If animals could talk, we would ask them to recall their own ancestries, in particular the secrets as to how they avoided almost inevitable annihilation in the face of daily assaults by predators, climactic cataclysms, deadly infections and innate diseases.In Tears of the Cheetah, medical geneticist and conservationist Stephen J. O'Brien narrates fast-moving science adventure stories that explore the mysteries of survival among the earth's most endangered and beloved wildlife. Here we uncover the secret histories of exotic species such as Indonesian orangutans, humpback whales, and the imperiled cheetah-the world's fastest animal which nonetheless cannot escape its own genetic weaknesses.Among these genetic detective stories we also discover how the Serengeti lions have lived with FIV (the feline version of HIV), where giant pandas really come from, how bold genetic action pulled the Florida panther from the edge of extinction, how the survivors of the medieval Black Death passed on a genetic gift to their descendents, and how mapping the genome of the domestic cat solved a murder case in Canada.With each riveting account of animal resilience and adaptation, a remarkable parallel in human medicine is drawn, adding yet another rationale for species conservation-mining their genomes for cures to our own fatal diseases. Tears of the Cheetah offers a fascinating glimpse of the insight gained when geneticists venutre into the wild.

    But our burrowing roots go back to the very beginnings of animal life on earth. Without burrowing, the planet would be very different today. Many animal lineages alive now—including our own—only survived a cataclysmic meteorite strike 65 million years ago because they went underground.On a grander scale, the chemistry of the planet itself had already been transformed many millions of years earlier by the first animal burrows, which altered whole ecosystems. Every day we walk on an earth filled with an under-ground wilderness teeming with life. Most of this life stays hidden, yet these animals and their subterranean homes are ubiquitous, ranging from the deep sea to mountains, from the equator to the poles.Burrows are a refuge from predators, a safe home for raising young, or a tool to ambush prey. Burrows also protect animals against all types of natural disasters: fires, droughts, storms, meteorites, global warmings—and coolings. In a book filled with spectacularly diverse fauna, acclaimed paleontologist and ichnologist Anthony Martin reveals this fascinating, hidden world that will continue to influence and transform life on this planet.

    Using meticulous multidisciplinary science, as well as reviewing the history of our understanding about evolution, this book makes the case that aging is not something that “just happens,” nor is it the result of wear and tear or a genetic inevitability. Rather, aging has a fascinating evolutionary purpose: to stabilize populations and ecosystems, which are ever-threatened by cyclic swings that can lead to extinction.When a population grows too fast it can put itself at risk of a wholesale wipeout. Aging has evolved to help us adjust our growth in a sustainable fashion as well as prevent an ecological crisis from starvation, predation, pollution, or infection.This dynamic new understanding of aging is provocative, entertaining, and pioneering, and will challenge the way we understand aging, death, and just what makes us human.

    They made the world theirs long before the rise of dinosaurs. Travelling forward into the Permian and then Triassic periods, we learn how our ancient mammal ancestors evolved from large hairy beasts with accelerating metabolisms to exploit miniaturisation, which was key to unlocking the traits that define mammals as we now know them. Elsa criss-crosses the globe to explore the sites where discoveries are being made and meet the people who make them. In Scotland, she traverses the desert dunes of prehistoric Moray, where quarry workers unearthed the footprints of Permian creatures from before the time of dinosaurs. In South Africa, she introduces us to animals, once called 'mammal-like reptiles', that gave scientists the first hints that our furry kin evolved from a lineage of egg-laying burrowers. In China, new, complete fossilised skeletons reveal mammals that were gliders, shovel-pawed Jurassic moles, and flat-tailed swimmers.This book radically reframes the narrative of our mammalian ancestors and provides a counterpoint to the stereotypes of mighty dinosaur overlords and cowering little mammals. It turns out the earliest mammals weren't just precursors, they were pioneers.

    Left untouched were many of the things known to cause cancer, including tobacco, the workplace, radiation, or the global environment. Proof of how the world in which we live and work affects whether we get cancer was either overlooked or suppressed. This has been no accident. The War on Cancer was run by leaders of industries that made cancer-causing products, and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies-a legacy that persists to this day. This is the gripping story of a major public health effort diverted and distorted for private gain. A portion of the profits from this book will go to support research on cancer prevention.

    Tripping over the Truth follows the story of cancers proposed metabolic origin from the vaunted halls of the German scientific golden age, to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.Transporting us on a rich narrative of humanities struggle to understand the cellular events that conspire to form malignancy, it reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit and fortitude. Ultimately we arrive at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease. For anyone affected by this terrifying disease, and the physicians who struggle to treat it, Tripping Over the Truth provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. Therapies that may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle-map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current "targeted" revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart -the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.

    When an epidemic hits, the EIS will be there to crack the case, however mysterious or deadly, saving countless lives in the process. Over the years they have successfully battled polio, cholera, and smallpox, to name a few, and in recent years have turned to the epidemics killing us now--smoking, obesity, and gun violence among them.The successful EIS model has spread internationally: former EIS officers on the staff of the Centers for Disease Control have helped to establish nearly thirty similar programs around the world. EIS veterans have gone on to become leaders in the world of public health in organizations such as the World Health Organization."Inside the Outbreaks" takes readers on a riveting journey through the history of this remarkable organization, following Epidemic Intelligence Service officers on their globetrotting quest to eliminate the most lethal and widespread threats to the world's health.

    It includes even more new monographs and the latest FDA approvals. This updated edition is a book that students can count on with vital information for Peds, as well as precautions for all vulnerable populations. From pediatrics to geriatrics and from pregnancy to breast feeding considerations, "Davis's Drug Guide for Nurses" addresses the entire lifespan.

    But we long to know more: how did these animals actually behave? We are fascinated by the daily lives of our fellow creatures--how they reproduce and raise their young, how they hunt their prey or elude their predators, and more. What would it be like to see prehistoric animals as they lived and breathed?From dinosaurs fighting to their deaths to elephant-sized burrowing ground sloths, this book takes readers on a global journey deep into the earth's past. Locked in Time showcases fifty of the most astonishing fossils ever found, brought together in five fascinating chapters that offer an unprecedented glimpse at the real-life behaviors of prehistoric animals. Dean R. Lomax examines the extraordinary direct evidence of fossils captured in the midst of everyday action, such as dinosaurs sitting on their eggs like birds, Jurassic flies preserved while mating, a T. rex infected by parasites. Each fossil, he reveals, tells a unique story about prehistoric life. Many recall behaviors typical of animals familiar to us today, evoking the chain of evolution that links all living things to their distant ancestors. Locked in Time allows us to see that fossils are not just inanimate objects: they can record the life stories of creatures as fully alive as any today. Striking and scientifically rigorous illustrations by renowned paleoartist Bob Nicholls bring these breathtaking moments to life.

    In this book you will see how commonly performed operations can be found to be useless or even harmful when properly evaluated. That these claims come from an experienced, practicing orthopedic surgeon who performs many of these operations himself, makes the unsettling argument particularly compelling. Of course no surgeon is recommending invasive surgery in bad faith, but Ian Harris argues that the evidence for the success for many common operations, including knee arthroscopies, back fusion or cardiac stenting, become current accepted practice without full examination of the evidence.

    While it’seasy to see that stress affects health and well-being, or that your blood pressure rises when you’re angry, cutting-edge research shows that the mind-body connection goes much further.Numerous studies on the brain’s interaction with the body demonstrate that health is directly affected by our social environments, socioeconomic status, culture, behaviors, relationships, psychological states, and habits of mind, among many factors. Current mind-body science reveals facts such as these: As few as eight weeks of mindfulness meditation can meaningfully boost your immune system. Extreme stress and low social support increase the risk of breast cancer by a factor of 9. Contact with nature is correlated with numerous positive health outcomes, including improved attention for children, reduced stress, and enhanced work performance. Chronic hostility portends calcification of the coronary arteries, even in young people. Expressive writing by patients is correlated with improved outcomes for both asthma and rheumatoid arthritis.Mind-body medicine—working in tandem with traditional medical practice—makes use of a large spectrum of psychological, physical, and behavioral treatments, drawn from many disciplines, in an approach to health care that aims to treat the whole person. It provides highly effective resources for preventing and treating a wide range of medical conditions, such as cardiovascular disease, stress, cancer, and depression—as well as for fostering the ultimate goals of health care: truly optimal and lasting physical health, and emotional and psychological well-being.A knowledge of this exciting field offers you critical understanding of the state of the art of health care and a significant new direction in medicine. But beyond valuable knowledge, a grounding in mind-body medicine gives you numerous practical, empowering tools for your own health care, as well as that of your family—tools that can make a profound difference for healthful, vibrant living.In Mind-Body Medicine: The New Science of Optimal Health, you’ll study this subject in compelling depth, with the expert guidance of Professor Jason M. Satterfield of the University of California, San Francisco. These 36 eye-opening lectures offer you a comprehensive overview of the field, providing rigorous answers to the questions of what makes us sick, what makes us well, and what we can do about it.You’ll look closely at the anatomical and biological systems through which what is “outside” in the environment gets “inside” to affect our minds and bodies. You’ll also examine recent research on subjects ranging from the impact our emotions and psychology have on health to the crucial roles that social, cultural, and behavioral factors play. And you’ll learn about effective mind-body treatments for numerous common medical conditions and diseases.Finally, you’ll finish the course with a toolbox of ideas and interventions for your personal wellness goals, empowering you to partner more effectively with your medical providers and maximize your own health.A Remarkable New Context for Health Care Professor Satterfield, a highly respected professor of clinical medicine and a specialist on the intersection of psychological factors and physical health, brings to the table his deep knowledge of mind-body science and extensive clinical experience in its application.In the course’s opening, he introduces you to the model of “biopsychosocial medicine,” which looks at the relationship between biological, psychological, and social factors in health.In studying how the biopsychosocial model is applied in modern medicine, you delve into these core subject areas:Biological pathways:You first investigate the anatomy and physiology of four biological systems through which the “outside” gets “in.” By reviewing a detailed study of the autonomic nervous system and the neuroendocrine system, discover how the brain activates the body’s two stress-response systems, and how these systems crucially affect health and well-being. Learn also about the physiology of immune function and the effects of stress on immune response and healing. Study the mechanisms of genetics as well as fascinating research indicating that your behavior can alter your genetic material, for better or worse—changes that can be passed on to future generations.Psychological factors in health: In the course of nine lectures, you look in depth at the critical ways in which psychology affects the body. Learn how negative emotional states such as anger and hostility can influence both the onset and progression of disease, and how positive emotions aid substantially in healing and wellness. Study how cognition—the ways in which we think and process our experiences—affects emotional states and behavior. Drawing from cognitive and other behavioral therapies, learn effective techniques for reshaping thinking, emotions, and behavior. Review evidence that certain personality types may be predisposed to conditions such as cardiovascular disease and depression, and learn how we can compensate for risk-carrying personality traits by working with cognitions and emotions. Investigate the neuroscience of behavior and the important effects of our behaviors on both disease and disease prevention. Look at stress as an integration of biological, cognitive, and social factors, and see how we can approach stress response and coping as a developmental skill. Social and ecological factors: You also study the important effects on health of factors such as culture, identity, socioeconomic status, social support, communities, and public health policy. Examine the studied correlations of income to health, education level to longevity, and ethnicity to susceptibility to disease, and consider how we can use this knowledge to benefit both individual and public health. Review research linking social support to health in many medical conditions, such as heart disease, cancer, and pregnancy; and do a detailed assessment to evaluate and strengthen your own social support network. Investigate how spiritual affiliations and practices have distinct physical benefits, such as reducing blood pressure, cortisol, and inflammation; improving lipid profiles and cardiovascular health; and extending life expectancy. Assess how physical environments affect health, how national and local culture impacts health-related behaviors, and how public initiatives can create healthier behaviors, environments, and communities.Tools and Strategies for Optimal WellnessBuilding on the biopsychosocial model, you study mind-body treatments for common conditions such as cardiovascular disease, stress, cancer, obesity, chronic pain, depression, anxiety, and post-traumatic stress disorder.Here, you learn about specific practices and interventions that you can use in your own health care program, such as these. Stress management: For both personal and occupational stress, learn about a spectrum of stress management approaches, from cognitive restructuring and perspective shifting to meditation, breathing techniques, relaxation training, and the learnable skill of resilience. Strategies for successful behavior change: With reference to concerns such as lifestyle change, weight management, and disease prevention, study the leading models of effective behavior change, as well as specific approaches such as the strategies of motivational interviewing, the four key elements of change, and the internal skills of self-regulation. Heart disease—prevention and treatment: Survey psychosocial interventions for heart disease, including a range of behavior change approaches, stress and emotion management, somatic quieting, social connection, and dramatic evidence that cardiac disease can be reversed through lifestyle change. Treatment of pain: Study mind-body factors in pain experience, and learn about treatments including cognitive and behavior change, acupuncture, mindfulness-based stress reduction, and biofeedback. Fatigue, headaches, insomnia: Investigate the variety of medical conditions that show no clear organic cause, such as chronic fatigue, tension headaches, and sleep disorders; and review effective psychological, physical, and behavioral approaches to treatment.Professor Satterfield’s teaching combines an extraordinary breadth of knowledge, clear and accessible explanations of the science involved, and a highly compassionate approach to patient care. He enriches the lectures with stories and case studies of patients in treatment for stress, heart conditions, insomnia, trauma, and other health challenges, showing you what mind-body medicine looks like in clinical practice and how you can integrate its lessons into your health program and daily life.With the knowledge and tools you’ll learn in Mind-Body Medicine: The New Science of Optimal Health, you can begin your own biopsychosocial assessment, identify your strengths and challenges in partnership with your medical providers, and take authentic steps toward your fullest physical and mental wellness.

    It clarifies the mishmash of conflicting news, research, hype, and hearsay regarding diet, nutrition, and supplementation, and further establishes the judicious Dr. Weil, the director of the Program in Integrative Medicine at the University of Arizona, as a savior of public well-being. If you've ever wondered what "partially hydrogenated soybean oil" really is, been perplexed by contrary news reports about recommended dosages for supplements, or questioned the safety of using aluminum pots for cooking, Dr. Weil will make it all clear. Weil (pronounced "while") bravely criticizes many of the major diet books on the market, and backs up his admonitions with science. He warns readers to not fall under "the spell" of the anticarbohydrate Atkins Diet, but also criticizes the eating plan advocated by Dr. Dean Ornish--which has been granted Medicare coverage for cardiac patients--as being too low fat for the majority of people. (The omega-3 fatty acids missing from Ornish's diet are essential for hormone production and the control of inflammation, he says.) It's also fascinating to learn that autism, Parkinson's disease, and Alzheimer's disease may be caused by omega-3 fatty acid deficiencies, while an excess of omega-6 fatty acids--very common in the typical American diet--can exacerbate arthritis symptoms. Weil's explanation of the chemistry of fats will prove difficult for most readers, but few will want to eat fast-food French fries ever again after reading his appalling reasons for avoiding them, which go way beyond their well-documented heart-clogging capabilities. After a thorough rundown of nutritional basics and a primer of micronutrients such as vitamins, minerals, fiber, and phytochemicals, Weil unveils what he feels is "the best diet in the world," with 85 recipes, such as Salmon Cakes and Oven-Fried Potatoes, that are healthy, tasty, quick to prepare, and complete with nutritional breakdowns. He includes a stirring chapter on safe weight loss (he sympathizes with the overweight and comically recalls his one-week trial of a safflower oil-diet while an undergraduate). Other, equally enlightening sections include tips for eating out and shopping for food (with warnings on various additives and a guide to organics), and a wondrous appendix with dietary recommendations for dozens of health concerns, including allergies, asthma, cancer prevention, mood disorders, and pregnancy. Eating Well is an indispensable consumer reference and one not afraid to lambaste the diet industry and empower the public with information about which the majority of doctors--to the detriment of the public health--are ignorant. --Erica Jorgensen

    Since the 1950s, standard treatment has involved determining a sex for these infants and performing surgery to normalize the infant’s genitalia. Over the past decade intersex advocates have mounted unprecedented challenges to treatment, offering alternative perspectives about the meaning and appropriate medical response to intersexuality and driving the field of those who treat intersex conditions into a deep crisis. Katrina Karkazis offers a nuanced, compassionate picture of these charged issues in Fixing Sex, the first book to examine contemporary controversies over the medical management of intersexuality in the United States from the multiple perspectives of those most intimately involved. Drawing extensively on interviews with adults with intersex conditions, parents, and physicians, Karkazis moves beyond the heated rhetoric to reveal the complex reality of how intersexuality is understood, treated, and experienced today. As she unravels the historical, technological, social, and political forces that have culminated in debates surrounding intersexuality, Karkazis exposes the contentious disagreements among theorists, physicians, intersex adults, activists, and parents—and all that those debates imply about gender and the changing landscape of intersex management. She argues that by viewing intersexuality exclusively through a narrow medical lens we avoid much more difficult questions. Do gender atypical bodies require treatment? Should physicians intervene to control the “sex” of the body? As this illuminating book reveals, debates over treatment for intersexuality force reassessment of the seemingly natural connections between gender, biology, and the body.

    New genetic technologies are transforming the way we live and promise treatments for otherwise incurable diseases. But these advances are also generating controversy, particularly surrounding issues such as cloning and designer babies. In 50 Genetics Ideas, Mark Henderson distils the central ideas of genetics in a series of clear and concise essays. Beginning with the theory of evolution, and covering such topics as the genome and how nature and nurture work together, he not only illuminates the role of genes in shaping our behaviour and sexuality, but also the very latest, cutting-edge developments in gene therapy and artificial life. Accessible and informative, 50 Genetics Ideas is a timely introduction to this young and ground-breaking strand of science.

    It will make you angry. It will amaze you with the courage of some of the people described in the book...The Autoimmune Epidemic is every bit as compelling as Upton Sinclair's The Jungle...It is also every bit as necessary as An Inconvenient Truth.... You will leave this book with no reservations about the veracity of the conclusions: put simply, there is no doubt that autoimmune diseases are on the rise and increasing environmental exposures of toxins and chemicals is fueling this rise. The research is sound. The conclusions unassailable.... Reading The Autoimmune Epidemic is a necessary first step. Reading The Autoimmune Epidemic is a life-altering event. It needs to be."