Barron Lerner thought he had heard it all. But in the mid-1990s, his father, an infectious diseases physician, told him a stunning story: he had physically placed his body over an end-stage patient who had stopped breathing, preventing his colleagues from performing cardiopulmonary resuscitation, even though CPR was the ethically and legally accepted thing to do. Over the next few years, the senior Dr. Lerner tried to speed the deaths of his seriously ill mother and mother-in-law to spare them further suffering.These stories angered and alarmed the younger Dr. Lerner—an internist, historian of medicine and bioethicist—who had rejected physician-based paternalism in favor of informed consent and patient autonomy. The Good Doctor is a fascinating and moving account of how Dr. Lerner came to terms with two very different images of his father: a revered clinician, teacher and researcher who always put his patients first, but also a physician willing to “play God,” opposing the very revolution in patients' rights that his son was studying and teaching to his own medical students.But the elder Dr. Lerner’s journals, which he had kept for decades, showed his son how his outdated paternalism had grown out of a fierce devotion to patient-centered medicine that was rapidly disappearing in a world of managed care, spiraling costs and health care reform. And they raised questions: Are paternalistic doctors just relics or should their expertise be used to overrule patients and families that make ill-advised choices? Does the growing use of personalized medicine—in which specific interventions may be best for specific patients—change the calculus between autonomy and paternalism? And how can we best use technologies that were invented to save lives but now too often prolong death? In an era of high-technology medicine, spiraling costs and healthcare reform, these questions could not be more relevant. As his father slowly died of Parkinson’s disease, Dr. Lerner faced these questions both personally and professionally. He found himself being pulled into his dad’s medical care, even though he had criticized his father for making medical decisions for his relatives. Did playing God—at least in some situations—actually make sense? Did doctors sometimes “know best?” A timely and compelling story of one family’s engagement with medicine over the last half century, The Good Doctor is an important book for those who treat illness—and those who struggle to overcome it.

    These new discoveries are part of an old tradition. In the seventeenth century the philosopher Thomas Hobbes, dismayed by the impending civil war in England, decided that he would work out what kind of government was needed for a stable society. His solution sparked a new way of thinking about human behavior in looking for the "scientific" rules of society.Adam Smith, Immanuel Kant, Auguste Comte, and John Stuart Mill pursued this idea from different political perspectives. But these philosophers lacked the tools that modern physics can now bring to bear on the matter. Philip Ball shows how, by using these tools, we can understand many aspects of mass human behavior. Once we recognize that we do not make most of our decisions in isolation but are affected by what others decide, we can start to discern a surprising and perhaps even disturbing predictability in our laws, institutions, and customs.Lively and compelling, Critical Mass is the first book to bring these new ideas together and to show how they fit within the broader historical context of a rational search for better ways to live.

    Yet consciousness is subjective, personal, and famously difficult to examine: philosophers have for centuries declared this mental entity so mysterious as to be impenetrable to science.In The Ravenous Brain, neuroscientist Daniel Bor departs sharply from this historical view, and builds on the latest research to propose a new model for how consciousness works. Bor argues that this brain-based faculty evolved as an accelerated knowledge gathering tool. Consciousness is effectively an idea factory -- that choice mental space dedicated to innovation, a key component of which is the discovery of deep structures within the contents of our awareness.This model explains our brains"; ravenous appetite for information -- and in particular, its constant search for patterns. Why, for instance, after all our physical needs have been met, do we recreationally solve crossword or Sudoku puzzles? Such behavior may appear biologically wasteful, but, according to Bor, this search for structure can yield immense evolutionary benefits -- it led our ancestors to discover fire and farming, pushed modern society to forge ahead in science and technology, and guides each one of us to understand and control the world around us. But the sheer innovative power of human consciousness carries with it the heavy cost of mental fragility.Bor discusses the medical implications of his theory of consciousness, and what it means for the origins and treatment of psychiatric ailments, including attention-deficit disorder, schizophrenia, manic depression, and autism. All mental illnesses, he argues, can be reformulated as disorders of consciousness -- a perspective that opens up new avenues of treatment for alleviating mental suffering.A controversial view of consciousness, The Ravenous Brain links cognition to creativity in an ingenious solution to one of science's biggest mysteries.

    Rochman takes an authoritative look at the latest hot-button issues in the world of pre- and postnatal testing and tells the stories of women and men struggling to understand the variety of tests and grappling with their results—revelations that are sometimes joyous, sometimes heartbreaking, and often profound.Propelled by human narratives and meticulously reported, The Gene Machine introduces us to scientists working to unlock the secrets of the human genome; gene counselors and spiritual advisers helping parents manage this complex new reality; and, of course, parents themselves, including the author, who glimpse the genetic futures of their children. The Gene Machine is both a scientific road map and a meditation on our power to shape the future, one that gets to the very core of what it means to be human.

    Though the answers may seem simple, their profound implications make the prisoner's dilemma one of the great unifying concepts of science. Watching players bluff in a poker game inspired John von Neumann--father of the modern computer and one of the sharpest minds of the century--to construct game theory, a mathematical study of conflict and deception. Game theory was readily embraced at the RAND Corporation, the archetypical think tank charged with formulating military strategy for the atomic age, and in 1950 two RAND scientists made a momentous discovery.Called the prisoner's dilemma, it is a disturbing and mind-bending game where two or more people may betray the common good for individual gain. Introduced shortly after the Soviet Union acquired the atomic bomb, the prisoner's dilemma quickly became a popular allegory of the nuclear arms race. Intellectuals such as von Neumann and Bertrand Russell joined military and political leaders in rallying to the preventive war movement, which advocated a nuclear first strike against the Soviet Union. Though the Truman administration rejected preventive war the United States entered into an arms race with the Soviets and game theory developed into a controversial tool of public policy--alternately accused of justifying arms races and touted as the only hope of preventing them.A masterful work of science writing, Prisoner's Dilemma weaves together a biography of the brilliant and tragic von Neumann, a history of pivotal phases of the cold war, and an investigation of game theory's far-reaching influence on public policy today. Most important, Prisoner's Dilemma is the incisive story of a revolutionary idea that has been hailed as a landmark of twentieth-century thought.

    This offbeat comment in 1980 launched Cytowic's exploration into the oddity called synesthesia. He is one of the few world authorities on the subject. Sharing a root with anesthesia (no sensation), synesthesia means joined sensation, whereby a voice, for example, is not only heard but also seen, felt, or tasted. The trait is involuntary, hereditary, and fairly common. It stayed a scientific mystery for two centuries until Cytowic's original experiments led to a neurological explanation--and to a new concept of brain organization that accentuates emotion over reason. That chicken dinner two decades ago led Cytowic to explore a deeper reality that, he argues, exists in everyone but is often just below the surface of awareness (which is why finding meaning in our lives can be elusive). In this medical detective adventure, Cytowic shows how synesthesia, far from being a mere curiosity, illuminates a wide swath of mental life and leads to a new view of what is means to be human--a view that turns upside down conventional ideas about reason, emotional knowledge, and self-understanding. This 2003 edition features a new afterword.

    The book was based on a course of public lectures delivered by Schrödinger in February 1943 at Trinity College, Dublin. Schrödinger's lecture focused on one important question: "how can the events in space and time which take place within the spatial boundary of a living organism be accounted for by physics and chemistry?" In the book, Schrödinger introduced the idea of an "aperiodic crystal" that contained genetic information in its configuration of covalent chemical bonds. In the 1950s, this idea stimulated enthusiasm for discovering the genetic molecule and would give both Francis Crick and James Watson initial inspiration in their research.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions & bitter rivalries. With humility unspoiled by false modesty, Watson relates his & Crick's desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

    But most people who lived during the 10,000 years before the nineteenth century thought just the opposite. Drawing on archaeology, anthropology, biology, and history, Ian Morris explains why. Fundamental long-term changes in values, Morris argues, are driven by the most basic force of all: energy. Humans have found three main ways to get the energy they need--from foraging, farming, and fossil fuels. Each energy source sets strict limits on what kinds of societies can succeed, and each kind of society rewards specific values. But if our fossil-fuel world favors democratic, open societies, the ongoing revolution in energy capture means that our most cherished values are very likely to turn out not to be useful any more. Foragers, Farmers, and Fossil Fuels offers a compelling new argument about the evolution of human values, one that has far-reaching implications for how we understand the past--and for what might happen next. Originating as the Tanner Lectures delivered at Princeton University, the book includes challenging responses by classicist Richard Seaford, historian of China Jonathan Spence, philosopher Christine Korsgaard, and novelist Margaret Atwood.

    Like artists and poets, they are free spirits who resist the restrictions their cultures impose on them. In their pursuit of Nature’s truths, they are guided as much by imagination as by reason, and their greatest theories have the uniqueness and beauty of great works of art.Dyson argues that the best way to understand science is by understanding those who practice it. He tells stories of scientists at work, ranging from Isaac Newton’s absorption in physics, alchemy, theology, and politics, to Ernest Rutherford’s discovery of the structure of the atom, to Albert Einstein’s stubborn hostility to the idea of black holes. His descriptions of brilliant physicists like Edward Teller and Richard Feynman are enlivened by his own reminiscences of them. He looks with a skeptical eye at fashionable scientific fads and fantasies, and speculates on the future of climate prediction, genetic engineering, the colonization of space, and the possibility that paranormal phenomena may exist yet not be scientifically verifiable.Dyson also looks beyond particular scientific questions to reflect on broader philosophical issues, such as the limits of reductionism, the morality of strategic bombing and nuclear weapons, the preservation of the environment, and the relationship between science and religion. These essays, by a distinguished physicist who is also a lovely writer, offer informed insights into the history of science and fresh perspectives on contentious current debates about science, ethics, and faith.

    We don't do a chemical analysis on food we eat.Trust and cooperation are the first problems we had to solve before we could become a social species. In the 21st century, they have become the most important problems we need to solve — again. Our global society has become so large and complex that our traditional trust mechanisms no longer work.Bruce Schneier, world-renowned for his level-headed thinking on security and technology, tackles this complex subject head-on. Society can't function without trust, and yet must function even when people are untrustworthy.Liars and Outliers reaches across academic disciplines to develop an understanding of trust, cooperation, and social stability. From the subtle social cues we use to recognize trustworthy people to the laws that punish the noncompliant, from the way our brains reward our honesty to the bank vaults that keep out the dishonest, keeping people cooperative is a delicate balance of rewards and punishments. It's a series of evolutionary tricks, social pressures, legal mechanisms, and physical barriers.In the absence of personal relationships, we have no choice but to substitute security for trust, compliance for trustworthiness. This progression has enabled society to scale to unprecedented complexity, but has also permitted massive global failures.At the same time, too much cooperation is bad. Without some level of rule-breaking, innovation and social progress become impossible. Society stagnates.Today's problems require new thinking, and Liars and Outliers provides that. It is essential that we learn to think clearly about trust. Our future depends on it.

    In the majority of cases individuals diagnosed as "brain dead" are the source of the organs without which transplants could not take place. In this compelling and provocative examination, Margaret Lock traces the discourse over the past thirty years that contributed to the locating of a new criterion of death in the brain, and its routinization in clinical practice in North America. She compares this situation with that in Japan where, despite the availability of the necessary technology and expertise, brain death was legally recognized only in 1997, and then under limited and contested circumstances. Twice Dead explores the cultural, historical, political, and clinical reasons for the ready acceptance of the new criterion of death in North America and its rejection, until recently, in Japan, with the result that organ transplantation has been severely restricted in that country. This incisive and timely discussion demonstrates that death is not self-evident, that the space between life and death is historically and culturally constructed, fluid, multiple, and open to dispute. In addition to an analysis of that professional literature on and popular representations of the subject, Lock draws on extensive interviews conducted over ten years with physicians working in intensive care units, transplant surgeons, organ recipients, donor families, members of the general public in both Japan and North America, and political activists in Japan opposed to the recognition of brain death. By showing that death can never be understood merely as a biological event, and that cultural, medical, legal, and political dimensions are inevitably implicated in the invention of brain death, Twice Dead confronts one of the most troubling questions of our era.

    Instead we remain poised and frozen, overwhelmed by an always-on, live-streamed reality that our human bodies and minds can never truly inhabit. And our failure to do so has had wide-ranging effects on every aspect of our lives.People spent the twentieth century obsessed with the future. We created technologies that would help connect us faster, gather news, map the planet, compile knowledge, and connect with anyone, at anytime. We strove for an instantaneous network where time and space could be compressed.Well, the future's arrived. We live in a continuous now enabled by Twitter, email, and a so-called real-time technological shift. Yet this now is an elusive goal that we can never quite reach. And the dissonance between our digital selves and our analog bodies has thrown us into a new state of anxiety: present shock.Rushkoff weaves together seemingly disparate events and trends into a rich, nuanced portrait of how life in the eternal present has affected our biology, behavior, politics, and culture. He explains how the rise of zombie apocalypse fiction signals our intense desire for an ending; how the Tea Party and Occupy Wall Street form two sides of the same post-narrative coin; how corporate investing in the future has been replaced by futile efforts to game the stock market in real time; why social networks make people anxious and email can feel like an assault. He examines how the tragedy of 9/11 disconnected an entire generation from a sense of history, and delves into why conspiracy theories actually comfort us.As both individuals and communities, we have a choice. We can struggle through the onslaught of information and play an eternal game of catch-up. Or we can choose to live in the present: favor eye contact over texting; quality over speed; and human quirks over digital perfection. Rushkoff offers hope for anyone seeking to transcend the false now.Absorbing and thought-provoking, Present Shock is a wide-ranging, deeply thought meditation on what it means to be human in real-time.

    Never before have the cultural powers- that-be been able to exert such control over what we can and can't do with the culture around us. Our society defends free markets and free speech; why then does it permit such top-down control? To lose our long tradition of free culture, Lawrence Lessig shows us, is to lose our freedom to create, our freedom to build, and, ultimately, our freedom to imagine.