But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    How she was treated by medical and legal officials reveals a lesser-known story of human and constitutional rights, entangled with the science of pathology and enduring questions about who Mary Mallon really was. How did her name become synonymous with deadly disease? And who is really responsible for the lasting legacy of Typhoid Mary? This thorough exploration includes an author's note, timeline, annotated source notes, and bibliography.

    But the true saga of her life has never been fully told. Now, drawing on unpublished manuscripts, letters, diaries, and land and financial records, Caroline Fraser—the editor of the Library of America edition of the Little House series—masterfully fills in the gaps in Wilder’s biography. Revealing the grown-up story behind the most influential childhood epic of pioneer life, she also chronicles Wilder's tumultuous relationship with her journalist daughter, Rose Wilder Lane, setting the record straight regarding charges of ghostwriting that have swirled around the books.The Little House books, for all the hardships they describe, are paeans to the pioneer spirit, portraying it as triumphant against all odds. But Wilder’s real life was harder and grittier than that, a story of relentless struggle, rootlessness, and poverty. It was only in her sixties, after losing nearly everything in the Great Depression, that she turned to children’s books, recasting her hardscrabble childhood as a celebratory vision of homesteading—and achieving fame and fortune in the process, in one of the most astonishing rags-to-riches episodes in American letters.Spanning nearly a century of epochal change, from the Indian Wars to the Dust Bowl, Wilder’s dramatic life provides a unique perspective on American history and our national mythology of self-reliance. With fresh insights and new discoveries, Prairie Fires reveals the complex woman whose classic stories grip us to this day.WINNER OF THE PULITZER PRIZEWINNER OF THE NATIONAL BOOK CRITICS CIRCLE AWARDWINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NON-FICTIONONE OF THE NEW YORK TIMES BOOK REVIEW'S 10 BEST BOOKS OF THE YEAROne of The New York Times Book Review's 10 Best Books of the YearThe first comprehensive historical biography of Laura Ingalls Wilder, the beloved author of the Little House on the Prairie books

    Kennedy, with an introduction by Caroline Kennedy and a foreword by Robert F. Kennedy.Written in 1955 by the then junior senator from the state of Massachusetts, John F. Kennedy's Profiles in Courage serves as a clarion call to every American.In this book Kennedy chose eight of his historical colleagues to profile for their acts of astounding integrity in the face of overwhelming opposition. These heroes, coming from different junctures in our nation’s history, include John Quincy Adams, Daniel Webster, Thomas Hart Benton, and Robert A. Taft.Now, a half-century later, the book remains a moving, powerful, and relevant testament to the indomitable national spirit and an unparalleled celebration of that most noble of human virtues. It resounds with timeless lessons on the most cherished of virtues and is a powerful reminder of the strength of the human spirit. Profiles in Courage is as Robert Kennedy states in the foreword: “not just stories of the past but a book of hope and confidence for the future. What happens to the country, to the world, depends on what we do with what others have left us."Along with vintage photographs and an extensive author biography, this book features Kennedy's correspondence about the writing project, contemporary reviews, a letter from Ernest Hemingway, and two rousing speeches from recipients of the Profile in Courage Award.  Introduction by John F. Kennedy’s daughter Caroline Kennedy, forward by John F. Kennedy’s brother Robert F. Kennedy.

    It proved fatal to at least a half-million Americans. Yet, the Spanish flu pandemic is largely forgotten today. In this vivid narrative, Alfred W. Crosby recounts the course of the pandemic during the panic-stricken months of 1918 and 1919, measures its impact on American society, and probes the curious loss of national memory of this cataclysmic event. In a new edition, with a new preface discussing the recent outbreaks of diseases, including the Asian flu and the SARS epidemic, America's Forgotten Pandemic remains both prescient and relevant. Alfred W. Crosby is a Professor Emeritus in American Studies, History and Geography at the University of Texas at Austin, where he taught for over 20 years. His previous books include Throwing Fire (Cambrige, 2002), the Measure of Reality (Cambridge, 1997) and Ecological Imperialism (cambridge, 1986). Ecological Imperialism was the winner of the 1986 Phi Beta Kappa book prize. The Measure of Reality was chosen by the Los Angeles Times as one of the 100 most important books of 1997.

    But he didn’t charge the parents of the preemies a penny; instead the public paid to see them. He claimed to have a survival rate of 85 percent. By contrast, most mainstream doctors in the early part of the 20th century regarded premature babies as “weaklings” and did little or nothing to save them.Prentice's meticulous research unravels the mystery of Couney’s origins, and reveals that the “incubator doctor” was not all that he seemed. She brings one of the most extraordinary stories in American medicine to life through interviews with Couney’s former “incubator babies.”Claire Prentice is an award-winning journalist and the author of The Lost Tribe of Coney Island: Headhunters, Luna Park, and the Man Who Pulled Off the Spectacle of the Century. She has contributed to the BBC, the Washington Post, the Times of London, The Guardian, the Smithsonian magazine, the Huffington Post, NPR, Marie Claire, and the Sydney Morning Herald.

    Susan Wicklund chronicles her emotional and dramatic twenty-year career on the front lines of the abortion war. Growing up in working class, rural Wisconsin, Wicklund had her own painful abortion at a young age. It was not until she became a doctor that she realized how many women shared her ordeal of an unwanted pregnancy—and how hidden this common experience remains. This is the story of Susan's love for a profession that means listening to women and helping them through one of the most pivotal and controversial events in their lives. Hers is also a calling that means sleeping on planes and commuting between clinics in different states—and that requires her to wear a bulletproof vest and to carry a .38 caliber revolver. This is also the story of the women whom Susan serves, women whose options are increasingly limited.Through these intimate, complicated, and inspiring accounts, Wicklund reveals the truth about the women's clinics that anti-abortion activists portray as little more than slaughterhouses for the unborn. As we enter the most fevered political fight over abortion America has ever seen, this raw and powerful memoir shows us what is at stake.

    But he was alive and trapped inside his own body for ten years.In January 1988 Martin Pistorius, aged twelve, fell inexplicably sick. First he lost his voice and stopped eating. Then he slept constantly and shunned human contact. Doctors were mystified. Within eighteen months he was mute and wheelchair-bound. Martin's parents were told an unknown degenerative disease left him with the mind of a baby and less than two years to live.Martin was moved to care centers for severely disabled children. The stress and heartache shook his parents’ marriage and their family to the core. Their boy was gone. Or so they thought.Ghost Boy is the heart-wrenching story of one boy’s return to life through the power of love and faith. In these pages, readers see a parent’s resilience, the consequences of misdiagnosis, abuse at the hands of cruel caretakers, and the unthinkable duration of Martin’s mental alertness betrayed by his lifeless body.We also see a life reclaimed—a business created, a new love kindled—all from a wheelchair. Martin's emergence from his own darkness invites us to celebrate our own lives and fight for a better life for others.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system.In Pain in America is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.

    What surfaced was terrifying: she was inhabited by 'the Troops'-92 individual personalities. This groundbreaking true story is made all the more extraordinary in that it was written by the Troops themselves. What they reveal is a spellbinding descent into a personal hell-and an ultimate deliverance for the woman they became.

    MacLeod and her husband encountered their dream while vacationing on a remote island in the Scottish Hebrides. Enthralled by its windswept beauty, they soon were the proud owners of a near-derelict croft house--a farmer's stone cottage--on "a small acre" of land. Mary assumed duties as the island's district nurse. Call the Nurse is her account of the enchanted years she and her family spent there, coming to know its folk as both patients and friends.In anecdotes that are by turns funny, sad, moving, and tragic, she recalls them all, the crofters and their laird, the boatmen and tradesmen, young lovers and forbidding churchmen. Against the old-fashioned island culture and the grandeur of mountain and sea unfold indelible stories: a young woman carried through snow for airlift to the hospital; a rescue by boat; the marriage of a gentle giant and the island beauty; a ghostly encounter; the shocking discovery of a woman in chains; the flames of a heather fire at night; an unexploded bomb from World War II; and the joyful, tipsy celebration of a ceilidh. Gaelic fortitude meets a nurse's compassion in these wonderful true stories from rural Scotland.

    Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."

    A woman without connections or status, More took the world of British letters by storm when she arrived in London from Bristol, becoming a best-selling author and acclaimed playwright and quickly befriending the author Samuel Johnson, the politician Horace Walpole, and the actor David Garrick. Yet she was also a leader in the Evangelical movement, using her cultural position and her pen to support the growth of education for the poor, the reform of morals and manners, and the abolition of Britain's slave trade."Fierce Convictions" weaves together world and personal history into a stirring story of life that intersected with Wesley and Whitefield's Great Awakening, the rise and influence of Evangelicalism, and convulsive effects of the French Revolution. A woman of exceptional intellectual gifts and literary talent, Hannah More was above all a person whose faith compelled her both to engage her culture and to transform it.

    Gifted Hands will transplace you into the operating room to witness surgeries that made headlines around the world, and into the private mind of a compassionate, God-fearing physician who lives to help others. In 1987, Dr. Carson gained worldwide recognition for his part in the first successful separation of Siamese twins joined at the back of the head -- an extremely complex and delicate operation that was five months of planning and twenty-two hours of actual surgery, involving a surgical plan that Carson helped initiate. Gifted Hands reveals a man with humility, decency, compassion, courage, and sensitivity who serves as a role model for young people (and everyone else) in need of encouragement to attempt the seemingly impossible and to excel in whatever they attempt. Dr. Carson also describes the key role that his highly intelligent though relatively uneducated mother played in his metamorphosis from an unmotivated ghetto youngster into one of the most respected neurosurgeons in the world.