In The Compatibility Gene, one of our foremost immunologists tells the remarkable history of these genes' discovery and the unlocking of their secrets. Davis shows how the compatibility gene is radically transforming our knowledge of the way our bodies work - and is having profound consequences for medical research and ethics. Looking to the future, he considers the startling possibilities of what these wondrous discoveries might mean for you and me.

    The world of insects is Howard Evans' "little-known planet," the realm of the cockroach and the cricket, the wasp and the bedbug. With the precision and authority of a distinguished biologist, and the wit and grace of an accomplished writer, Howard Evans muses on the uniqueness of dragonflies, the romantic impulses of butterflies, the musicianship of crickets, and the mysteries of the firefly. The insect realm never fails to enlighten, entertain, and sometimes provoke: as Evans asks, "Is the fly a more intricate machine than he appears, or are we less clever than we suppose ourselves to be?"

    The first epidemic to emerge in the era of climate change, the disease infects half a million people in the US and Europe each year, and untold multitudes in Canada, China, Russia, and Australia. Mary Beth Pfeiffer shows how we have contributed to this growing menace, and how modern medicine has underestimated its danger. She tells the heart-rending stories of families destroyed by a single tick bite, of children disabled, and of one woman’s tragic choice after an exhaustive search for a cure. Pfeiffer also warns of the emergence of other tick-borne illnesses that make Lyme more difficult to treat and pose their own grave risks. Lyme is an impeccably researched account of an enigmatic disease, making a powerful case for action to fight ticks, heal patients, and recognize humanity’s role in a modern scourge.

    What is it like to try to heal the body when the mind is under attack? In this book, Dr. Allan Ropper and Brian Burrell take the reader behind the scenes at Harvard Medical School's neurology unit to show how a seasoned diagnostician faces down bizarre, life-altering afflictions. Like Alice in Wonderland, Dr. Ropper inhabits a world where absurdities abound:• A figure skater whose body has become a ticking time-bomb • A salesman who drives around and around a traffic rotary, unable to get off • A college quarterback who can't stop calling the same play • A child molester who, after falling on the ice, is left with a brain that is very much dead inside a body that is very much alive • A mother of two young girls, diagnosed with ALS, who has to decide whether a life locked inside her own head is worth livingHow does one begin to treat such cases, to counsel people whose lives may be changed forever? How does one train the next generation of clinicians to deal with the moral and medical aspects of brain disease? Dr. Ropper and his colleague answer these questions by taking the reader into a rarified world where lives and minds hang in the balance.

    Visiting it almost daily for one year to trace nature’s path through the seasons, he brings the forest and its inhabitants to vivid life.Each of this book’s short chapters begins with a simple observation: a salamander scuttling across the leaf litter; the first blossom of spring wildflowers. From these, Haskell spins a brilliant web of biology and ecology, explaining the science that binds together the tiniest microbes and the largest mammals and describing the ecosystems that have cycled for thousands—sometimes millions—of years. Each visit to the forest presents a nature story in miniature as Haskell elegantly teases out the intricate relationships that order the creatures and plants that call it home.Written with remarkable grace and empathy, The Forest Unseen is a grand tour of nature in all its profundity. Haskell is a perfect guide into the world that exists beneath our feet and beyond our backyards.

    Mammoths, camels, and lions walked the ground that has become Wilshire Boulevard in Los Angeles and foraged on the marsh land now buried beneath Chicago's streets. Then, just as the first humans reached the Americas, these Ice Age giants vanished forever. In Once and Future Giants, science writer Sharon Levy digs through the evidence surrounding Pleistocene large animal ("megafauna") extinction events worldwide, showing that understanding this history--and our part in it--is crucial for protecting the elephants, polar bears, and other great creatures at risk today. These surviving relatives of the Ice Age beasts now face an intensified replay of that great die-off, as our species usurps the planet's last wild places while driving a warming trend more extreme than any in mammalian history. Inspired by a passion for the lost Pleistocene giants, some scientists advocate bringing elephants and cheetahs to the Great Plains as stand-ins for their extinct native brethren. By reintroducing big browsers and carnivores to North America, they argue, we could rescue some of the planet's most endangered animals while restoring healthy prairie ecosystems. Critics, including biologists enmeshed in the struggle to restore native species like the gray wolf and the bison, see the proposal as a dangerous distraction from more realistic and legitimate conservation efforts. Deftly navigating competing theories and emerging evidence, Once and Future Giants examines the extent of human influence on megafauna extinctions past and present, and explores innovative conservation efforts around the globe. The key to modern-day conservation, Levy suggests, may lie fossilized right under our feet.

    Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein reveals the “invigorating history” (Nature) of hormones and the age-old quest to control them through the back rooms, basements, and labs where endocrinology began.

    A sprightly, lavishly illustrated book on the science of human survival.How do people survive extremes of heat, cold, depth, speed and altitude? This book explores the limits of human survival and the physiological adaptations which enable us to exist under extreme conditions. In man’s battle for survival in the harshest of environments, the knowledge imparted by physiology, the ‘logic of life’, is crucial. What causes mountain sickness? Why is it possible to reach the top of Everest without supplementary oxygen, yet be killed if a plane depressurises suddenly at the same altitude. Why are astronauts unable to stand without fainting when they return to Earth? Why do human divers get the bends but sperm whales don’t? Will men always be able to run faster than women? Why don’t penguins get frostbite?

    Our instincts—for food, sex, or territorial protection— evolved for life on the savannahs 10,000 years ago, not in today’s world of densely populated cities, technological innovations, and pollution. We now have access to a glut of larger-than-life objects, from candy to pornography to atomic weapons—that gratify these gut instincts with often-dangerous results. Animal biologists coined the term “supernormal stimuli” to describe imitations that appeal to primitive instincts and exert a stronger pull than real things, such as soccer balls that geese prefer over eggs. Evolutionary psychologist Deirdre Barrett applies this concept to the alarming disconnect between human instinct and our created environment, demonstrating how supernormal stimuli are a major cause of today’s most pressing problems, including obesity and war. However, Barrett does more than show how unfettered instincts fuel dangerous excesses. She also reminds us that by exercising self-control we can rein them in, potentially saving ourselves and civilization. 55 illustrations.

    Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    Kropotkin based this classic on his observations of natural phenomena and history, forming a work of stunning and well-reasoned scholarship. Essential to the understanding of human evolution as well as social organization, it offers a powerful counterpoint to the tenets of Social Darwinism. It also cites persuasive evidence of human nature's innate compatibility with anarchist society."Kropotkin's basic argument is correct," noted evolutionary biologist Stephen Jay Gould. "Struggle does occur in many modes, and some lead to cooperation among members of a species as the best pathway to advantage for individuals." Anthropologist Ashley Montagu declared that "Mutual Aid will never be any more out of date than will the Declaration of Independence. New facts may increasingly become available, but we can already see that they will serve largely to support Kropotkin's conclusion that 'in the ethical progress of man, mutual support—not mutual struggle—has had the leading part.'" Physician and author Alex Comfort asserted that "Kropotkin profoundly influenced human biology by his theory of Mutual Aid. . . . He was one of the first systematic students of animal communities, and may be regarded as the founder of modern social ecology."

    Barash, there are even more things that we don't know, genuine evolutionary mysteries that perplex the best minds in biology. Paradoxically, many of these mysteries are very close to home, involving some of the most personalaspects of being human.Homo Mysterious examines a number of these evolutionary mysteries, exploring things that we don't yet know about ourselves, laying out the best current hypotheses, and pointing toward insights that scientists are just beginning to glimpse. Why do women experience orgasm? Why do men have a shorterlifespan than women? Why does homosexuality exist? Why does religion exist in virtually every culture? Why do we have a fondness for the arts? Why do we have such large brains? And why does consciousness exist? Readers are plunged into an ocean of unknowns--the blank spots on the human evolutionarymap, the terra incognita of our own species--and are introduced to the major hypotheses that currently occupy scientists who are attempting to unravel each puzzle (including some solutions proposed here for the first time). Throughout the book, readers are invited to share the thrill of science atits cutting edge, a place where we know what we don't know, and, moreover, where we know enough to come up with some compelling and seductive explanations.Homo Mysterious is a guide to creative thought and future explorations, based on the best, most current thinking by evolutionary scientists. It captures the allure of the not-yet-known for those interested in stretching their scientific imaginations.

    According to this false-yet-familiar story, the divisions between men and women are in nature alone and not part of culture. Drawing on evolutionary science, psychology, neuroscience, endocrinology, and philosophy, Testosterone Rex disproves this ingrained myth and calls for a more equal society based on both sexes’ full human potential.

    This "entertaining and enchanting" work (Washington Post Book World) chronicles how Watson's fascination grew into a lifelong quest to understand the nature and behavior of this impressive creature.From that moment on, Watson's fascination grew into a lifelong obsession with understanding the nature and behavior of this impressive creature. Around the world, the elephant—at once a symbol of spiritual power and physical endurance—has been worshipped as a god and hunted for sport."Watson's insights and speculations are dazzling, but what lends them power is his extraordinary knowledge of evolutionary biology and animal behavior, ethnography and South African history" (Wade Davis, National Geographic Society). "Like a shaman, Watson conjures up the spirit of the massive beast" (Publishers Weekly), documents the animal's wide-ranging capabilities to remember and to mourn, and reminds us of its rich mythic origins, its evolution, and its devastation in recent history. Part meditation on an elusive animal, part evocation of the power of place, Elephantoms presents an alluring mix of the mysteries of nature and the wonders of childhood.

    Making use of remarkable scientific discoveries that transform our understanding of how natural systems work, George Monbiot explores a new, positive environmentalism that shows how damaged ecosystems on land and at sea can be restored, and how this restoration can revitalize and enrich our lives. Challenging what he calls his “ecological boredom,” Monbiot weaves together a beautiful and riveting tale of wild places, wildlife, and wild people. Roaming the hills of Britain and the forests of Europe, kayaking off the coast of Wales with dolphins and seabirds, he seeks out the places that still possess something of the untamed spirit he would like to resurrect.He meets people trying to restore lost forests and bring back missing species—such as wolves, lynx, wolverines, wild boar, and gray whales—and explores astonishing evidence that certain species, not just humans, have the power to shape the physical landscape. This process of rewilding, Monbiot argues, offers an alternative to a silent spring: the chance of a raucous summer in which ecological processes resume and humans draw closer to the natural world.