But the historic landfall of October 1492 was only a secondary event of the year. The preceding January, they had accepted the surrender of Muslim Granada, ending centuries of Islamic rule in their peninsula. And later that year, they had ordered the expulsion or forced baptism of Spain's Jewish minority, a cruel crusade undertaken in an excess of zeal for their Catholic faith. Europe, in the century of Ferdinand and Isabella, was also awakening to the glories of a new age, the Renaissance, and the Spain of the "Catholic Kings" - as Ferdinand and Isabella came to be known - was not untouched by this brilliant revival of learning. Here, from the noted historian Malveena McKendrick, is their remarkable story.

    0

    At times a painter, sculptor, inventor, draftsman, and anatomist, Leonardo's life cannot easily be summarized. And yet, Nicholl skillfully traces the artist's early days as an illegitimate child in Tuscany; his apprenticeship with Verrocchio in Florence; his service with some of the most powerful Renaissance families; his relationships with Michelangelo and Machiavelli; and his final days at the French royal court. In addition, Nicholl looks beyond the well-known stories of Leonardo's famous masterpieces, and gives us a glimpse into the artist's everyday life. We learn of Leonardo's penchant for jokes, his fascination with flight, his obsessive note making, and even what he ate. Nicholl weaves these details together in a fascinating portrait that goes far towards revealing the enigmatic figure who continues to fascinate present-day readers.

    Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    Going back to the beginnings of human history, Mabey shows how flowers, trees, and plants have been central to human experience not just as sources of food and medicine but as objects of worship, actors in creation myths, and symbols of war and peace, life and death.Writing in a celebrated style that the Economist calls “delightful and casually learned,” Mabey takes readers from the Himalayas to Madagascar to the Amazon to our own backyards. He ranges through the work of writers, artists, and scientists such as da Vinci, Keats, Darwin, and van Gogh and across nearly 40,000 years of human history: Ice Age images of plant life in ancient cave art and the earliest representations of the Garden of Eden; Newton’s apple and gravity, Priestley’s sprig of mint and photosynthesis, and Wordsworth’s daffodils; the history of cultivated plants such as maize, ginseng, and cotton; and the ways the sturdy oak became the symbol of British nationhood and the giant sequoia came to epitomize the spirit of America.Complemented by dozens of full-color illustrations, The Cabaret of Plants is the magnum opus of a great naturalist and an extraordinary exploration of the deeply interwined history of humans and the natural world.

    Offering both a critique of the conventional historiography and an alternate history of the war informed by Cuban sources, Perez explores the assumptions that have shaped our understanding of the "Spanish-American War--a construct, he argues, that denies the Cubans' participation in their own struggle for liberation from Spanish rule. Perez examines historical accounts of the destruction of the battleship Maine, the representation of public opinion as a precipitant of war, and the treatment of the military campaign in Cuba. Equally important, he shows how historical narratives have helped sustain notions of America's national purpose and policy, many of which were first articulated in 1898. Cuba insinuated itself into one of the most important chapters of U.S. history, and what happened on the island in the final decade of the nineteenth century--and the way in which what happened was subsequently represented--has had far-reaching implications, many of which continue to resonate today.

    Days later, the madman was dead and Denis was framed for murder. A riveting exposé of the fierce debates, deadly politics, and cutthroat rivalries behind the first transfusion experiments, Blood Work takes us from dissection rooms in palaces to the streets of Paris, providing an unforgettable portrait of an era that wrestled with the same questions about morality and experimentation that haunt medical science today.

    With the Big Bang, it went from a state of unimaginable density to an all-encompassing cosmic fireball to a simmering fluid of matter and energy, laying down the seeds for everything from dark matter to black holes to one rocky planet orbiting a star near the edge of a spiral galaxy that happened to develop life. But what happens at the end of the story? In billions of years, humanity could still exist in some unrecognizable form, venturing out to distant space, finding new homes and building new civilizations. But the death of the universe is final. What might such a cataclysm look like? And what does it mean for us? Dr. Katie Mack has been contemplating these questions since she was eighteen, when her astronomy professor first informed her the universe could end at any moment, setting her on the path toward theoretical astrophysics. Now, with lively wit and humor, she unpacks them in The End of Everything, taking us on a mind-bending tour through each of the cosmos’ possible finales: the Big Crunch; the Heat Death; Vacuum Decay; the Big Rip; and the Bounce. In the tradition of Neil DeGrasse’s bestseller Astrophysics for People in a Hurry, Mack guides us through major concepts in quantum mechanics, cosmology, string theory, and much more, in a wildly fun, surprisingly upbeat ride to the farthest reaches of everything we know.

    The book explores the coded significances associated with various blooms, from flowers for a lover to flowers for an enemy.The language of flowers was historically used as a means of secret communication. It soared in popularity during the 19th century, especially in Victorian England and the U.S., when proper etiquette discouraged open displays of emotion. Mysterious and playful, the language of flowers has roots in everything from the characteristics of the plant to its presence in folklore and history. Researched and illustrated by popular artist Jessica Roux, this book makes a stunning display piece, conversation-starter, or thoughtful gift.

    In this sensational and macabre story, we meet the surgeon who counted not only luminaries Benjamin Franklin, Lord Byron, Adam Smith, and Thomas Gainsborough among his patients but also “resurrection men” among his close acquaintances. A captivating portrait of his ruthless devotion to uncovering the secrets of the human body, and the extraordinary lengths to which he went to do so—including body snatching, performing pioneering medical experiments, and infecting himself with venereal disease—this rich historical narrative at last acknowledges this fascinating man and the debt we owe him today.

    This work recounts the adventurous life of his beloved 'Cello Prieto, ' tracing its history through each of its previous owners from Stradivari in 1720 to the author himself

    This accessible biography chronicles Wilberforce's extraordinary role as a human rights activist, cultural reformer, and member of Parliament.At the center of this heroic life was a passionate twenty-year fight to abolish the British slave trade, a battle Wilberforce won in 1807, as well as efforts to abolish slavery itself in the British colonies, a victory achieved just three days before his death in 1833.Metaxas discovers in this unsung hero a man of whom it can truly be said: he changed the world. Before Wilberforce, few thought slavery was wrong. After Wilberforce, most societies in the world came to see it as a great moral wrong.To mark the 200th anniversary of the abolition of the British slave trade, HarperSanFrancisco and Bristol Bay Productions have joined together to commemorate the life of William Wilberforce with the feature-length film Amazing Grace and this companion biography, which provides a fuller account of the amazing life of this great man than can be captured on film.This account of Wilberforce's life will help many become acquainted with an exceptional man who was a hero to Abraham Lincoln and an inspiration to the anti-slavery movement in America.

    She conjures up early operating theaters--no place for the squeamish--and surgeons, working before anesthesia, who were lauded for their speed and brute strength. These medical pioneers knew that the aftermath of surgery was often more dangerous than their patients' afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn't have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the deadly riddle and change the course of history.Fitzharris dramatically recounts Lister's discoveries in gripping detail, culminating in his audacious claim that germs were the source of all infection--and could be countered by antiseptics. Focusing on the tumultuous period from 1850 to 1875, she introduces us to Lister and his contemporaries--some of them brilliant, some outright criminal--and takes us through the grimy medical schools and dreary hospitals where they learned their art, the deadhouses where they studied anatomy, and the graveyards they occasionally ransacked for cadavers.Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.

    Revolutionary Backlash argues otherwise. According to Rosemarie Zagarri, the debate over women's rights began not in the decades prior to 1848 but during the American Revolution itself. Integrating the approaches of women's historians and political historians, this book explores changes in women's status that occurred from the time of the American Revolution until the election of Andrew Jackson.Although the period after the Revolution produced no collective movement for women's rights, women built on precedents established during the Revolution and gained an informal foothold in party politics and male electoral activities. Federalists and Jeffersonians vied for women's allegiance and sought their support in times of national crisis. Women, in turn, attended rallies, organized political activities, and voiced their opinions on the issues of the day. After the publication of Mary Wollstonecraft's A Vindication of the Rights of Woman, a widespread debate about the nature of women's rights ensued. The state of New Jersey attempted a bold experiment: for a brief time, women there voted on the same terms as men.Yet as Rosemarie Zagarri argues in Revolutionary Backlash, this opening for women soon closed. By 1828, women's politicization was seen more as a liability than as a strength, contributing to a divisive political climate that repeatedly brought the country to the brink of civil war. The increasing sophistication of party organizations and triumph of universal suffrage for white males marginalized those who could not vote, especially women. Yet all was not lost. Women had already begun to participate in charitable movements, benevolent societies, and social reform organizations. Through these organizations, women found another way to practice politics.

    Hockney’s extensive research led him to conclude that artists such as Caravaggio, Velázquez, da Vinci, and other hyperrealists actually used optics and lenses to create their masterpieces.In this passionate yet pithy book, Hockney takes readers on a journey of discovery as he builds a case that mirrors and lenses were used by the great masters to create their highly detailed and realistic paintings and drawings. Hundreds of the best-known and best-loved paintings are reproduced alongside his straightforward analysis. Hockney also includes his own photographs and drawings to illustrate techniques used to capture such accurate likenesses. Extracts from historical and modern documents and correspondence with experts from around the world further illuminate this thought-provoking book that will forever change how the world looks at art.Secret Knowledge will open your eyes to how we perceive the world and how we choose to represent it.