Tracing his rise from a pragmatic local official in Kentucky to the leader of the Republican opposition in Washington, the book tracks McConnell’s transformation from a moderate Republican who supported abortion rights and public employee unions to the embodiment of partisan obstructionism and conservative orthodoxy on Capitol Hill. Driven less by a shift in ideological conviction than by a desire to win elections and stay in power at all costs, McConnell’s transformation exemplifies the “permanent campaign” mindset that has come to dominate American government. From his first race for local office in 1977—when the ad crew working on it nicknamed McConnell “love-me-love-me” for his insecurity and desire to please—to his fraught accommodation of the Tea Party, McConnell’s political career is a story of ideological calcification and a vital mirror for understanding this country’s own political development and what is wrought when politicians serve not at the behest of country, but at the behest of party and personal aggrandizement.

    His Origin of Species forever changed our concept of the world’s creation. Darwin’s revolutionary career is the perfect vehicle for historian Paul Johnson. Marked by the insightful observation, spectacular wit, and highly readable prose for which Johnson is so well regarded, Darwin brings the gentleman-scientist and his times brilliantly into focus. From Darwin’s birth into great fortune to his voyage aboard the Beagle, to the long-delayed publication of his masterpiece, Johnson delves into what made this Victorian gentleman into a visionary scientist—and into the tragic flaws that later led Darwin to support the burgeoning eugenics movement.Johnson’s many admirers as well as history and science buffs will be grateful for this superb account of Darwin and the everlasting impact of his discoveries.

    Science writer and biologist Hanne Strager brings Darwin to life while offering the essential elements of evolution and how they affect us today.Much has been written on Darwin's life, his groundbreaking work, and the influence he has had on modern scientific thought and advancements, but most books assume a certain level of scientific knowledge. A Modest Genius changes that, offering an accessible, easy-to-understand discussion of Darwin's work.Readers follow Darwin from his early years through his travels. Hanne Strager explains how Darwin assembled the pieces of a fascinating puzzle while also describing the fundamental principles of evolution.Darwin's theory, by necessity, was incomplete when he proposed it. He lacked modern knowledge of the fossil record, DNA, and genetics. Strager explains how advances in these and other scientific areas expanded on Darwin's original work. She also discusses the ongoing conflict between religion and evolution, including the famous Scopes Monkey Trial and the battle Darwin himself fought between faith and intellect.Bold, exciting, and easily understood, A Modest Genius offers an opportunity to understand one of the greatest scientific breakthroughs of the modern age.

    Inheritance Conventional wisdom dictates that our genetic destiny is fixed at conception. But Dr. Moalem's groundbreaking book shows us that the human genome is far more fluid and fascinating than your ninth grade biology teacher ever imagined. By bringing us to the bedside of his unique and complex patients, he masterfully demonstrates what rare genetic conditions can teach us all about our own health and well-being. In the brave new world we're rapidly rocketing into, genetic knowledge has become absolutely crucial. Inheritance provides an indispensable roadmap for this journey by teaching you: -Why you may have recovered from the psychological trauma caused by childhood bullying-but your genes may remain scarred for life. -How fructose is the sugar that makes fruits sweet-but if you have certain genes, consuming it can buy you a one-way trip to the coroner's office. -Why ingesting common painkillers is like dosing yourself repeatedly with morphine-if you have a certain set of genes. -How insurance companies legally use your genetic data to predict the risk of disability for you and your children-and how that impacts the coverage decisions they make for your family. -How to have the single most important conversation with your doctor-one that can save your life. And finally: -Why people with rare genetic conditions hold the keys to medical problems affecting millions. In this trailblazing book, Dr. Moalem employs his wide-ranging and entertaining interdisciplinary approach to science and medicine-- explaining how art, history, superheroes, sex workers, and sports stars all help us understand the impact of our lives on our genes, and our genes on our lives. Inheritance will profoundly alter how you view your genes, your health--and your life.

    In college, I ran against Kenyans, and wondered whether endurance genes might have traveled with them from East Africa. At the same time, I began to notice that a training group on my team could consist of five men who run next to one another, stride for stride, day after day, and nonetheless turn out five entirely different runners. How could this be?We all knew a star athlete in high school. The one who made it look so easy. He was the starting quarterback and shortstop; she was the all-state point guard and high-jumper. Naturals. Or were they?The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training?The truth is far messier than a simple dichotomy between nature and nurture. In the decade since the sequencing of the human genome, researchers have slowly begun to uncover how the relationship between biological endowments and a competitor’s training environment affects athleticism. Sports scientists have gradually entered the era of modern genetic research.In this controversial and engaging exploration of athletic success, Sports Illustrated senior writer David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving this great riddle. He investigates the so-called 10,000-hour rule to uncover whether rigorous and consistent practice from a young age is the only route to athletic excellence.Along the way, Epstein dispels many of our perceptions about why top athletes excel. He shows why some skills that we assume are innate, like the bullet-fast reactions of a baseball or cricket batter, are not, and why other characteristics that we assume are entirely voluntary, like an athlete’s will to train, might in fact have important genetic components.This subject necessarily involves digging deep into sensitive topics like race and gender. Epstein explores controversial questions such as:Are black athletes genetically predetermined to dominate both sprinting and distance running, and are their abilities influenced by Africa’s geography?Are there genetic reasons to separate male and female athletes in competition?Should we test the genes of young children to determine if they are destined for stardom?Can genetic testing determine who is at risk of injury, brain damage, or even death on the field?Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.

    He seized the opportunity to do something "noble." Using an electric saw, Harvey sliced through the skull and gingerly removed the organ that would both define and haunt the rest of his life. Harvey struck a controversial deal with Einstein's family to keep the brain, swearing to safeguard it from souvenir hunters and publicity seekers, and to make it available only for serious scientific inquiry. Not a neuroscientist himself, he became the unlikely custodian of this object of intense curiosity and speculation, and the self-styled bulwark against the relentless power of Einstein's growing celebrity. Bridging the post-war era and the new millennium, Possessing Genius is the first comprehensive account of the circuitous path the brain took with Harvey during the decades it remained in his possession. Harvey permitted Einstein's gray matter to be sliced, diced, probed, prodded, and weighed by those hoping to solve the enigma and locate the source of genius itself. The brain was more than a subject of scientific investigation, it was a kind of holy relic; the history of its adventures since 1955 reflects the vicissitudes and vanities underpinning what we believe makes us human. Abraham has gathered together all of the fascinating details and documents of the brain's saga--including previously unpublished correspondence between Harvey and Otto Nathan, the executor of Einstein's estate—and from them woven a story that is both deeply engrossing and highly illuminating.

    The bestselling author of 'Damaged' tells the story of Dawn, a sweet and seemingly well-balanced girl whose outward appearance masks a traumatic childhood of suffering at the hands of the very people who should have cared for her.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    Suddenly the boy who had stood in the shadows, dreaming of ruling the world, was a public figure, and his popularity soared. Russia and an infatuated West were determined to see the progressive leader of their dreams, even as he seized control of media, sent political rivals and critics into exile or to the grave, and smashed the country's fragile electoral system, concentrating power in the hands of his cronies.As a journalist living in Moscow, Masha Gessen experienced this history firsthand, and for The Man Without a Face she has drawn on information and sources no other writer has tapped. Her account of how a "faceless" man maneuvered his way into absolute-and absolutely corrupt-power has the makings of a classic of narrative nonfiction.

    This critically acclaimed biography offers an unprecedented look at William Masters and Virginia Johnson, their pioneering studies on intimacy, and their lasting impact on the love lives of today's men and women.

    This adventure in science and imagination, which the Medical Tribune said might herald "a Copernican revolution for the life sciences," leads the reader through unexplored jungles and uncharted aspects of mind to the heart of knowledge.In a first-person narrative of scientific discovery that opens new perspectives on biology, anthropology, and the limits of rationalism, The Cosmic Serpent reveals how startlingly different the world around us appears when we open our minds to it.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    In The Violinist's Thumb, he explores the wonders of the magical building block of life: DNA.There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists. Kean's vibrant storytelling makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.

    Pairing Charles Darwin and a rare species of barnacle as her unlikely protagonists, Rebecca Stott has written an absorbing work of history that guides readers through the treacherous shoals of nineteenth-century biology. Beginning her scientific detective story in the 1820s, even before Darwin's Beagle voyage, Stott examines the mystery of why Darwin waited over two decades between formulating his pivotal theory of natural selection and publishing it. Lavishly illustrated, filled with riddles and concepts that challenge our notion of Victorian science, Darwin and the Barnacle is a thrilling account of how genius proceeds through indirection—and how one small item of curiosity contributed to history's most spectacular scientific breakthrough.