What drives the drug trade, and how has it come to be what it is today? A global history of the acquisition of progressively more potent means of altering ordinary waking consciousness, this book is the first to provide the big picture of the discovery, interchange, and exploitation of the planet's psychoactive resources, from tea and kola to opiates and amphetamines.

    Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery. Both men were practicing medicine at the same time in the 1880s: Freud at the Vienna General Hospital, Halsted at New York’s Bellevue Hospital. Markel writes that Freud began to experiment with cocaine as a way of studying its therapeutic uses—as an antidote for the overprescribed morphine, which had made addicts of so many, and as a treatment for depression.  Halsted, an acclaimed surgeon even then, was curious about cocaine’s effectiveness as an anesthetic and injected the drug into his arm to prove his theory. Neither Freud nor Halsted, nor their colleagues, had any idea of the drug’s potential to dominate and endanger their lives. Addiction as a bona fide medical diagnosis didn’t even exist in the elite medical circles they inhabited.  In An Anatomy of Addiction, Markel writes about the life and work of each man, showing how each came to know about cocaine; how Freud found that the drug cured his indigestion, dulled his aches, and relieved his depression. The author writes that Freud, after a few months of taking the magical drug, published a treatise on it, Über Coca, in which he described his “most gorgeous excitement.” The paper marked a major shift in Freud’s work: he turned from studying the anatomy of the brain to exploring the human psyche.  Halsted, one of the most revered of American surgeons, became the head of surgery at the newly built Johns Hopkins Hospital and then professor of surgery, the hospital’s most exalted position, committing himself repeatedly to Butler Hospital, an insane asylum, to withdraw from his out-of control cocaine use.  Halsted invented modern surgery as we know it today: devising new ways to safely invade the body in search of cures and pioneering modern surgical techniques that controlled bleeding and promoted healing. He insisted on thorough hand washing, on scrub-downs and whites for doctors and nurses, on sterility in the operating room—even inventing the surgical glove, which he designed and had the Goodyear Rubber Company make for him—accomplishing all of this as he struggled to conquer his unyielding desire for cocaine.  An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction as he conquered his own world with his visionary healing gifts. Here is the full story, long overlooked, told in its rich historical context.

    Neck-deep in work that can be messy and confounding and naive in the ways of public communication, scientists are often unable to package their insights into the neat narratives that the public requires. Enter celebrities, advocates, lobbyists, and the funders behind them, who take advantage of scientists' reluctance to provide easy answers, flooding the media with misleading or incorrect claims about health risks. Amid this onslaught of spurious information, Americans are more confused than ever about what's good for them and what isn't. In Bad Advice, Paul A. Offit shares hard-earned wisdom on the dos and don'ts of battling misinformation. For the past twenty years, Offit has been on the front lines in the fight for sound science and public heath. Stepping into the media spotlight as few scientists have done--such as being one of the first to speak out against conspiracy theories linking vaccines to autism--he found himself in the crosshairs of powerful groups intent on promoting pseudoscience. Bad Advice discusses science and its adversaries: not just the manias stoked by slick charlatans and their miracle cures but also corrosive, dangerous ideologies such as Holocaust and climate-change denial.

    From such twenty-first-century forces, we have seen declines in previous global health gains, with sharp increases in vaccine-preventable and neglected diseases on the Arabian Peninsula, in Venezuela, in parts of Africa, and even on the Gulf Coast of the United States. In Preventing the Next Pandemic, international vaccine scientist and tropical disease and coronavirus expert Peter J. Hotez, MD, PhD, argues that we can--and must--rely on vaccine diplomacy to address this new world order in disease and global health. Detailing his years in the lab developing new vaccines, Hotez also recounts his travels around the world to shape vaccine partnerships with people in countries both rich and poor in an attempt to head off major health problems. Building on the legacy of Dr. Albert Sabin, who developed the oral polio vaccine with Soviet scientists at the height of the Cold War, he explains how he is still working to refresh and redirect vaccine diplomacy toward neglected and newly emerging diseases.Hotez reveals how--during his Obama-era tenure as the US Science Envoy for the Middle East and North Africa, which coincided with both the rise in these geopolitical forces and climate change--he witnessed tropical infectious diseases and established vaccine partnerships that may still combat them up close. He explores why, since 2015, we've seen the decline of global cooperation and cohesion, to the detriment of those programs that are meant to benefit the most vulnerable people in the world. Unfortunately, Hotez asserts, these negative global events kick off a never-ending loop. Problems in a country may lead to disease outbreaks, but those outbreaks can lead to further problems--such as the impact of coronavirus on China's society and economy, which has been felt around the globe. Zeroing in on the sociopolitical and environmental factors that drive our most controversial and pressing global health concerns, Hotez proposes historically proven methods to soothe fraught international relations while preparing us for a safer, healthier future. He hammers home the importance of public engagement to communicate the urgency of embracing science during troubled times.Touching on a range of disease, from leishmaniasis, schistosomiasis, and Middle East Respiratory Syndrome (MERS) to COVID-19, Preventing the Next Pandemic has always been a timely goal, but it will be even more important in a COVID and post-COVID world.

    Why should he or anyone else care what became of his corpse? In The Work of the Dead, acclaimed cultural historian Thomas Laqueur examines why humanity has universally rejected Diogenes’s argument. No culture has been indifferent to mortal remains. Even in our supposedly disenchanted scientific age, the dead body still matters—for individuals, communities, and nations. A remarkably ambitious history, The Work of the Dead offers a compelling and richly detailed account of how and why the living have cared for the dead, from antiquity to the twentieth century.The book draws on a vast range of sources—from mortuary archaeology, medical tracts, letters, songs, poems, and novels to painting and landscapes in order to recover the work that the dead do for the living: making human communities that connect the past and the future. Laqueur shows how the churchyard became the dominant resting place of the dead during the Middle Ages and why the cemetery largely supplanted it during the modern period. He traces how and why since the nineteenth century we have come to gather the names of the dead on great lists and memorials and why being buried without a name has become so disturbing. And finally, he tells how modern cremation, begun as a fantasy of stripping death of its history, ultimately failed—and how even the ashes of the victims of the Holocaust have been preserved in culture.A fascinating chronicle of how we shape the dead and are in turn shaped by them, this is a landmark work of cultural history.

    He was left untreated and unattended to for thirty-four hours in the Emercency Room, where he ultimately died from an easily treatable infection. McCallum and Perry show that Sinclair’s tragically avoidable death reflects a particular structure of indifference born of and maintained by colonialism.

    It is impossible not to be drawn in to the provocative (often contentious) discussion that Harvey Mansfield sets before us. This is the first comprehensive study of manliness, a quality both bad and good, mostly male, often intolerant, irrational, and ambitious. Our “gender-neutral society” does not like it but cannot get rid of it.Drawing from science, literature, and philosophy, Mansfield examines the layers of manliness, from vulgar aggression, to assertive manliness, to manliness as virtue, and to philosophical manliness. He shows that manliness seeks and welcomes drama, prefers times of war, conflict, and risk, and brings change or restores order at crucial moments. Manly men in their assertiveness raise issues, bring them to the fore, and make them public and political—as for example, the manliness of the women’s movement.After a wide-ranging tour from stereotypes to Hemingway and Achilles, to Nietzsche, to feminism, and to Plato, the author returns to today’s problem of “unemployed manliness.” Formulating a reasoned defense of a quality hardly obedient to reason, he urges men, and especially women, to understand and accept manliness, and to give it honest and honorable employment.

    Using hundreds of first-hand accounts and sources, Smith bring us from the Neolithic age to the present, peppering her engaging prose with enlightening and often surprising details.Subconscious cleanliness has been with us since the first cell ejected a foreign invader. Even at the earliest stages of human development, our bodies produced pleasure-giving chemical opiates when things smelled or felt clean, inducing us to do things like bathing and removing dirty clothes. The need to be clean led directly to socialization, as we turned to our fellows for help with those hard to reach spots. In Eurasia during the Bronze Age, an emerging hierarchy of wealthy elites turned their love of grooming into an explosion of the cosmetic and luxury goods industry, greatly effecting the culture and economy of a vast area and leading to advances in chemistry and medicine. The history that follows, from Greece and Rome, where citizens focused much of their leisure time on perfecting, bathing, or just writing about the model athletic body, through Europe in the middle ages and the following centuries, is full of intriguing customs, convoluted treatises, and many reversals. Baths were good for you, baths were bad for you, baths were good again--but only if they were quite cold. Even the enlightened medical knowledge of modern times could not stop an onslaught of health remedies, treatments, spas, and New Age nature cures that were to follow. While today we are immeasurably closer--perhaps too close--to knowing just what "clean" means to our bodies, we are still just as far as we ever were on agreeing what it means to our souls. This engrossing and highly original work will introduce you to the customs and ideas of a myriad of cultures from centuries of human history. Not only will you gain a new perspective on the wonderful diversity of the world, but you'll never look at your toothbrush the same way again.

    Yet, David Wootton argues, from the fifth century BC until the 1930s, doctors actually did more harm than good. In this controversial new account of the history of medicine, he asks just how much good it has done us over the years, and how much harm it continues to do today.

    Some view taking another person's life as just and reasonable punishment while others see it as an inhumane and barbaric act. But the intensity of feeling that capital punishment provokes often obscures its long and varied history in this country.Now, for the first time, we have a comprehensive history of the death penalty in the United States. Law professor Stuart Banner tells the story of how, over four centuries, dramatic changes have taken place in the ways capital punishment has been administered and experienced. In the seventeenth and eighteenth centuries, the penalty was standard for a laundry list of crimes--from adultery to murder, from arson to stealing horses. Hangings were public events, staged before audiences numbering in the thousands, attended by women and men, young and old, black and white alike. Early on, the gruesome spectacle had explicitly religious purposes--an event replete with sermons, confessions, and last minute penitence--to promote the salvation of both the condemned and the crowd. Through the nineteenth century, the execution became desacralized, increasingly secular and private, in response to changing mores. In the twentieth and twenty-first centuries, ironically, as it has become a quiet, sanitary, technological procedure, the death penalty is as divisive as ever.By recreating what it was like to be the condemned, the executioner, and the spectator, Banner moves beyond the debates, to give us an unprecedented understanding of capital punishment's many meanings. As nearly four thousand inmates are now on death row, and almost one hundred are currently being executed each year, the furious debate is unlikely to diminish. The Death Penalty is invaluable in understanding the American way of the ultimate punishment.

    In Becoming Evil, social psychologist James Waller uncovers the internal and external factors that can lead ordinary people to commit extraordinary acts of evil. Waller debunks the common explanations for genocide- group think, psychopathology, unique cultures- and offers a more sophisticated and comprehensive psychological view of how anyone can potentially participate in heinous crimes against humanity. He outlines the evolutionary forces that shape human nature, the individual dispositions that are more likely to engage in acts of evil, and the context of cruelty in which these extraordinary acts can emerge. Illustrative eyewitness accounts are presented at the end of each chapter. An important new look at how evil develops, Becoming Evil will help us understand such tragedies as the Holocaust and recent terrorist events. Waller argues that by becoming more aware of the things that lead to extraordinary evil, we will be less likely to be surprised by it and less likely to be unwitting accomplices through our passivity.

    The Nazis hated Sigmund Freud with a particular vehemence: they detested his "soul-destroying glorification of the instinctual life." Here Mark Edmundson traces Hitler and Freud's oddly converging lives, then zeroes in on Freud's last two years, during which, with the help of Marie Bonaparte, he was at last rescued from Vienna and brought safely to London. There he was honored as he never had been during his long, controversial life. At the same time he endured the last of more than thirty operations for cancer of the jaw. Confronting certain death, Freud, in typical fashion, did not let fame make him complacent, but instead wrote his most provocative book, Moses and Monotheism, in which he questioned the legacy of the greatest Jewish leader. Focusing on Freud's last two years, Edmundson is able to probe Freud's ideas about death, and also about the human proclivity to embrace fascism in politics and fundamentalism in religion. Edmundson suggests new and important ways to view Freud's legacy, at a time when these forces are once again shaping world events.

    Barron Lerner thought he had heard it all. But in the mid-1990s, his father, an infectious diseases physician, told him a stunning story: he had physically placed his body over an end-stage patient who had stopped breathing, preventing his colleagues from performing cardiopulmonary resuscitation, even though CPR was the ethically and legally accepted thing to do. Over the next few years, the senior Dr. Lerner tried to speed the deaths of his seriously ill mother and mother-in-law to spare them further suffering.These stories angered and alarmed the younger Dr. Lerner—an internist, historian of medicine and bioethicist—who had rejected physician-based paternalism in favor of informed consent and patient autonomy. The Good Doctor is a fascinating and moving account of how Dr. Lerner came to terms with two very different images of his father: a revered clinician, teacher and researcher who always put his patients first, but also a physician willing to “play God,” opposing the very revolution in patients' rights that his son was studying and teaching to his own medical students.But the elder Dr. Lerner’s journals, which he had kept for decades, showed his son how his outdated paternalism had grown out of a fierce devotion to patient-centered medicine that was rapidly disappearing in a world of managed care, spiraling costs and health care reform. And they raised questions: Are paternalistic doctors just relics or should their expertise be used to overrule patients and families that make ill-advised choices? Does the growing use of personalized medicine—in which specific interventions may be best for specific patients—change the calculus between autonomy and paternalism? And how can we best use technologies that were invented to save lives but now too often prolong death? In an era of high-technology medicine, spiraling costs and healthcare reform, these questions could not be more relevant. As his father slowly died of Parkinson’s disease, Dr. Lerner faced these questions both personally and professionally. He found himself being pulled into his dad’s medical care, even though he had criticized his father for making medical decisions for his relatives. Did playing God—at least in some situations—actually make sense? Did doctors sometimes “know best?” A timely and compelling story of one family’s engagement with medicine over the last half century, The Good Doctor is an important book for those who treat illness—and those who struggle to overcome it.

    This was the work of an elite group known as Unit 731, led by Japan's answer to Joseph Mengele, Dr Shiro Ishii.Under their initiative, thousands of individuals were held captive and infected with virulent strains of anthrax, plague, cholera, and other epidemic and viral diseases. Soon entire Chinese villages were being hit with biological bombs. Even American POWs were targeted. All told, more than 250,000 people were infected, and the vast majority died. Yet, after the war, US occupation forces under General Douglas MacArthur struck a deal with these doctors that shielded them from accountability.Provocative, alarming and utterly compelling, A Plague Upon Humanity draws on important original research to expose one of the most shameful chapters in human history.

    Mosse provides the first historical account of the masculine stereotype in modern Western culture, tracing the evolution of the idea of manliness to reveal how it came to embody physical beauty, courage, moral restraint, and a strong will. This stereotype, he finds, originated in the tumultuous changes of the eighteenth century, as Europe's dominant aristocrats grudgingly yielded to the rise of the professional, bureaucratic, and commercial middle classes. Mosse reveals how the new bourgeoisie, faced with a bewildering, rapidly industrialized world, latched onto the knightly ideal of chivalry. He also shows how the rise of universal conscription created a soldierly man as an ideal type. In bringing his examination up to the present, Mosse studies the key historical roles of the so-called fairer sex (women) and unmanly men (Jews and homosexuals) in defining and maintaining the male stereotype, and considers the possible erosion of that stereotype in our own time.