems important or appealing, whatever the topic that fascinates the general reader, the Very Short Introductions series has a handy and affordable guide that will likely prove indispensable.

    The authors introduce the general reader to some of the most important basic findings, concepts, and procedures of evolutionary biology, as it has developed since the first publications of Darwin and Wallace on the subject, over 140 years ago. They show how evolution provides a unifying set of principles for the whole of biology and sheds light on the relation of human beings to the universe and each other.

    Travel fast enough and you could weigh as much as a jumbo jet, be flattened thinner than a CD without feeling a thing-and live forever! As for the angles of a triangle, they do not always have to add up to 180 degrees. And then, of course, there are black holes. These are but a few of the extraordinary consequences of Einstein's theory of relativity. It is now over a hundred years since he made these discoveries, and yet the general public is still largely unaware of them. Filled with illuminating anecdotes and fascinating accounts of experiments, this book aims to introduce the interested lay person to the subject of relativity in a way which is accessible and engaging and at the same time scientifically rigorous. With relatively few mathematical equations--nothing more complicated than the Pythagoras's Theorem--this VSI packs a lot time into very little space, and for anyone who has felt intimidated by Einstein's groundbreaking theory, it offers the perfect place to start. About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Michael Inwood's lucid introduction to Heidegger's thought focuses on his most important work, Being and Time, and its major themes of existence in the world, inauthenticity, guilt, destiny, truth, and the nature of time. These themes are then reassessed in the light of Heidegger's later work, together with the extent of his philosophical importance and influence. This is an invaluable guide to the complex and voluminous thought of a major twentieth-century existentialist philosopher.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam

    It is truly a vital field, central to the health of society, but it is often poorly understood, largely due to misrepresentations in the media. In this Very Short Introduction, an internationally recognized authority on epidemiology, Dr. Rodolfo Saracci, provides a wealth of information on this key field, dispelling some of the myths surrounding the study of epidemiology, and explaining what epidemiology is and how vital it is to the discovery, control, and prevention of disease in world populations. Dr. Saracci provides a general explanation of the principles behind clinical trials, and explains the nature of basic statistics concerning disease. He also looks at the ethical and political issues related to obtaining and using information concerning patients, and trials involving placebos.

    Allen and Cowling start with the simple "prokaryotic" cell--cells with no nucleus--and show how the bodies of more complex plants and animals consist of billions of "eukaryotic" cells, of varying kinds, adapted to fill different roles--red blood cells, muscle cells, branched neurons. The authors also show that each cell is an astonishingly complex chemical factory, the activities of which we have only begun to unravel in the past fifty years.

    It examines the impact of the revolution on society as a whole--on different classes, ethnic groups, the army, men and women, youth. Its centralconcern is to understand how one structure of domination was replaced by another. The book registers the primacy of politics, but situates political developments firmly in the context of massive economic, social, and cultural change. Since the fall of Communism there has been much reflection on thesignificance of the Russian Revolution. The book rejects the currently influential, liberal interpretation of the revolution in favor of one that sees it as rooted in the contradictions of a backward society which sought modernization and enlightenment and ended in political tyranny.

    Indeed, for all the effort to reduce nuclear stockpiles to zero and to keep other nations (such as Iran) from developing nuclear capability, it seems that the Bomb is here to stay. In this gripping Very Short Introduction, Joseph M. Siracusa, an internationally respected authority on nuclear arms, provides a comprehensive, accessible, and at times chilling overview of the most deadly weapon ever invented. Siracusa explains the history of the arms race and the politics of the bomb, ranging from the technology of nuclear weapons, to the revolutionary implications of the H-bomb and the politics of nuclear deterrence. The issues are set against a backdrop of the changing international landscape, from the early days of development, through the Cold War, to the present-day controversy over George W. Bush's National Missile Defense, and the role of nuclear weapons in an Age of Terror. Providing an accessible and eye-opening backdrop to one of the most unsettling aspects of the modern world, this compact introduction is must reading.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    From humble beginnings on the seven hills beside the Tiber, the city of Rome grew to dominate the ancient Mediterranean. Led by her senatorial aristocracy, Republican armies defeated Carthage and the successor kingdoms of Alexander the Great, and brought the surrounding peoples to east and west into the Roman sphere. In this Very Short Introduction, David M. Gwynn provides a fascinating introduction to the history of the Roman Republic, ranging from the origins of Rome and the vivid Roman legends that surround the foundations of the city, to the overthrow of the monarchy in 509 BC, the five hundred years of republican rule, the rise of Julius Caesar and Caesar Augustus, and the establishment of the Principate. Gwynn considers the political structure of the Republic, including its unique constitution, and he highlights literary and material sources, bringing to life the culture and society of Republican Rome. He also reflects on the Roman values and beliefs of the time, in order to shed light on the Republic's dramatic rise and fall. Finally, Gwynn reflects on the remarkable legacy of the Roman Republic, including its modern-day resonance and legacy in literature and in film, where it is often presented as a model, a source of inspiration, but also a warning.