A lyrical journey from hope to despair and back again, The First Cell explores cancer from every angle: medical, scientific, cultural, and personal. Indeed, Raza describes how she bore the terrible burden of being her own husband's oncologist as he succumbed to leukemia. Like When Breath Becomes Air, The First Cell is no ordinary book of medicine, but a book of wisdom and grace by an author who has devoted her life to making the unbearable easier to bear.

    Now known mostly as a disease of the tropics, malaria led to the demise of the Roman Empire 2,000 years ago and ravaged Europe for years afterwards. At the start of the 17th century, Jesuit priests developed quinine, an alkaloid made out of the bitter red bark of the cinchona tree from the Andes. When quinine arrived in Europe, the Protestant powers resisted the medicine fearing that it was a Popish poison. Quinine’s reputation improved, however, when King Charles II was cured of malaria through its offices. Through the centuries, wars were fought to control the supply-through the building of the Panama Canal and into WWII--until Americans synthesized quinine for the first time in 1944.Rocco describes the ravages of the disease, the search for a cure, and the quest to steal and smuggle cinchona seeds out of South America. The Miraculous Fever Tree deftly illuminates the religious and scientific rivalries, intrepid exploration and colonization evinced by the search for quinine.

    There are no fences, no guards, no locked gates. But McLean Hospital is a mental institution-one of the most famous, most elite, and once most luxurious in America. McLean "alumni" include Olmsted himself, Robert Lowell, Sylvia Plath, James Taylor and Ray Charles, as well as (more secretly) other notables from among the rich and famous. In its "golden age," McLean provided as genteel an environment for the treatment of mental illness as one could imagine. But the golden age is over, and a downsized, downscale McLean-despite its affiliation with Harvard University-is struggling to stay afloat. Gracefully Insane, by Boston Globe columnist Alex Beam, is a fascinating and emotional biography of McLean Hospital from its founding in 1817 through today. It is filled with stories about patients and doctors: the Ralph Waldo Emerson prot'g' whose brilliance disappeared along with his madness; Anne Sexton's poetry seminar, and many more. The story of McLean is also the story of the hopes and failures of psychology and psychotherapy; of the evolution of attitudes about mental illness, of approaches to treatment, and of the economic pressures that are making McLean-and other institutions like it-relics of a bygone age. This is a compelling and often oddly poignant reading for fans of books like Plath's The Bell Jar and Susanna Kaysen's Girl, Interrupted (both inspired by their author's stays at McLean) and for anyone interested in the history of medicine or psychotherapy, or the social history of New England.

    Otto’s subjects include the pioneering dentist who made Shirley Temple and Judy Garland’s teeth sparkle on the silver screen and helped create the all-American image of “pearly whites”; Deamonte Driver, the young Maryland boy whose tragic death from an abscessed tooth sparked congressional hearings; and a marketing guru who offers advice to dentists on how to push new and expensive treatments and how to keep Medicaid patients at bay.In one of its most disturbing findings, Teeth reveals that toothaches are not an occasional inconvenience, but rather a chronic reality for millions of people, including disproportionate numbers of the elderly and people of color. Many people, Otto reveals, resort to prayer to counteract the uniquely devastating effects of dental pain.Otto also goes back in time to understand the roots of our predicament in the history of dentistry, showing how it became separated from mainstream medicine, despite a century of growing evidence that oral health and general bodily health are closely related.Muckraking and paradigm-shifting, Teeth exposes for the first time the extent and meaning of our oral health crisis. It joins the small shelf of books that change the way we view society and ourselves—and will spark an urgent conversation about why our teeth matter.This is an alternate cover edition of ISBN 9781620971444.

    Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.

    Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein reveals the “invigorating history” (Nature) of hormones and the age-old quest to control them through the back rooms, basements, and labs where endocrinology began.

    

    In this now-classic study, Michael Bliss unearths a wealth of material, ranging from scientists& unpublished memoirs to the confidential appraisals of insulin by members of the Nobel Committee. He also resolves a longstanding controversy dating to the awarding of the Nobel to F. G. Banting and J. J. R. Macleod for their work on insulin: because each insisted on sharing the credit with an additional associate, medical opinion was intensely divided over the allotment of credit for the discovery. Bliss also offers a wealth of new detail on such subjects as the treatment of diabetes before insulin and the life-and-death struggle to manufacture it.Bliss;s excellent account of the insulin story is a rare dissection of the anatomy of scientific discovery, and serves as a model of how rigorous historical method can correct the myths and legends sometimes perpetrated in the scientific literature.

    For hundreds of years, medical students around the world have learned the secrets of medicine by looking at real cases, involving real people and featuring real symptoms. But what happens when those medical cases are a mystery? How do doctors diagnose illnesses and save lives using the best knowledge they have about health and disease? What differences (and similarities) are there between the ways doctors work today and the ways they worked thousands of years ago? In these 10 eye-opening lectures by a practicing doctor and medical educator, you’ll walk through a series of medical mystery cases ripped from history and involving well-known historical figures whose identities are nevertheless hidden from you. Every one of these cases (featuring presidents, scientists, singers, kings, and queens) requires you to use your detective skills to identify and diagnose the mystery patient just like the doctors that attended them. In the process, you’ll learn fascinating insights into medicine: both the medicine that was practiced thousands of years ago and the medicine doctors practice today. What are the historic and modern consequences of fever? How do doctors diagnose and treat cardiovascular disease and alcoholism? How does radiation and heavy metal poisoning affect the human body? What so-called “modern” diseases were actually documented in the ancient past? Solving these mystery cases will give you a new perspective on how the human body works - and on some world-changing figures whom you’ve never viewed from a doctor’s point of view.

    Award-winning author Jonathan Edlow, M.D., shows the doctor as detective and the epidemiologist as elite sleuth in stories that are as gripping as the best thrillers.In these stories a notorious stomach bug turns a suburban dinner party into a disaster that almost claims its host; a diminutive woman routinely eats more than her football-playing boyfriend but continually loses weight; a young executive is diagnosed with lung cancer, yet the tumors seem to wax and wane inexplicably. Written for the lay person who wishes to better grasp how doctors decipher the myriad clues and puzzling symptoms they often encounter, each story presents a very different case where doctors must work to find the accurate diagnosis before it is too late. Edlow uses his unique ability to relate complex medical concepts in a writing style that is clear, engaging and easily understandable. The resulting stories both entertain us and teach us much about medicine, its history and the subtle interactions among pathogens, humans, and the environment.

    Ballet dancers and rock musicians, professors and thieves-"anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care-ended up here. So did Victoria Sweet, who came for two months and stayed for twenty years. Laguna Honda, lower tech but human paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished. Gradually, the place transformed the way she understood her work. Alongside the modern view of the body as a machine to be fixed, her extraordinary patients evoked an older idea, of the body as a garden to be tended. God's Hotel tells their story and the story of the hospital itself, which, as efficiency experts, politicians, and architects descended, determined to turn it into a modern "health care facility," revealed its own surprising truths about the essence, cost, and value of caring for body and soul.

    This trial serves as the backdrop for Superbugs, and the results will impact nothing less than the future of humanity.Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more.

    Linda Stratmann’s dark and splendid social history reveals the nineteenth century as a gruesome battleground where poisoners went head-to-head with authorities who strove to detect poisons, control their availability, and bring the guilty to justice. She corrects many misconceptions about particular poisons and documents how the evolution of issues such as marital rights and the legal protection of children impacted poisonings. Combining archival research with a novelist’s eye, Stratmann charts the era’s inexorable rise of poison cases both shocking and sad.

    We know her today primarily as a saintly character, perhaps as a heroic reformer of Britain’s health-care system. The reality is more involved and far more fascinating. In an utterly beguiling narrative that reads like the best Victorian fiction, acclaimed author Gillian Gill tells the story of this richly complex woman and her extraordinary family.Born to an adoring wealthy, cultivated father and a mother whose conventional facade concealed a surprisingly unfettered intelligence, Florence was connected by kinship or friendship to the cream of Victorian England’s intellectual aristocracy. Though moving in a world of ease and privilege, the Nightingales came from solidly middle-class stock with deep traditions of hard work, natural curiosity, and moral clarity. So it should have come as no surprise to William Edward and Fanny Nightingale when their younger daughter, Florence, showed an early passion for helping others combined with a precocious bent for power. Far more problematic was Florence’s inexplicable refusal to marry the well-connected Richard Monckton Milnes. As Gill so brilliantly shows, this matrimonial refusal was at once an act of religious dedication and a cry for her freedom–as a woman and as a leader. Florence’s later insistence on traveling to the Crimea at the height of war to tend to wounded soldiers was all but incendiary–especially for her older sister, Parthenope, whose frustration at being in the shade of her more charismatic sibling often led to illness. Florence succeeded beyond her wildest dreams. But at the height of her celebrity, at the age of thirty-seven, she retired to her bedroom and remained there for most of the rest of her life, allowing visitors only by appointment.Combining biography, politics, social history, and consummate storytelling, Nightingales is a dazzling portrait of an amazing woman, her difficult but loving family, and the high Victorian era they so perfectly epitomized. Beautifully written, witty, and irresistible, Nightingales is truly a tour de force.From the Hardcover edition.