This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Sarah Krasnostein's The Trauma Cleaner is a love letter to an extraordinary ordinary life. In Sandra Pankhurst she discovered a woman capable of taking a lifetime of hostility and transphobic abuse and using it to care for some of society's most in-need people.Sandra Pankhurst founded her trauma cleaning business to help people whose emotional scars are written on their houses. From the forgotten flat of a drug addict to the infested home of a hoarder, Sandra enters properties and lives at the same time. But few of the people she looks after know anything of the complexity of Sandra's own life. Raised in an uncaring home, Sandra's miraculous gift for warmth and humour in the face of unspeakable personal tragedy mark her out as a one-off.

    Mona Hanna-Attisha, alongside a team of researchers, parents, friends, and community leaders, discovered that the children of Flint, Michigan, were being exposed to lead in their tap water--and then battled her own government and a brutal backlash to expose that truth to the world. At the center of the story is Dr. Mona herself--an immigrant, doctor, scientist, and mother whose family's activist roots inspired her pursuit of justice.What the Eyes Don't See is a riveting account of a shameful disaster that became a tale of hope, the story of a city on the ropes that came together to fight for justice, self-determination, and the right to build a better world for their--and all of our--children.

    Before Carrie Brownstein codeveloped and starred in the wildly popular TV comedy Portlandia, she was already an icon to young women for her role as a musician in the feminist punk band Sleater-Kinney. The band was a key part of the early riot- grrrl and indie rock scenes in the Pacific Northwest, known for their prodigious guitar shredding and their leftist lyrics against war, traditionalism, and gender roles.Hunger Makes Me a Modern Girl is the deeply personal and revealing narrative of Brownstein's life in music, from ardent fan to pioneering female guitarist to comedic performer and luminary in the independent rock world. Though Brownstein struggled against the music industry's sexist double standards, by 2006 she was the only woman to earn a spot on Rolling Stone readers' list of the "25 Most Underrated Guitarists of All-Time." This book intimately captures what it feels like to be a young woman in a rock-and-roll band, from her days at the dawn of the underground feminist punk-rock movement that would define music and pop culture in the 1990s through today.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    This alarmed authorities, who feared certain "over-sexed" women could destroy civilization if allowed to reproduce and pass on their defects. Set against this backdrop, The Unfit Heiress chronicles the fight for inheritance, both genetic and monetary, between Ann Cooper Hewitt and her mother Maryon.In 1934, aided by a California eugenics law, the socialite Maryon Cooper Hewitt had her "promiscuous" daughter declared feebleminded and sterilized without her knowledge. She did this to deprive Ann of millions of dollars from her father's estate, which contained a child-bearing stipulation. When a sensational court case ensued, the American public was captivated. So were eugenicists, who saw an opportunity to restrict reproductive rights in America for decades to come.

    Clichés around marriage—eternal bliss, domestic harmony, soul mates—leave out the real stuff. After marriage you may still want to sleep with other people. Sometimes your partner will bore the hell out of you. And when stuck paying for your spouse’s mistakes, you might miss being single.In Wedding Toasts I’ll Never Give, Ada Calhoun presents an unflinching but also loving portrait of her own marriage, opening a long-overdue conversation about the institution as it truly is: not the happy ending of a love story or a relic doomed by high divorce rates, but the beginning of a challenging new chapter of which “the first twenty years are the hardest.”Calhoun’s funny, poignant personal essays explore the bedrooms of modern coupledom for a nuanced discussion of infidelity, existential anxiety, and the many other obstacles to staying together. Both realistic and openhearted, Wedding Toasts I’ll Never Give offers a refreshing new way to think about marriage as a brave, tough, creative decision to stay with another person for the rest of your life. “What a burden,” Calhoun calls marriage, “and what a gift.”

    Her father's hidden liquor bottles, the strange cancers in children in the neighborhood, the truth about what was made at Rocky Flats (cleaning supplies, her mother guessed)—best not to inquire too deeply into any of it.But as Iversen grew older, she began to ask questions. She learned about the infamous 1969 Mother's Day fire, in which a few scraps of plutonium spontaneously ignited and—despite the desperate efforts of firefighters—came perilously close to a "criticality," the deadly blue flash that signals a nuclear chain reaction. Intense heat and radiation almost melted the roof, which nearly resulted in an explosion that would have had devastating consequences for the entire Denver metro area. Yet the only mention of the fire was on page 28 of the Rocky Mountain News, underneath a photo of the Pet of the Week. In her early thirties, Iversen even worked at Rocky Flats for a time, typing up memos in which accidents were always called "incidents."And as this memoir unfolds, it reveals itself as a brilliant work of investigative journalism—a detailed and shocking account of the government's sustained attempt to conceal the effects of the toxic and radioactive waste released by Rocky Flats, and of local residents' vain attempts to seek justice in court. Here, too, are vivid portraits of former Rocky Flats workers—from the healthy, who regard their work at the plant with pride and patriotism, to the ill or dying, who battle for compensation for cancers they got on the job.Based on extensive interviews, FBI and EPA documents, and class-action testimony, this taut, beautifully written book promises to have a very long half-life.

    Vincent DiMaio and veteran crime writer Ron Franscell guide us behind the morgue doors to tell a fascinating life story through the cases that have made Di Maio famous-from the exhumation of assassin Lee Harvey Oswald to the complex issues in the shooting of Florida teenager Trayvon Martin.Beginning with his street-smart Italian origins in Brooklyn, the book spans 40 years of work and more than 9,000 autopsies, and Di Maio's eventual rise into the pantheon of forensic scientists. One of the country's most methodical and intuitive criminal pathologists will dissect himself, maintaining a nearly continuous flow of suspenseful stories, revealing anecdotes, and enough macabre insider details to rivet the most fervent crime fans.

    Doctors couldn’t explain why, and Jacinta wondered if it might be in her head. She could barely function, was frequently unable to eat or get out of bed for days, and gradually turned into a shadow of herself. Eventually she got a diagnosis: Crohn’s disease. But knowing this wouldn’t stop her life from spiralling into a big mess of doctors, hospitals and medical disasters.What’s most extraordinary about Jacinta’s story is how common it is. Nearly half of Australians live with a chronic illness, but most of these conditions are not obvious, often endured in secrecy and little understood. They are unseen.With compelling candour, Jacinta trains a microscope on the unique challenges of living with an invisible condition. She lays bare the struggles with shame, loss of identity, the threat of mortality, and the profoundly complex relationships between the chronically ill and their own bodies, as well as with those around them. It’s a story of trying to fix an unfixable illness, getting beaten down then clawing back up, and how that experience can shape a life.

    He often came across as a man possessed, holding forth on culture and politics while mixing in personal revelations – all with mercurial, tongue-twisting intensity as he inhabited and shed one character after another with lightning speed.But as Dave Itzkoff shows in this revelatory biography, Williams’s comic brilliance masked a deep well of conflicting emotions and self-doubt, which he drew upon in his comedy and in celebrated films like Dead Poets Society; Good Morning, Vietnam; The Fisher King; Aladdin; and Mrs. Doubtfire, where he showcased his limitless gift for improvisation to bring to life a wide range of characters. And in Good Will Hunting he gave an intense and controlled performance that revealed the true range of his talent.Itzkoff also shows how Williams struggled mightily with addiction and depression – topics he discussed openly while performing and during interviews – and with a debilitating condition at the end of his life that affected him in ways his fans never knew. Drawing on more than a hundred original interviews with family, friends, and colleagues, as well as extensive archival research, Robin is a fresh and original look at a man whose work touched so many lives.

    The book is an analysis of physical suffering and its relation to the numerous vocabularies and cultural forces--literary, political, philosophical, medical, religious--that confront it. Elaine Scarry bases her study on a wide range of sources: literature and art, medical case histories, documents on torture compiled by Amnesty International, legal transcripts of personal injury trials, and military and strategic writings by such figures as Clausewitz, Churchill, Liddell Hart, and Kissinger, She weaves these into her discussion with an eloquence, humanity, and insight that recall the writings of Hannah Arendt and Jean-Paul Sartre. Scarry begins with the fact of pain's inexpressibility. Not only is physical pain enormously difficult to describe in words--confronted with it, Virginia Woolf once noted, "language runs dry"--it also actively destroys language, reducing sufferers in the most extreme instances to an inarticulate state of cries and moans. Scarry analyzes the political ramifications of deliberately inflicted pain, specifically in the cases of torture and warfare, and shows how to be fictive. From these actions of "unmaking" Scarry turns finally to the actions of "making"--the examples of artistic and cultural creation that work against pain and the debased uses that are made of it. Challenging and inventive, The Body in Pain is landmark work that promises to spark widespread debate.

    But nowhere is this drive to do better more important than in medicine, where lives are on the line with every decision. In his new book, Atul Gawande explores how doctors strive to close the gap between best intentions and best performance in the face of obstacles that sometimes seem insurmountable. Gawande's gripping stories of diligence, ingenuity, and what it means to do right by people take us to battlefield surgical tents in Iraq, to labor and delivery rooms in Boston, to a polio outbreak in India, and to malpractice courtrooms around the country. He discusses the ethical dilemmas of doctors participation in lethal injections, examines the influence of money on modern medicine, and recounts the astoundingly contentious history of hand washing. And as in all his writing, Gawande gives us an inside look at his own life as a practicing surgeon, offering a searingly honest firsthand account of work in a field where mistakes are both unavoidable and unthinkable. At once unflinching and compassionate, Better is an exhilarating journey narrated by arguably the best nonfiction doctor-writer around (Salon). Gawande's investigation into medical professionals and how they progress from merely good to great provides rare insight into the elements of success, illuminating every area of human endeavor.

    What she does, with clarity, beauty, and candor, is to document, often in their most extreme moments, the complex lives of others. It’s her work, but it’s much more than that: it’s her singular calling.Lynsey Addario was just finding her way as a young photographer when September 11 changed the world. One of the few photojournalists with experience in Afghanistan, she gets the call to return and cover the American invasion. She makes a decision she would often find herself making—not to stay home, not to lead a quiet or predictable life, but to set out across the world, face the chaos of crisis, and make a name for herself.Addario finds a way to travel with a purpose. She photographs the Afghan people before and after the Taliban reign, the civilian casualties and misunderstood insurgents of the Iraq War, as well as the burned villages and countless dead in Darfur. She exposes a culture of violence against women in the Congo and tells the riveting story of her headline-making kidnapping by pro-Qaddafi forces in the Libyan civil war.Addario takes bravery for granted but she is not fearless. She uses her fear and it creates empathy; it is that feeling, that empathy, that is essential to her work. We see this clearly on display as she interviews rape victims in the Congo, or photographs a fallen soldier with whom she had been embedded in Iraq, or documents the tragic lives of starving Somali children. Lynsey takes us there and we begin to understand how getting to the hard truth trumps fear.As a woman photojournalist determined to be taken as seriously as her male peers, Addario fights her way into a boys’ club of a profession. Rather than choose between her personal life and her career, Addario learns to strike a necessary balance. In the man who will become her husband, she finds at last a real love to complement her work, not take away from it, and as a new mother, she gains an all the more intensely personal understanding of the fragility of life.Watching uprisings unfold and people fight to the death for their freedom, Addario understands she is documenting not only news but also the fate of society. It’s What I Do is more than just a snapshot of life on the front lines; it is witness to the human cost of war.

    A month later, none of that was true. Levy picks you up and hurls you through the story of how she built an unconventional life and then watched it fall apart with astonishing speed. Like much of her generation, she was raised to resist traditional rules—about work, about love, and about womanhood. “I wanted what we all want: everything. We want a mate who feels like family and a lover who is exotic, surprising. We want to be youthful adventurers and middle-aged mothers. We want intimacy and autonomy, safety and stimulation, reassurance and novelty, coziness and thrills. But we can’t have it all.” In this profound and beautiful memoir, Levy chronicles the adventure and heartbreak of being “a woman who is free to do whatever she chooses.” Her own story of resilience becomes an unforgettable portrait of the shifting forces in our culture, of what has changed—and of what is eternal.