For centuries, royal families have feared the gut-roiling, vomit-inducing agony of a little something added to their food or wine by an enemy. To avoid poison, they depended on tasters, unicorn horns, and antidotes tested on condemned prisoners. Servants licked the royal family’s spoons, tried on their underpants and tested their chamber pots.Ironically, royals terrified of poison were unknowingly poisoning themselves daily with their cosmetics, medications, and filthy living conditions. Women wore makeup made with mercury and lead. Men rubbed turds on their bald spots. Physicians prescribed mercury enemas, arsenic skin cream, drinks of lead filings, and potions of human fat and skull, fresh from the executioner. The most gorgeous palaces were little better than filthy latrines. Gazing at gorgeous portraits of centuries past, we don’t see what lies beneath the royal robes and the stench of unwashed bodies; the lice feasting on private parts; and worms nesting in the intestines.In The Royal Art of Poison, Eleanor Herman combines her unique access to royal archives with cutting-edge forensic discoveries to tell the true story of Europe’s glittering palaces: one of medical bafflement, poisonous cosmetics, ever-present excrement, festering natural illness, and, sometimes, murder.

    The next morning, things take a sharp turn as she’s led from work to the emergency room. By the end of the week, a neurologist delivers a devastating prognosis: Sarah suffered a traumatic brain injury that has caused her IQ to plummet, with no hope of recovery. Her brain has irrevocably changed.Afraid of judgment and deemed no longer fit for work, Sarah isolates herself from the outside world. She spends months at home, with her dogs as her only source of companionship, battling a personality she no longer recognizes and her shock and rage over losing simple functions she’d taken for granted. Her life is consumed by fear and shame until a chance encounter gives Sarah hope that her brain can heal. That conversation lights a small flame of determination, and Sarah begins to push back, painstakingly reteaching herself to read and write, and eventually reentering the workforce and a new, if unpredictable, life.In this highly intimate account of devastation and renewal, Sarah pulls back the curtain on life with traumatic brain injury, an affliction where the wounds are invisible and the lasting effects are often misunderstood. Over years of frustrating setbacks and uncertain triumphs, Sarah comes to terms with her disability and finds love with a woman who helps her embrace a new, accepting sense of self.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

     Elinor Cleghorn became an unwell woman ten years ago. She was diagnosed with an autoimmune disease after a long period of being told her symptoms were anything from psychosomatic to a possible pregnancy. As Elinor learned to live with her unpredictable disease she turned to history for answers, and found an enraging legacy of suffering, mystification, and misdiagnosis.In Unwell Women, Elinor Cleghorn traces the almost unbelievable history of how medicine has failed women by treating their bodies as alien and other, often to perilous effect. The result is an authoritative and groundbreaking exploration of the relationship between women and medical practice, from the wandering womb of Ancient Greece to the rise of witch trials across Europe, and from the dawn of hysteria as a catchall for difficult-to-diagnose disorders to the first forays into autoimmunity and the shifting understanding of hormones, menstruation, menopause, and conditions like endometriosis.Packed with character studies and case histories of women who have suffered, challenged, and rewritten medical orthodoxy--and the men who controlled their fate--this is a revolutionary examination of the relationship between women, illness, and medicine. With these case histories, Elinor pays homage to the women who suffered so strides could be made, and shows how being unwell has become normalized in society and culture, where women have long been distrusted as reliable narrators of their own bodies and pain. But the time for real change is long overdue: answers reside in the body, in the testimonies of unwell women--and their lives depend on medicine learning to listen.

    What happened during those blackouts has made Sybil's experience one of the most famous psychological cases in the world.

    The crime scene suggested a ferocious struggle, and police initially assumed it was a burglary gone awry. Before her death, Sherri had confided to her parents that an ex-girlfriend of John's, a Los Angeles police officer, had threatened her. The Rasmussens urged the LAPD to investigate the ex-girlfriend, but the original detectives only pursued burglary suspects, and the case went cold.DNA analysis did not exist when Sherri was murdered. Decades later, a swab from a bite mark on Sherri's arm revealed her killer was in fact female, not male. A DNA match led to the arrest and conviction of veteran LAPD Detective Stephanie Lazarus, John's onetime girlfriend.The Lazarus Files delivers the visceral experience of being inside a real-life murder mystery. McGough reconstructs the lives of Sherri, John and Stephanie; the love triangle that led to Sherri's murder; and the homicide investigation that followed. Was Stephanie protected by her fellow officers? What did the LAPD know, and when did they know it? Are there other LAPD cold cases with a police connection that remain unsolved?

    Illuminating, completely engaging—it's essential reading for all since we all know someone whose life, family or friends are touched by the disease that directly afflicts a fifth of Canadians. In her early twenties, while outwardly thriving in her dream job and enjoying warm familial support and a strong social network, award-winning journalist Anna Mehler Paperny found herself trapped by feelings of failure and despair. Her first suicide attempt—ingesting a deadly mix of sleeping pills and antifreeze—landed her in the ICU, followed by weeks of enforced detention that ran the gamut of horrifying, boring, hilarious, and absurd. This was Anna's entry into the labyrinthine psychiatric care system responsible for providing care to millions of Canadians.As she struggled to survive the psych ward and as an outpatient—enduring the "survivor's" shame of facing concerned family, friends, and co-workers; finding (or not) the right therapist, the right meds; staying healthy, insured, and employed—Anna could not help but turn her demanding journalist's eye on her condition and on the system in which she found herself. She set off on a quest to "know her enemy," interviewing leading practitioners in the field across Canada and the US—from psychiatrists to neurological experts, brain-mapping pioneers to heroic family practitioners, and others dabbling in novel hypotheses. She reveals in courageously frank detail her own experiences with the pharmacological pitfalls and side effects of long-term treatment, and offers moving case studies of conversations with others, opening wide a window into how we treat (and fail to treat) the disease that accounts for more years swallowed up by disability than any other in the world.

    . . The book works on two levels, much like a good Holmes case."--TimeFor all the scores of biographies of Arthur Conan Doyle, creator of the most famous detective in the world, there is no recent book that tells this remarkable story--in which Conan Doyle becomes a real-life detective on an actual murder case. In Conan Doyle for the Defense, Margalit Fox takes us step by step inside Conan Doyle's investigative process and illuminates a murder mystery that is also a morality play for our time--a story of ethnic, religious, and anti-immigrant bias.In 1908, a wealthy woman was brutally murdered in her Glasgow home. The police found a convenient suspect in Oscar Slater--an immigrant Jewish cardsharp--who, despite his obvious innocence, was tried, convicted, and consigned to life at hard labor in a brutal Scottish prison. Conan Doyle, already world famous as the creator of Sherlock Holmes, was outraged by this injustice and became obsessed with the case. Using the methods of his most famous character, he scoured trial transcripts, newspaper accounts, and eyewitness statements, meticulously noting myriad holes, inconsistencies, and outright fabrications by police and prosecutors. Finally, in 1927, his work won Slater's freedom.Margalit Fox, a celebrated longtime writer for The New York Times, has "a nose for interesting facts, the ability to construct a taut narrative arc, and a Dickens-level gift for concisely conveying personality" (Kathryn Schulz, New York). In Conan Doyle for the Defense, she immerses readers in the science of Edwardian crime detection and illuminates a watershed moment in the history of forensics, when reflexive prejudice began to be replaced by reason and the scientific method.Praise for Conan Doyle for the Defense"Splendid . . . The ingredients are too good to pass up: a famous detective novelist actually playing detective, a man serving time for a murder he did not commit, and a criminal justice system slowly, and reluctantly, reckoning with the advent of forensic science." -- Sarah Weinman, The New Republic "Entertaining."--Newsday

    Every day she tries to bring care and comfort to those reaching the end of their lives and to help make dying more bearable. Rachel's training was put to the test in 2017 when her beloved GP father was diagnosed with terminal cancer. She learned that nothing - even the best palliative care - can sugar-coat the pain of losing someone you love. And yet, she argues, in a hospice there is more of what matters in life - more love, more strength, more kindness, more joy, more tenderness, more grace, more compassion - than you could ever imagine. For if there is a difference between people who know they are dying and the rest of us, it is simply this: that the terminally ill know their time is running out, while we live as though we have all the time in the world. Dear Life is a book about the vital importance of human connection, by the doctor we would all want by our sides at a time of crisis. It is a love letter - to a father, to a profession, to life itself.

    Guy Leschziner's patients, there is no rest for the weary in mind and body. Insomnia, narcolepsy, night terrors, sleep apnea, and sleepwalking are just a sampling of conditions afflicting sufferers who cannot sleep--and their experiences in trying are the stuff of nightmares. Demoniac hallucinations frighten people into paralysis. Restless legs rock both the sleepless and their sleeping partners with unpredictable and uncontrollable kicking. Out-of-sync circadian rhythms confuse the natural body clock's days and nights.Then there are the extreme cases. A woman in a state of deep sleep who gets dressed, unlocks her car, and drives for several miles before returning to bed. The man who has spent decades cleaning out kitchens while "sleep-eating." The teenager prone to the serious, yet unfortunately nicknamed "Sleeping Beauty Syndrome" stuck in a cycle of excessive unconsciousness, binge eating, and uncharacteristic displays of aggression and hyper-sexuality while awake.With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.

    It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict?In a blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores the morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function.Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom.

    Cole's harrowing account of his life spent in the ER and on the battlegrounds, fighting to save lives. In addition to his gripping stories of treating victims of gunshot wounds, stabbings, attempted suicides, flesh-eating bacteria, car crashes, industrial accidents, murder, and war, the book also covers the years during Cole's residency training when he was faced with 120-hour work weeks, excessive sleep deprivation, and the pressures of having to manage people dying of traumatic injury, often with little support.  Unlike the authors of other medical memoirs, Cole trained to be a surgeon in the military and served as a physician member of a Marine Corps reconnaissance unit, United States Special Operations Command (USSOCOM), and on a Navy Reserve SEAL team.  From treating war casualties in Afghanistan and Iraq to his experiences as a civilian trauma surgeon treating alcoholics, drug addicts, criminals, and the mentally deranged, TRAUMA is an intense look at one man's commitment to his country and to those most desperately in need of aid.

    I have loved and been loved. I have been given much and I have given something in return. Above all, I have been a sentient being, a thinking animal, on this beautiful planet, and that in itself has been an enormous privilege and adventure.” —Oliver SacksNo writer has succeeded in capturing the medical and human drama of illness as honestly and as eloquently as Oliver Sacks. During the last few months of his life, he wrote a set of essays in which he movingly explored his feelings about completing a life and coming to terms with his own death. “It is the fate of every human being,” Sacks writes, “to be a unique individual, to find his own path, to live his own life, to die his own death.”Together, these four essays form an ode to the uniqueness of each human being and to gratitude for the gift of life.

    “Wake up, you filthy beasts!” Wendy Hamill would shout to her children in the mornings before school. Startled from their dreams, Kirk and his two brothers couldn’t help but wonder—would they find enough food in the house for breakfast? Following a rancorous split from New York’s upper-class society, newly divorced Wendy and her three sons are exiled from the East Coast elite circle. Wendy’s middle son, Kirk, is eight when she moves the family to her native Bermuda, leaving the three young boys to fend for themselves as she chases after the highs of her old life: alcohol, a wealthy new suitor, and other indulgences. After eventually leaving his mother’s dysfunctional orbit for college in New Orleans, Kirk begins to realize how different his family and upbringing is from that of his friends and peers. Split between extreme privilege—early years living in luxury on his family’s private compound—and bare survival—rationing food and water during the height of his mother’s alcoholism—Kirk is used to keeping up appearances and burying his inconvenient truths from the world, until he’s eighteen and falls in love for the first time. A fascinating window into the life of extreme privilege and a powerful story of self-acceptance, Filthy Beasts recounts Kirk’s unforgettable journey through luxury hotels and charity stores, private enclaves and public shame as he confronts his family’s many imperfections, accepts his unconventional childhood, and finally comes to terms with his own hidden secrets.

    Babe Paley—known for her high-profile marriage to CBS founder William Paley and her ranking in the International Best-Dressed Hall of Fame—was one of the reigning monarchs of New York’s high society in the 1950s. Replete with gossip, scandal, betrayal, and a vibrant cast of real-life supporting characters, readers will be seduced by this startling new look at the infamous society swans.