The latest edition offers greatly expanded coverage of directed mutagenesis and protein engineering, therapeutic agents, and genetic engineering of plants. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. Over 480 figures, including 200 that are new in this edition, illustrate all key concepts. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. As in previous editions, the authors clearly explain all concepts and techniques to provide maximum understanding of the subject, avoiding confusing scientific jargon and excessive detail wherever possible. Each chapter concludes with a summary, references, and review questions. Ideally suited as a text for third- and fourth-year undergraduates as well as graduate students, this book is also an excellent reference for health professionals, scientists, engineers, or attorneys interested in biotechnology.

    In the third edition of this best-selling guide, you'll find these topics:- 83 exercises for free weights, machines, bands, and balls- 30 workouts for increasing size, endurance, and strength- Sport-specific programs for tennis, golf, cycling, running, and more- Eating plans and nutrition advice for adding lean muscle and losing fatStrength Training Past 50 will keep you active, healthy, and looking great with workouts and programs designed just for you.

    With it has come vast amounts of data in a variety of fields such as medicine, biology, finance, and marketing. The challenge of understanding these data has led to the development of new tools in the field of statistics, and spawned new areas such as data mining, machine learning, and bioinformatics. Many of these tools have common underpinnings but are often expressed with different terminology. This book describes the important ideas in these areas in a common conceptual framework. While the approach is statistical, the emphasis is on concepts rather than mathematics. Many examples are given, with a liberal use of color graphics. It should be a valuable resource for statisticians and anyone interested in data mining in science or industry. The book's coverage is broad, from supervised learning (prediction) to unsupervised learning. The many topics include neural networks, support vector machines, classification trees and boosting—the first comprehensive treatment of this topic in any book. Trevor Hastie, Robert Tibshirani, and Jerome Friedman are professors of statistics at Stanford University. They are prominent researchers in this area: Hastie and Tibshirani developed generalized additive models and wrote a popular book of that title. Hastie wrote much of the statistical modeling software in S-PLUS and invented principal curves and surfaces. Tibshirani proposed the Lasso and is co-author of the very successful An Introduction to the Bootstrap. Friedman is the co-inventor of many data-mining tools including CART, MARS, and projection pursuit.

    … The book the National Security Agency wanted never to be published." –Wired Magazine "…monumental… fascinating… comprehensive… the definitive work on cryptography for computer programmers…" –Dr. Dobb's Journal"…easily ranks as one of the most authoritative in its field." —PC Magazine"…the bible of code hackers." –The Millennium Whole Earth CatalogThis new edition of the cryptography classic provides you with a comprehensive survey of modern cryptography. The book details how programmers and electronic communications professionals can use cryptography—the technique of enciphering and deciphering messages-to maintain the privacy of computer data. It describes dozens of cryptography algorithms, gives practical advice on how to implement them into cryptographic software, and shows how they can be used to solve security problems. Covering the latest developments in practical cryptographic techniques, this new edition shows programmers who design computer applications, networks, and storage systems how they can build security into their software and systems. What's new in the Second Edition? * New information on the Clipper Chip, including ways to defeat the key escrow mechanism * New encryption algorithms, including algorithms from the former Soviet Union and South Africa, and the RC4 stream cipher * The latest protocols for digital signatures, authentication, secure elections, digital cash, and more * More detailed information on key management and cryptographic implementations

    You'll also learn how to make your programs interactive and how to test your code safely before adding it to a project. In the second half of the book, you'll put your new knowledge into practice with three substantial projects: a Space Invaders-inspired arcade game, data visualizations with Python's super-handy libraries, and a simple web app you can deploy online.As you work through Python Crash Course, you'll learn how to: Use powerful Python libraries and tools, including matplotlib, NumPy, and PygalMake 2D games that respond to keypresses and mouse clicks, and that grow more difficult as the game progressesWork with data to generate interactive visualizationsCreate and customize simple web apps and deploy them safely onlineDeal with mistakes and errors so you can solve your own programming problemsIf you've been thinking seriously about digging into programming, Python Crash Course will get you up to speed and have you writing real programs fast. Why wait any longer? Start your engines and code!

    This concise introduction shows you how to perform statistical analysis computationally, rather than mathematically, with programs written in Python.You'll work with a case study throughout the book to help you learn the entire data analysis process—from collecting data and generating statistics to identifying patterns and testing hypotheses. Along the way, you'll become familiar with distributions, the rules of probability, visualization, and many other tools and concepts.Develop your understanding of probability and statistics by writing and testing codeRun experiments to test statistical behavior, such as generating samples from several distributionsUse simulations to understand concepts that are hard to grasp mathematicallyLearn topics not usually covered in an introductory course, such as Bayesian estimationImport data from almost any source using Python, rather than be limited to data that has been cleaned and formatted for statistics toolsUse statistical inference to answer questions about real-world data

    Turing’s openness about his homosexuality at a time when it was an imprisonable offense ultimately led to his untimely lo death at the age of only forty-one. In Alan Turing: Unlocking the Enigma, David Boyle reveals the mysteries behind the man and his remarkable career. Aged just 22, Turing was elected a fellow at King's College, Cambridge on the strength of a dissertation in which he proved the central limit theorem. By the age of 33, he had been awarded the OBE by King George VI for his wartime services: Turing was instrumental in cracking the Nazi Enigma machines at the top secret code breaking establishment at Bletchley Park during the Second World War.But his achievements were to be tragically overshadowed by the paranoia of the post-War years. Hounded for his supposedly subversive views and for his sexuality, Turing was prosecuted in 1952, and forced to accept the humiliation of hormone treatment to avoid a prison sentence. Just two years later, at the age of 41 he was dead. The verdict: cyanide poisoning.Was Turing’s death accidental as his mother always claimed? Or did persistent persecution drive him to take him own life?Alan Turing: Unlocking the Enigma seeks to find the man behind the science, illuminating the life of a person who is still a shadowy presence behind his brilliant achievements.

    Whether you are a student, software developer, tech entrepreneur, or researcher in computer science, this authoritative and self-contained book tells you everything you need to know about the new global money for the Internet age.How do Bitcoin and its block chain actually work? How secure are your bitcoins? How anonymous are their users? Can cryptocurrencies be regulated? These are some of the many questions this book answers. It begins by tracing the history and development of Bitcoin and cryptocurrencies, and then gives the conceptual and practical foundations you need to engineer secure software that interacts with the Bitcoin network as well as to integrate ideas from Bitcoin into your own projects. Topics include decentralization, mining, the politics of Bitcoin, altcoins and the cryptocurrency ecosystem, the future of Bitcoin, and more.An essential introduction to the new technologies of digital currencyCovers the history and mechanics of Bitcoin and the block chain, security, decentralization, anonymity, politics and regulation, altcoins, and much moreFeatures an accompanying website that includes instructional videos for each chapter, homework problems, programming assignments, and lecture slidesAlso suitable for use with the authors' Coursera online courseElectronic solutions manual (available only to professors)

    This long-awaited revision contains changes throughout the text. There are new implementations of most of the major programming systems in the book, including the interpreters and compilers, and the authors have incorporated many small changes that reflect their experience teaching the course at MIT since the first edition was published. A new theme has been introduced that emphasizes the central role played by different approaches to dealing with time in computational models: objects with state, concurrent programming, functional programming and lazy evaluation, and nondeterministic programming. There are new example sections on higher-order procedures in graphics and on applications of stream processing in numerical programming, and many new exercises. In addition, all the programs have been reworked to run in any Scheme implementation that adheres to the IEEE standard.

    You'll progress from a complete beginner regarding Arduino programming and electronics knowledge to intermediate skills and the confidence to create your own amazing Arduino projects. Absolutely no experience in programming or electronics required!Rather than requiring you to wade through pages of theory before you start making things, this book has a hands-on approach. You will dive into making projects right from the start, learning how to use various electronic components and how to program the Arduino to control or communicate with those components.Each project is designed to build upon the knowledge learned in earlier projects and to further your knowledge in programming as well as skills with electronics. By the end of the book you will be able create your own projects confidently and with creativity.Please note: the print version of this title is black & white; the eBook is full color. You can download the color diagrams in the book from http: //www.apress.com/9781430232407

    Focused on helping students understand and construct proofs and expanding their mathematical maturity, this best-selling text is an accessible introduction to discrete mathematics. Johnsonbaugh's algorithmic approach emphasizes problem-solving techniques. The Seventh Edition reflects user and reviewer feedback on both content and organization.

    These topics lie at the heart of many exciting areas of contemporary science and engineering - communication, signal processing, data mining, machine learning, pattern recognition, computational neuroscience, bioinformatics, and cryptography. This textbook introduces theory in tandem with applications. Information theory is taught alongside practical communication systems, such as arithmetic coding for data compression and sparse-graph codes for error-correction. A toolbox of inference techniques, including message-passing algorithms, Monte Carlo methods, and variational approximations, are developed alongside applications of these tools to clustering, convolutional codes, independent component analysis, and neural networks. The final part of the book describes the state of the art in error-correcting codes, including low-density parity-check codes, turbo codes, and digital fountain codes -- the twenty-first century standards for satellite communications, disk drives, and data broadcast. Richly illustrated, filled with worked examples and over 400 exercises, some with detailed solutions, David MacKay's groundbreaking book is ideal for self-learning and for undergraduate or graduate courses. Interludes on crosswords, evolution, and sex provide entertainment along the way. In sum, this is a textbook on information, communication, and coding for a new generation of students, and an unparalleled entry point into these subjects for professionals in areas as diverse as computational biology, financial engineering, and machine learning.

    We are living in an age where data comes in abundance, and thanks to the self-learning algorithms from the field of machine learning, we can turn this data into knowledge. Automated speech recognition on our smart phones, web search engines, e-mail spam filters, the recommendation systems of our favorite movie streaming services – machine learning makes it all possible.Thanks to the many powerful open-source libraries that have been developed in recent years, machine learning is now right at our fingertips. Python provides the perfect environment to build machine learning systems productively.This book will teach you the fundamentals of machine learning and how to utilize these in real-world applications using Python. Step-by-step, you will expand your skill set with the best practices for transforming raw data into useful information, developing learning algorithms efficiently, and evaluating results.You will discover the different problem categories that machine learning can solve and explore how to classify objects, predict continuous outcomes with regression analysis, and find hidden structures in data via clustering. You will build your own machine learning system for sentiment analysis and finally, learn how to embed your model into a web app to share with the world

    Each chapter is relatively self-contained and can be used as a unit of study. The algorithms are described in English and in a pseudocode designed to be readable by anyone who has done a little programming. The explanations have been kept elementary without sacrificing depth of coverage or mathematical rigor.

    This book provides the first complete identification guides to the birds of this teeming tropical paradise. It gives descriptions of 820 regional species, illustrated in 88 specially commissioned color plates accompanied by notes detailing distinctive features and habitats. Entries cover nomenclature, plumage, markings, voice, global range, distribution and regional status, habits, and diet. The main text gives practical information on where to find many exotic species, citing major birdwatching locations. Introductory chapters discuss habitats, climate, land-use, and conservation concerns. Professional ornithologists and amateur bird watchers alike will find this the indispensable bird guide for eastern Malaysia and western Indonesia for many years to come. It is also an unrivalled source of information for casual travellers and ecotourists.