Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    Making remarkable connections across brain function, myth, and anthropology, Dr. Shlain shows why pre-literate cultures were principally informed by holistic, right-brain modes that venerated the Goddess, images, and feminine values. Writing drove cultures toward linear left-brain thinking and this shift upset the balance between men and women, initiating the decline of the feminine and ushering in patriarchal rule. Examining the cultures of the Israelites, Greeks, Christians, and Muslims, Shlain reinterprets ancient myths and parables in light of his theory. Provocative and inspiring, this book is a paradigm-shattering work that will transform your view of history and the mind.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    The late-night passing of a beloved aunt summons a childhood bully who shows up minutes later, after twenty-five years, to be forgiven and to heal a broken doctor. This ER doctor finds God's opposite in: a battered child's bruises covered over by make-up, a dying patient whose son finally shows up at the end to reclaim the man's high-top sneakers, the rich or celebrity patients loaded with prescription drugs from doctor friends who end up addicted. But, his real outrage is directed at our cavalier treatment of the elderly, If you put a G-tube in your 80-year-old mother with Alzheimer's because she's no longer eating, you will probably have a fast track to hell.

    Applying the same objective criteria to legal and illegal substances, an argument is made that legality is not a clear measure for harm. Tackling a variety of questions, such as Which is more harmful—Ecstasy or alcohol? Can addiction be cured? and Does the "War on Drugs" have serious unintended effects that can hurt children?, this analysis equips readers with the ability to make educated decisions regarding drugs both personally and in their communities. Broadening the scope of the discussion, a framework is explored for formulating national drug policies that will minimize a myriad of harms—social, medical, criminal, financial, and environmental.

    They always keep a bag packed. They seldom have more than twenty-four hours' notice before they are dispatched. The phone calls that tell them to head to the airport, sometimes in the middle of the night, may give them no more information than the country they are traveling to and the epidemic they will tackle when they get there.The universal human instinct is to run from an outbreak of disease. These doctors run toward it.They are the disease detective corps of the U.S. Centers for Disease Control and Prevention (CDC), the federal agency that tracks and tries to prevent disease outbreaks and bioterrorist attacks around the world. They are formally called the Epidemic Intelligence Service (EIS) -- a group founded more than fifty years ago out of fear that the Korean War might bring the use of biological weapons -- and, like intelligence operatives in the traditional sense, they perform their work largely in anonymity. They are not household names, but over the years they were first to confront the outbreaks that became known as hantavirus, Ebola virus, and AIDS. Now they hunt down the deadly threats that dominate our headlines: West Nile virus, anthrax, and SARS.In this riveting narrative, Maryn McKenna -- the only journalist ever given full access to the EIS in its fifty-three-year history -- follows the first class of disease detectives to come to the CDC after September 11, the first to confront not just naturally occurring outbreaks but the man-made threat of bioterrorism. They are talented researchers -- many with young families -- who trade two years of low pay and extremely long hours for the chance to be part of the group that has helped eradicate smallpox, push back polio, and solve the first major outbreaks of Legionnaires' disease, toxic shock syndrome, and "E. coli" O157.Urgent, exhilarating, and compelling, "Beating Back the Devil" goes with the EIS as they try to stop epidemics -- before the epidemics stop us.

    Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

    There is no cure. In a few days 90 percent of its victims are dead. A secret military SWAT team of soldiers and scientists is mobilized to stop the outbreak of this exotic "hot" virus. The Hot Zone tells this dramatic story, giving a hair-raising account of the appearance of rare and lethal viruses and their "crashes" into the human race. Shocking, frightening, and impossible to ignore, The Hot Zone proves that truth really is scarier than fiction.

    Etcoff, a faculty member at Harvard Medical School and a practicing psychologist at Massachusetts General Hospital, skewers the enduring myth that the pursuit of beauty is a learned behavior.Etcoff puts forth that beauty is neither a cultural construction, an invention of the fashion industry, nor a backlash against feminism, but instead is in our biology. It's an essential and ineradicable part of human nature that is revered and ferociously pursued in nearly every civilizatoin--and for good reason. Those features to which we are most attracted are often signals of fertility and fecundity. When seen in the context of a Darwinian struggle for survival, our sometimes extreme attempts to attain beauty--both to become beautiful ourselves and to acquire an attractive partner--become understandable. Moreover, if we come to understand how the desire for beauty is innate, then we can begin to work in our interests, and not soley for the interests of our genetic tendencies.

    Fifty years after the sexual revolution, we are told that we live in a time of unprecedented sexual freedom; that if anything, we are too free now. But beneath the veneer of glossy hedonism, millennial journalist Rachel Hills argues that we are controlled by a new brand of sexual convention: one which influences all of us—woman or man, straight or gay, liberal or conservative. At the root of this silent code lies The Sex Myth—the defining significance we invest in sexuality that once meant we were dirty if we did have sex, and now means we are defective if we don’t do it enough. Equal parts social commentary, pop culture, and powerful personal anecdotes from people across the English-speaking world, The Sex Myth exposes the invisible norms and unspoken assumptions that shape the way we think about sex today.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    With wisdom, humor, and scientific aplomb, medical students and sex educators Nina Brochmann and Ellen Støkken Dahl take readers on a fascinating journey of female sexual organs and sexual health--from the clitoris to contraception to cervical cancer.More than a user's manual, this book is demystification, and tribute to the vagina that we have been waiting for. The Wonder Down Under is filled with astonishing, important, and little-known information--relayed with both medical expertise and genuine empathy. Did you know, for instance, that female and male sex organs are merely variations on the same basic structure? Or that there's no such thing as a virginity test--because a broken hymen is not a meaningful indicator of whether or not someone's had sex?Brochmann and Dahl have written a tour-de-force about the biology, anatomy, and reality of the female body, stopping along the way to explain how misinformation and silence about the vagina have been harmful to women over time. The Wonder Down Under makes crucial contributions to the discussion: the book was an instant bestseller that sold out in its native Norway in just three days. Since then it has been acquired by publishers in more than two dozen countries around the world.The Wonder Down Under is a joyful and indispensable book that will educate readers of all kinds and equip a new generation to make informed choices about their sexual health and happiness.

    I'm going to do this in a similar way I've done it for sex and relationships in my work over the last couple decades for young people and adults alike: by talking out loud, shamelessly and frankly, about what others are afraid or ashamed to, much in the way your favorite loudmouth aunt might have if she made this kind of stuff her life's work and if your family also didn't always apparently forget to invite her to everything."Corinna has been on the cutting edge of health for more than twenty years, always talking about what people are most afraid, ashamed, or embarrassed of. What Fresh Hell Is This? is no different. It's a companion for everyone who's reached this "what to expect when you're not expected to expect anything" time of life. It's a health-forward, feminist, no b.s. (and damn funny) perimenopause guide for the generation that time forgot (aka GenXers), offering straightforward descriptions of our bodies, minds, lives and what's going on with them during this time of hormonal chaos. Heather Corinna tells you what to expect and what to do, all while busting some myths and offering real self-care tips so you can get through this. With practical, clear information that also includes affected populations who have long been left out of the discussion, like those with disabilities, queer, transgender, nonbinary and other gender-diverse people, the working class and other marginalized folks, What Fresh Hell Is This? an accessible and inclusive guide for anyone who is experiencing the hot fire of perimenopause.

    You can't be a woman or girl (or, increasingly, a man or boy) in America today and not grapple with the size and shape of your body, your daughter's body, other women's bodies. Even the most confident people have to find a way through a daily gauntlet of voices and images talking, admonishing, warning us about what size we should be, how much we should weigh, what we should eat and what we shouldn't. Obsessing about weight has become a ritual and a refrain, punctuating our every relationship, including the ones with ourselves. It's time to change the conversation around weight. Harriet Brown has explored the conundrums of weight and body image for more than a decade, as a science journalist, as a woman who has struggled with weight, as a mother, wife, and professor. In this book, she describes how biology, psychology, metabolism, media, and culture come together to shape our ongoing obsession with our bodies, and what we can learn from them to help us shift the way we think. Brown exposes some of the myths behind the rhetoric of obesity, gives historical and contemporary context for what it means to be "fat," and offers readers ways to set aside the hysteria and think about weight and health in more nuanced and accurate ways.

    In Wicked Plants, Stewart takes on over two hundred of Mother Nature’s most appalling creations. It’s an A to Z of plants that kill, maim, intoxicate, and otherwise offend. You’ll learn which plants to avoid (like exploding shrubs), which plants make themselves exceedingly unwelcome (like the vine that ate the South), and which ones have been killing for centuries (like the weed that killed Abraham Lincoln's mother). Menacing botanical illustrations and splendidly ghastly drawings create a fascinating portrait of the evildoers that may be lurking in your own backyard. Drawing on history, medicine, science, and legend, this compendium of bloodcurdling botany will entertain, alarm, and enlighten even the most intrepid gardeners and nature lovers.