Includes detailed maps and information on all the characters and creatures contained in the medieval world of RuneScape.

    Bronowski was both a distinguished mathematician and a poet, a philosopher of science and a literary critic who wrote a well-known study of William Blake. Dr. Bronowski's very career was founded on the premise of an intimate connection between science and the humanities, disciplines which are still generally thought to be worlds apart.The Common Sense of Science, a book which remains as topical today as it was when it first appeared twenty-five years ago, articulates and develops Bronowski's provocative idea that the sciences and the arts fundamentally share the same imaginative vision.

    The result is a wealth of stimulating ideas set among clear explanations drawn from a revelatory decade in biology."—Andrew H. Knoll, author of Life on a Young Planet"Thought-provoking and lucidly written. . . . The Plausibility of Life will help readers understand not just the plausibility of evolution, but its remarkable, inventive powers." —Sean Carroll, author of Endless Forms Most Beautiful: The New Science of Evo Devo“Remarkably lucid and comprehensive, this new theoretical synthesis will . . . shift the grounds for debate in the controversy surrounding organic evolution.”—Booklist (starred review)

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    As these units join their RAF cousins during the Battle of Britain, famous woman aviator Amelia Earhart (who survived her world-circling flight) emerges as a rallying point for those willing to stand against fascism.

    government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work.At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society. The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry.From the Hardcover edition.

    Lewis Dartnell considers some of the fascinating questions facing researchers today. Could life exist anywhere else in the universe? What might aliens really look like? Dartnell explains why Earth is uniquely suited for life and reveals our profound connection to the cosmos.

    Little is known about Alpha Trion, and the rest of the Thirteen Primes have been shrouded in mystery—until now. Transformers: The Covenant of Primus reveals the stories of these ancient heroes for the first time. It chronicles the saga of Optimus Prime and Megatron and covers the full history of the Transformers. Never-before-seen illustrations depict battles, portraits of the Thirteen Primes, and detailed scenes of the Transformers’ world. Offering insight into their origins, the Golden Age of exploration, the great civil war between the Autobots and Decepticons, and much more, this book is the definitive in-world history of the Transformers.Product Features:Autobot shield case with three-part interlocking manual opening system and three classic Transformers audio effectsHardcover book with newly commissioned cover art, 20 newly commissioned illustrations, and many never-before-seen images from the Hasbro archive

    A. Salvatore was born in Massachusetts in 1959. His first published novel was The Crystal Shard. He has since published more than a dozen novels, including the New York Times bestsellers The Halfling's Gem, Sojourn, The Legacy, and Starless Night. He makes his home in Massachusetts with his wife, Diane, and their three children. "From the Paperback edition."

    Our instincts—for food, sex, or territorial protection— evolved for life on the savannahs 10,000 years ago, not in today’s world of densely populated cities, technological innovations, and pollution. We now have access to a glut of larger-than-life objects, from candy to pornography to atomic weapons—that gratify these gut instincts with often-dangerous results. Animal biologists coined the term “supernormal stimuli” to describe imitations that appeal to primitive instincts and exert a stronger pull than real things, such as soccer balls that geese prefer over eggs. Evolutionary psychologist Deirdre Barrett applies this concept to the alarming disconnect between human instinct and our created environment, demonstrating how supernormal stimuli are a major cause of today’s most pressing problems, including obesity and war. However, Barrett does more than show how unfettered instincts fuel dangerous excesses. She also reminds us that by exercising self-control we can rein them in, potentially saving ourselves and civilization. 55 illustrations.

    They unearthed a treasure trove of Cretaceous dinosaurs and mammals, including several new species, that has already helped to reshape our understanding of the dinosaur age. In Dinosaurs of the Flaming Cliffs, team leader Michael Novacek, Provost of Science of the American Museum of Natural History and Curator of Vertebrate Paleontology, re-creates the day-to-day drama of field exploration over the past six years in the Gobi and recounts his and his colleagues' historic discoveries, reported in front-page headlines across the world. In a remarkable narrative that interweaves expedition chapters with in-depth scientific discussions on the nature and importance of the fossil record, Novacek takes us on a journey that explores the very nature of scientific inquiry and dinosaur research.

    From the "phantom pain" experienced by people who have lost their limbs to the uncanny faculty of "blindsight," Humphrey argues that raw sensations are central to all conscious states and that consciousness must have evolved, just like all other mental faculties, over time from our ancestors' bodily responses to pain and pleasure. '

    This is the paperback edition of Shah's companion volume to the The Commanding Self, wherein he sets out to illuminate the barriers which prevent deeper knowledge and understanding.

    With the help of a beguiling mix of illustrated optical illusions and puzzles, anecdotes, mathematics, and philosophy, Ings reveals age-old mysteries from how humans perceive color to Woody Allen's ability to raise the inner corners of his eyebrows." A Natural History of Seeing delves into both the evolution of sight and the evolution of our understanding of sight. It gives us the natural science - the physics of light and the biology of animals and humans alike - while also addressing Leonardo da Vinci's theories of perception in painting and Homer's confused and strangely limited sense of color. Panoramic in every sense, it reaches back to the first seers (and to ancient beliefs that vision is the product of mysterious optic rays) and forward to the promise of modern experiments in making robots that see.