The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    How many of us understand the way seizures affect the brain, how the heart is connected to wellbeing, or the why the foot carries the key to our humanity? In Adventures in Human Being, award-winning author Gavin Francis leads readers on a journey into the hidden pathways of the human body, offering a guide to its inner workings and a celebration of its marvels.Drawing on his experiences as a surgeon, ER specialist, and family physician, Francis blends stories from the clinic with episodes from medical history, philosophy, and literature to describe the body in sickness and in health, in living and in dying. At its heart, Adventures in Human Being is a meditation on what it means to be human. Poetic, eloquent, and profoundly perceptive, this book will transform the way you view your body.

    Like you, the elements have lives: personalities and attitudes, talents and shortcomings, stories rich with meaning. You may think of them as the inscrutable letters of the periodic table but you know them much better than you realise. Welcome to a dazzling tour through history and literature, science and art. Here you'll meet iron that rains from the heavens and noble gases that light the way to vice. You'll learn how lead can tell your future while zinc may one day line your coffin. You'll discover what connects the bones in your body with the Whitehouse in Washington, the glow of a streetlamp with the salt on your dinner table. From ancient civilisations to contemporary culture, from the oxygen of publicity to the phosphorus in your pee, the elements are near and far and all around us. Unlocking their astonishing secrets and colourful pasts, Periodic Tales will take you on a voyage of wonder and discovery, excitement and novelty, beauty and truth. Along the way, you'll find that their stories are our stories, and their lives are inextricable from our own.

    And it is ignorance--not knowledge--that is the true engine of science.Most of us have a false impression of science as a surefire, deliberate, step-by-step method for finding things out and getting things done. In fact, says Firestein, more often than not, science is like looking for a black cat in a dark room, and there may not be a cat in the room. The processis more hit-or-miss than you might imagine, with much stumbling and groping after phantoms. But it is exactly this not knowing, this puzzling over thorny questions or inexplicable data, that gets researchers into the lab early and keeps them there late, the thing that propels them, the verydriving force of science. Firestein shows how scientists use ignorance to program their work, to identify what should be done, what the next steps are, and where they should concentrate their energies. And he includes a catalog of how scientists use ignorance, consciously or unconsciously--aremarkable range of approaches that includes looking for connections to other research, revisiting apparently settled questions, using small questions to get at big ones, and tackling a problem simply out of curiosity. The book concludes with four case histories--in cognitive psychology, theoreticalphysics, astronomy, and neuroscience--that provide a feel for the nuts and bolts of ignorance, the day-to-day battle that goes on in scientific laboratories and in scientific minds with questions that range from the quotidian to the profound.Turning the conventional idea about science on its head, Ignorance opens a new window on the true nature of research. It is a must-read for anyone curious about science.

    Permanent positions are scarce, science survival is rarely part of formal graduate training, and a good mentor is hard to find. This exceptional volume explains what stands between you and fulfilling long-term research career. Bringing the key survival skills into focus, A Ph.D. Is Not Enough! proposes a rational approach to establishing yourself as a scientist. It offers sound advice of selecting a thesis or postdoctoral adviser, choosing among research jobs in academia, government laboratories, and industry, preparing for an employment interview, and defining a research program. This book will help you make your oral presentations effective, your journal articles compelling, and your grant proposals successful. A Ph.D. Is Not Enough should be required reading for anyone on the threshold of a career in science.

    After 3.8 billion years humankind is about to start evolving by new rules...From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives -- sex, war, love, and death.At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

    Lavishly illustrated with engravings, woodcuts, and original drawings and diagrams, Sciencia will inspire readers of all ages to take an interest in the interconnected knowledge of the modern sciences.Beautifully produced in thirteen different colors of ink, Sciencia is an essential reference and an elegant gift.Wooden Books was founded in 1999 by designer John Martineau near Hay-on-Wye. The aim was to produce a beautiful series of recycled books based on the classical philosophies, arts and sciences. Using the Beatrix Potter formula of text facing picture pages, and old-styles fonts, along with hand-drawn illustrations and 19th century engravings, the books are designed not to date. Small but stuffed with information. Eco friendly and educational. Big ideas in a tiny space. There are over 1,000,000 Wooden Books now in print worldwide and growing.

    Cox and Forshaw's contention? There is no need for quantum mechanics to be viewed this way. There is a lot of mileage in the 'weirdness' of the quantum world, and it often leads to confusion and, frankly, bad science. The Quantum Universe cuts through the Wu Li and asks what observations of the natural world made it necessary, how it was constructed, and why we are confident that, for all its apparent strangeness, it is a good theory.The quantum mechanics of The Quantum Universe provide a concrete model of nature that is comparable in its essence to Newton’s laws of motion, Maxwell’s theory of electricity and magnetism, and Einstein’s theory of relativity.

    But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    He maintains at the outset that the importance of a physical law isn't "how clever we are to have found it out, but...how clever nature is to pay attention to it" & tends his discussions toward a final exposition of the elegance & simplicity of all scientific laws. Rather than an essay on the most significant achievements in modern science, The Character of Physical Law is a statement of what is most remarkable in nature. His enlightened approach, wit & enthusiasm make this a memorable exposition of the scientist's craft. The Law of Gravitation is the principal example. Relating the details of its discovery & stressing its mathematical character, he uses it to demonstrate the essential interaction of mathematics & physics. He views mathematics as the key to any system of scientific laws, suggesting that if it were possible to fill out the structure of scientific theory completely, the result would be an integrated set of axioms. The principles of conservation, symmetry & time-irreversibility are then considered in relation to developments in classical & modern physics. In his final lecture he develops his own analysis of the process & future of scientific discovery. Like any set of oral reflections, The Character of Physical Law has value as a demonstration of a mind in action. The reader is particularly lucky in Feynman. One of the most eminent & imaginative modern physicists, he was Professor of Theoretical Physics at the California Institute of Technology until his death in 1988. He's best known for work on the quantum theory of the electromagnetic field, as well as for later research in the field of low-temperature physics. In 1954 he received the Albert Einstein Award for an "outstanding contribution to knowledge in mathematical & physical sciences"; in 1965 he was appointed to Foreign Membership in the Royal Society & was awarded the Nobel Prize.

    But in The Music of Life, world renowned physiologist Denis Noble argues that, to truly understand life, we must look beyondthe selfish gene to consider life on a much wider variety of levels. Life, Noble asserts, is a kind of music, a symphonic interplay between genes, cells, organs, body, and environment. He weaves this musical metaphor throughout this personal and deeply lyrical work, illuminating ideas that might otherwise be daunting to non-scientists. In elegant prose, Noblesets out a cutting-edge alternative to the gene's eye view, offering a radical switch of perception in which genes are seen as prisoners and the organism itself is a complex system of many interacting levels. In his more expansive view, life emerges as a process, the ebb and flow of activity in anintricate web of connections. He introduces readers to the realm of systems biology, a field that has been growing in strength in the past decade. Noble, himself one of the founders of this field, argues modern systems biology may be the view we need to adopt to gain a deeper understanding of thenature of life. Drawing on his experiences in his research on the heartbeat, and on evolutionary biology, development, medicine, philosophy, linguistics, and Chinese culture, Noble presents us with a profound and very modern reflection on the nature of life.

    This book investigates what cannot be known. Rather than exploring the amazing facts that science, mathematics, and reason have revealed to us, this work studies what science, mathematics, and reason tell us cannot be revealed. In The Outer Limits of Reason, Noson Yanofsky considers what cannot be predicted, described, or known, and what will never be understood. He discusses the limitations of computers, physics, logic, and our own thought processes.Yanofsky describes simple tasks that would take computers trillions of centuries to complete and other problems that computers can never solve; perfectly formed English sentences that make no sense; different levels of infinity; the bizarre world of the quantum; the relevance of relativity theory; the causes of chaos theory; math problems that cannot be solved by normal means; and statements that are true but cannot be proven. He explains the limitations of our intuitions about the world -- our ideas about space, time, and motion, and the complex relationship between the knower and the known.Moving from the concrete to the abstract, from problems of everyday language to straightforward philosophical questions to the formalities of physics and mathematics, Yanofsky demonstrates a myriad of unsolvable problems and paradoxes. Exploring the various limitations of our knowledge, he shows that many of these limitations have a similar pattern and that by investigating these patterns, we can better understand the structure and limitations of reason itself. Yanofsky even attempts to look beyond the borders of reason to see what, if anything, is out there.

    Strevens calls this scientific code the iron rule of explanation, and reveals the way in which the rule, precisely because it is unreasonably close-minded, overcomes individual prejudices to lead humanity inexorably toward the secrets of nature.“With a mixture of philosophical and historical argument, and written in an engrossing style” (Alan Ryan), The Knowledge Machine provides captivating portraits of some of the greatest luminaries in science’s history, including Isaac Newton, the chief architect of modern science and its foundational theories of motion and gravitation; William Whewell, perhaps the greatest philosopher-scientist of the early nineteenth century; and Murray Gell-Mann, discoverer of the quark. Today, Strevens argues, in the face of threats from a changing climate and global pandemics, the idiosyncratic but highly effective scientific knowledge machine must be protected from politicians, commercial interests, and even scientists themselves who seek to open it up, to make it less narrow and more rational—and thus to undermine its devotedly empirical search for truth.Rich with illuminating and often delightfully quirky illustrations, The Knowledge Machine, written in a winningly accessible style that belies the import of its revisionist and groundbreaking concepts, radically reframes much of what we thought we knew about the origins of the modern world.

    Marvel at the Dual Slit experiment as a tiny atom passes through 2 separate openings at the same time. Ponder the peculiar communication of quantum particles, which can remain in touch no matter how far apart. Join the genius jewel thief as he carries out a quantum measurement on a diamond without ever touching the object in question. With its clean, colorful layout and conversational tone, this text will hook you into the conundrum that is quantum mechanics.

    Join renowned neuroscientist David Eagleman for a journey into the questions at the mysterious heart of our existence. What is reality? Who are “you”? How do you make decisions? Why does your brain need other people? How is technology poised to change what it means to be human?  In the course of his investigations, Eagleman guides us through the world of extreme sports, criminal justice, facial expressions, genocide, brain surgery, gut feelings, robotics, and the search for immortality.  Strap in for a whistle-stop tour into the inner cosmos. In the infinitely dense tangle of billions of brain cells and their trillions of connections, something emerges that you might not have expected to see in there: you.