Americans are rarely afraid of sacrifice and hard work when they mean building a better future, but when was the last time you heard of a leader of anything making a sacrifice for the greater good? The people can only win when they make it clear to the powers that be that making the right choices, even the hard ones, is the key to winning the next election.Explains in rollicking stories ranging from the profane to the profound that most hard choices are only "hard" because the polls conflict with your principles. Ed Rendell rose to the top of Philadelphia, then Pennsylvania, then national politics, by doing what he thought was right, and there were plenty of times that looked like it would be his downfall as well. This book revisits the high points of Ed Rendell's career and current landscape to define the political fights his peers seem just as afraid of winning as losing.Rendell is a former head of the Democratic National Committee, a current MSNBC Senior Political Analyst, and a Partner at Ballard Spahr LLP

    Missing from these accounts is a consideration of the technologies behind the creation of the globalized economy. What makes it possible for us to move billions of tons of raw materials and manufactured goods from continent to continent? Why are we able to fly almost anywhere on the planet within twenty-four hours? In "Prime Movers of Globalization," Vaclav Smil offers a history of two key technical developments that have driven globalization: the high-compression non-sparking internal combustion engines invented by Rudolf Diesel in the 1890s and the gas turbines designed by Frank Whittle and Hans-Joachim Pabst von Ohain in the 1930s. The massive diesel engines that power cargo ships and the gas turbines that propel jet engines, Smil argues, are more important to the global economy than any corporate structure or international trade agreement. Smil compares the efficiency and scale of these two technologies to prime movers of the past, including the sail and the steam engine. The lengthy processes of development, commercialization, and diffusion that the diesel engine and the gas turbine went through, he argues, provide perfect examples of gradual technical advances that receive little attention but have resulted in epochal shifts in global affairs and the global economy.

    But natural selection has given us a suite of beneficial social features, including our capacity for love, friendship, cooperation, and learning. Beneath all of our inventions -- our tools, farms, machines, cities, nations -- we carry with us innate proclivities to make a good society.In Blueprint, Nicholas A. Christakis introduces the compelling idea that our genes affect not only our bodies and behaviors, but also the ways in which we make societies, ones that are surprisingly similar worldwide.With many vivid examples -- including diverse historical and contemporary cultures, communities formed in the wake of shipwrecks, commune dwellers seeking utopia, online groups thrown together by design or involving artificially intelligent bots, and even the tender and complex social arrangements of elephants and dolphins that so resemble our own -- Christakis shows that, despite a human history replete with violence, we cannot escape our social blueprint for goodness.In a world of increasing political and economic polarization, it's tempting to ignore the positive role of our evolutionary past. But by exploring the ancient roots of goodness in civilization, Blueprint shows that our genes have shaped societies for our welfare and that, in a feedback loop stretching back many thousands of years, societies are still shaping our genes today.

    While it is one of the largest scientific projects ever attempted—as breathtaking as the first moon landing or the Human Genome Project—the questions it answers are meaningful for every one of us: What are the world’s health problems? Who do they hurt? How much? Where? Why?Murray argues that the ideal existence isn’t simply the longest but the one lived well and with the least illness. Until we can accurately measure how people live and die, we cannot understand what makes us sick or do much to improve it. Challenging the accepted wisdom of the WHO and the UN, the charismatic and controversial health maverick has made enemies—and some influential friends, including Bill Gates who gave Murray a $100 million grant.In Epic Measures, journalist Jeremy N. Smith offers an intimate look at Murray and his groundbreaking work. From ranking countries’ healthcare systems (the U.S. is 37th) to unearthing the shocking reality that world governments are funding developing countries at only 30% of the potential maximum efficiency when it comes to health, Epic Measures introduces a visionary leader whose unwavering determination to improve global health standards has already changed the way the world addresses issues of health and wellness, sets policy, and distributes funding.

    It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquity, the few tablespoons of blood discharged by 800 million women are still regarded as taboo; menstruation is perhaps the single most demonized biological event.Rose George, author of The Big Necessity, is renowned for her intrepid work on topics that are invisible but vitally important. In Nine Pints, she takes us from ancient practices of bloodletting to modern “hemovigilance” teams that track blood-borne diseases. She introduces Janet Vaughan, who set up the world’s first system of mass blood donation during the Blitz, and Arunachalam Muruganantham, known as “Menstrual Man” for his work on sanitary pads for developing countries. She probes the lucrative business of plasma transfusions, in which the U.S. is known as the “OPEC of plasma.” And she looks to the future, as researchers seek to bring synthetic blood to a hospital near you.Spanning science and politics, stories and global epidemics, Nine Pints reveals our life's blood in an entirely new light.

    If we continue with current farming practices, vast amounts of wilderness will be lost, millions of birds and billions of insects will die, and the public will lose billions of dollars as a consequence of environmental degradation. Clearly, there must be a better way to meet the need for increased food production.Written as part memoir, part instruction, and part contemplation, Tomorrow's Table argues that a judicious blend of two important strands of agriculture--genetic engineering and organic farming--is key to helping feed the world's growing population in an ecologically balanced manner. PamelaRonald, a geneticist, and her husband, Raoul Adamchak, an organic farmer, take the reader inside their lives for roughly a year, allowing us to look over their shoulders so that we can see what geneticists and organic farmers actually do. The reader sees the problems that farmers face, trying toprovide larger yields without resorting to expensive or environmentally hazardous chemicals, a problem that will loom larger and larger as the century progresses. They learn how organic farmers and geneticists address these problems.This book is for consumers, farmers, and policy decision makers who want to make food choices and policy that will support ecologically responsible farming practices. It is also for anyone who wants accurate information about organic farming, genetic engineering, and their potential impacts onhuman health and the environment.

    Our bodies are hardwired for sweets, so food giants have developed fifty-six types of sugar to add to their products, creating in us the expectation that everything should be cloying; we've evolved to prefer fast, convenient meals, hence our modern-day preference for ready-to-eat foods. Moss goes on to show how the processed food industry--including major companies like Nestlé, Mars, and Kellogg's--has tried not only to evade this troubling discovery about the addictiveness of food but to actually exploit it. For instance, in response to recent dieting trends, food manufacturers have simply turned junk food into junk diets, filling grocery stores with "diet" foods that are hardly distinguishable from the products that got us into trouble in the first place. As obesity rates continue to climb, manufacturers are now claiming to add ingredients that can effortlessly cure our compulsive eating habits. An account of the legal battles, insidious marketing campaigns, and cutting-edge food science that have brought us to our current public health crisis, Moss lays out all that the food industry is doing to exploit and deepen our addictions, and shows us why what we eat has never mattered more.From the #1 New York Times bestselling author of Salt Sugar Fat comes a powerful exposé of how the processed food industry exploits our evolutionary instincts, the emotions we associate with food, and legal loopholes in their pursuit of profit over public health.

    It’s not just that the grid has grown old and is now in dire need of basic repair. Today, as we invest great hope in new energy sources--solar, wind, and other alternatives--the grid is what stands most firmly in the way of a brighter energy future. If we hope to realize this future, we need to re-imagine the grid according to twenty-first-century values. It’s a project which forces visionaries to work with bureaucrats, legislators with storm-flattened communities, moneymen with hippies, and the left with the right. And though it might not yet be obvious, this revolution is already well under way.Cultural anthropologist Gretchen Bakke unveils the many facets of America's energy infrastructure, its most dynamic moments and its most stable ones, and its essential role in personal and national life. The grid, she argues, is an essentially American artifact, one which developed with us: a product of bold expansion, the occasional foolhardy vision, some genius technologies, and constant improvisation. Most of all, her focus is on how Americans are changing the grid right now, sometimes with gumption and big dreams and sometimes with legislation or the brandishing of guns.The Grid tells--entertainingly, perceptively--the story of what has been called “the largest machine in the world”: its fascinating history, its problematic present, and its potential role in a brighter, cleaner future.

    Japan was going to dominate, then China. Countries were called “tigers” or “mini-dragons,” and were seen as not just development prodigies, but as a unified bloc, culturally and economically similar, and inexorably on the rise.Joe Studwell has spent two decades as a reporter in the region, and The Financial Times said he “should be named chief myth-buster for Asian business.” In How Asia Works, Studwell distills his extensive research into the economies of nine countries—Japan, South Korea, Taiwan, Indonesia, Malaysia, Thailand, the Philippines, Vietnam, and China—into an accessible, readable narrative that debunks Western misconceptions, shows what really happened in Asia and why, and for once makes clear why some countries have boomed while others have languished.Studwell’s in-depth analysis focuses on three main areas: land policy, manufacturing, and finance. Land reform has been essential to the success of Asian economies, giving a kick start to development by utilizing a large workforce and providing capital for growth. With manufacturing, industrial development alone is not sufficient, Studwell argues. Instead, countries need “export discipline,” a government that forces companies to compete on the global scale. And in finance, effective regulation is essential for fostering, and sustaining growth. To explore all of these subjects, Studwell journeys far and wide, drawing on fascinating examples from a Philippine sugar baron’s stifling of reform to the explosive growth at a Korean steel mill.Thoroughly researched and impressive in scope, How Asia Works is essential reading for anyone interested in the development of these dynamic countries, a region that will shape the future of the world.

    As these divides deepen, we have lost the sense of ethical obligation to others that was crucial to the rise of post-war social democracy. So far these rifts have been answered only by the revivalist ideologies of populism and socialism, leading to the seismic upheavals of Trump, Brexit, and the return of the far-right in Germany. We have heard many critiques of capitalism but no one has laid out a realistic way to fix it, until now.In a passionate and polemical book, celebrated economist Paul Collier outlines brilliantly original and ethical ways of healing these rifts—economic, social and cultural—with the cool head of pragmatism, rather than the fervor of ideological revivalism. He reveals how he has personally lived across these three divides, moving from working-class Sheffield to hyper-competitive Oxford, and working between Britain and Africa, and acknowledges some of the failings of his profession.Drawing on his own solutions as well as ideas from some of the world’s most distinguished social scientists, he shows us how to save capitalism from itself—and free ourselves from the intellectual baggage of the twentieth century.

    David Agus tackles these fundamental questions and dismantles misperceptions about what “health” really means. Presenting an eye-opening picture of the human body and all the ways it works—and fails—Dr. Agus shows us how a new perspective on our individual health will allow us to achieve a long, vigorous life. Offering insights and access to powerful new technologies that promise to transform medicine, Dr. Agus emphasizes his belief that there is no “right” answer, no master guide that is “one size fits all.” Each one of us must get to know our bodies in uniquely personal ways, and he shows us exactly how to do that. A bold call for all of us to become our own personal health advocates, The End of Illness is a moving departure from orthodox thinking.

    Nobel Peace Prize recipient for averting hunger and famine, Dr. Norman Borlang is credited with saving hundreds of millions of lives from starvation-more than any other person in history? Loved by millions around the world, Dr. Borlang is recognized as one of the most influential men of the twentieth century.

    Pisano answers this question by providing an incisive critique of the industry. Pisano not only reveals the underlying causes of biotech's problems; he offers the most sophisticated analysis yet on how the industry works. And he provides clear prescriptions for companies, investors, and policy makers seeking ways to improve the industry's performance. According to Pisano, the biotech industry's problems stem from its special character as a science-based business. This character poses three unique business challenges: how to finance highly risky investments under profound uncertainty and long time horizons for R&D, how to learn rapidly enough to keep pace with advances in drug science knowledge, and how to integrate capabilities across a broad spectrum of scientific and technological knowledge bases.The key to fixing the industry? Business models, organisational structures, and financing arrangements that place greater emphasis on integration and long-term learning over shorter—term 'monetisation' of intellectual property. Pisano maintains that all industry players—biotech firms, investors, universities, pharmaceutical companies, government regulators—can play a role in righting the industry. The payoff? Valuable improvements in health care, and a shinier future for human well-being.

    Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia.In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease.From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it.Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

    In the process he tackles the question that has obsessed historians ever since: What made eighteenth-century Britain such fertile soil for inventors? Rosen’s answer focuses on a simple notion that had become enshrined in British law the century before: that people had the right to own and profit from their ideas.    The result was a period of frantic innovation revolving particularly around the promise of steam power. Rosen traces the steam engine’s history from its early days as a clumsy but sturdy machine, to its coming-of-age driving the wheels of mills and factories, to its maturity as a transporter for people and freight by rail and by sea. Along the way we enter the minds of such inventors as Thomas Newcomen and James Watt, scientists including Robert Boyle and Joseph Black, and philosophers John Locke and Adam Smith—all of whose insights, tenacity, and ideas transformed first a nation and then the world. William Rosen is a masterly storyteller with a keen eye for the “aha!” moments of invention and a gift for clear and entertaining explanations of science. The Most Powerful Idea in the World will appeal to readers fascinated with history, science, and the hows and whys of innovation itself.