The Vaccine Race: Science, Politics, and the Human Costs of Defeating Disease
Meredith Wadman - 2017
In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.
The Mosquito: A Human History of Our Deadliest Predator
Timothy C. Winegard - 2019
As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.
Deadliest Enemy: Our War Against Killer Germs
Michael T. Osterholm - 2017
And as outbreaks of COVID-19, Ebola, MERS, and Zika have demonstrated, we are woefully underprepared to deal with the fallout. So what can -- and must -- we do in order to protect ourselves from mankind's deadliest enemy?Drawing on the latest medical science, case studies, policy research, and hard-earned epidemiological lessons, Deadliest Enemy explores the resources and programs we need to develop if we are to keep ourselves safe from infectious disease. The authors show how we could wake up to a reality in which many antibiotics no longer cure, bioterror is a certainty, and the threat of a disastrous influenza or coronavirus pandemic looms ever larger. Only by understanding the challenges we face can we prevent the unthinkable from becoming the inevitable.Deadliest Enemy is high scientific drama, a chronicle of medical mystery and discovery, a reality check, and a practical plan of action.
Bottle of Lies: The Inside Story of the Generic Drug Boom
Katherine Eban - 2019
Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.
Collider: The Search for the World's Smallest Particles
Paul Halpern - 2009
But what is the Higgs boson and why is it often referred to as the God Particle? Why are the Higgs and the LHC so important? Getting a handle on the science behind the LHC can be difficult for anyone without an advanced degree in particle physics, but you don't need to go back to school to learn about it. In Collider, award-winning physicist Paul Halpern provides you with the tools you need to understand what the LHC is and what it hopes to discover.Comprehensive, accessible guide to the theory, history, and science behind experimental high-energy physicsExplains why particle physics could well be on the verge of some of its greatest breakthroughs, changing what we think we know about quarks, string theory, dark matter, dark energy, and the fundamentals of modern physicsTells you why the theoretical Higgs boson is often referred to as the God particle and how its discovery could change our understanding of the universeClearly explains why fears that the LHC could create a miniature black hole that could swallow up the Earth amount to a tempest in a very tiny teapot"Best of 2009 Sci-Tech Books (Physics)"-Library Journal"Halpern makes the search for mysterious particles pertinent and exciting by explaining clearly what we don't know about the universe, and offering a hopeful outlook for future research."-Publishers WeeklyIncludes a new author preface, "The Fate of the Large Hadron Collider and the Future of High-Energy Physics"The world will not come to an end any time soon, but we may learn a lot more about it in the blink of an eye. Read Collider and find out what, when, and how.
The Killer of Little Shepherds: A True Crime Story and the Birth of Forensic Science
Douglas Starr - 2010
At the end of the nineteenth century, serial murderer Joseph Vacher, known and feared as "The Killer of Little Shepherds," terrorized the French countryside. He eluded authorities for years--until he ran up against prosecutor Emile Fourquet and Dr. Alexandre Lacassagne, the era's most renowned criminologist. The two men--intelligent and bold--typified the Belle Epoque, a period of immense scientific achievement and fascination with science's promise to reveal the secrets of the human condition. With high drama and stunning detail, Douglas Starr revisits Vacher's infamous crime wave, interweaving the story of how Lacassagne and his colleagues were developing forensic science as we know it. We see one of the earliest uses of criminal profiling, as Fourquet painstakingly collects eyewitness accounts and constructs a map of Vacher's crimes. We follow the tense and exciting events leading to the murderer's arrest. And we witness the twists and turns of the trial, celebrated in its day. In an attempt to disprove Vacher's defense by reason of insanity, Fourquet recruits Lacassagne, who in the previous decades had revolutionized criminal science by refining the use of blood-spatter evidence, systematizing the autopsy, and doing groundbreaking research in psychology. Lacassagne's efforts lead to a gripping courtroom denouement. "The Killer of Little Shepherds" is an important contribution to the history of criminal justice, impressively researched and thrillingly told.
The Remedy: Robert Koch, Arthur Conan Doyle, and the Quest to Cure Tuberculosis
Thomas Goetz - 2014
In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB—often called consumption—was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy—a remedy that would be his undoing. When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event. Touring the ward of reportedly cured patients, he was horrified. Koch’s "remedy" was either sloppy science or outright fraud. But to a world desperate for relief, Koch’s remedy wasn’t so easily dismissed. As Europe’s consumptives descended upon Berlin, Koch urgently tried to prove his case. Conan Doyle, meanwhile, returned to England determined to abandon medicine in favor of writing. In particular, he turned to a character inspired by the very scientific methods that Koch had formulated: Sherlock Holmes. Capturing the moment when mystery and magic began to yield to science, The Remedy chronicles the stunning story of how the germ theory of disease became a true fact, how two men of ambition were emboldened to reach for something more, and how scientific discoveries evolve into social truths.
Aroused: The History of Hormones and How They Control Just About Everything
Randi Hutter Epstein - 2018
Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein reveals the “invigorating history” (Nature) of hormones and the age-old quest to control them through the back rooms, basements, and labs where endocrinology began.
I Love Green Smoothies: 50 Recipes to Get You Started Drinking Your Way to a Sexy, Slim, Youthful You!
Katherine Stromick - 2012
Green Smoothies are a mix of greens, vegetables and flavorful fruits making you feel amazing and helping to:Lose WeightDetoxify the BodyIncrease EnergyFight Heart DiseasePrevent Diabetes, Depression and Certain CancersBoost the Immune SystemImprove Skin and HairThese delicious Green Smoothie recipes will help you lose weight, have increased energy, and improve your overall health!
Why is the Penis Shaped Like That?: And Other Reflections on Being Human
Jesse Bering - 2010
Exploring the history of cannibalism, the neurology of people who are sexually attracted to animals, the evolution of human body fluids, the science of homosexuality, and serious questions about life and death, Bering astutely covers a generous expanse of our kaleidoscope of quirks and origins.With his characteristic irreverence and trademark cheekiness, Bering leaves no topic unturned or curiosity unexamined, and he does it all with an audaciously original voice. Whether you're interested in the psychological history behind the many facets of sexual desire or the evolutionary patterns that have dictated our current mystique and phallic physique, Why Is the Penis Shaped Like That? is bound to create lively discussion and debate for years to come.
Do No Harm: Stories of Life, Death and Brain Surgery
Henry Marsh - 2014
Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.
Fat Chance: Beating the Odds Against Sugar, Processed Food, Obesity, and Disease
Robert H. Lustig - 2012
Now, in this much anticipated book, he documents the science and the politics that has led to the pandemic of chronic disease over the last 30 years.In the late 1970s when the government mandated we get the fat out of our food, the food industry responded by pouring more sugar in. The result has been a perfect storm, disastrously altering our biochemistry and driving our eating habits out of our control.To help us lose weight and recover our health, Lustig presents personal strategies to readjust the key hormones that regulate hunger, reward, and stress; and societal strategies to improve the health of the next generation. Compelling, controversial, and completely based in science, Fat Chance debunks the widely held notion to prove “a calorie is NOT a calorie”, and takes that science to its logical conclusion to improve health worldwide.
How We Die: Reflections of Life's Final Chapter
Sherwin B. Nuland - 1994
This new edition includes an all-embracing and incisive afterword that examines the current state of health care and our relationship with life as it approaches its terminus. It also discusses how we can take control of our own final days and those of our loved ones.Shewin Nuland's masterful How We Die is even more relevant than when it was first published.
Blood and Guts: A History of Surgery
Richard Hollingham - 2008
But getting here has not been a simple story of selfless men working tirelessly in the pursuit of medical advancement. Instead it's a bloodstained tale of blunders, arrogance, mishap and murder. In trying to keep us alive, surgeons have all too often killed us off, and life-saving solutions have often come from the most surprising places. Accompanying a major BBC series, "Blood and Guts" is an incredible story of stolen corpses, medical fraud, lobotomized patients - and every now and then courageous advances that have saved the lives of millions around the world. You may think twice before going under the knife.
Under the Knife: A History of Surgery in 28 Remarkable Operations
Arnold van de Laar - 2014
In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.