Devlin's Textbook of Biochemistry with Clinical Correlations presents the biochemistry of mammalian cells, relates events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to humans. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this sixth edition is an indispensable tool for students and professionals in the medical or health sciences. Key Features of the Sixth Edition Over 250 Clinical Correlations highlighting the significance of the biochemistry to clinical conditions and diseases MCAT-Style Questions with annontated answers in every chapter - in a format similar to that used by the National Board of Medical Examiners More than 1,200 high-quality, full-color illustrations A concise appendix reviewing important Organic Chemistry Concepts New to the Sixth Edition: Fully Updated with a significant revision of all chapters and major topics Two new chapters: Fundamentals of Signal Transduction and Cell Cycle, Programmed Cell Death, and Cancer A Glossary that explains important biochemical terms New sections on the Basal Lamina Protein Complex and Molecular Motors

    But there is one other crucial factor, which is much less well known. The same team had done it before. The truth is that many of those most closely involved in cracking the Enigma code – Alistair Denniston, Frank Birch, Dilly Knox – had wrestled with German naval codes for most of the First World War. By the end of the war they had been successfully cracking a new code every day, from their secret Room 40 at the Old Admiralty Building, in a London blacked out for Zeppelin Raids.The techniques they developed then, the ideas that they came to rely on, the people they came to trust, had been developed the hard way, under intense pressure and absolute secrecy during World War I. Before Enigma tells their story and explains how they managed to crack the supposedly indecipherable code. The book outlines the capture of the Magdeburg and the Hobart, discusses the use of cracked codes to bring German fleets to battle at Dogger Bank and Jutland, and focuses on individuals such as Winston Churchill and Admiral Sir Reginald ‘Blinker’ Hall and their importance in the development of a British naval code tradition. Praise for David Boyle ‘Exhilarating’ - Daily Mail David Boyle is a British author and journalist who writes mainly about history and new ideas in economics, money, business and culture. He lives in Crystal Palace, London. His books include Alan Turing: Unlocking the Enigma, Operation Primrose, Rupert Brooke: England’s Last Patriot, Peace on Earth: The Christmas Truce of 1914, Jerusalem: England’s National Anthem and Unheard Unseen: Warfare in the Dardanelles .Endeavour Press is the UK's leading independent digital publisher. For more information on our titles please sign up to our newsletter at www.endeavourpress.com. Each week you will receive updates on free and discounted ebooks. Follow us on Twitter: @EndeavourPress and on Facebook via http://on.fb.me/1HweQV7. We are always interested in hearing from our readers. Endeavour Press believes that the future is now.

    Beginning in the 1950s when doctors still paid house calls but regularly withheld the truth from their patients, Amy Gutmann and Jonathan D. Moreno explore an unprecedented revolution in health care and explain the problem with America’s wanting everything that medical science has to offer without debating its merits and its limits. The result: Americans today pay far more for health care while having among the lowest life expectancies and highest infant mortality of any affluent nation.Gutmann and Moreno—“incisive, influential, and pragmatic thinkers” (Arthur Caplan)—demonstrate that the stakes have never been higher for prolonging and improving life. From health care reform and death-with-dignity to child vaccinations and gene editing, they explain how bioethics came to dominate the national spotlight, leading and responding to a revolution in doctor-patient relations, a burgeoning world of organ transplants, and new reproductive technologies that benefit millions but create a host of legal and ethical challenges.With striking examples, the authors show how breakthroughs in cancer research, infectious disease, and drug development provide Americans with exciting new alternatives, yet often painful choices. They address head-on the most fundamental challenges in American health care: Why do we pay so much for health care while still lacking universal coverage? How can medical studies adequately protect individuals who volunteer for them? What’s fair when it comes to allocating organs for transplants in truly life-and-death situations?A lucid and provocative blend of history and public policy, this urgent work exposes the American paradox of wanting to have it all without paying the price.

    Staff nursing in a ward where she's challenged by an inventory driven ward sister, she reckons it's time to swap such trivialities for life as a district nurse.Independent thinking is one thing, but Jane's about to find that the drama on district can demand instant reaction; and without hospital back up, she's usually the one having to provide it. She meets a rich cast of patients all determined to follow their own individual star, and goes to Edinburgh where Queen Victoria's Jubilee Institute's nurse training is considered the cr me de la cr me of the district nursing world.Call Me Sister recalls Jane's challenging and often hilarious route to realizing her own particular dream.

    In his hallmark friendly style, he explores the universal impact of being the right size. By examining stories ranging from Alice in Wonderland to Gulliver's Travels, he shows that humans have always been fascinated by things big and small. Why then does size always reside on the fringes of science and never on the center stage? Why do biologists and others ponder size only when studying something else--running speed, life span, or metabolism? Why Size Matters, a pioneering book of big ideas in a compact size, gives size its due by presenting a profound yet lucid overview of what we know about its role in the living world. Bonner argues that size really does matter--that it is the supreme and universal determinant of what any organism can be and do. For example, because tiny creatures are subject primarily to forces of cohesion and larger beasts to gravity, a fly can easily walk up a wall, something we humans cannot even begin to imagine doing.Bonner introduces us to size through the giants and dwarfs of human, animal, and plant history and then explores questions including the physics of size as it affects biology, the evolution of size over geological time, and the role of size in the function and longevity of living things.As this elegantly written book shows, size affects life in its every aspect. It is a universal frame from which nothing escapes.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    Countless behaviors separate us from the rest of the animal kingdom, but all of them can be traced one way or another to six traits that are unique to the human race—our big toe, our opposable thumb, our oddly shaped pharynx, and our ability to laugh, kiss, and cry. At first glance these may not seem to be connected but they are. Each marks a fork in the evolutionary road where we went one way and the rest of the animal kingdom went another. Each opens small passageways on the peculiar geography of the human heart and mind.Walter weaves together fascinating insights from complexity theory, the latest brain scanning techniques, anthropology, artificial intelligence, cognitive psychology, and robotics to explore how the smallest of changes over the past six million years – all shaped by the forces of evolution -- have enabled a primate once on the brink of extinction to evolve into a creature that would one day create all of the grand and exuberant edifices of human culture.As the story of each trait unfolds, Walter explains why our brains grew so large and complex, why we find one another sexually attractive, how toolmaking laid the mental groundwork for language, why we care about what others think, and how we became the creature that laughs and cries and falls in love. Thumbs, Toes and Tears is original, informative, and delightfully thought-provoking.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    A school cafeteria lunch is infected with a drug-resistant strain of E. coli.... Thousands in a bustling shopping mall inhale a lethal mist of smallpox, turning each individual into a highly infectious agent of suffering and death....Dr. Michael Osterholm knows all too well the horrifying scenarios he describes. In this eye-opening account, the nation’s leading expert on bioterrorism sounds a wake-up call to the terrifying threat of biological attack — and America’s startling lack of preparedness. He demonstrates the havoc these silent killers can wreak, exposes the startling ease with which they can be deployed, and asks probing questions about America’s ability to respond to such attacks. Are most doctors and emergency rooms able to diagnose correctly and treat anthrax, smallpox, and other potential tools in the bioterrorist’s arsenal? Is the government developing the appropriate vaccines and treatments? The answers are here in riveting detail — what America has and hasn’t done to prevent the coming bioterrorist catastrophe. Impeccably researched, grippingly told, Living Terrors presents the unsettling truth about the magnitude of the threat. And more important, it presents the ultimate insider’s prescription for change: what we must do as a nation to secure our freedom, our future, our lives.

    And survival is never a given. Somehow, a blind, defenseless tiger kitten must evolve into a deadly, efficient predator; a chimp must learn to distinguish edible plants from lethal poisons; a baby buffalo must be able to pick its mother out of a herd of hundreds. Contrary to common belief, not everything is "hardwired" -- or instinctual -- in the animal kingdom. Many skills a wild animal needs to thrive, to grow, to be what nature intended, must be developed through play, painstaking teaching, and often treacherous trial and error. The coming-of-age processes of the myriad creatures of plain, forest, ocean, and jungle are truly fascinating and often astonishing natural events.In Becoming a Tiger, Susan McCarthy, co-author of the critically acclaimed New York Times bestseller When Elephants Weep, offers readers an in-depth look into the amazing ways baby animals learn not only about themselves, but about their world and ours -- and how to survive in both. Based on extensive scientific research done in the lab, in controlled "natural" settings, as well as in the wild, her findings provide stunning new insights into the lives and development of Earth's nonhuman inhabitants -- not only tigers, but lions, bears, bats, rats, birds, dolphins, whales, apes, elephants, and dozens of other species.Sharing stories and discoveries at once captivating, funny, breathtaking, provocative, and heartwarming, Susan McCarthy carries us on a remarkable journey into untamed places, immersing us in the fascinating, complex, and hitherto unimagined societies and cultures of the beasts and birds. Along the way she shines a brilliant new light on subjects scientists, biologists, and zoologists have only begun to explore, revealing startling truths about the behavior, and sometimes humanlike foibles, of creatures great and small.Warm, informative, and beautifully written, Becoming a Tiger is an enthralling reading experience for animal lovers everywhere. In the transformation tales of playful pups, big-footed cubs, and scrawny chicks becoming deadly hunters, able foragers, and deft nest-builders are valuable and enriching life lessons for members of our own inquisitive, ever-developing species.

    While it’seasy to see that stress affects health and well-being, or that your blood pressure rises when you’re angry, cutting-edge research shows that the mind-body connection goes much further.Numerous studies on the brain’s interaction with the body demonstrate that health is directly affected by our social environments, socioeconomic status, culture, behaviors, relationships, psychological states, and habits of mind, among many factors. Current mind-body science reveals facts such as these: As few as eight weeks of mindfulness meditation can meaningfully boost your immune system. Extreme stress and low social support increase the risk of breast cancer by a factor of 9. Contact with nature is correlated with numerous positive health outcomes, including improved attention for children, reduced stress, and enhanced work performance. Chronic hostility portends calcification of the coronary arteries, even in young people. Expressive writing by patients is correlated with improved outcomes for both asthma and rheumatoid arthritis.Mind-body medicine—working in tandem with traditional medical practice—makes use of a large spectrum of psychological, physical, and behavioral treatments, drawn from many disciplines, in an approach to health care that aims to treat the whole person. It provides highly effective resources for preventing and treating a wide range of medical conditions, such as cardiovascular disease, stress, cancer, and depression—as well as for fostering the ultimate goals of health care: truly optimal and lasting physical health, and emotional and psychological well-being.A knowledge of this exciting field offers you critical understanding of the state of the art of health care and a significant new direction in medicine. But beyond valuable knowledge, a grounding in mind-body medicine gives you numerous practical, empowering tools for your own health care, as well as that of your family—tools that can make a profound difference for healthful, vibrant living.In Mind-Body Medicine: The New Science of Optimal Health, you’ll study this subject in compelling depth, with the expert guidance of Professor Jason M. Satterfield of the University of California, San Francisco. These 36 eye-opening lectures offer you a comprehensive overview of the field, providing rigorous answers to the questions of what makes us sick, what makes us well, and what we can do about it.You’ll look closely at the anatomical and biological systems through which what is “outside” in the environment gets “inside” to affect our minds and bodies. You’ll also examine recent research on subjects ranging from the impact our emotions and psychology have on health to the crucial roles that social, cultural, and behavioral factors play. And you’ll learn about effective mind-body treatments for numerous common medical conditions and diseases.Finally, you’ll finish the course with a toolbox of ideas and interventions for your personal wellness goals, empowering you to partner more effectively with your medical providers and maximize your own health.A Remarkable New Context for Health Care Professor Satterfield, a highly respected professor of clinical medicine and a specialist on the intersection of psychological factors and physical health, brings to the table his deep knowledge of mind-body science and extensive clinical experience in its application.In the course’s opening, he introduces you to the model of “biopsychosocial medicine,” which looks at the relationship between biological, psychological, and social factors in health.In studying how the biopsychosocial model is applied in modern medicine, you delve into these core subject areas:Biological pathways:You first investigate the anatomy and physiology of four biological systems through which the “outside” gets “in.” By reviewing a detailed study of the autonomic nervous system and the neuroendocrine system, discover how the brain activates the body’s two stress-response systems, and how these systems crucially affect health and well-being. Learn also about the physiology of immune function and the effects of stress on immune response and healing. Study the mechanisms of genetics as well as fascinating research indicating that your behavior can alter your genetic material, for better or worse—changes that can be passed on to future generations.Psychological factors in health: In the course of nine lectures, you look in depth at the critical ways in which psychology affects the body. Learn how negative emotional states such as anger and hostility can influence both the onset and progression of disease, and how positive emotions aid substantially in healing and wellness. Study how cognition—the ways in which we think and process our experiences—affects emotional states and behavior. Drawing from cognitive and other behavioral therapies, learn effective techniques for reshaping thinking, emotions, and behavior. Review evidence that certain personality types may be predisposed to conditions such as cardiovascular disease and depression, and learn how we can compensate for risk-carrying personality traits by working with cognitions and emotions. Investigate the neuroscience of behavior and the important effects of our behaviors on both disease and disease prevention. Look at stress as an integration of biological, cognitive, and social factors, and see how we can approach stress response and coping as a developmental skill. Social and ecological factors: You also study the important effects on health of factors such as culture, identity, socioeconomic status, social support, communities, and public health policy. Examine the studied correlations of income to health, education level to longevity, and ethnicity to susceptibility to disease, and consider how we can use this knowledge to benefit both individual and public health. Review research linking social support to health in many medical conditions, such as heart disease, cancer, and pregnancy; and do a detailed assessment to evaluate and strengthen your own social support network. Investigate how spiritual affiliations and practices have distinct physical benefits, such as reducing blood pressure, cortisol, and inflammation; improving lipid profiles and cardiovascular health; and extending life expectancy. Assess how physical environments affect health, how national and local culture impacts health-related behaviors, and how public initiatives can create healthier behaviors, environments, and communities.Tools and Strategies for Optimal WellnessBuilding on the biopsychosocial model, you study mind-body treatments for common conditions such as cardiovascular disease, stress, cancer, obesity, chronic pain, depression, anxiety, and post-traumatic stress disorder.Here, you learn about specific practices and interventions that you can use in your own health care program, such as these. Stress management: For both personal and occupational stress, learn about a spectrum of stress management approaches, from cognitive restructuring and perspective shifting to meditation, breathing techniques, relaxation training, and the learnable skill of resilience. Strategies for successful behavior change: With reference to concerns such as lifestyle change, weight management, and disease prevention, study the leading models of effective behavior change, as well as specific approaches such as the strategies of motivational interviewing, the four key elements of change, and the internal skills of self-regulation. Heart disease—prevention and treatment: Survey psychosocial interventions for heart disease, including a range of behavior change approaches, stress and emotion management, somatic quieting, social connection, and dramatic evidence that cardiac disease can be reversed through lifestyle change. Treatment of pain: Study mind-body factors in pain experience, and learn about treatments including cognitive and behavior change, acupuncture, mindfulness-based stress reduction, and biofeedback. Fatigue, headaches, insomnia: Investigate the variety of medical conditions that show no clear organic cause, such as chronic fatigue, tension headaches, and sleep disorders; and review effective psychological, physical, and behavioral approaches to treatment.Professor Satterfield’s teaching combines an extraordinary breadth of knowledge, clear and accessible explanations of the science involved, and a highly compassionate approach to patient care. He enriches the lectures with stories and case studies of patients in treatment for stress, heart conditions, insomnia, trauma, and other health challenges, showing you what mind-body medicine looks like in clinical practice and how you can integrate its lessons into your health program and daily life.With the knowledge and tools you’ll learn in Mind-Body Medicine: The New Science of Optimal Health, you can begin your own biopsychosocial assessment, identify your strengths and challenges in partnership with your medical providers, and take authentic steps toward your fullest physical and mental wellness.

    This thorough revision provides a survey by groups, emphasizing adaptive morphology and physiology, while covering anatomical ground plans and basic developmental patterns. New co-author Richard Fox brings to the revision his expertise as an ecologist, offering a good balance to Ruppert's background as a functional morphologist. Rich illustrations and extensive citations make the book extremely valuable as a teaching tool and reference source.

    Maybe your teacher took the controversial stand that the Civil War was all about states’ rights… or maybe you learned all about the horrors slavery, but never quite figured out why things didn’t get better after the war ended. If you didn’t go to school in the United States, things are even more confusing. When the media is full of references to the Confederate flag, the legacy of slavery, and poverty in the American South, you might have a vague sense that things are bad because of the Civil War… but why? Why does a war that happened over a hundred and fifty years ago still cast a shadow over the United States? This book will tell you why. It will lead you, step-by-step, through the causes of the Civil War, and the effects. But unlike your high school history teacher, it won’t put you to sleep with long-winded biographies and lists of dates. The names you’ll learn are the big players, the ones with big personalities, who made big differences. In just a few minutes a day, you can read bite-sized stories from the Civil War – quick, easy explanations to guide you through the main points, with just enough scary, surprising, or just plain strange facts to keep you coming back for more. Each chapter ends with a bonus helping of trivia and some quick questions to test your knowledge. By the time you’re finished, you’ll know all the facts your history teacher never taught you – from who said slavery was a “positive good” (and why they thought that), to who dressed up in women’s clothing to escape from Union soldiers.

    But something went terribly wrong. By day's end, some would be alive. Others would not. A close-knit community would be devastated, forced to endure. This gripping true story centers on what happened to one courageous and flawed young man who survived, and how his life quickly spiraled out of control in the next two years. It is a story about love, unbreakable friendship, and "king" corn. “There are some forty-five thousand items in the average American supermarket and more than a quarter of them now contain corn,” writes Michael Pollan in The Omnivore’s Dilemma. But as international dependence on the highly subsidized crop for cattle feed, corn syrup and ethanol has surged—so have deaths by corn. Based on three years of reporting and interviews with the people involved and thousands of pages of court documents, transcripts, police reports, journalist Erika Hayasaki brings to life (in narrative nonfiction-style) this world of people who risk and sometimes lose their lives for this powerful commodity. Hayasaki, a former national correspondent for the Los Angeles Times, is the author of The Death Class: A True Story About Life (Simon & Schuster 2014), as well as the Kindle Single, Dead or Alive (2012). She is an assistant professor in the Literary Journalism Program at the University of California, Irvine, and a regular contributor to Newsweek and The Atlantic. *Cover design by Kristen RadtkePraise for DROWNED BY CORN:THE CHICAGO TRIBUNE: "The descriptions of the accident are chilling: a blow-by-blow account of the grain pulling the young men under and the dramatic rescue of Will, who survived after being buried past his chest. The piece follows Will as his grief sends him into a downward spiral. "Drowned by Corn" is a gripping narrative of tenderness and horror, friendship and loss." — Megan KirbySAN FRANCISCO CHRONICLE: "Erika Hayasaki’s suspenseful account of the deaths of Paco and Wyatt and the harrowing rescue of Will is the stuff of nightmares. But what elevates this fine work of investigative journalism is her portrayal of Will in the aftermath: his survival guilt, his struggle with alcohol and drugs, his strained relationships and his eventual discovery of a way to endure his and his town’s unspeakable losses." — Porter Shreve

    Siracusa's overview, wrap-up, and critique of everything new in OS X 10.10 Yosemite.