O'Connell’s collection of stories and essays, written during thirty years of caring for homeless persons in Boston, gently illuminates the humanity and raw courage of those who struggle to survive and find meaning and hope while living on the streets.

    As the defiant but sensitive young genius is creating his theory of relativity, a new conception of time, he imagines many possible worlds. In one, time is circular, so that people are fated to repeat triumphs and failures over and over. In another, there is a place where time stands still, visited by lovers and parents clinging to their children. In another, time is a nightingale, sometimes trapped by a bell jar.Now translated into thirty languages, Einstein’s Dreams has inspired playwrights, dancers, musicians, and painters all over the world. In poetic vignettes, it explores the connections between science and art, the process of creativity, and ultimately the fragility of human existence.

    A formidable debut, it is a profound and unforgettable depiction of today’s doctors, patients, and hospitals.Provocative, heartbreaking, and darkly humorous, Bloodletting & Miraculous Cures introduces readers to a masterful new voice in fiction. A practicing ER physician, Vincent Lam delivers a precise and intimate portrait of the medical profession in his fiction debut. These twelve interwoven stories follow a group of young doctors as they move from the challenges of medical school to the intense world of emergency rooms, evacuation missions, and terrifying new viruses. Winner of the prestigious Giller Prize, Bloodletting & Miraculous Cures marks the arrival of a deeply humane and preternaturally gifted writer. Fitz, Ming, Chen, and Sri are the four ambitious protagonists of Bloodletting & Miraculous Cures. They fall in love as they study for their exams, face moral dilemmas as they split open cadavers, confront police who rough up their patients, and treat schizophrenics with pathologies similar to their own. In one harrowing story set amidst the 2003 SARS crisis, which the author witnessed firsthand, two of these doctors suddenly become the patients. Bloodletting & Miraculous Cures invites us into a world where the ordinary becomes the critical in a matter of seconds. A formidable debut, it is a profound and unforgettable depiction of today’s doctors, patients, and hospitals.

    A slip of the hand and life ebbs away.The balance between life and death is so delicate, and the heart surgeon walks that rope between the two. In the operating room there is no time for doubt. It is flesh, blood, rib-retractors and pumping the vital organ with your bare hand to squeeze the life back into it. An off-day can have dire consequences – this job has a steep learning curve, and the cost is measured in human life. Cardiac surgery is not for the faint of heart.Professor Stephen Westaby took chances and pushed the boundaries of heart surgery. He saved hundreds of lives over the course of a thirty-five year career and now, in his astounding memoir, Westaby details some of his most remarkable and poignant cases – such as the baby who had suffered multiple heart attacks by six months old, a woman who lived the nightmare of locked-in syndrome, and a man whose life was powered by a battery for eight years.A powerful, important and incredibly moving book, Fragile Lives offers an exceptional insight into the exhilarating and sometimes tragic world of heart surgery, and how it feels to hold someone’s life in your hands.

    In this captivating story, Manguso recalls her struggle: arduous blood cleansings, collapsed veins, multiple chest catheters, depression, the deaths of friends and strangers, addiction, and, worst of all for a writer, the trite metaphors that accompany prolonged illness. A book of tremendous grace, The Two Kinds of Decay transcends the very notion of what an illness story can and should be.

    And here is the world after Mark was released from a mental hospital to find his family forever altered. At the late age of twenty-eight—and after nineteen rejections—Mark was accepted to Harvard Medical School, where he gained purpose, a life, and some control over his condition.The brilliantly evoked events of Mark Vonnegut’s life are at once perfectly unique and achingly relatable. There are the manic episodes, during which he felt burdened with saving the world, juxtaposed against the real-world responsibilities of running a pediatric practice. At times he felt that his parents’ lives would improve if only they had a few hundred more bucks in their bank account, while at other points his father’s fame merely heightened expectations that he be better, funnier (and crazier) than the average person.Ultimately a tribute to the small, daily, and positive parts of a life interrupted by bipolar disorder, Just Like Someone Without Mental Illness Only More So is a wise, unsentimental, and inspiring book that will resonate with generations of readers.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    Otis Brawley is the chief medical and scientific officer of The American Cancer Society, an oncologist with a dazzling clinical, research, and policy career. How We Do Harm pulls back the curtain on how medicine is really practiced in America. Brawley tells of doctors who select treatment based on payment they will receive, rather than on demonstrated scientific results; hospitals and pharmaceutical companies that seek out patients to treat even if they are not actually ill (but as long as their insurance will pay); a public primed to swallow the latest pill, no matter the cost; and rising healthcare costs for unnecessary—and often unproven—treatments that we all pay for. Brawley calls for rational healthcare, healthcare drawn from results-based, scientifically justifiable treatments, and not just the peddling of hot new drugs.Brawley's personal history – from a childhood in the gang-ridden streets of black Detroit, to the green hallways of Grady Memorial Hospital, the largest public hospital in the U.S., to the boardrooms of The American Cancer Society—results in a passionate view of medicine and the politics of illness in America - and a deep understanding of healthcare today. How We Do Harm is his well-reasoned manifesto for change.

    For a single mother living paycheck to paycheck who had always been the caregiver rather than the one needing care, the catastrophic illness was both a crisis and an initiation into new ideas about mortality and the gendered politics of illness.A twenty-first-century Illness as Metaphor, as well as a harrowing memoir of survival, The Undying explores the experience of illness as mediated by digital screens, weaving in ancient Roman dream diarists, cancer hoaxers and fetishists, cancer vloggers, corporate lies, John Donne, pro-pain ”dolorists,” the ecological costs of chemotherapy, and the many little murders of capitalism. It excoriates the pharmaceutical industry and the bland hypocrisies of ”pink ribbon culture” while also diving into the long literary line of women writing about their own illnesses and ongoing deaths: Audre Lorde, Kathy Acker, Susan Sontag, and others.A genre-bending memoir in the tradition of The Argonauts, The Undying will break your heart, make you angry enough to spit, and show you contemporary America as a thing both desperately ill and occasionally, perversely glorious.

    Yiyun Li confronts grief and transforms it into art, in a book of surprising beauty and love.The narrator writes, "I had but one delusion, which I held onto with all my willpower: we once gave Nikolai a life of flesh and blood; and I'm doing it over again, this time by words."Written in the months after the author lost a child to suicide and composed as a story cycle, this conversation between mother and child unfolds in a timeless world. Deeply intimate, poignant, and moving, these conversations portray the love and complexity in a relationship across generations, even as they capture the pain of sadness, longing, and loss.In writing this book, Yiyun Li was inspired by a line from Proust's Remembrance of Things Past "Ideas come to us as the successors to griefs, and griefs, at the moment when they change into ideas, lose some part of their power to injure the heart; the transformation itself, even, for an instant, releases suddenly a little joy."Meeting life's deepest sorrow with originality, precision and poise, Where Reasons End is suffused with intimacy, inescapable pain, and fierce love.

    From Sarajevo under siege in 1993 to clandestine hospitals in rebel-held eastern Aleppo, he has carried out lifesaving operations in the most challenging conditions, and with none of the resources of a major metropolitan hospital. He is now widely acknowledged as the most experienced trauma surgeon in the world.War Doctor is his extraordinary story, encompassing his surgeries in nearly every major conflict zone since the end of the Cold War, as well as his struggles to return to a “normal” life and routine after each trip. Culminating in his recent trips to war-torn Syria—and the untold story of his efforts to help secure a humanitarian corridor out of besieged Aleppo to evacuate some 50,000 people—War Doctor is a blend of medical memoir, personal journey, and nonfiction thriller that provides unforgettable, at times raw, insight into the human toll of war.

    Alongside remarkable stories of people who have lost these abilities but adapted with courage, resilience and ingenuity, there is an added, personal element: one day in late 2005, Sacks became aware of a dazzling, flashing light in one part of his visual field; it was not the familiar migraine aura he had experienced since childhood, and just two days later a malignant tumor in one eye was diagnosed. In subsequent journal entries - some of which are included in The Mind's Eye - he chronicled the experience of living with cancer, recording both the effects of the tumor itself, and radiation therapy. In turning himself into a case history, Sacks has given us perhaps his most intimate, impressive and insightful (no pun intended) book yet.

    It takes in calculating beauties and sadistic husbands along with such real-life supporting characters as Colette, the Duchess of Windsor, Montgomery Clift, and Tallulah Bankhead. Above all, this malevolently funny book displays Capote at his most relentlessly observant and murderously witty.

    In his first-ever work of autobiography, the comedian and New York Times bestselling author tells how a freakish medical condition descended upon him one October afternoon and led him to the brink of death – in a New York hospital “consistently rated one of the ten best in the country.” What happens when “one of the funniest people in America” (CBS News Sunday Morning) comes face to face with his own mortality? An Unexpected Twist is in equal parts harrowing and hilarious – and a moving affirmation of what it means to be alive.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.