. . when it comes to the legacy of this country's war on drugs, we should all share his outrage." --The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy lifeDr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a colleague, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism.Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars.Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    As the mother of forensic science, Frances Glessner Lee is the reason why homicide detectives are a thing. She is responsible for the popularity of forensic science in television shows and pop culture. Long overlooked in the history books, this extremely detailed and thoroughly researched biography will at long last tell the story of the life and contributions of this pioneering woman.

    . . .There was a time in my life when I walked through the world known to myself and others as an athlete. It was part of my own definition of who I was and certainly the part I most respected. When I was a young man, I was well-built and agile and ready for the rough and tumble of games, and athletics provided the single outlet for a repressed and preternaturally shy boy to express himself in public....I lost myself in the beauty of sport and made my family proud while passing through the silent eye of the storm that was my childhood.” So begins Pat Conroy’s journey back to 1967 and his startling realization “that this season had been seminal and easily the most consequential of my life.” The place is the Citadel in Charleston, South Carolina, that now famous military college, and in memory Conroy gathers around him his team to relive their few triumphs and humiliating defeats. In a narrative that moves seamlessly between the action of the season and flashbacks into his childhood, we see the author’s love of basketball and how crucial the role of athlete is to all these young men who are struggling to find their own identity and their place in the world.In fast-paced exhilarating games, readers will laugh in delight and cry in disappointment. But as the story continues, we gradually see the self-professed “mediocre” athlete merge into the point guard whose spirit drives the team. He rallies them to play their best while closing off the shouts of “Don’t shoot, Conroy” that come from the coach on the sidelines. For Coach Mel Thompson is to Conroy the undermining presence that his father had been throughout his childhood. And in these pages finally, heartbreakingly, we learn the truth about the Great Santini.In My Losing Season Pat Conroy has written an American classic about young men and the bonds they form, about losing and the lessons it imparts, about finding one’s voice and one’s self in the midst of defeat. And in his trademark language, we see the young Conroy walk from his life as an athlete to the writer the world knows him to be.

    She tried everything to appease her wakefulness: from medication to therapy, changes in her diet to changes in her living arrangements. Nothing seemed to help.The Shapeless Unease is Harvey's darkly funny and deeply intelligent anatomy of her insomnia, an immersive interior monologue of a year without one of the most basic human needs. Original and profound, and narrated with a lucid breathlessness, this is a startlingly insightful exploration of memory, writing and influence, death and the will to survive, from "this generation's Virginia Woolf" (Telegraph).

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Wittman, the founder of the FBI’s Art Crime Team, pulls back the curtain on his career for the first time.Rising from humble roots as the son of an antiques dealer, Wittman built a twenty-year career that was nothing short of extraordinary. He went undercover, usually unarmed, to catch art thieves, scammers, and black market traders in Paris and Philadelphia, Rio and Santa Fe, Miami and Madrid.In this memoir, Wittman relates the stories behind his recoveries of priceless art and antiquities: The golden armor of an ancient Peruvian warrior king. The Rodin sculpture that inspired the Impressionist movement. The headdress Geronimo wore at his final Pow-Wow. The rare Civil War battle flag carried into battle by one of the nation’s first African-American regiments.The breadth of Wittman’s exploits is unmatched: He traveled the world to rescue paintings by Rockwell and Rembrandt, Pissarro, Monet and Picasso, often working undercover overseas at the whim of foreign governments. Closer to home, he recovered an original copy of the Bill of Rights and cracked the scam that rocked the PBS series Antiques Roadshow.By the FBI’s accounting, Wittman saved hundreds of millions of dollars worth of art and antiquities. He says the statistic isn’t important. After all, who’s to say what is worth more --a Rembrandt self-portrait or an American flag carried into battle? They're both priceless.The art thieves and scammers Wittman caught run the gamut from rich to poor, smart to foolish, organized criminals to desperate loners.  The smuggler who brought him a looted 6th-century treasure turned out to be a high-ranking diplomat.  The appraiser who stole countless heirlooms from war heroes’ descendants was a slick, aristocratic con man.  The museum janitor who made off with locks of George Washington's hair just wanted to make a few extra bucks, figuring no one would miss what he’d filched.In his final case, Wittman called on every bit of knowledge and experience in his arsenal to take on his greatest challenge: working undercover to track the vicious criminals behind what might be the most audacious art theft of all.

     The daughter of acclaimed British actor Sir John Mills was still a preteen when she began her acting career and was quickly thrust into the spotlight. Under the wing of Walt Disney himself, Hayley Mills was transformed into one of the biggest child starlets of the 1960s through her iconic roles in Pollyanna, The Parent Trap, and many more. She became one of only twelve actors in history to be bestowed with the Academy Juvenile Award, presented at the Oscars by its first recipient, Shirley Temple, and went on to win a number of awards including a Golden Globe, multiple BAFTAs, and a Disney Legacy Award.Now, in her charming and forthright memoir, she provides a unique window into when Hollywood was still 'Tinseltown' and the great Walt Disney was at his zenith, ruling over what was (at least in his own head) still a family business. This behind-the-scenes look at the drama of having a sky-rocketing career as a young teen in an esteemed acting family will offer both her childhood impressions of the wild and glamorous world she was swept into, and the wisdom and broader knowledge that time has given her. Hayley will delve intimately into her relationship with Walt Disney, as well as the emotional challenges of being bound to a wholesome, youthful public image as she grew into her later teen years, and how that impacted her and her choices--including marrying a producer over 30 years her senior when she was 20! With her regrets, her joys, her difficulties, and her triumphs, this is a compelling read for any fan of classic Disney films and an inside look at a piece of real Hollywood history.

    He was bound for a New Jersey dueling ground to settle his bitter dispute with Aaron Burr. Hamilton took just two men with him: his “second” for the duel, and Dr. David Hosack.As historian Victoria Johnson reveals in her groundbreaking biography, Hosack was one of the few points the duelists did agree on. Summoned that morning because of his role as the beloved Hamilton family doctor, he was also a close friend of Burr. A brilliant surgeon and a world-class botanist, Hosack—who until now has been lost in the fog of history—was a pioneering thinker who shaped a young nation.Born in New York City, he was educated in Europe and returned to America inspired by his newfound knowledge. He assembled a plant collection so spectacular and diverse that it amazes botanists today, conducted some of the first pharmaceutical research in the United States, and introduced new surgeries to American. His tireless work championing public health and science earned him national fame and praise from the likes of Thomas Jefferson, James Madison, Alexander von Humboldt, and the Marquis de Lafayette.One goal drove Hosack above all others: to build the Republic’s first botanical garden. Despite innumerable obstacles and near-constant resistance, Hosack triumphed when, by 1810, his Elgin Botanic Garden at last crowned twenty acres of Manhattan farmland. “Where others saw real estate and power, Hosack saw the landscape as a pharmacopoeia able to bring medicine into the modern age” (Eric W. Sanderson, author of Mannahatta). Today what remains of America’s first botanical garden lies in the heart of midtown, buried beneath Rockefeller Center.Whether collecting specimens along the banks of the Hudson River, lecturing before a class of rapt medical students, or breaking the fever of a young Philip Hamilton, David Hosack was an American visionary who has been too long forgotten. Alongside other towering figures of the post-Revolutionary generation, he took the reins of a nation. In unearthing the dramatic story of his life, Johnson offers a lush depiction of the man who gave a new voice to the powers and perils of nature.

    Doctors predicted that she would never intellectually develop beyond the abilities of a small child. Although she made some progress after years of intensive behavioral and communication therapy, Carly remained largely unreachable. Then, at the age of ten, she had a breakthrough. While working with her devoted therapists Howie and Barb, Carly reached over to their laptop and typed in "HELP TEETH HURT," much to everyone's astonishment. This was the beginning of Carly's journey toward self-realization. Although Carly still struggles with all the symptoms of autism, which she describes with uncanny accuracy and detail, she now has regular, witty, and profound conversations on the computer with her family, her therapists, and the many thousands of people who follow her via her blog, Facebook, and Twitter. In Carly's Voice, her father, Arthur Fleischmann, blends Carly's own words with his story of getting to know his remarkable daughter. One of the first books to explore firsthand the challenges of living with autism, it brings readers inside a once-secret world and in the company of an inspiring young woman who has found her voice and her mission.

    Alexander von Humboldt (1769 – 1859) was an intrepid explorer and the most famous scientist of his age. In North America, his name still graces four counties, thirteen towns, a river, parks, bays, lakes, and mountains. His restless life was packed with adventure and discovery, whether he was climbing the highest volcanoes in the world or racing through anthrax-infected Siberia or translating his research into bestselling publications that changed science and thinking. Among Humboldt's most revolutionary ideas was a radical vision of nature, that it is a complex and interconnected global force that does not exist for the use of humankind alone. Now Andrea Wulf brings the man and his achievements back into focus: his daring expeditions and investigation of wild environments around the world and his discoveries of similarities between climate and vegetation zones on different continents. She also discusses his prediction of human-induced climate change, his remarkable ability to fashion poetic narrative out of scientific observation, and his relationships with iconic figures such as Simón Bolívar and Thomas Jefferson. Wulf examines how Humboldt's writings inspired other naturalists and poets such as Darwin, Wordsworth, and Goethe, and she makes the compelling case that it was Humboldt's influence that led John Muir to his ideas of natural preservation and that shaped Thoreau's Walden.With this brilliantly researched and compellingly written book, Andrea Wulf shows the myriad fundamental ways in which Humboldt created our understanding of the natural world, and she champions a renewed interest in this vital and lost player in environmental history and science.

    It is 4 a.m. I have run arrest calls, treated life-threatening bleeding, held the hand of a young woman dying of cancer, scuttled down miles of dim corridors wanting to sob with sheer exhaustion, forgotten to eat, forgotten to drink, drawn on every fibre of strength that I possess to keep my patients safe from harm.'How does it feel to be spat out of medical school into a world of pain, loss and trauma that you feel wholly ill-equipped to handle? To be a medical novice who makes decisions which - if you get them wrong - might forever alter, or end, a person's life?In 'Your Life in My Hands', television journalist turned junior doctor Rachel Clarke captures the extraordinary realities of life on the NHS frontline. During last year's historic junior doctor strikes, Rachel was at the forefront of the campaign against the government's imposed contract upon young doctors. Her heartfelt, deeply personal account of life as a junior doctor in today's NHS is both a powerful polemic on the degradation of Britain's most vital public institution and a love letter of optimism and hope to that same health service.

    And in so doing, he offers something for everyone, no matter which strand draws you in.”—The New York Times Book ReviewIn November 2014, thirteen members of the Biden family gathered on Nantucket for Thanksgiving, a tradition they had been celebrating for the past forty years; it was the one constant in what had become a hectic, scrutinized, and overscheduled life. The Thanksgiving holiday was a much-needed respite, a time to connect, a time to reflect on what the year had brought, and what the future might hold. But this year felt different from all those that had come before. Joe and Jill Biden’s eldest son, Beau, had been diagnosed with a malignant brain tumor fifteen months earlier, and his survival was uncertain. “Promise me, Dad,” Beau had told his father. “Give me your word that no matter what happens, you’re going to be all right.” Joe Biden gave him his word.Promise Me Dad chronicles the year that followed, which would be the most momentous and challenging in Joe Biden’s extraordinary life and career. As vice president, Biden traveled more than a hundred thousand miles that year, across the world, dealing with crises in Ukraine, Central America, and Iraq. When a call came from New York, or Capitol Hill, or Kyiv, or Baghdad—“Joe, I need your help”—he responded. For twelve months, while Beau fought for and then lost his life, the vice president balanced the twin imperatives of living up to his responsibilities to his country and his responsibilities to his family. And never far away was the insistent and urgent question of whether he should seek the presidency in 2016.The year brought real triumph and accomplishment, and wrenching pain. But even in the worst times, Biden was able to lean on the strength of his long, deep bonds with his family, on his faith, and on his deepening friendship with the man in the Oval Office, Barack Obama.Writing with poignancy and immediacy, Joe Biden allows readers to feel the urgency of each moment, to experience the days when he felt unable to move forward as well as the days when he felt like he could not afford to stop.This is a book written not just by the president, but by a father, grandfather, friend, and husband. Promise Me Dad is a story of how family and friendships sustain us and how hope, purpose, and action can guide us through the pain of personal loss into the light of a new future.

    senator Joe Biden when he called her out of the blue to ask her on a date.Growing up, Jill had wanted two things: a marriage like her parents'--strong, loving, and full of laughter--and a career. An early heartbreak had left her uncertain about love, until she met Joe. But as they grew closer, Jill faced difficult questions: How would politics shape her family and professional life? And was she ready to become a mother to Joe's two young sons?She soon found herself falling in love with her three "boys," learning to balance life as a mother, wife, educator, and political spouse. Through the challenges of public scrutiny, complicated family dynamics, and personal losses, she grew alongside her family, and she extended the family circle at every turn: with her students, military families, friends and staff at the White House, and more.This is the story of how Jill built a family--and a life--of her own. From the pranks she played to keep everyone laughing to the traditions she formed that would carry them through tragedy, hers is the spirited journey of a woman embracing many roles.Where the Light Enters is a candid, heartwarming glimpse into the creation of a beloved American family, and the life of a woman at its center.

    Now Miss Hepburn breaks her long-kept silence about her private life in this absorbing and provocative memoir.A NEW YORK TIMES Notable Book of the YearA Book-of-the-Month-Club Main Selection