We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    A manic cross between Mark Leyner, Fran Lebowitz, and the National Enquirer, Sedaris’s collection of essays is a rollicking tour through the national Zeitgeist: a do-it-yourself suburban dad saves money by performing home surgery; a man who is loved too much flees the heavyweight champion of the world; a teenage suicide tries to incite a lynch mob at her funeral; a bitter Santa abuses the elves.David Sedaris made his debut on NPR’s Morning Edition with “SantaLand Diaries”, recounting his strange-but-true experiences as an elf at Macy’s, and soon became one of the show’s most popular commentators. With a perfect eye and a voice infused with as much empathy as wit, Sedaris writes stories and essays that target the soulful ridiculousness of our behavior. Barrel Fever is like a blind date with modern life, and anything can happen.Parade --Music for lovers --The last you'll hear from me --My manuscript --Firestone --We get along --Glen's homophobia newsletter vol. 3, no. 2 --Don's story --Season's greeting to our friends and family!!! --Jamboree --After Malison --Barrel fever --Diary of a smoker --Giantess --The curly kind --SantaLand diaries

    The phrase also aptly describes America’s medical system when it comes to treating the underprivileged. Medical students learn on the bodies of the poor—and the poor suffer from their mistakes.Rachel Pearson confronted these harsh realities when she started medical school in Galveston, Texas. Pearson, herself from a working-class background, remains haunted by the suicide of a close friend, experiences firsthand the heartbreak of her own errors in a patient’s care, and witnesses the ruinous effects of a hurricane on a Texas town’s medical system. In a free clinic where the motto is “All Are Welcome Here,” she learns how to practice medicine with love and tenacity amidst the raging injustices of a system that favors the rich and the white. No Apparent Distress is at once an indictment of American health care and a deeply moving tale of one doctor’s coming-of-age.

    Writer, M.D. celebrates this rich tradition with a collection of fiction and nonfiction by today’s most beloved physician-writers, including,• Abraham Verghese, on the lost art of the physical exam• Pauline Chen, on the bond between a med student and her first cadaver• Atul Gawande, on the ethical dilemmas of a young surgical intern• Danielle Ofri, on the devastation of losing a patient• Ethan Canin, on love, poetry, and growing oldThese essays and stories illuminate the inner lives of men and women who deal with trauma, illness, mortality, and grief on a daily basis. Read together, they provide a candid, moving, one-of-a-kind glimpse behind the doctor’s mask.

    Sadie’s lover calls her as he drives to meet his wife at marriage counseling. Gwen pines for her roommate, a man who will hold her hand but then tells her that her palm is sweaty. And Sasha agrees to have a drink with her married lover’s wife and then immediately regrets it. These are the women of Single, Carefree, Mellow, and in these eleven sublime stories they are grappling with unwelcome houseguests, disastrous birthday parties, needy but loyal friends, and all manner of love, secrets, and betrayal. In “Cranberry Relish” Josie’s ex—a man she met on Facebook—has a new girlfriend he found on Twitter. In “Blue Heron Bridge” Nina is more worried that the Presbyterian minister living in her garage will hear her kids swearing than about his finding out that she’s sleeping with her running partner. And in “The Rhett Butlers” a teenager loses her virginity to her history teacher and then outgrows him. In snappy, glittering prose that is both utterly hilarious and achingly poignant, Katherine Heiny chronicles the ways in which we are unfaithful to each other, both willfully and unwittingly. Maya, who appears in the title story and again in various states of love, forms the spine of this linked collection, and shows us through her moments of pleasure, loss, deceit, and kindness just how fickle the human heart can be.

     Early studies of the functions of the human brain used a simple method: wait for misfortune to strike-strokes, seizures, infectious diseases, lobotomies, horrendous accidents-and see how the victim coped. In many cases survival was miraculous, and observers could only marvel at the transformations that took place afterward, altering victims' personalities. An injury to one section can leave a person unable to recognize loved ones; some brain trauma can even make you a pathological gambler, pedophile, or liar. But a few scientists realized that these injuries were an opportunity for studying brain function at its extremes. With lucid explanations and incisive wit, Sam Kean explains the brain's secret passageways while recounting forgotten stories of common people whose struggles, resiliency, and deep humanity made modern neuroscience possible.

    She tackles eros and intimacy with a deceptively light touch, a keen awareness of how their nervous systems tangle and sometimes short-circuit, and a genius for revealing our most vulnerable, spirited selves. In “Desert Hearts,” a woman takes a job selling sex toys in San Francisco rather than embark on the law career she pursued only for the sake of her father. In “Pearl and the Swiss Guy Fall in Love,” a woman realizes she much prefers the company of her pit bull—and herself—to the neurotic foreign fling who won’t decamp from her apartment. In “How Am I Supposed to Talk to You?” a daughter hauls a suitcase of lingerie to Mexico for her flighty, estranged mother to resell there, wondering whether her personal mission—to come out—is worth the same effort. And in “Barbara the Slut,” a young woman with an autistic brother, a Princeton acceptance letter, and a love of sex navigates her high school’s toxic, slut-shaming culture with open eyes. With heart, sass, and pitch-perfect characters, Barbara the Slut is a head-turning debut from a writer with a limitless career before her.

    They casserole. They pinwheel. They pump the salad spinner like it's a CPR dummy. And then they kill a party crasher, carefully stepping around the body to pull cookies out of the oven. These twelve irresistible stories take us from a haunted prewar Manhattan apartment building to the set of a rigged reality television show, from the unique initiation ritual of a book club to the getaway car of a pageant princess on the lam, from the gallery opening of a tinfoil artist to the fitting room of a legendary lingerie shop. Vicious, fresh, and nutty as a poisoned Goo Goo Cluster, American Housewife is an uproarious, pointed commentary on womanhood.

    Handsome, famous, and talented, Goodyear is nonetheless coming apart at the seams. And the coaches, writers, wives, girlfriends, petty criminals, and diehard fans following his every move are eager to find out why--as they hide secrets of their own.Humming with the energy of a ballpark before the first pitch, Emily Nemens' The Cactus League unravels the tightly connected web of people behind a seemingly linear game. Narrated by a sportscaster, Goodyear's story is interspersed with tales of Michael Taylor, a batting coach trying to stay relevant; Tamara Rowland, a resourceful spring-training paramour, looking for one last catch; Herb Allison, a legendary sports agent grappling with his decline; and a plethora of other richly drawn characters, all striving to be seen as the season approaches. It's a journey that, like the Arizona desert, brims with both possibility and destruction.Anchored by an expert knowledge of baseball's inner workings, Emily Nemens's The Cactus League is a propulsive and deeply human debut that captures a strange desert world that is both exciting and unforgiving, where the most crucial games are the ones played off the field.

    Venturing inside minds and landscapes that are at once recognisable and utterly strange, these stories reaffirm Wallace's reputation as one of his generation's pre-eminent talents, expanding our ides and pleasures fiction can afford.Among the stories are 'The Depressed Person', a dazzling and blackly humorous portrayal of a woman's mental state; 'Adult World', which reveals a woman's agonised consideration of her confusing sexual relationship with her husband; and 'Brief Interviews with Hideous Men', a dark, hilarious series of portraits of men whose fear of women renders them grotesque. Wallace's stories present a world where the bizarre and the banal are interwoven and where hideous men appear in many different guises. Thought-provoking and playful, this collection confirms David Foster Wallace as one of the most imaginative young writers around. Wallace delights in leftfield observation, mining the ironic, the surprising and the illuminating from every situation. This collection will delight his growing number of fans, and provide a perfect introduction for new readers.

    They always keep a bag packed. They seldom have more than twenty-four hours' notice before they are dispatched. The phone calls that tell them to head to the airport, sometimes in the middle of the night, may give them no more information than the country they are traveling to and the epidemic they will tackle when they get there.The universal human instinct is to run from an outbreak of disease. These doctors run toward it.They are the disease detective corps of the U.S. Centers for Disease Control and Prevention (CDC), the federal agency that tracks and tries to prevent disease outbreaks and bioterrorist attacks around the world. They are formally called the Epidemic Intelligence Service (EIS) -- a group founded more than fifty years ago out of fear that the Korean War might bring the use of biological weapons -- and, like intelligence operatives in the traditional sense, they perform their work largely in anonymity. They are not household names, but over the years they were first to confront the outbreaks that became known as hantavirus, Ebola virus, and AIDS. Now they hunt down the deadly threats that dominate our headlines: West Nile virus, anthrax, and SARS.In this riveting narrative, Maryn McKenna -- the only journalist ever given full access to the EIS in its fifty-three-year history -- follows the first class of disease detectives to come to the CDC after September 11, the first to confront not just naturally occurring outbreaks but the man-made threat of bioterrorism. They are talented researchers -- many with young families -- who trade two years of low pay and extremely long hours for the chance to be part of the group that has helped eradicate smallpox, push back polio, and solve the first major outbreaks of Legionnaires' disease, toxic shock syndrome, and "E. coli" O157.Urgent, exhilarating, and compelling, "Beating Back the Devil" goes with the EIS as they try to stop epidemics -- before the epidemics stop us.

    While she loves the odd little town, there is one thing she didn’t anticipate: just how heartbreaking it would be leaving her friends behind. And when you’re a childless thirtysomething freelance writer who works at home, making new friends can be quite a challenge.After a series of false starts nearly gets her exiled from town, Maye decides that her last chance to connect with her new neighbors is to enter the annual Sewer Pipe Queen Pageant, a kooky but dead-serious local tradition open to contestants of all ages and genders. Aided by a deranged former pageant queen with one eyebrow, Maye doesn’t just make a splash, she uncovers a sinister mystery that has haunted the town for decades.“[Laurie Notaro] may be the funniest writer in this solar system.”–The Miami Herald

    . . Will stand by itself as one of our funniest, most telling anatomies of human love and vulnerability.” —The New York Times Book Review, cover).These eight masterly stories reveal Lorrie Moore at her most mature and in a perfect configuration of craft, mind, and bewitched spirit, as she explores the passage of time and summons up its inevitable sorrows and hilarious pitfalls to reveal her own exquisite, singular wisdom.In “Debarking,” a newly divorced man tries to keep his wits about him as the United States prepares to invade Iraq, and against this ominous moment, we see—in all its irresistible wit and darkness—the perils of divorce and what can follow in its wake . . .In “Foes,” a political argument goes grotesquely awry as the events of 9/11 unexpectedly manifest themselves at a fund-raising dinner in Georgetown . . . In “The Juniper Tree,” a teacher visited by the ghost of her recently deceased friend is forced to sing “The Star-Spangled Banner” in a kind of nightmare reunion . . . And in “Wings,” we watch the inevitable unraveling of two once-hopeful musicians, neither of whom held fast to their dreams nor struck out along other paths, as Moore deftly depicts the intricacies of dead-ends-ville and the workings of regret . . .Here are people beset, burdened, buoyed; protected by raising teenage children; dating after divorce; facing the serious illness of a longtime friend; setting forth on a romantic assignation abroad, having it interrupted mid-trip, and coming to understand the larger ramifications and the impossibility of the connection . . . stories that show people coping with large dislocation in their lives, with risking a new path to answer the desire to be in relation—to someone . . .Gimlet-eyed social observation, the public and private absurdities of American life, dramatic irony, and enduring half-cracked love wend their way through each of these narratives in a heartrending mash-up of the tragic and the laugh-out-loud—the hallmark of life in Lorrie-Moore-land.--jacket

    As Professor of Anatomy and Forensic Anthropology, she focuses on mortal remains in her lab, at burial sites, at scenes of violence, murder and criminal dismemberment, and when investigating mass fatalities due to war, accident or natural disaster. In All that Remains she reveals the many faces of death she has come to know, using key cases to explore how forensic science has developed, and what her work has taught her. Do we expect a book about death to be sad? Macabre? Sue’s book is neither. There is tragedy, but there is also humour in stories as gripping as the best crime novel. Our own death will remain a great unknown. But as an expert witness from the final frontier, Sue Black is the wisest, most reassuring, most compelling of guides.

    The novel intricately weaves together three timelines: the story of Greyson’s travels (Rome, Israel, Santiago, Thailand, Uganda); the progressive unraveling of his own father seen through Greyson’s childhood eyes; and the intricacies and estrangements of his marriage. The entire narrative unfolds in the time it takes him undergo twelve 30-second electroshock treatments in a New York psychiatric ward.