At his death last spring, Roueche left behind seven new narratives that have never been published in book form. This book collects these works along with one earlier classic--all relating true tales of strange illnesses, rare diseases, and the brilliant minds who race to understand and conquer them.

    With swashbuckling wit and fierce honesty, she dishes on herself and her colleagues as they try to prod reluctant governments to fund HIV prevention for the people who need it most—drug injectors, gay men, sex workers, and johns.Pisani chats with flamboyant Indonesian transsexuals about their boob jobs and watches Chinese streetwalkers turn away clients because their SUVs aren't nice enough. With verve and clarity, she shows the general reader how her profession really works; how easy it is to draw wrong conclusions from "objective" data; and, shockingly, how much money is spent so very badly. "Exhibit A": the 45 billion taxpayer dollars the Bush administration is committing to international AIDS programs.

    In Running to Extremes, she attempts to answer that question and many more about ultramarathon running. In the past few years, Lisa has taken part in some of the most gruelling races on earth. Not content with having run the Badwater Ultramarathon once, she's been back and done it a second time. She's also completed the Gobi March and a race in the Egyptian Sahara. However, none of these could have prepared her for her greatest challenge to date: La Ultra, a 222-kilometre non-stop race over two Himalayan mountain passes. Running to Extremes tells the stories behind these races and provides plenty of advice for runners of all levels and distances. Filled with training tips, gear lists, information on nutrition and supplements, advice on mental preparation and, most importantly, a focus on how to keep yourself healthy while training and racing, it will inspire and motivate runners and non-runners alike.

    In the majority of cases individuals diagnosed as "brain dead" are the source of the organs without which transplants could not take place. In this compelling and provocative examination, Margaret Lock traces the discourse over the past thirty years that contributed to the locating of a new criterion of death in the brain, and its routinization in clinical practice in North America. She compares this situation with that in Japan where, despite the availability of the necessary technology and expertise, brain death was legally recognized only in 1997, and then under limited and contested circumstances. Twice Dead explores the cultural, historical, political, and clinical reasons for the ready acceptance of the new criterion of death in North America and its rejection, until recently, in Japan, with the result that organ transplantation has been severely restricted in that country. This incisive and timely discussion demonstrates that death is not self-evident, that the space between life and death is historically and culturally constructed, fluid, multiple, and open to dispute. In addition to an analysis of that professional literature on and popular representations of the subject, Lock draws on extensive interviews conducted over ten years with physicians working in intensive care units, transplant surgeons, organ recipients, donor families, members of the general public in both Japan and North America, and political activists in Japan opposed to the recognition of brain death. By showing that death can never be understood merely as a biological event, and that cultural, medical, legal, and political dimensions are inevitably implicated in the invention of brain death, Twice Dead confronts one of the most troubling questions of our era.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Today, it is the most common form of officially classified mental illness. Scott Stossel gracefully guides us across the terrain of an affliction that is pervasive yet too often misunderstood. Drawing on his own long-standing battle with anxiety, Stossel presents an astonishing history, at once intimate and authoritative, of the efforts to understand the condition from medical, cultural, philosophical, and experiential perspectives. He ranges from the earliest medical reports of Galen and Hippocrates, through later observations by Robert Burton and Søren Kierkegaard, to the investigations by great nineteenth-century scientists, such as Charles Darwin, William James, and Sigmund Freud, as they began to explore its sources and causes, to the latest research by neuroscientists and geneticists. Stossel reports on famous individuals who struggled with anxiety, as well as on the afflicted generations of his own family. His portrait of anxiety reveals not only the emotion’s myriad manifestations and the anguish anxiety produces but also the countless psychotherapies, medications, and other (often outlandish) treatments that have been developed to counteract it. Stossel vividly depicts anxiety’s human toll—its crippling impact, its devastating power to paralyze—while at the same time exploring how those who suffer from it find ways to manage and control it. My Age of Anxiety is learned and empathetic, humorous and inspirational, offering the reader great insight into the biological, cultural, and environmental factors that contribute to the affliction.

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.

    Eyes wide open. I was standing at an open window, staring at the dizzying curve of Riverside Drive, five floors below. I’d stopped, somehow, poised, about to jump.Growing up the good girl in an Irish American family full of drinkers and terrible sleepers, Kathleen Frazier was twelve when her seemingly innocent sleepwalking turned dangerous. Over the next few years, she was a popular A+ student by day, the star of her high school musical. At night, she both longed for and dreaded sleep.Frazier moved to Manhattan in the 1980s, hoping for a life in the theater but getting a run of sleepwalking performances instead. Efforts to abate her malady with drinking failed miserably. She became promiscuous, looking for nighttime companionship. Could a bed partner save her from flinging herself down a flight of stairs or out an open window? Exhaustion stalked her, and rest and love were seemingly out of reach.This is the journey Frazier illuminates in her intimate memoir. While highlighting her quest to beat her sleep terrors and insomnia, this is ultimately a story of health, hope, and redemption.

    In riveting first-person prose, Dr. Brendan Reilly takes us to the front lines of medicine today. Whipsawed by daily crises and frustrations, Reilly must deal with several daunting challenges simultaneously: the extraordinary patients under his care on the teeming wards of a renowned teaching hospital; the life-threatening illnesses of both of his ninety-year-old parents; and the tragic memory of a cold case from long ago that haunts him still. As Reilly’s patients and their families survive close calls, struggle with heartrending decisions, and confront the limits of medicine’s power to cure, One Doctor lays bare a fragmented, depersonalized, business-driven health-care system where real caring is hard to find. Every day, Reilly sees patients who fall through the cracks and suffer harm because they lack one doctor who knows them well and relentlessly advocates for their best interests.Filled with fascinating characters in New York City and rural New England — people with dark secrets, mysterious illnesses, impossible dreams, and many kinds of courage — One Doctor tells their stories with sensitivity and empathy, reminding us of professional values once held dear by all physicians. But medicine has changed enormously during Reilly’s career, for both better and worse, and One Doctor is a cautionary tale about those changes. It is also a hopeful, inspiring account of medicine’s potential to improve people’s lives, Reilly’s quest to understand the "truth" about doctoring, and a moving testament to the difference one doctor can make.

    He continued to make great music while slowly returning to his Catholic roots. His hard-won wisdom filters through his stories whether he's recalling how he went shopping with John Lennon and ended up on the cover of Sgt. Peppers Lonely Hearts Club Band or what it was like to travel in the Jim Crow South with Sam Cooke.Praise for Dion... "To this day nobody, nobody can rock like Dion."—Lou Reed "He always had the name that said it all...Dion."—Bruce Springsteen "If you want to hear a great singer, listen to Dion. His genius has never deserted him."—Bob DylanThe audio edition of this book can be downloaded via Audible.

    You’ve had a martini or three, and you mingle through the crowd, wondering how long you need to stay before going out for pizza. Suddenly you’re introduced to someone new, Dr. Nice Tomeetya. You forget the pizza. Now is the perfect time to bring up all those strange questions you’d like to ask during an office visit with your own doctor but haven’t had the guts (or more likely the time) to do so. You’re filled with liquid courage . . . now is your chance! If you’ve ever wanted to ask a doctor . . .•How do people in wheelchairs have sex?•Why do I get a killer headache when I suck down my milkshake too fast?•Can I lose my contact lens inside my head forever?•Why does asparagus make my pee smell?•Why do old people grow hair on their ears?•Is the old adage “beer before liquor, never sicker, liquor before beer . . .” really true? . . . then Why Do Men Have Nipples? is the book for you.Compiled by Billy Goldberg, an emergency medicine physician, and Mark Leyner, bestselling author and well-known satirist, Why Do Men Have Nipples? offers real factual and really funny answers to some of the big questions about the oddities of our bodies.

    And she got one-coming at her at forty miles per hour. Hit by a car and suffering debilitating injuries, and with no health insurance, the fashionista attempts to bounce back into her (thrift store-purchased) Jimmy Choos even as she deals with short-term memory loss, stalker ambulance drivers, trying to stay vegan on food stamps, crazy judges, hot doctors, and unsympathetic government workers.Inspired by her acclaimed one-woman show, this is a bitingly funny and keenly observed account of the cracks in our medical and social welfare system and how one woman's resilience combined with a generous dollop of humor helped her fight her way to recovery.

    Louis. For most of his life, he was an all-around normal kid. He excelled in sports and academics, and cherished his time at home with his family. It wasn’t until he turned fifteen that things went seriously wrong. While attending his first high school party, he was introduced to pot and alcohol. Needless to say, he gave in to the pressure. A month after that, he discovered heroin. The drug had just made its way into the suburban party scene, and Jude was sure that he could get away with doing it only once. He was sadly mistaken. Within a few short months, his entire life was in shambles. His fate appeared certain, but it was just the beginning.​In a series of events that leaves you grasping for the next page, Jude spares no amount of detail in his account of his near-decade long struggle with drug addiction, and the horrors he witnessed along the way.

    This critically acclaimed biography offers an unprecedented look at William Masters and Virginia Johnson, their pioneering studies on intimacy, and their lasting impact on the love lives of today's men and women.

    Catherine Sager captured her family's trip across the American West in her journal. Her story describes the terrible journey which the early Oregon settlers made in order to settle and colonise a new territory with many hardships and heartaches along the way.This account today is regarded as one of the most authentic accounts of the American westward migration. This edition has extra contextual information such as paintings, maps and facts to enhance the gripping narrative of Catherine Sager. The Sager Family Catehrine's father, Henry Sager was described as a restless one in her journal. Before 1844 he had moved his growing family three times. In April 1844 Henry and his family took part in the great westward migration and started their journey along the Oregon Trail. During their journey both he and his wife lost their lives and left their seven children orphaned. They were later adopted by Marcus Whitman and Narcissa Whitman, missionaries in what is now Washington, the children were orphaned a second time, when both their new parents were killed during the Whitman massacre in November 1847. Catherine Sager's account About 1860 Catherine, the oldest of the Sager girls, wrote a first-hand account of their journey across the plains and their life with the Whitmans. Catherine's writing is clear, vivid and honest. She details pioneer life, the happy time she had with the Whitman's and the brutal massacre of the Whitman's by Indians. A survivor, she was also taken captive by the Indians. Her story shows how difficult life was for the early pioneers and gives a true insight into the early American West. What was the Oregon trail? The Oregon Trail is a 2,200-mile (3,500 km) historic east–west large-wheeled wagon route and emigrant trail that connected the Missouri River to valleys in Oregon. The eastern part of the Oregon Trail spanned part of the future state of Kansas and nearly all of what are now the states of Nebraska and Wyoming. The western half of the trail spanned most of the future states of Idaho and Oregon.From the early to mid-1830s the Oregon Trail and its many offshoots were used by about 400,000 settlers, ranchers, farmers, miners, and businessmen and their families. Chapters Across the PlainsHome Life at the Whitman'sThe Waiilatpu MassacreIn Captivity