The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    It not only caused widespread radioactive contamination, but even more importantly, it claimed many lives and caused panic worldwide about the safety of nuclear power. In short, it changed the face of nuclear energy globally.Discover the real story of the Chernobyl Nuclear Power Plant and the infamous disaster that bears its name, as well as its long aftermath.Discover a plethora of topics such asBackground of the Chernobyl DisasterApril 25-26: The Failed Safety TestApril 26-27: The Crisis UnfoldsClean Up and RemediationThe World RespondsInvestigations into the Chernobyl DisasterAnd much more!

    He did not claim he was God’s agent. Did he believe in God? Did he look for a sign when he was desperate? Did he follow the Divine Will? Many believers are not followers; many followers are not believers. Is he a believer or a follower or both?

    Its step-by-step approach guides you through the process, helping you formulate a nursing diagnosis based on known information and assessment findings; identify the appropriate nursing diagnosis; and create a care plan that includes desired outcomes, interventions, and evidence-based rationales. Nursing Diagnosis Handbook is an essential care planning resource you will turn to again and again throughout your nursing education and career.Provides care plans for every NANDA-I approved nursing diagnosis.Includes examples of and suggested NIC and NOC interventions and outcomes for each care plan.A convenient A-to-Z organization in Sections I and II helps you quickly locate key information.Evidence-based practice information is incorporated throughout.Includes complete coverage of pediatric, geriatric, and multicultural considerations, as well as home care and client/family teaching guidelines for each condition.A Care Plan Constructor on the Evolve website helps you create customized plans of care.Features the most up-to-date 2007-2008 NANDA-I approved nursing diagnoses, including approximately 15 new, 20 revised, and 5 replacement diagnoses.Provides a more detailed explanation of NIC and NOC taxonomies and their use in care planning.Explanations of assessment versus action interventions help guide you to the correct choice of intervention.Covers important information on concept mapping.Patient/Family Teaching sections offer expanded wellness and health promotion information.Clustered wellness nursing diagnoses are quick and easy to locate.Includes the latest evidence-based nursing rationales.

    It is packed with vital new information in addition to the basic story of its beginnings and where it is today. Included is startling commentary on the alleged secrets and how they will change the world forever. Underlying the story is the disclosure by the Mother of Jesus that she will never come to earth again in apparition. THE LAST APPARITION is a must read!

      In 1979, seemingly overnight—moving at a clip some thirty years faster than the rest of the world—Iran became the first revolutionary theocracy in modern times. Since then, the country has been largely a black box to the West, a sinister presence looming over the horizon. But inside Iran, a breathtaking drama has unfolded since then, as religious thinkers, political operatives, poets, journalists, and activists have imagined and reimagined what Iran should be. They have drawn as deeply on the traditions of the West as of the East and have acted upon their beliefs with urgency and passion, frequently staking their lives for them.   With more than a decade of experience reporting on, researching, and writing about Iran, Laura Secor narrates this unprecedented history as a story of individuals caught up in the slipstream of their time, seizing and wielding ideas powerful enough to shift its course as they wrestle with their country’s apparatus of violent repression as well as its rich and often tragic history. Essential reading at this moment when the fates of our countries have never been more entwined, Children of Paradise will stand as a classic of political reporting; an indelible portrait of a nation and its people striving for change.

    It is our turn," writes Conrad Black in this scintillating manifesto for how Canada can achieve an exalted role in world affairs. For over 400 years we have toiled in the shadows of our potential and achieved an indifferent recognition among other nations. Chipper, patient, and courteous, we have pursued an improbable destiny as a splendid nation in the northern section of the new world, a demi-continent of relatively good and ably self-governing people, but most would agree we have neither developed a vivid national personality nor realized our true potential. Our main chance, writes Black, is now before us and it is not in the usual realms of military or economic dominance. With the rest of the West engaged in a sterile and platitudinous left-right tug of war, Canada has the opportunity to lead the advanced world to its next stage of development in the arts of government. By transforming itself into a controlled and sensible public policy laboratory, it can forge new solutions to the tiresome problems besetting welfare, education, health care, foreign policy, and other governmental sectors the world over, and make an enormous contribution to the welfare of mankind. Canada has no excuse not to lead in this field, argues Black, who offers nineteen visionary policy proposals of his own. "This is the destiny, and the vocation, Canada could have, not in the next century, but in the next five years of imaginative government.

    Touch it and you die. Every politician knows this truism, which is why no one wants to debate it. Privately, many of them understand that the health care system, which costs about $200 billion a year in public and private money, cannot continue as it is—increasingly ill-adapted to an aging population with public costs growing faster than government revenues. In Chronic Condition, Jeffrey Simpson meets health care head on and explores the only four options we have to end this growing crisis: cuts in spending, tax increases, privatization, and reaping savings through increased efficiency. He examines the tenets of the Medicare system that Canadians cling to so passionately. Here, he finds that many other countries have more extensive public health systems, and Canadian health care produces only average value for money. In fact, our rigid system for some health care needs and a costly system for other needs—drugs, dentistry, and home care—is really the worst of both worlds. Chronic Condition breaks the silence about the huge changes and real choices that Canadians face.

    Once mired in controversy and doubt, ST6 has blossomed into one of the most accomplished fighting units the world has ever known. Having taken down the highest of high-value targets, rescued American hostages in Africa, the Middle East, Asia, and the Indian Ocean, and served as the silent guardian of the Coalition's conventional forces, SEAL Team Six has defined the post-9/11 world as much as it has been defined by it. The follow-up to SHAPING THE WORLD FROM THE SHADOWS -- the definitive open-source guide to Delta Force -- BEYOND NEPTUNE SPEAR is a contextual examination of DEVGRU's post-9/11 existence, from the most high-profile operations to the little-known missions that are still barely more than whispers. "Once again, Chris Martin has proven himself to be one of journalism's sharpest observers of U.S. special operations forces. BEYOND NEPTUNE SPEAR is a remarkable synthesis of the history, operations, and organization of SEAL Team Six. It is the most comprehensive guide to the unit ever published." - D.B. Grady, co-author of THE COMMAND: DEEP INSIDE THE PRESIDENT'S SECRET ARMY. "BEYOND NEPTUNE SPEAR tells much of what you wanted to know about SEAL Team Six post-9/11 but didn’t ask for fear of getting shot. Chris Martin begins with Team Six’s “rogue” beginnings then quickly springs into its operations post-9/11 until present. Although a short book, you’ll get bang for your buck here. For newcomers to the topic, BEYOND NEPTUNE SPEAR provides an exhaustive overview of Team Six’s current happenings. For experts on Team Six, Chris’s work provides an excellent summary of the post-9/11 Team with occasional information you probably missed. The reference page alone is a treasure for studying/reviewing the unit that whacked bin Laden. Also, because Chris used open sources to write this book, you don’t have to fear stealing government secrets and taking a bullet to the head." -Stephen Templin, New York Times bestselling co-author of SEAL TEAM SIX.

    His profound and poetic speeches are famous around the world, evidence of the greatness of American’s most beloved leader. But did you know that the sixteenth president of the United States was also a backwoods hillbilly from America’s western frontier, with a Kentucky accent so thick you could cut it? Or that he liked wrestling matches, dirty jokes, and had a reputation for telling hilarious, R-rated stories that weren’t suitable for mixed company? From his childhood working as a virtual slave for an abusive father, to sailing a river raft to New Orleans, to the Illinois General Assembly, Congress, and the White House, the story of Abraham Lincoln’s life is the story of America. He mourned the deaths of almost everyone he loved, endured marriage to a wife whose mental health issues made her a domestic abuser, and lost more elections than he won. But Abraham Lincoln believed in one thing above all: that everyone deserved a fair shot at the American dream. Why did John Wilkes Booth really shoot Abraham Lincoln? The truth is as shocking now as it was in 1865.

    

    In the aftermath of the Battle of Britain, airmen filled a small Sussex town where pioneering plastic surgeon Archibald McIndoe established revolutionary surgical and therapeutic treatments.For the child Liz Byrski, growing up in a small Sussex town, the burnt faces of these airmen filled her nightmares.In her late sixties, Liz returned to make peace with her memories and to speak not only with the survivors – known as the Guinea Pig Club – but with the nurses who played a vital and unorthodox role in their treatment, sometimes at a significant personal cost.

    

     Attu was the westernmost island in the Aleutian chain, located one thousand miles from Alaska, and subject to brutal weather all year round. Prior to the war it had been home to two Americans and forty-five Aleut hunters and their families, but in June 1942 the Japanese had seized the island and now had over two-thousand troops on the barren island threatening the security of the U.S. mainland. The Battle of the Komandorski Islands in the Bering Sea on March 26, 1943, cleared the way for attempt to retake the island of Attu. Code-named Operation Landgrab, the U.S. military planned for the invasion to take place in May. Army planners had initially thought this would be a quick operation, but instead of being a short invasion it dragged on for over two weeks. The Japanese had realized that their options were limited and so launched a last-ditch banzai charge against the American frontline that was suffering from brutal Arctic conditions, equipment failures and food shortages. Although the U.S. military was able to recapture the island it had cost the lives of over five hundred American soldiers. Robert J. Mitchell, Sewell T. Tyng and Nelson Drummond’s book The Capture of Attu provides fascinating insight into this ferocious conflict. Part One of the book provides an overview of the military campaign while Part Two provides personal narratives of the soldiers who fought. This book attempts to put the reader on the battlefield with the ground soldier. Men who fought on Attu, officers and enlisted men, told their stories to Lieutenant Robert J. Mitchell of the 32d Infantry, one of the regiments engaged. These stories tell of the discomforts and perils, the failures and successes, the fear and courage, the many fights between small groups and the occasional humor, of which battle consists. Robert J. Mitchell served as a lieutenant in the US Army's 7th Infantry Division in World War II, being stationed on Attu Island off of Alaska as well as other areas of the Pacific. He was shot in the chest while on Attu and carried the bullet for the rest of his life. While recuperating, he wrote the stories of the other men in his hospital tent. For this he was made an aide to the general in charge of media for the rest of the war. He passed away in 1992. His co-authors Sewell T. Tyng and Nelson Drummond also served on Attu and passed away in 1946 and 1999 respectively. Their book The Capture of Attu was first published in 1944.

    The white slave trade was rampant, and along with all the vice crimes, murders became a weekly occurrence. Law enforcement seemed to turn a blind eye, and cries of political corruption were heard in the state capital. This scenario replayed itself over and over again during the past century as mobsters and madams ruled and murders plagued the city and county at an alarming rate.