The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain.Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

    In 1887, 23-year-old reporter Nellie Bly had herself committed to a New York City asylum for 10 days to expose the horrific conditions for 19th-century century mental patients.

    I was mentally and physically broken. So fractured, I hadn't eaten properly or slept well, or even changed my expression for months. I sat in a cubicle, behind paper-thin curtains, listening to the rest of the hospital happen around me, and I shook with the effort of not crying. I was an inch away from defeat, from the acceptance of a failure I assumed would be inevitable, but I knew I had to carry on. I had to somehow walk through it.Because I wasn't the patient. I was the doctor."A frank account of mental health from both sides of the doctor-patient divide, from the bestselling author of The Trouble with Goats and Sheep and Three Things About Elsie, based on her own experience as a doctor working on a psychiatric ward.

    In my case, blinking my left eyelid is my only means of communication.’In December 1995, Jean-Dominique Bauby, editor-in-chief of French ‘Elle’ and the father of two young children, suffered a massive stroke and found himself paralysed and speechless, but entirely conscious, trapped by what doctors call ‘locked-in syndrome’. Using his only functioning muscle – his left eyelid – he began dictating this remarkable story, painstakingly spelling it out letter by letter.His book offers a haunting, harrowing look inside the cruel prison of locked-in syndrome, but it is also a triumph of the human spirit.

    From difficult births and unexpected deaths to moral quandaries and bureaucratic disasters, O'Mahony documents life in the halls that all of us will visit at some point in our lives with his characteristic wit and dry and unsentimental intelligence. As the Coronavirus crisis demands more and more of the medical profession and the people who support it, Seamus O'Mahony describes his work on the front lines of a pandemic in a harrowing final chapter. This is not a conventional medical memoir: it's the collective biography of one of our great modern institutions, the general hospital, through the eyes of a brilliant writer who happens to be a gifted doctor.

    She followed with two other smash bestsellers: Cherry and Lit, which were critical hits as well.For thirty years Karr has also taught the form, winning graduate teaching prizes for her highly selective seminar at Syracuse, where she mentored such future hit authors as Cheryl Strayed, Keith Gessen, and Koren Zailckas. In The Art of Memoir, she synthesizes her expertise as professor and therapy patient, writer and spiritual seeker, recovered alcoholic and “black belt sinner,” providing a unique window into the mechanics and art of the form that is as irreverent, insightful, and entertaining as her own work in the genre.Anchored by excerpts from her favorite memoirs and anecdotes from fellow writers’ experience, The Art of Memoir lays bare Karr’s own process. (Plus all those inside stories about how she dealt with family and friends get told— and the dark spaces in her own skull probed in depth.) As she breaks down the key elements of great literary memoir, she breaks open our concepts of memory and identity, and illuminates the cathartic power of reflecting on the past; anybody with an inner life or complicated history, whether writer or reader, will relate.Joining such classics as Stephen King’s On Writing and Anne Lamott’s Bird by Bird, The Art of Memoir is an elegant and accessible exploration of one of today’s most popular literary forms—a tour de force from an accomplished master pulling back the curtain on her craft.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Kim Miller is an immaculately put-together woman with a great career, a loving boyfriend, and a beautifully tidy apartment in Brooklyn. You would never guess that she spent her childhood hiding behind the closed doors of her family’s idyllic Long Island house, navigating between teetering stacks of aging newspaper, broken computers, and boxes upon boxes of unused junk festering in every room—the product of her father’s painful and unending struggle with hoarding. In this coming-of-age story, Kim brings to life her experience of growing up in a rat-infested home, concealing her father’s shameful secret from friends for years, and of the emotional burden that ultimately led to an attempt to take her own life. And in beautiful prose, Miller sheds light on her complicated yet loving relationship with her parents that has thrived in spite of the odds. Coming Clean is a story about recognizing where we come from and the relationships that define us—and about finding peace in the homes we make for ourselves.

    After she suffers a brief but serious illness at the age of ninety-one, they resolve to change their relationship by beginning a year-long conversation unlike any they had ever had before. The result is a correspondence of surprising honesty and depth in which they discuss their lives, the things that matter to them, and what they still want to learn about each other.Both a son’s love letter to his mother and an unconventional mom’s life lessons for her grown son, The Rainbow Comes and Goes offers a rare window into their close relationship and fascinating life stories, including their tragedies and triumphs. In these often humorous and moving exchanges, they share their most private thoughts and the hard-earned truths they’ve learned along the way. In their words their distinctive personalities shine through—Anderson’s journalistic outlook on the world is a sharp contrast to his mother’s idealism and unwavering optimism.An appealing memoir with inspirational advice, The Rainbow Comes and Goes is a beautiful and affectionate celebration of the universal bond between a parent and a child, and a thoughtful reflection on life, reminding us of the precious insight that remains to be shared, no matter our age.

    Lauren Collins discovered this firsthand when, in her early thirties, she moved to London and fell for a Frenchman named Olivier—a surprising turn of events for someone who didn’t have a passport until she was in college. But what does it mean to love someone in a second language? Collins wonders, as her relationship with Olivier continues to grow entirely in English. Are there things she doesn’t understand about Olivier, having never spoken to him in his native tongue? Does “I love you” even mean the same thing as “Je t’aime”? When the couple, newly married, relocates to Francophone Geneva, Collins—fearful of one day becoming "a Borat of a mother" who doesn’t understand her own kids—decides to answer her questions for herself by learning French. When in French is a laugh-out-loud funny and surprising memoir about the lengths we go to for love, as well as an exploration across culture and history into how we learn languages—and what they say about who we are. Collins grapples with the complexities of the French language, enduring excruciating role-playing games with her classmates at a Swiss language school and accidentally telling her mother-in-law that she’s given birth to a coffee machine. In learning French, Collins must wrestle with the very nature of French identity and society—which, it turns out, is a far cry from life back home in North Carolina. Plumbing the mysterious depths of humanity’s many forms of language, Collins describes with great style and wicked humor the frustrations, embarrassments, surprises, and, finally, joys of learning—and living in—French.

    The center of Tamara’s universe is Shopsin’s, her family’s legendary corner store/restaurant/hangout, run by her inimitable dad, Kenny—a brilliant, loquacious, contrary, huge-hearted man who, aside from dishing up New York’s best egg salad on rye, is Village sheriff, philosopher, and fixer all at once. We follow Kenny as he pursues his destiny through early factory jobs, superintendent gigs, and crossword-puzzle mania. His temper flares as often as his humor, keeping Tamara, her mom, and her siblings constantly off-balance but giddy to be along for the always bracing ride. And the cast of supporting characters is unforgettable—oddballs and misfits, cops and con men, sax players and waitresses, longshoremen and poets, and crafty Willoughby “Willy” Jones, an old-time swindler and lady-killer from the South who improbably becomes Kenny’s foil and best friend. All comers find a place at Shopsin’s table and feast on Kenny’s tall tales and trenchant advice along with the incomparable chili con carne.At its core, Arbitrary Stupid Goal is about the secrets of living an unconventional life, which is becoming a forgotten art. It’s a place where serendipity trumps logic and overplanning can cause you to miss out on the fun of a midnight walk to the giant bubbling margarita glass perched precariously over the Mexican joint on Seventh Avenue. It’s about taking the day as it flows, treasuring experiences over things, and embracing the crazy but essential messiness of relationships.Filled with clever illustrations and witty, nostalgic photographs and graphics, and told in a sly, elliptical narrative that is both hilarious and endearing, Arbitrary Stupid Goal is an offbeat memory-book mosaic that will encourage readers to rediscover the vital spontaneity that we may have unwisely traded for the shelter of predictability.

    The daughter of immigrants, she was raised in an Oakland, California community that cared deeply about social justice; her parents--an esteemed economist from Jamaica and an admired cancer researcher from India--met as activists in the civil rights movement when they were graduate students at Berkeley. Growing up, Harris herself never hid her passion for justice, and when she became a prosecutor out of law school, a deputy district attorney, she quickly established herself as one of the most innovative change agents in American law enforcement. She progressed rapidly to become the elected District Attorney for San Francisco, and then the chief law enforcement officer of the state of California as a whole. Known for bringing a voice to the voiceless, she took on the big banks during the foreclosure crisis, winning a historic settlement for California's working families. Her hallmarks were applying a holistic, data-driven approach to many of California's thorniest issues, always eschewing stale "tough on crime" rhetoric as presenting a series of false choices. Neither "tough" nor "soft" but smart on crime became her mantra. Being smart means learning the truths that can make us better as a community, and supporting those truths with all our might. That has been the pole star that guided Harris to a transformational career as the top law enforcement official in California, and it is guiding her now as a transformational United States Senator, grappling with an array of complex issues that affect her state, our country, and the world, from health care and the new economy to immigration, national security, the opioid crisis, and accelerating inequality.By reckoning with the big challenges we face together, drawing on the hard-won wisdom and insight from her own career and the work of those who have most inspired her, Kamala Harris offers in The Truths We Hold a master class in problem-solving, in crisis management, and leadership in challenging times. Through the arc of her own life, on into the great work of our day, she communicates a vision of shared struggle, shared purpose, and shared values. In a book rich in many home truths, not least is that a relatively small number of people work very hard to convince a great many of us that we have less in common than we actually do, but it falls to us to look past them and get on with the good work of living our common truth. When we do, our shared effort will continue to sustain us and this great nation, now and in the years to come.

    As the mother of forensic science, Frances Glessner Lee is the reason why homicide detectives are a thing. She is responsible for the popularity of forensic science in television shows and pop culture. Long overlooked in the history books, this extremely detailed and thoroughly researched biography will at long last tell the story of the life and contributions of this pioneering woman.

    Bit by bit a mysterious illness stole away the pieces of his life: First, it took the strength of his legs, then his voice, and his ability to eat. Finally, even the sound of a footstep in his room became unbearable. The Puzzle Solver follows several years in which he desperately sought answers from specialist after specialist, where at one point his 6'3" frame dropped to 115 lbs. For years, he underwent endless medical tests, but doctors told him there was nothing wrong. Then, finally, a diagnosis: Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis.In the 80s, when an outbreak of people immobilized by an indescribable fatigue were reported near Lake Tahoe, Nevada, doctors were at a loss to explain the symptoms. The condition would alternatively be nicknamed Raggedy Ann Syndrome or the Yuppie Disease, and there was no cure or answers about treatment. They were to remain sick.But there was one answer: Whitney's father, Ron Davis, PhD, a world-class geneticist at Stanford University whose legendary research helped crack the code of DNA, suddenly changed the course of his career in a race against time to cure his son's debilitating condition.In The Puzzle Solver, journalist Tracie White, who first wrote a viral and award-winning piece on Davis and his family in Stanford Medicine, tells his story. In gripping prose, she masterfully takes readers along on this journey with Davis to solve one of the greatest mysteries in medicine. In a piercing investigative narrative, closed doors are opened, and masked truths are exposed as Davis uncovers new proof confirming that Chronic Fatigue Syndrome is a biological disease.At the heart of this book is a moving story that goes far beyond medicine, this is a story about how the power of love -- and science -- can shine light in even the darkest, most hidden, corners of the world.

    It's about a bus trip really, because it's my view from the Number 12 bus (mostly top deck, the seat at the front on the right), a double-decker that plies its way from Dulwich, in South East London, where I was living, to where I sometimes work - at the BBC, in the heart of the capital. It's not a sensible way to write a memoir at all, probably, but it's the way things pop into your head as you travel, so it's my way'.From London facts including where to find the blue plaque for Una Marson, 'The first black woman programme maker at the BBC', to discovering the best Spanish coffee under Southwark's railway arches; from a brief history of lady gangsters at Elephant and Castle to memories of climbing Mount Sinai and, at the request of a fellow traveller, reading aloud the Ten Commandments; from the story behind Pissarro's painting of Dulwich Station to performing in Footlights with Emma Thompson; from painful memoires of being sent to Coventry while at a British boarding school to thinking about how Wombells Travelling Circus of 1864 haunts Peckham Rye;from anecdotes about meeting Prince Charles, Monica Lewinsky and Grayson Perry to Bake-Off antics; from stories of a real and lasting friendship with John McCarthy to the importance of family and the daunting navigation of the Zambezi River in her father's canoe, this Sandi Toksvig-style memoir is, as one would expect and hope, packed full of surprises. A funny and moving trip through memories, musings and the many delights on the Number 12 route, Between the Stops is also an inspiration to us all to get off our phones, look up and to talk to each other because as Sandi says: 'some of the greatest trips lie on our own doorstep'.