Administered off-label in small daily doses (0.5 to 4.5 mg), this generic drug is extremely affordable and presents few known side effects. So why has it languished in relative medical obscurity? The LDN Book explains the drug’s origins, its primary mechanism, and the latest research from practicing physicians and pharmacists as compiled by Linda Elsegood of The LDN Research Trust, the world’s largest LDN charity organization with over 19,000 members worldwide. Featuring ten chapters contributed by medical professionals on LDN’s efficacy and two patient-friendly appendices, The LDN Book is a comprehensive resource for doctors, pharmacists, and patients who want to learn more about how LDN is helping people now, and a clarion call for further research that could help millions more.

    Significant numbers of poorly designed programs have been created by less-experienced developers, resulting in applications that are inefficient and hard to maintain and extend. Increasingly, software system professionals are discovering just how difficult it is to work with these inherited, non-optimal applications. For several years, expert-level object programmers have employed a growing collection of techniques to improve the structural integrity and performance of such existing software programs. Referred to as refactoring, these practices have remained in the domain of experts because no attempt has been made to transcribe the lore into a form that all developers could use... until now. In Refactoring: Improving the Design of Existing Software, renowned object technology mentor Martin Fowler breaks new ground, demystifying these master practices and demonstrating how software practitioners can realize the significant benefits of this new process.

     At any given moment, somewhere in the world someone struggles with the same software design problems you have. You know you don't want to reinvent the wheel (or worse, a flat tire), so you look to Design Patterns--the lessons learned by those who've faced the same problems. With Design Patterns, you get to take advantage of the best practices and experience of others, so that you can spend your time on...something else. Something more challenging. Something more complex. Something more fun. You want to learn about the patterns that matter--why to use them, when to use them, how to use them (and when NOT to use them). But you don't just want to see how patterns look in a book, you want to know how they look "in the wild". In their native environment. In other words, in real world applications. You also want to learn how patterns are used in the Java API, and how to exploit Java's built-in pattern support in your own code. You want to learn the real OO design principles and why everything your boss told you about inheritance might be wrong (and what to do instead). You want to learn how those principles will help the next time you're up a creek without a design pattern. Most importantly, you want to learn the "secret language" of Design Patterns so that you can hold your own with your co-worker (and impress cocktail party guests) when he casually mentions his stunningly clever use of Command, Facade, Proxy, and Factory in between sips of a martini. You'll easily counter with your deep understanding of why Singleton isn't as simple as it sounds, how the Factory is so often misunderstood, or on the real relationship between Decorator, Facade and Adapter. With Head First Design Patterns, you'll avoid the embarrassment of thinking Decorator is something from the "Trading Spaces" show. Best of all, in a way that won't put you to sleep! We think your time is too important (and too short) to spend it struggling with academic texts. If you've read a Head First book, you know what to expect--a visually rich format designed for the way your brain works. Using the latest research in neurobiology, cognitive science, and learning theory, Head First Design Patterns will load patterns into your brain in a way that sticks. In a way that lets you put them to work immediately. In a way that makes you better at solving software design problems, and better at speaking the language of patterns with others on your team.

    The author incudes OOD, UML, Design Patterns, Agile and XP methods with a detailed description of a complete software design for reusable programs in C++ and Java. Using a practical, problem-solving approach, it shows how to develop an object-oriented application -- from the early stages of analysis, through the low-level design and into the implementation. Walks readers through the designer's thoughts -- showing the errors, blind alleys, and creative insights that occur throughout the software design process. KEY TOPICS: Covers: Statics and Dynamics; Principles of Class Design; Complexity Management; Principles of Package Design; Analysis and Design; Patterns and Paradigm Crossings. Explains the principles of OOD, one by one, and then demonstrates them with numerous examples, completely worked-through designs, and case studies. Covers traps, pitfalls, and work arounds in the application of C++ and OOD and then shows how Agile methods can be used. Discusses the methods for designing and developing big software in detail. Features a three-chapter, in-depth, single case study of a building security system. MARKET: For Software Engineers, Programmers, and Analysts who want to understand how to design object oriented software with state of the art methods.

    Uber and Airbnb are household names: redefining neighbourhoods, challenging the way governments regulate business and changing the way we travel.In the spirit of iconic Silicon Valley renegades like Steve Jobs and Bill Gates, a new generation of entrepreneurs is sparking yet another cultural upheaval through technology. They are among the Upstarts, idiosyncratic founders with limitless drive and an abundance of self-confidence. Young, hungry and brilliant, they are rewriting the traditional rules of business, changing our day-to-day lives and often sidestepping serious ethical and legal obstacles in the process.The Upstarts is the definitive account of a dawning age of tenacity, creativity, conflict and wealth. In Brad Stone’s highly anticipated and riveting account of the most radical companies of the new Silicon Valley, we find out how it all started, and how the world is wildly different than it was ten years ago.

    This is the first book in his poker tells trilogy, following by Verbal Poker Tells (2014) and Exploiting Poker Tells (2017). This book will teach you how professional poker players analyze the facial expressions, body posture, physical gestures, and verbal statements of opponents in a live poker game. More importantly, it will give you a mental framework for thinking about and remembering poker tells by emphasizing how common situations can be similar or can be different (for example, the big difference between a Post-Bet situation and a Waiting-For-Action situation). Reading Poker Tells also contains other tips on general poker psychology, including methods for deceiving and manipulating opponents, and ways to stay "unreadable". Many people have said that the greatest value they got from this book was in being able to eliminate some common tells that they were unknowingly displaying.

     We all know what a .300 hitter looks like. The same with a 20-game winner. Those numbers are ingrained in our brains. But do they mean as much as we think? Do we feel the same way when we hear a batter has a .390 wOBA? How about a pitcher with a 1.2 WHIP? These statistics are the future of modern baseball, and no fan should be in the dark about how these metrics apply to the game.In the last twenty years, an avalanche of analytics has taken over the way the game is played, managed, and assessed, but the statistics that drive the sport (metrics like wRC+, FIP, and WAR, just to name a few) read like alphabet soup to a large number of fans who still think batting average, RBIs, and wins are the best barometers for baseball players.In A Fan’s Guide to Baseball Analytics, MLB.com reporter and columnist Anthony Castrovince has taken on the role as explainer to help such fans understand why the old stats don’t always add up. Readers will also learn where these modern stats came from, what they convey, and how to use them to evaluate players of the present, past, and future. For instance, what if we told you that when Joe DiMaggio had his famous 56-game hitting streak in 1941, helping him win the AL MVP, that there was, perhaps, someone more deserving? In fact, the great Ted Williams actually had a higher fWAR, bWAR, wRC+, OPS, OPS+, ISO, RC . . . well, you get the picture. So, streak or no streak, Williams should have been league MVP.An introductory course on sabermetrics, A Fan’s Guide to Baseball Analytics is an easily digestible resource that readers can keep turning back to when they see a modern metric referenced in today’s baseball coverage.

    Badham’s list of “12 Questions You Must Ask Before Stepping On Set” is an absolute must in any filmmaker’s toolbox. Whether actor, director, cinematographer, production designer, or any other creative, Badham gives you the tools to deconstruct and solve scenes that either don’t work or need sharpening. Continuing the work begun in his best-selling book I’ll Be In My Trailer, Badham shares more insights into working with difficult actors, rehearsal techniques, and getting the best performance from your cast.

    Whether you aspire to become a Search Engine Marketing PPC Professional or just want to learn more about Google AdWords Pay Per Click advertising to use it in your own business. PPC advertising can drive some really great - really targeted traffic to practically any website AND you can do it fairly inexpensively if you learn how to do it right. Google AdWords is most certainly the best place to start, as practically every other pay per click platform has in some form or another modeled its foundation around the basic AdWords type PPC concepts. What this book is about: Google AdWords - An Introduction, is a guide for you to run through and see if you think that Google AdWords is something you want to learn more about… This book is for you if: You would like to see at a very high level, how you can use PPC / Google AdWords to drive highly targeted traffic to ANY website. or You're thinking about maybe becoming a Certified Google AdWords Professional and taking on clients of your own, and running their pay-per-click campaigns for them and GET PAID. or You may be thinking about working directly for a business or advertising agency and running PPC campaigns for them as a Search Engine Marketing – PPC Professional. Becoming a Certified Google AdWords Professional opens many, many doors in the world of online marketing. I'll show you how to become Google Certified and get on the fast track to becoming a Search Engine Marketing - PPC Professional that is in extremely high demand in the digital marketing space today. This book may also be for you if: You find yourself at a crossroads and: 1 - You’re stuck in a dead-end job: customer service, sales or otherwise and you’re wanting to improve your job status, career choices and your PAY. 2 - You’re thinking about becoming an AdWords Certified Consultant serving your own clients as a consultant or at an agency. 3 - You’re an entrepreneur, coach or business owner and you want to learn more about paid media buying to market yourself and your business online. This book is intended to help you to get a high level vision and overview of the Google AdWords & Pay Per Click Advertising. Whatever your current situation, this book will give you a taste of what it’s like inside the world of Pay Per Click Advertising. After reading through once or twice… YOU WILL KNOW IF PPC is right for you at this point and time in your business/career/life. What this book is NOT about. This book is not about the latest and greatest tips and tricks for using Google AdWords… I do offer extensive AdWords PPC training through my web site: http://ppcequation.com - Both free and paid training can be found there. I just want to be 100% transparent with you and let you know that this book is not going to make you a PPC expert in one read. It's simply an introduction to the industry, either for the business owner / entrepreneur wanting to drive more traffic to his offerings or for someone thinking about becoming a Pay Per Click Professional as a career. Take a look inside at the table of contents before you order to see all that's covered... I guarantee you will find some great takeaways... gold nuggets and bonuses within. So please: Read, Relax and Enjoy!

    

    I would love to write that book, but at this time I have no indication that such a book would be worth writing. Most books fail in the market, and most of them fail not because they are poorly written or edited, but because there aren’t enough people interested in them. They are not the right it.What you are reading now is a pretotype edition of the book. I wrote and “edited” it in days instead of months, just to test the level of interest in such a book. I had a few friends and colleagues review it, but don’t be surprised if you find typos, misspellings, bad grammar, awkward formatting and all sorts of misteaks.Releasing it in its present state is not easy for me.The toughest thing about pretotyping is not developing pretotypes, that’s the fun part. The tough part is getting over our compulsion for prema- ture perfectionism and our desire to add more features, or content, before releasing the first version. The tough part is getting our pretotypes in front of people, where they will be judged, criticized and – possibly – rejected.Reid Hoffman, founder of LinkedIn once said: “If you are not embarrassed by the first version of your product, you’ve launched too late.”I am plenty embarrassed. I must be on the right track.http://www.pretotyping.org/pretotype-...

    In this new collection, human desire pulls with the force and rhythm of a sea tide, emerging from and receding into mysteries larger than any individual life. The book begins with the reverential title poem and concludes with four works that reflect the power of place to shape revelation; the way stone and sky and birdsong can point the way home. Whether tracing the sensual devotion of bodily presence or the painful heartbreak of impermanence, the poems keep faith with love's appearances and disappearances, and the promises we make and break on its behalf.

    As traffic volume and data demands increase, these applications become more complicated and brittle, exposing risks and compromising availability. This practical guide shows IT, devops, and system reliability managers how to prevent an application from becoming slow, inconsistent, or downright unavailable as it grows.Scaling isn't just about handling more users; it's also about managing risk and ensuring availability. Author Lee Atchison provides basic techniques for building applications that can handle huge quantities of traffic, data, and demand without affecting the quality your customers expect.In five parts, this book explores:Availability: learn techniques for building highly available applications, and for tracking and improving availability going forwardRisk management: identify, mitigate, and manage risks in your application, test your recovery/disaster plans, and build out systems that contain fewer risksServices and microservices: understand the value of services for building complicated applications that need to operate at higher scaleScaling applications: assign services to specific teams, label the criticalness of each service, and devise failure scenarios and recovery plansCloud services: understand the structure of cloud-based services, resource allocation, and service distribution

    In The Master Algorithm, Pedro Domingos lifts the veil to give us a peek inside the learning machines that power Google, Amazon, and your smartphone. He assembles a blueprint for the future universal learner--the Master Algorithm--and discusses what it will mean for business, science, and society. If data-ism is today's philosophy, this book is its bible.

    How has Google done it? Veteran technology reporter Steven Levy was granted unprecedented access to the company, and in this revelatory book he takes readers inside Google headquarters—the Googleplex—to show how Google works.While they were still students at Stanford, Google cofounders Larry Page and Sergey Brin revolutionized Internet search. They followed this brilliant innovation with another, as two of Google’s earliest employees found a way to do what no one else had: make billions of dollars from Internet advertising. With this cash cow, Google was able to expand dramatically and take on other transformative projects: more efficient data centers, open-source cell phones, free Internet video (YouTube), cloud computing, digitizing books, and much more.The key to Google’s success in all these businesses, Levy reveals, is its engineering mind-set and adoption of such Internet values as speed, openness, experimentation, and risk taking. After its unapologetically elitist approach to hiring, Google pampers its engineers—free food and dry cleaning, on-site doctors and masseuses—and gives them all the resources they need to succeed. Even today, with a workforce of more than 23,000, Larry Page signs off on every hire.But has Google lost its innovative edge? With its newest initiative, social networking, Google is chasing a successful competitor for the first time. Some employees are leaving the company for smaller, nimbler start-ups. Can the company that famously decided not to be evil still compete?No other book has ever turned Google inside out as Levy does with In the Plex.