Our Inheritance 2. Mendel and Genes 3. Genes and Chromosomes 4. The Search for the GeneDNA 5. DNA Structure and Replication 6. DNA Expression in Proteins 7. Genes, Enzymes, and Metabolism 8. From DNA to Protein 9. Genomes 10. Manipulating GenesRecombinant DNA 11. Isolating Genes and DNA 12. BiotechnologyGenetic Engineering 13. Biotechnology and the Environment 14. Manipulating DNA by PCR and Other Methods 15. DNA in IdentificationForensics 16. DNA and Evolution 17. DNA and Human Evolution 18. Molecular MedicineGenetic Screening 19. Molecular MedicineThe Immune System 20. Molecular MedicineCancer 21. Molecular MedicineGene Therapy 22. Molecular MedicineCloning and Stem Cells 23. Genetics and Agriculture 24. Biotechnology and Agriculture

    Kasser launches an ambitious and exciting inquiry into what makes science science, using the tools of philosophy to ask: * Why is science so successful? * Is there such a thing as the scientific method? * How do we distinguish science from pseudoscience? * Is science rational, cumulative, and progressive? Focusing his investigation on the vigorous debate over the nature of science that unfolded during the past 100 years, Professor Kasser covers important philosophers such as Karl Popper, W. V. Quine, Thomas Kuhn, Paul Feyerabend, Imre Lakatos, Carl Hempel, Nelson Goodman, and Bas van Fraassen.All of these thinkers responded in one way or another to logical positivism, the dominant movement influencing the philosophy of science during the first half of the 20 th century. Logical positivism attempted to ground science exclusively in what could be known through direct experience and logic.It sounds reasonable, but logical positivism proved to be riddled with serious problems, and its eventual demise is an object lesson in how truly difficult it is—perhaps impossible—to secure the logical foundations of a subject that seems so unassailably logical: science.

    One of the first paleoanthropologists to study fossil evidence and genetic information together in order to test hypotheses about human prehistory, Professor Hawks is adept at looking at human origins not just with one lens, but with two.He has traveled around the world to examine delicate skeletal remains and pore over the complex results of genetic testing. His research and scholarship on human evolutionary history has been featured in a variety of publications, including Science, American Journal of Physical Anthropology, Slate, and Journal of Human Evolution.But more than that, Professor Hawks has crafted a course that demonstrates the passion and excitement involved in the field of paleoanthropology. With his engaging lecturing style and his use of fossil finds taken from his personal collection, Professor Hawks will capture your attention and show you all the drama and excitement to be found in eavesdropping on the latest debates about human evolutionary history.

    But is old age all doom and gloom?Not at all! While it's true that some functions in the aging brain decline, neuroscientists have discovered that many other brain functions remain stable - or even improve - as we age. Furthermore, nurture plays as significant a role as nature, and there are a number of strategies you can implement to stave off declining brain function, including:Incorporating physical activity into your routineEating a healthy dietMaintaining a vibrant social lifeReducing your stressThe science behind the aging brain tells a fascinating - and often counterintuitive - story. Is "aging" a disease or merely a natural occurrence that produces disease-like symptoms? If humans are biologically programmed to survive and thrive, why do we age at all? Is it possible (or even desirable) to "cure" aging altogether?Delve into these questions and more in The Aging Brain. Taught by a neuroscientist and award-winning professor at the University of Michigan, these 12 eye-opening lectures will give you a wealth of new insights into what happens to the brain over time - as well as strategies to mitigate the effects of aging and enhance your quality of life into old age.With a mix of scientific research and practical applications, Professor Polk brings cutting-edge science to life. He takes you down to the cellular and even molecular levels of the brain to show you why certain functions decline, how some aspects of brain aging are under genetic control, and what you can do to prolong your health and keep your mind sharp. Aging affects us all, but you have some control over how it affects you.

    What makes evolution such a profoundly provocative concept, so convincing to most scientists, yet so socially and politically divisive? The Theory of Evolution: A History of Controversy is an examination of the varied elements that so often make this science the object of strong sentiments and heated debate. Professor Edward J. Larson leads you through the "evolution" of evolution, with an eye toward enhancing your understanding of the development of the theory itself and the roots of the controversies that surround it. In these lectures you will: Explore pre-Darwinian theories of the origins of life, from Genesis and the ancient Greeks to such 18th- and 19th-century scientists as Georges Cuvier and Chevalier de Lamarck Follow the life and work of Charles Darwin, and the impact of his 1859 masterpiece, On the Origin of Species. Darwin's theory of evolution by natural selection was immediately recognized as a threat to traditional religion, but was quickly accepted (the first printing of Origin of Species sold out on the first day) Examine the history of evolutionary science after Darwin-a fascinating story that includes the "rediscovery," after 35 years, of Gregor Mendel's work on genetic variation; the unearthing of prehominid, or early human, fossils by Raymond Dart in 1925 and the Leakey family in the 1950s; and the confusion created by the sensational, but later discredited, discovery of Piltdown Man-a fake evolutionary "missing link"-in 1912 Trace the history of religious objections to evolution, from those of Darwin's own time to contemporary efforts to teach creation science in American schools. This includes a detailed discussion of the famous Scopes "monkey trial," which in fact was a staged media event, designed to create publicity for the town of Dayton, Tennessee. Are Our Genes more Important than We Are? This course makes it clear that the history of controversy surrounding evolution is not limited to a dispute between science and religion. Even within the scientific community, the fine details of the theory of evolution have long been a matter of passionate dispute. In fact, in the last third of the 19th century, the principal objections were scientific, not religious. Although the fossil record was a key piece of evidence for evolution, it had gaps that could be used to argue against the theory. And both proponents and critics wondered how altruistic human qualities such as love and generosity could possibly have evolved through the competitive, often harsh, processes that Darwin described. From Professor Larson's presentation, you will learn that new ideas in evolution science have often created new controversies. For example, is it truly possible, as some scientists now maintain, that humans exist merely to ensure the survival of their genes? Such research has created disagreement among scientists about the degree to which evolution drives human behavior, and has further alienated many segments of the public. Evolution's "Dark Side": Social Darwinism In these lectures, you will review perhaps the most sinister controversy associated with the theory of evolution: social Darwinism. From the beginning, the Darwinian theory of evolution has been linked to economic and political views. Thomas Malthus's theories of population growth and competition for limited resources even inspired Darwin's thinking on natural selection. Unfortunately, later supporters of evolution carried this line of thinking too far. Beginning with Herbert Spencer, who coined the term "survival of the fittest," Darwin's ideas were used as evidence for a wide range of social beliefs, from laissez-faire capitalism to racism, colonialism, and, in perhaps the worst application, Nazism. In the United States, social Darwinism has served as a basis for the creation of IQ tests and for eugenics programs that resulted in the forced sterilization of thousands of mentally ill or retarded Americans. Unsettling Implications: The Growing Gulf Between Science and Religion During the late 19th century, largely through the efforts of scientists who sought to integrate evolutionary science with spiritual belief, evolution was widely accepted by the religious community in the United States. Today, this is hardly the case. In his last four lectures, Professor Larson examines the trends that have, since 1920, widened the gulf between science and religion. These include an increase in fundamentalist Protestantism, the weakening of liberal Protestantism as a counteracting force, and the growing power of a firmly conservative South. In the 1960s, federally funded neo-Darwinian textbooks provoked a conservative backlash. Beginning with the publication of Henry M. Morris's The Genesis Flood, efforts to gain equal time for the teaching of creation science, based on biblical teachings, gathered strength. Rebuffed by the courts, creationism continues to thrive through the increasing numbers of private Christian schools and through home schooling. The growing gulf between science and religion has unsettling implications for our society. Large segments of the American population reject the naturalism of current evolutionary thinking. Nine of 10 Americans believe in spiritual causes for life, with only 10 percent accepting the purely naturalistic explanations espoused by evolution. Strikingly, these statistics are almost exactly the opposite among the scientific community. A Pulitzer Prize-Winning Teacher As both a historian of science and a professor of law, Professor Edward J. Larson brings exceptional qualifications to this subject. His book, Summer for the Gods: The Scopes Trial and America's Continuing Debate Over Science and Religion, won the 1998 Pulitzer Prize in History. His analysis provides an invaluable perspective on the volatile history of what is arguably the single most significant idea of modern times.

    This is a world tour of prehistory with profound links to who we are and how we live today.2.5 Million Years of HistoryThis 36-lecture narrative covers human prehistory from our beginnings more than 2.5 million years ago up to and beyond the advent of the world's first preindustrial civilizations.Due to the large spans of time and geography covered in this series, these lectures are divided into six sections:Section I: BeginningsThis section surveys the archaic world of the first humans, you travel into the remote past, learning why the late Harvard biologist Stephen Jay Gould was probably right to observe that we all come from the same African twig on the bushy tree of human evolution.You examine prehistory from Australopithecus africanus through Homo habilis (the first tool-making hominid), and Homo erectus (whose remains were first found on Java but whose origins lie in Africa) through the hardy Neanderthals who lived and hunted successfully in Europe despite the bitter grip of the last Ice Age 100,000 and more years ago. You focus on the first human settlement of Africa as early as 800,000 years ago.Section II: Modern HumansThis section tells the story of the great diaspora of anatomically modern humans in the late Ice Age. Whether and how these modern humans spread from the African tropics into southwestern Asia and beyond remains one of the great controversies among scholars of prehistory.You follow Homo sapiens sapiens north into Europe some 45,000 years ago. You meet the Cro-Magnons, among the first known artists as well as hunter-gatherers, who exhibited degrees of spiritual awareness, social interaction, and fluid intelligence.You venture into the frigid open plains of the Ukraine and Eurasia, where big-game hunters flourished in spite of nine-month winters. Moving to the Americas, debate over the origins of the first human settlement continues.Section III: Farmers and HerdersThis section describes perhaps the most important development in all human prehistory: the beginnings of agriculture and animal domestication.This defining chapter began about 12,000 years ago, when hunter-gatherers in the Near East broke from the long human tradition of intensely mobile foraging and turned to more settled ways of life built around cultivating cereal grains or tending animals.Section IV: Eastern Mediterranean CivilizationsProfessor Fagan describes early civilizations in an increasingly complex eastern Mediterranean world, discussing many theories accounting for the appearance of urban civilization and overall attributes of preindustrial civilizations.You examine Sumerian civilization in Mesopotamia and the intricate patchwork of city-states between the Tigris and Euphrates Rivers. You explore ancient Egypt, the Minoan civilization of Crete, the Mycenaeans, and the Hittites.You learn about the Uluburun shipwreck of southern Turkey, a sealed capsule of international trade from 3,000 years ago.Section V: Africans and AsiansYou analyze the beginnings of South Asian civilization and the mysterious Harappan civilization of the Indus, which traded with Mesopotamia. Professor Fagan resumes the story of South Asian civilization after the collapse of the Harappan and shows how Mauryan rulers on the Ganges encouraged trading much farther afield.You see the impact of monsoons which revolutionized maritime trading among Africa, India, and Southeast Asia, and explore Meroe, Aksum, and the coastal civilization of East Africa.Several lectures cover the beginnings of civilization in China and Southeast Asia.Section VI: Ancient AmericansProfessor Fagan takes you into sophisticated chiefdoms and civilizations that developed in the Americas over the past 3,500 years, including Pueblo cultures of the North American Southwest and the Mississippian culture of the South and Southeast. You learn about Mesoamerican civilization, primordial Olmec culture of the lowlands, and the spectacular ancient Maya civilization.Moving to the highlands, you visit the city-states of Monte Albán in the Valley of Oaxaca and Teotihuacán near the Valley of Mexico. Professor Fagan also describes the rise of Aztec civilization, followed by a journey to the Andes. Finally, you explore the southern highlands, with the rise of Tiwanaku near Lake Titicaca, the Chimu civilization of the coast, and the huge Inka empire.The series closes by analyzing the closing centuries of prehistoric times during the European age of discovery and summarizing the main issues and themes of the course: * What was involved in the archaic world * The appearance and spread of modern humans * Food production * The development of states.

    Owing to the work of an astonishing range of visionary thinkers, this fascinating period was the era in which the foundations of the modern Western world were laid. In the medieval era's great minds we find the roots of many aspects of today's world - from the religious/philosophical thought of Augustine, Ambrose of Milan, and Thomas Aquinas to the scientific innovations of Avicenna and Alhacen, the enlightened statesmanship of Charlemagne and Lorenzo de Medici, and the literary creations of Dante and Chaucer.In these 24 lectures, Professor Armstrong leads you on an enthralling journey into the lives of the seminal thinkers of the Middle Ages. In this gallery of extraordinary minds, you'll encounter the leading lights of a world-shaping era, including figures such as Maimonides, Hildegard of Bingen, Bernard of Clairvaux, Peter Abelard, and Francesco Petrarch. Professor Armstrong goes to great lengths to bring these historic figures to life, revealing both the great intellectual contributions and the personal strivings, challenges, and triumphs of some of history's most remarkable human beings. These compelling lectures take you deeply into the heart of one of civilization's most dynamic and impactful eras.Listening Length: 11 hours and 59 minutes

    For example, the matter that comprises all stars, planets, and living things turns out to be just a fraction of what actually exists. Moreover, we think that we control our actions, but data analytics can predict, with astonishing accuracy, when we will wake up, what we will buy, and even whom we will marry.The quest to pin down what's real and what's illusory is both philosophical and scientific, a metaphysical search for ultimate reality that goes back to the ancient Greeks. For the last 400 years, this search has been increasingly guided by scientists, who create theories and test them in order to define and redefine reality. And we have developed the power to alter our own reality in major ways - to defeat diseases, compensate for disabilities, and augment our intellect with computers. Where is that trend going?Experience the thrill of this exciting quest in 36 wide-ranging lectures that touch on many aspects of the ceaseless search for reality. From the birth of the universe to brain science, discover that separating the real from the illusory is an exhilarating intellectual adventure.Scientists and philosophers are not alone in grappling, at an intellectual level, with reality. Some of the most accessible interpretations are by painters, novelists, filmmakers, and other artists whose works not only draw on the latest discoveries but also sometimes inspire them. Explore examples such as Alice in Wonderland, pointillism, cubism, surrealism, and reality TV.And since dealing with reality is an experience we all share, this course is designed for people of all backgrounds.

    Defining American English Dialects2. The Foundations of American English3. From English in America to American English4. The Rise of American Language Standards5. Where Is General American English?6. Mapping American Dialects7. Ethnicity and American English8. African American English9. Mobility, Media, and Contemporary English10. The History of American Language Policy11. Latino Language and Dialects in America12. Where Is American English Headed?

    There is no better way to study the big questions in philosophy than to compare how the world's greatest minds have analyzed these questions, defined the terms, and then reasoned out potential solutions. Once you've compared the arguments, the final step is always deciding for yourself whether you find an explanation convincing.This course gives you the tools to follow and create logical arguments while exploring famous philosophers' viewpoints on these important questions. Although progress has been made toward answers, brilliant thinkers have continued to wrestle with many big questions that inspire thoughtful people everywhere. These questions include: What is knowledge? Does God exist? Do humans have free will? What is right and wrong? How should society be organized?Given the complexity of these big questions, it should be no surprise that many controversies are far from settled. In fact, by the end of these 36 lectures, you may be even less sure of the right answers to some of the questions than you were at the beginning. But being a philosopher means constantly testing your views - giving a reasoned defense if you believe you are right and modifying your ideas when you realize you are wrong. You'll discover that great thinkers before you have offered convincing answers to hard questions, philosophers after them have made equally persuasive objections, and then still others have refined the debate even further - causing the issues to come into sharper and sharper focus.Join Plato, St. Anselm, Descartes, Locke, Hume, Kant, Mill, Smith, Marx, Rawls, and many others in an exploration of fundamental questions. Get ready to think big!

    

    King (William and Mary University) delves into the story of how, why, where, and when we became human. These lectures will help you understand the forces that have shaped, and continue to shape, our species. "An evolutionary perspective on human behavior," notes Dr. King, "results in more than just knowledge about dates and sites when and where specific evolutionary milestones likely occurred." "It is also a window on the past and future of our species. An entirely new way of thinking comes into focus when we consider the human species within an evolutionary perspective."A Century of ScholarshipWhile covering these subjects in this 24-lecture series, Dr. King synthesizes the best that more than a century of scientific scholarship has to offer across a variety of disciplines. Biological anthropologists study primate anatomy and behavior both to understand evolution and to learn more about our common ancestor. Biological anthropologists are joined by molecular anthropologists to better understand hominids by studying fossils, ancient skeletal remains, and lifestyle information such as cave art and stone tools. Case Studies that Clarify Evolution and Its Power Dr. King begins by explaining key mechanisms through which evolution functions, citing famous and definitive case studies that demonstrate these forces. In one such landmark study, for example, biologists Peter and Rosemary Grant returned to the Galapagos Islands more than 100 years after Darwin's first voyage to conduct research on island finches. In 1977, a drought-induced scarcity of soft, edible seeds brought forth in the very next generation a population of finches with larger, stronger beaks capable of crushing larger, tougher seeds. Extraordinarily, in 1985, heavy rains produced a surplus of softer seeds, and natural selection produced a succeeding generation of the smaller-beaked variety. Evolution had occurred in two different directions within a decade. This "natural selection" is the theoretical tool of evolution, which helps us make sense of these facts. Why Evolution Remains Important to Us Today Perhaps the greatest measure of this theory's power is its relevance to our lives today. - Did you know that the gene which causes sickle cell anemia must be inherited from both parents to cause the disease but the disease does not occur when only a single gene is inherited? - Or that the single gene, in fact, affords protection from malaria? Or that race, a category so securely ingrained in our consciousness, is practically meaningless in biological terms? - Or how to evaluate the claim that a gene can be responsible for a certain personality trait? A Glimpse Into Our Selected Primate Heritage With an understanding of the basic mechanisms of evolutionary change in hand, the course looks at how our ancient primate ancestors adapted. Consider the anatomical features we share with monkeys, great apes, and other primates. Our large brains, grasping hands, and forward-facing eyes allowing us to perceive depth are critical to the way we function in the world. Yet the fossil record tells us that some 70 million years ago these distinctive primate features did not exist. What caused the first primates to emerge from existing mammalian populations? One proposed solution was that the appearance of insects living in the lower canopies of trees offered a plentiful food resource to those species adapted to procure it. Could depth perception and grasping ability have provided an advantage here, and hence been naturally selected? This is the function of biological anthropology: confronting the facts, then suggesting and testing possibilities. A Course as Much About the Present as the PastWith so much of evolutionary history taken up with the past, the insights gained in these lectures may tempt you to add questions of your own: - Is human evolution still a force in today's world? Hasn't our modern, mobile culture rendered evolution irrelevant? - In fact, human evolution is a stronger force than ever, interacting with human culture in complex ways. Issues such as obesity, AIDS, and genetics are all discussed. And you may well find these lectures opening your eyes to the extraordinary ways in which the biological power of natural selection is still at work in the world today. Course Lecture Titles1. What is Biological Anthropology? 2. How Evolution Works 3. The Debate Over Evolution 4. Matter Arising—New Species 5. Prosimians, Monkeys, and Apes 6. Monkey and Ape Social Behavior 7. The Mind of the Great Ape 8. Models for Human Ancestors? 9. Introducing the Hominids 10. Lucy and Company 11. Stones and Bones 12. Out of Africa 13. Who Were the Neandertals? 14. Did Hunting Make Us Human? 15. The Prehistory of Gender 16. Modern Human Anatomy and Behavior 17. On the Origins of Homo sapiens 18. Language 19. Do Human Races Exist? 20. Modern Human Variation 21. Body Fat, Diet, and Obesity 22. The Body and Mind Evolving 23. Tyranny of the Gene? 24. Evolution and Our Future

    Yet, as the 1700s began, the mysteries of the universe were pondered by "natural philosophers"—the term "scientist" didn't even exist until the mid 19th century—whose explanations couldn't help but be influenced by the religious thought and political and social contexts that shaped their world.The radical ideas of the Enlightenment were especially important and influential. In this course you see how the work of these natural philosophers prepared the way for the more familiar world of science we recognize today.

    The infamous Jack the Ripper slayings. The alleged survival of Anastasia Romanov, the youngest daughter of the murdered Tsar. Seven-time Tour de France winner Lance Armstrong's public fall from grace. The Chicago Tylenol poisonings and the copycat crimes that followed. Step into the world of forensic science and study the most fascinating crimes and mysteries from the last two centuries in the 24 lectures of Forensic History: Crimes, Frauds, and Scandals . Professor Murray, a forensic anthropologist with nearly 30 years of experience in the field, has crafted lectures that are a remarkable blend of storytelling and science - a whirlwind tour that takes you from the gas-lit streets of Victorian London to small-town America. As you journey around the world and into the past, you'll re-examine modern history's great crimes and scandals using the tools and insights of forensic science. In doing so, you'll learn how cutting-edge advancements in science and technology are applied to investigations and how to evaluate evidence and think like a forensic scientist. Using her extensive background in the field and her skill at weaving riveting stories, Professor Murray invites you peer over the shoulders of investigators as they examine some of the most famous crimes in history, as well as cases that shed light on what happens when the justice system goes awry. Whether they're controversial or by-the-book, solved or unsolved, hot or cold, these cases are an opportunity to gain deeper insight into the historic and cutting-edge methods and tools forensic scientists use on the job. Having participated in hundreds of investigations in America and abroad, Professor Murray intersperses these historical examinations with some of her own, equally intriguing, personal experiences.Please note there is a 293 page book included in this course so please do not Notabook again.