AA has become so infused in our society that it is practically synonymous with addiction recovery. Yet the evidence shows that AA has only a 5–10 percent success rate—hardly better than no treatment at all. Despite this, doctors, employers, and judges regularly refer addicted people to treatment programs and rehab facilities based on the 12-step model.   In The Sober Truth, acclaimed addiction specialist Dr. Lance Dodes exposes the deeply flawed science that the 12-step industry has used to support its programs. Dr. Dodes analyzes dozens of studies to reveal a startling pattern of errors, misjudgments, and biases. He also pores over the research to highlight the best peer-reviewed studies available and discovers that they reach a grim consensus on the program’s overall success.   But The Sober Truth is more than a book about addiction. It is also a book about science and how and why AA and rehab became so popular, despite the discouraging data. Dr. Dodes explores the entire story of AA’s rise, from its origins in early fundamentalist religious and mystical beliefs to its present-day place of privilege in politics and media.  The Sober Truth includes true stories from Dr. Dodes’s thirty-five years of clinical practice, as well as firsthand accounts submitted by addicts through an open invitation on the Psychology Today website. These stories vividly reveal the experience of walking the steps and attending some of the nation’s most famous rehabilitation centers.  The Sober Truth builds a powerful response to the monopoly of the 12-step program and explodes the myth that these programs offer an acceptable or universal solution to the deeply personal problem of addiction. This book offers new and actionable information for addicts, their families, and medical providers, and lays out better ways to understand addiction for those seeking a more effective and compassionate approach to this treatable problem.

    Days later, the madman was dead and Denis was framed for murder. A riveting exposé of the fierce debates, deadly politics, and cutthroat rivalries behind the first transfusion experiments, Blood Work takes us from dissection rooms in palaces to the streets of Paris, providing an unforgettable portrait of an era that wrestled with the same questions about morality and experimentation that haunt medical science today.

    Using his own research and experiences throughout the world, Lieberman recounts without jargon how and why humans evolved to walk, run, dig, and do other necessary and rewarding physical activities while avoiding needless exertion.Exercised is entertaining and enlightening but also constructive. As our increasingly sedentary lifestyles have contributed to skyrocketing rates of obesity and diseases such as diabetes, Lieberman audaciously argues that to become more active we need to do more than medicalize and commodify exercise.Drawing on insights from evolutionary biology and anthropology, Lieberman suggests how we can make exercise more enjoyable, rather than shaming and blaming people for avoiding it. He also tackles the question of whether you can exercise too much, even as he explains why exercise can reduce our vulnerability to the diseases mostly likely to make us sick and kill us.

    But it took a team of Oxford scientists headed by Howard Florey and Ernst Chain four more years to develop it as the first antibiotic, and the most important family of drugs in the twentieth century. At once the world was transformed—major bacterial scourges such as blood poisoning and pneumonia, scarlet fever and diphtheria, gonorrhea and syphilis were defeated as penicillin helped to foster not only a medical revolution but a sexual one as well. In his wonderfully engaging book, acclaimed author Eric Lax tells the real story behind the discovery and why it took so long to develop the drug. He reveals the reasons why credit for penicillin was misplaced, and why this astonishing achievement garnered a Nobel Prize but no financial rewards for Alexander Fleming, Florey, and his team. The Mold in Dr. Florey’s Coat is the compelling story of the passage of medicine from one era to the next and of the eccentric individuals whose participation in this extraordinary accomplishment has, until now, remained largely unknown.

    They had little trouble getting in. With scant scrutiny, many gained entry on their own as self-styled war "refugees," their pasts easily disguised and their war crimes soon forgotten. But some had help and protection from the U.S. government. The CIA, the FBI, and the military all put Hitler's minions to work as spies, intelligence assets, and leading scientists and engineers, whitewashing their histories. For the first time, once-secret government records and interviews tell the full story not only of the Nazi scientists brought to America, but of the German spies and con men who followed them and lived for decades as ordinary citizens. Only years after their arrival did private sleuths and government prosecutors begin trying to identify the hidden Nazis. But even then, American intelligence agencies secretly worked to protect a number of their prized spies from exposure. Today, a few Nazis still remain on our soil. Investigative reporter Eric Lichtblau, relying on a trove of newly discovered documents and scores of interviews with participants in this little-known chapter of postwar history, tells the shocking and shameful story of how America became a safe haven for Hitler's men.

    There is evidence from the archaeological record that Mycobacterium tuberculosis and its human hosts have been together for a very long time. The very mention of tuberculosis brings to mind romantic images of great literary figures pouring out their souls in creative works as their bodies were being decimated by consumption. It is a disease that at various times has had a certain glamour associated with it.From the medieval period to the modern day, Helen Bynum explores the history and development of tuberculosis throughout the world, touching on the various discoveries that have emerged about the disease over time, and focusing on the experimental approaches of Rene Laennec (1781-1826) and Robert Koch (1842-1910). Bynum also examines the place tuberculosis holds in the popular imagination and its role in various forms of the dramatic arts.The story of tuberculosis since the 1950s is complex, and Bynum describes the picture emerging from the World Health Organization of the difficulties that attended the management of the disease in the developing world. In the meantime, tuberculosis has emerged again in the West, both among the urban underclass and in association with a new infection - HIV. The disease has returned with a vengeance - in drug-resistant form. The story of tuberculosis is far from over.

    Leslie Jamison deftly excavates the stories we tell about addiction--both her own and others'--and examines what we want these stories to do, and what happens when they fail us.All the while, she offers a fascinating look at the larger history of the recovery movement, and at the literary and artistic geniuses whose lives and works were shaped by alcoholism and substance dependence, including John Berryman, Jean Rhys, Raymond Carver, Billie Holiday, David Foster Wallace, and Denis Johnson, as well as brilliant figures lost to obscurity but newly illuminated here.For the power of her striking language and the sharpness of her piercing observations, Jamison has been compared to such iconic writers as Joan Didion and Susan Sontag. Yet her utterly singular voice also offers something new. With enormous empathy and wisdom, Jamison has given us nothing less than the story of addiction and recovery in America writ large, a definitive and revelatory account that will resonate for years to come.

    Arthur Allen reveals a history of vaccination that is both illuminated with hope and shrouded by controversy - covering Jenner's discovery to Pasteur's vaccines for rabies and cholera, to those that safeguarded the children of the 20th century.

    But the wonderful development, however, in a few months, of a large, heterogeneous collection of men into a solid, keen, self-sacrificing unit, was but another instance of the way in which war improves the character and temperament of man. It was entirely new for men who were formerly in a regiment, full of traditions, to find themselves in the[...].

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    But why are they on the rise?     Science writer Moises Velasquez-Manoff offers a new and controversial way of thinking about autoimmune disease—one that may foster a paradigm shift in the way we think about health and hygiene.     In the early twentieth century, the dawn of improved hygiene, water treatment, vaccines, and antibiotics saved countless lives, eradicating diseases that had plagued humanity for millennia. But in the wake of this triumph, a new threat arose: The human immune system began to malfunction.     A growing body of evidence suggests that the very steps we took to cure these maladies have also eradicated organisms that once kept our bodies in balance. To combat this “epidemic of absence,” a group of scientists has begun deliberately reintroducing parasitic worms—helminthes—to calm the immune system of their hosts. This book takes a close look at the scientists at the vanguard of “worm therapy,” which has been proven to not only preempt immune malfunction, but to send a number of disorders—from Crohn’s Disease to multiple sclerosis to asthma—into remission.     Exploring the greater context of rampant immune system dysfunction in the developed world, and its implications for developing countries, Velasquez-Manoff offers an eye-opening and elegant portrait of science’s new view of the human organism.

    He made pills, powders, and potions that could kill or maim without a trace--including some intended for Fidel Castro and other foreign leaders. He paid prostitutes to lure clients to CIA-run bordellos, where they were secretly dosed with mind-altering drugs. His experiments spread LSD across the United States, making him a hidden godfather of the 1960s counterculture. For years he was the chief supplier of spy tools used by CIA officers around the world.Stephen Kinzer, author of groundbreaking books about U.S. clandestine operations, draws on new documentary research and original interviews to bring to life one of the most powerful unknown Americans of the twentieth century. Gottlieb's reckless experiments on "expendable" human subjects destroyed many lives, yet he considered himself deeply spiritual. He lived in a remote cabin without running water, meditated, and rose before dawn to milk his goats.During his twenty-two years at the CIA, Gottlieb worked in the deepest secrecy. Only since his death has it become possible to piece together his astonishing career at the intersection of extreme science and covert action. Poisoner in Chief reveals him as a clandestine conjurer on an epic scale.

    C. Gwynne’s Empire of the Summer Moon spans two astonishing stories. The first traces the rise and fall of the Comanches, the most powerful Indian tribe in American history. The second entails one of the most remarkable narratives ever to come out of the Old West: the epic saga of the pioneer woman Cynthia Ann Parker and her mixed-blood son Quanah, who became the last and greatest chief of the Comanches. Although readers may be more familiar with the tribal names Apache and Sioux, it was in fact the legendary fighting ability of the Comanches that determined just how and when the American West opened up. Comanche boys became adept bareback riders by age six; full Comanche braves were considered the best horsemen who ever rode. They were so masterful at war and so skillful with their arrows and lances that they stopped the northern drive of colonial Spain from Mexico and halted the French expansion westward from Louisiana. White settlers arriving in Texas from the eastern United States were surprised to find the frontier being rolled backward by Comanches incensed by the invasion of their tribal lands. So effective were the Comanches that they forced the creation of the Texas Rangers and account for the advent of the new weapon specifically designed to fight them: the six-gun. The war with the Comanches lasted four decades, in effect holding up the development of the new American nation. Gwynne’s exhilarating account delivers a sweeping narrative that encompasses Spanish colonialism, the Civil War, the destruction of the buffalo herds, and the arrival of the railroads—a historical feast for anyone interested in how the United States came into being. Against this backdrop Gwynne presents the compelling drama of Cynthia Ann Parker, a lovely nine-year-old girl with cornflower-blue eyes who was kidnapped by Comanches from the far Texas frontier in 1836. She grew to love her captors and became infamous as the "White Squaw" who refused to return until her tragic capture by Texas Rangers in 1860. More famous still was her son Quanah, a warrior who was never defeated and whose guerrilla wars in the Texas Panhandle made him a legend. S. C. Gwynne’s account of these events is meticulously researched, intellectually provocative, and, above all, thrillingly told.

    But to those who collect them, the map trade can be a cutthroat business, inhabited by quirky and sometimes disreputable characters in search of a finite number of extremely rare objects. Once considered a respectable antiquarian map dealer, E. Forbes Smiley spent years doubling as a map thief —until he was finally arrested slipping maps out of books in the Yale University library. The Map Thief delves into the untold history of this fascinating high-stakes criminal and the inside story of the industry that consumed him. Acclaimed reporter Michael Blanding has interviewed all the key players in this stranger-than-fiction story, and shares the fascinating histories of maps that charted the New World, and how they went from being practical instruments to quirky heirlooms to highly coveted objects. Though pieces of the map theft story have been written before, Blanding is the first reporter to explore the story in full—and had the rare privilege of having access to Smiley himself after he’d gone silent in the wake of his crimes. Moreover, although Smiley swears he has admitted to all of the maps he stole, libraries claim he stole hundreds more—and offer intriguing clues to prove it. Now, through a series of exclusive interviews with Smiley and other key individuals, Blanding teases out an astonishing tale of destruction and redemption. The Map Thief interweaves Smiley’s escapades with the stories of the explorers and mapmakers he knew better than anyone. Tracking a series of thefts as brazen as the art heists in Provenance and a subculture as obsessive as the oenophiles in The Billionaire’s Vinegar, Blanding has pieced together an unforgettable story of high-stakes crime.

    Grant's life has typically been misunderstood. All too often he is caricatured as a chronic loser and inept businessman, fond of drinking to excess; or as the triumphant but brutal Union general of the Civil War; or as a credulous and hapless president whose tenure came to symbolize the worst excesses of the Gilded Age. These stereotypes don't come close to capturing adequately his spirit and the sheer magnitude of his monumental accomplishments. A biographer at the height of his powers, Chernow has produced a portrait of Grant that is a masterpiece, the first to provide a complete understanding of the general and president whose fortunes rose and fell with dizzying speed and frequency. Before the Civil War, Grant was flailing. His business ventures had been dismal, and despite distinguished service in the Mexican War, he ended up resigning from the army in disgrace amid recurring accusations of drunkenness. But in the Civil War, Grant began to realize his remarkable potential, soaring through the ranks of the Union army, prevailing at the Battle of Shiloh and in the Vicksburg campaign and ultimately defeating the legendary Confederate general Robert E. Lee after a series of unbelievably bloody battles in Virginia. Along the way Grant endeared himself to President Lincoln and became his most trusted general and the strategic genius of the war effort. His military fame translated into a two-term presidency, but one plagued by corruption scandals involving his closest staff. All the while Grant himself remained more or less above reproach. But, more importantly, he never failed to seek freedom and justice for black Americans, working to crush the Ku Klux Klan and earning the admiration of Frederick Douglass, who called him 'the vigilant, firm, impartial, and wise protector of my race." After his presidency, he was again brought low by a trusted colleague, this time a dashing young swindler on Wall Street, but he resuscitated his image by working with Mark Twain to publish his memoirs, which are recognized as a masterpiece of the genre. With his famous lucidity, breadth, and meticulousness, Chernow finds the threads that bind these disparate stories together, shedding new light on the man whom Walt Whitman described as "nothing heroic... and yet the greatest hero." His probing portrait of Grant's lifelong struggle with alcoholism transforms our understanding of the man at the deepest level. This is America's greatest biographer, bringing movingly to life one of America's finest but most underappreciated presidents. The definitive biography, Grant is a grand synthesis of painstaking research and literary brilliance that makes sense of all sides of Grant's life, explaining how this simple Midwesterner could at once be so ordinary and so extraordinary.