Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    As the cancer progressed and was treated, the author experienced behavioral and cognitive symptoms connected to a range of mental disorders, including her professional specialty, schizophrenia. Lipska's family and associates were alarmed by the changes in her behavior, which she failed to acknowledge herself. Gradually, after a course of immunotherapy, Lipska returned to normal functioning, recalled her experience and, through her knowledge of neuroscience, identified the ways in which her brain changed during treatment. Lipska admits her condition was unusual; after recovery she was able to return to her research and resume her athletic training and compete in a triathalon. Most patients with similar brain cancers rarely survive to describe their ordeal. Lipska's memoir, coauthored with journalist McArdle, shows that strength and courage but also a encouraging support network are vital to recovery

    We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    From that single beginning, Ferguson’s life will take four simultaneous and independent fictional paths. Four identical Fergusons made of the same DNA, four boys who are the same boy, go on to lead four parallel and entirely different lives. Family fortunes diverge. Athletic skills and sex lives and friendships and intellectual passions contrast. Each Ferguson falls under the spell of the magnificent Amy Schneiderman, yet each Amy and each Ferguson have a relationship like no other. Meanwhile, readers will take in each Ferguson’s pleasures and ache from each Ferguson’s pains, as the mortal plot of each Ferguson’s life rushes on.As inventive and dexterously constructed as anything Paul Auster has ever written, yet with a passion for realism and a great tenderness and fierce attachment to history and to life itself that readers have never seen from Auster before. 4 3 2 1 is a marvelous and unforgettably affecting tour de force.

    Night Falls Fast is tragically timely: suicide has become one of the most common killers of Americans between the ages of fifteen and forty-five.An internationally acknowledged authority on depressive illnesses, Dr. Jamison has also known suicide firsthand: after years of struggling with manic-depression, she tried at age twenty-eight to kill herself. Weaving together a historical and scientific exploration of the subject with personal essays on individual suicides, she brings not only her remarkable compassion and literary skill but also all of her knowledge and research to bear on this devastating problem. This is a book that helps us to understand the suicidal mind, to recognize and come to the aid of those at risk, and to comprehend the profound effects on those left behind. It is critical reading for parents, educators, and anyone wanting to understand this tragic epidemic.

    In this captivating fusion of science, history and personal memoir, writer David Adam explores the weird thoughts that exist within every mind, and how they drive millions of us towards obsessions and compulsions.David has suffered from OCD for twenty years, and The Man Who Couldn’t Stop is his unflinchingly honest attempt to understand the condition and his experiences. What might lead an Ethiopian schoolgirl to eat a wall of her house, piece by piece; or a pair of brothers to die beneath an avalanche of household junk that they had compulsively hoarded? At what point does a harmless idea, a snowflake in a clear summer sky, become a blinding blizzard of unwanted thoughts? Drawing on the latest research on the brain, as well as historical accounts of patients and their treatments, this is a book that will challenge the way you think about what is normal, and what is mental illness.Told with fierce clarity, humour and urgent lyricism, this extraordinary book is both the haunting story of a personal nightmare, and a fascinating doorway into the darkest corners of our minds.

    Their extraordinary meeting and the two years they spent in one another’s company serves as the basis for an investigation into the nature of human identity, belief, and delusion that is poignant, amusing, and at times disturbing. Displaying the sympathy and subtlety of a gifted novelist, Rokeach draws us into the lives of three troubled and profoundly different men who find themselves “confronted with the ultimate contradiction conceivable for human beings: more than one person claiming the same identity.”

     Although one in five Americans now takes at least one psychotropic drug, the fact remains that nearly seventy years after doctors first began prescribing them, we still don't know exactly how or why these drugs work--or don't work--on what ails our brains. Blue Dreams offers the explosive story of the discovery, invention, people, and science behind our licensed narcotics, as told by a riveting writer and psychologist who shares her own intimate experience with the highs and lows of psychiatry's drugs. Lauren Slater's account ranges from the earliest, Thorazine and lithium, up through Prozac and other antidepressants, as well as Ecstasy, "magic mushrooms," the most cutting-edge memory drugs, and even neural implants. Along the way, she narrates the history of psychiatry itself, illuminating the imprint its colorful little capsules have left on millions of brains worldwide, and demonstrating how these wonder drugs may heal us or hurt us.

    Mikhail Bulgakov was flung into the depths of freezing rural Russia which, in 1916-17, was still largely unaffected by such novelties as the motor car, the telephone or electric light. How his alter-ego copes (or fails to cope) with the new and often appalling responsibilities of a lone doctor in a vast country practice — on the eve of Revolution — is described in Bulgakov's delightful blend of candid realism and imaginative exuberance.

    The Other Brain is the story of glia, which make up approximately 85 percent of the cells in the brain. Long neglected as little more than cerebral packing material ("glia" means glue), glia are sparking a revolution in brain science.Glia are completely different from neurons, the brain cells that we are familiar with. Scientists are discovering that glia have their own communication network, which operates in parallel to the more familiar communication among neurons. Glia provide the insulation for the neurons, and glia even regulate the flow of information between neurons.But it is the potential breakthroughs for medical science that are the most exciting frontier in glia research today. Diseases such as brain cancer and multiple sclerosis are caused by diseased glia. Glia are now believed to play an important role in such psychiatric illnesses as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson's and Alzheimer's. They are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. Scientists have discovered that glia repair the brain and spinal cord after injury and stroke. The more we learn about these cells that make up the "other" brain, the more important they seem to be.Written by a neuroscientist who is a leader in the research to reveal the secrets of these brain cells, The Other Brain offers a firsthand account of science in action. It takes us into the laboratories where important discoveries are being made, and it explains how scientists are learning that glial cells come in different types, with different capabilities. It tells the story of glia research from its origins to the most recent discoveries and gives readers a much more complete understanding of how the brain works and where the next breakthroughs in brain science and medicine are likely to come.

    This is the startling theme of Philip Roth’s wrenching new book: a wartime polio epidemic in the summer of 1944 and the effect it has on a closely knit, family-oriented Newark community and its children. At the center of Nemesis is a vigorous, dutiful twenty-three-year-old playground director, Bucky Cantor, a javelin thrower and weightlifter, who is devoted to his charges and disappointed with himself because his weak eyes have excluded him from serving in the war alongside his contemporaries. Focusing on Cantor’s dilemmas as polio begins to ravage his playground—and on the everyday realities he faces—Roth leads us through every inch of emotion such a pestilence can breed: the fear, the panic, the anger, the bewilderment, the suffering, and the pain. Moving between the smoldering, malodorous streets of besieged Newark and Indian Hill, a pristine children’s summer camp high in the Poconos—whose “mountain air was purified of all contaminants”—Roth depicts a decent, energetic man with the best intentions struggling in his own private war against the epidemic. Roth is tenderly exact at every point about Cantor’s passage into personal disaster, and no less exact about the condition of childhood. Through this story runs the dark questions that haunt all four of Roth’s late short novels, Everyman, Indignation, The Humbling, and now Nemesis: What kind of accidental choices fatally shape a life? How does the individual withstand the onslaught of circumstance?

    Haunting, troubling, and mesmerizing, it shines a brilliant, unwavering light into the darkest recesses of a man’s psyche.To all appearances, John Wilder has all the trappings of success, circa 1960: a promising career in advertising, a loving family, a beautiful apartment, even a country home. John’s evenings are spent with associates at quiet Manhattan lounges and his weekends with friends at glittering cocktail parties. But something deep within this seemingly perfect life has long since gone wrong. Something has disturbed John’s fragile peace, and he can no longer find solace in fleeting affairs or alcohol. The anger, the drinking, and the recklessness are building to a crescendo—and they’re about to take down John’s family and his career. What happens next will send John on a long, strange journey—at once tragic and inevitable.

    Updated information is included about the associated features, culture, age & gender features, prevalence, course & familial pattern of mental disorders. The DSM-IV-TR(R) brings this essential diagnostic tool to-date, to promote effective diagnosis, treatment & quality of care. One can get all the essential diagnostic information from the DSM-IV(R) along with important updates not in the '94 edition. Benefit from new research into Schizophrenia, Asperger's Disorder & other conditions. Utilize additional information about the epidemiology & other facets of DSM conditions. Update ICD-9-CM codes implemented since 1994 including Conduct Disorder, Dementia, Somatoform Disorders.Use of the manual DSM-IV-TR classification Multiaxial assessment Disorders usually 1st diagnosed in infancy, childhood or adolescenceDelirium, dementia & amnestic & other cognitive disordersMental disorders due to a general medical condition Substance-related disorders Schizophrenia & other psychotic disordersMood disorders Anxiety disordersSomatoform disordersFactitious disordersDissociative disordersSexual & gender identity disordersEating disorders Sleep disorders Impulse-control disorders not elsewhere classifiedAdjustment disordersPersonality disordersOther conditions that may be a focus of clinical attentionAdditional codes Appendix A: Decision trees for differential diagnosis Appendix B: Criteria sets & axes provided for further study Appendix C: Glossary of technical terms Appendix D: Highlights of changes in DSM-IV text revisionAppendix E: Alphabetical listing of DSM-IV-TR diagnoses & codesAppendix F: Numerical listing of DSM-IV-TR diagnoses & codesAppendix G: ICD-9-CM codes for selected general medical conditions & medication-induced disordersAppendix H: DSM-IV classification with ICD-10 codesAppendix I: Outline for cultural formulation & glossary of culture-bound syndromesAppendix J: DSM-IV contributorsAppendix K: DSM-IV text revision advisers

    He had a beautiful wife, three lovely children, a nice house...and all the mistresses he desired. He had it all -- all, that is, but happiness. Slocum was discontent. Inevitably, inexorably, his discontent deteriorated into desolation until...something happened. Something Happened is Joseph Heller's wonderfully inventive and controversial second novel satirizing business life and American culture. The story is told as if the reader was overhearing the patter of Bob Slocum's brain -- recording what is going on at the office, as well as his fantasies and memories that complete the story of his life. The result is a novel as original and memorable as his Catch-22.