The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    

    He was 19 years old when he won the 2005 French Open in his very first appearance at the event. A left-hander with a booming forehand, Nadal had been known as a clay-court specialist since playing his first pro tournaments in 2001. His aggressive style, flowing hair, and muscular build have made him a fan favorite as well. He won his first singles title in 2004, and had a breakout season in 2005, winning at Monte Carlo, Rome, Barcelona, and Stuttgart as well as at Roland Garros. He won the French Open again in 2006, 2007, and 2008, defeating rival Roger Federer in the final each time. In 2008 he broke through at Wimbledon, beating Federer to win the men's singles title in a spectacular fashion. No Nadal fan will want to be without this comprehensive biography.

    The scholastics, he argues, established and developed the subjective utility and scarcity theory of value, as well as the theory that prices, or the value of money, depend on its supply and demand. This continental, or 'pre-Austrian' tradition, was destroyed, rather than developed, by Adam Smith whose strong Calvinist tendencies towards glorifying labour, toil and thrift is contrasted with the emphasis in scholastic economic thought towards labour in the service of consumption.Tracing economic thought from the Greeks to the Scottish Enlightenment, this book is notable for its inclusion of all the important figures in each school of thought with their theories assessed in historical context. Classical Economics, the second volume of Professor Rothbard's history of economic thought from an Austrian perspective, is also available.

    But its failure to recover from the economic collapse of the early 1990s was unprecedented, and today it confronts an array of disturbing social trends. Japan has the highest suicide rate and lowest birthrate of all industrialized countries, and a rising incidence of untreated cases of depression. Equally as troubling are the more than one million young men who shut themselves in their rooms, withdrawing from society, and the growing numbers of "parasite singles," the name given to single women who refuse to leave home, marry, or bear children. In "Shutting Out the Sun," Michael Zielenziger argues that Japan's rigid, tradition-steeped society, its aversion to change, and its distrust of individuality and the expression of self are stifling economic revival, political reform, and social evolution. Giving a human face to the country's malaise, Zielenziger explains how these constraints have driven intelligent, creative young men to become modern-day hermits. At the same time, young women, better educated than their mothers and earning high salaries, are rejecting the traditional path to marriage and motherhood, preferring to spend their money on luxury goods and travel. Smart, unconventional, and politically controversial, "Shutting Out the Sun" is a bold explanation of Japan's stagnation and its implications for the rest of the world.

    In fact, they worked so well that the science teacher then began posting his discoveries to his own Web site, which he dubbed Useless Information. Well-researched and clearly sourced, Silverman's unusual tidbits have gained a wide following.In Einstein's Refrigerator, Silverman collects more than 30 of the most fascinating stories he has gathered--tales of forgotten genius, great blunders, and incredible feats of survival, as well as answers to puzzling questions.Einstein's Refrigerator is a remarkable book with spellbinding stories. Whatever happened to the refrigerator Einstein helped invent? While it never became a commercial success, its underlying concepts became the basis for cooling nuclear breeder reactors.

     Blended learning allows a partnership that gives teachers more time and energy to innovate and personalize learning while providing students the opportunity to be active agents driving their own growth. Balance With Blended Learning provides teachers with strategies to actively engage students in setting goals, monitoring development, reflecting on growth, using feedback, assessing work quality, and communicating their progress with parents. It includes Practical strategies for teachers who are overwhelmed by their workloads Vignettes written by teachers across disciplines Ready-to-use templates to help students track their progress Stories from the author's experience as a teacher and blended learning coach

    Chosen as a Main Selection of the Military Book Club.

    strategic defense. Ninety percent of all U.S. military forces in Japan are located on Okinawa, one of the Ryukyu Islands, and it was through these troops that the martial art of karate was exported to the U.S.In Okinawa: History of an Island People, noted Eastern affairs specialist George Kerr recounts the fascinating history of the island and its environs, from 1314 A.D. to the late twentieth century. The histories of Japan, Okinawa and the entire Pacific region are crucially intertwined so the study of this fascinating chain of islands is crucial to understanding all of East Asia. First published in 1958, this edition features a new introduction and appendix by Okinawa history scholar Mitsugu Sakihara, making this the most comprehensive resource on the small, vital, and intriguing island of Okinawa.

    We call this imprisonment schooling, yet wonder why kids become bored and misbehave. Even outside of school children today seldom play and explore without adult supervision, and are afforded few opportunities to control their own lives. The result: anxious, unfocused children who see schooling—and life—as a series of hoops to struggle through.In Free to Learn, developmental psychologist Peter Gray argues that our children, if free to pursue their own interests through play, will not only learn all they need to know, but will do so with energy and passion. Children come into this world burning to learn, equipped with the curiosity, playfulness, and sociability to direct their own education. Yet we have squelched such instincts in a school model originally developed to indoctrinate, not to promote intellectual growth.To foster children who will thrive in today’s constantly changing world, we must entrust them to steer their own learning and development. Drawing on evidence from anthropology, psychology, and history, Gray demonstrates that free play is the primary means by which children learn to control their lives, solve problems, get along with peers, and become emotionally resilient. This capacity to learn through play evolved long ago, in hunter-gatherer bands where children acquired the skills of the culture through their own initiatives. And these instincts still operate remarkably well today, as studies at alternative, democratically administered schools show. When children are in charge of their own education, they learn better—and at lower cost than the traditional model of coercive schooling.A brave, counterintuitive proposal for freeing our children from the shackles of the curiosity-killing institution we call school, Free to Learn suggests that it’s time to stop asking what’s wrong with our children, and start asking what’s wrong with the system. It shows how we can act—both as parents and as members of society—to improve children’s lives and promote their happiness and learning.

    This unique budgetary survival guide will enhance your instructional, technical, and managerial skills not only as the school′s leader but also as the school′s visionary, planning coordinator, and budgeting manager.

    This acclaimed guide puts the entire range of the Montessori system within your reach, so you can make the most of your child?s vital years. Teaching Montessori in the Home has already helped thousands of parents with the techniques, exercises, and easy-to-make Montessori materials that are essential for success. It demonstrates how you can develop your child?s sensory awareness and practical life skills, as well as lay the foundation of preliminary reading, writing, and math.The author is recognized as one of the most influential proponents of the Montessori method in the United States and throughout the world due to her concise, accessible writing style. This bestselling book grants you the opportunity to teach your child at home and gain a truly rewarding experience. ?Hainstock takes great pains here to offer the reader a very thoughtful yet concise introduction to the Montessori philosophy.? ?from Lee Havis?s introduction.

    then, by golly, stick a tiara on your head and go teach something!" Do you wish that you had the chance to sit down with a seasoned homeschooling veteran over a cup of tea and ask every question that comes to mind? Mother of seven and twelve year homeschooling veteran Rebecca Frech is the common-sense voice of experience and reassurance that you've been hoping to find. Teaching in Your Tiara is a soup-to-nuts homeschooling book that walks you through the first years - deciding that home education is right for your family, choosing the right curriculum, understanding learning styles, not raising socially awkward kids, maintaining your own identity, and more. Whether you're the parent who's already committed to homeschooling or you're just dipping your toe into the pool of consideration, this book is for you! Rebecca's logic, honesty, and humor will leave you both amused and well-informed about the realities of homeschooling and what it could mean for your family.

    Teaching Music with Passion is a one-of-a-kind, collective masterpiece of thoughts, ideas and suggestions about the noble profession of music education. Both inspirational and instructional, it will surely change the way you teach (and think) about music. Filled with personal experiences, anecdotes and wonderful quotations, this book is an easy-to-read, essential treasure! "One of the most 'real' writings I have read during my 35 years in music education." Mel Clayton, President, MENC: The National Association for Music Education Click here for a YouTube video on Teaching Music with Passion

    An 82-year old woman is jailed for 10 months for stealing fried chicken. Like nearly all defendants in Japan, they both plead guilty.What happens between plea and sentencing is the subject of True Crime Japan. In this fascinating crime book journalist and longtime Japan resident Paul Murphy provides a glimpse of Japanese society through a year's worth of criminal court cases in Matsumoto, a city 140 miles to the west of Tokyo. The defendants in these cases range from ruthless mobsters to average citizens, often committing similar crimes in rather different ways, and for different reasons. Based on court hearings and interviews with the defendants, their families, neighbors and lawyers—Murphy explores not only the motives of offenders but the culture of crime and punishment in Japan.The resulting true crime book provides a lens through which to view this honor-shame based, conformist culture, and shows how, in its role within that culture, the court system reveals Japan to be, surprisingly to some, a land of true individuals.