That her mother died of the disease, that her own chance of inheriting it was fifty-fifty, that her sister and father directed much of the extraordinary biomedical research to find the gene and a cure, make Wexler's story both astonishingly intimate and scientifically compelling.Alice Wexler's graceful and eloquent account goes beyond the specifics of Huntington's disease to explore the dynamics of family secrets, of living at risk, and the drama and limits of biomedical research. Mapping Fate will be a touchstone for anyone with questions about genetic illness and the possibilities and perils of genetic testing.

    Soon it was gone, only to be succeeded by another. And another. Strange, Karinthy thought, it had been years since Budapest had streetcars. Only then did he realize he was suffering from an auditory hallucination of extraordinary intensity. What in fact Karinthy was suffering from was a brain tumor, not cancerous but hardly benign, though it was only much later—after spells of giddiness, fainting fits, friends remarking that his handwriting had altered, and books going blank before his eyes—that he consulted a doctor and embarked on a series of examinations that would lead to brain surgery. Karinthy’s description of his descent into illness and his observations of his symptoms, thoughts, and feelings, as well as of his friends’ and doctors’ varied responses to his predicament, are exact and engrossing and entirely free of self-pity. A Journey Round My Skull is not only an extraordinary piece of medical testimony, but a powerful work of literature—one that dances brilliantly on the edge of extinction.

    Fans around the world are drawn to Her Grace’s voice, her wit, her life-affirming love for all humanity, and the fun and friendship of the community that’s sprung up around her.

    After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find  an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write an exploration of family, history, and love.

    Eilene Zimmerman noticed that her ex-husband looked thin, seemed distracted, and was frequently absent from activities with their children. She thought he looked sick and needed to see a doctor, and indeed, he told her he had been diagnosed with an autoimmune disorder. Yet in many ways, Peter also seemed to have it all: a beautiful house by the beach purchased after their divorce, expensive cars, and other luxuries that came with an affluent life. Eilene assumed his odd behavior was due to stress and overwork--he was a senior partner at a prominent law firm and had been working more than 60 hours a week for the last 20 years.Although they were divorced, Eilene and Peter had been partners and friends for decades, so, when her calls to Peter were not returned for several days, Eilene went to his house to see if he was OK.So begins Smacked, a brilliant, moving memoir of Eilene's shocking discovery, one that sets her on a journey to find out how a man she knew for nearly 30 years became a drug addict, and hid it so well that neither she nor anyone else in his life suspected what was happening. Eilene discovers that Peter led a secret life, one that started with pills and ended with opioids, cocaine and methamphetamine. Peter was also addicted to work; the last call he ever made was to dial into a conference call.Eilene is determined to learn all she can about Peter's hidden life, and also about drug addiction among ambitious and high achieving professionals like him. Through extensive research and interviews, she presents a picture of drug dependence today in that moneyed, upwardly mobile world. She also embarks on a journey to recreate her life in the wake of loss, both of the person--and the relationship--that profoundly defined the woman she had become.Smacked takes readers on an intimate journey into a little-known part of the drug epidemic, through the story of one man, one woman and one family.

    Eva Hoffman spent her early years in Cracow, among family friends who, like her parents, had escaped the Holocaust and were skeptical of the newly imposed Communist state. Hoffman's parents managed to immigrate to Canada in the 1950s, where Eva was old enough to feel like a stranger--bland food, a quieter life, and schoolmates who hardly knew where Poland was. Still, there were neighbors who knew something of Old World ways, and a piano teacher who was classically Middle European in his neurotic enthusiasm for music. Her true exile came in college in Texas, where she found herself among people who were frightened by and hostile to her foreignness. Later, at Harvard, Hoffman found herself initially alienated by her burgeoning intellectualism; her parents found it difficult to comprehend. Her sense of perpetual otherness was extended by encounters with childhood friends who had escaped Cracow to grow up in Israel, rather than Canada or the United States, and were preoccupied with soldiers, not scholars. Lost in Translation is a moving memoir that takes the specific experience of the exile and humanizes it to such a degree that it becomes relevant to the lives of a wider group of readers.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    an instant classic of the genre." --Dwight Garner, New York Times - A New York Times Critics' Top Book of 2021 - A New York Times Book Review Editors' Choice - Named a Best Nonfiction Book of 2021 by Kirkus MIT psychologist and bestselling author of Reclaiming Conversation and Alone Together, Sherry Turkle's intimate memoir of love and workFor decades, Sherry Turkle has shown how we remake ourselves in the mirror of our machines. Here, she illuminates our present search for authentic connection in a time of uncharted challenges. Turkle has spent a career composing an intimate ethnography of our digital world; now, marked by insight, humility, and compassion, we have her own.In this vivid and poignant narrative, Turkle ties together her coming-of-age and her pathbreaking research on technology, empathy, and ethics. Growing up in postwar Brooklyn, Turkle searched for clues to her identity in a house filled with mysteries. She mastered the codes that governed her mother's secretive life. She learned never to ask about her absent scientist father--and never to use his name, her name. Before empathy became a way to find connection, it was her strategy for survival.Turkle's intellect and curiosity brought her to worlds on the threshold of change. She learned friendship at a Harvard-Radcliffe on the cusp of coeducation during the antiwar movement, she mourned the loss of her mother in Paris as students returned from the 1968 barricades, and she followed her ambition while fighting for her place as a woman and a humanist at MIT. There, Turkle found turbulent love and chronicled the wonders of the new computer culture, even as she warned of its threat to our most essential human connections. The Empathy Diaries captures all this in rich detail--and offers a master class in finding meaning through a life's work.

    She finds that you cannot immunize your child, or yourself, from the world.In this bold, fascinating book, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. As she hears more and more fears about vaccines, Biss researches what they mean for her own child, her immediate community, America, and the world, both historically and in the present moment. She extends a conversation with other mothers to meditations on Voltaire's Candide, Bram Stoker's Dracula, Rachel Carson's Silent Spring, Susan Sontag's AIDS and Its Metaphors, and beyond.On Immunity is a moving account of how we are all interconnected-our bodies and our fates.

    Mona Hanna-Attisha, alongside a team of researchers, parents, friends, and community leaders, discovered that the children of Flint, Michigan, were being exposed to lead in their tap water--and then battled her own government and a brutal backlash to expose that truth to the world. At the center of the story is Dr. Mona herself--an immigrant, doctor, scientist, and mother whose family's activist roots inspired her pursuit of justice.What the Eyes Don't See is a riveting account of a shameful disaster that became a tale of hope, the story of a city on the ropes that came together to fight for justice, self-determination, and the right to build a better world for their--and all of our--children.

    She faced terrifying hallucinations, paralysis and excruciating sleepiness aspects of dream sleep taking place while wide awake.Yet, narcolepsy was a wake-up call for Julie. Her illness propelled her onto a journey she never imagined from lying paralyzed on her apartment floor to dancing euphorically at a nightclub; from the classrooms of Harvard Medical School to the start line of the Boston Marathon.Wide Awake and Dreaming is a revealing first-hand account of dreams gone wrong with narcolepsy. It s the brave story of one woman trampling over barriers and finding light in the darkest of circumstances.

    Plagued with fear that her friends and family will be taken from her if she's not watching--that her mother will die, or forget she has children and just move away--Stern treats every parting as her last. Shuttled between a barefoot bohemian life with her mother in Greenwich Village, and a sanitized, stricter world of affluence uptown with her father, Stern has little she can depend on. And when Etan Patz disappears down the block from their MacDougal Street home, she can't help but believe that all her worst fears are about to come true. Tenderly delivered and expertly structured, Stern's memoir is a document of the transformation of New York City and a deep, personal, and comedic account of the trials and errors of seeing life through a very unusual lens.

    Her husband having died of heart disease, Martha Weinman Lear articulates her feelings toward the medical treatment, her personal strengths and weaknesses, and how she survived her own fears.

    She is one of the hardest-working actresses of any era, and her sense of humor and perennial optimism have seen her through half a century of industry changes and delighted millions of fans.Now, during Betty's sixty-first year on screen, a year in which she has enjoyed a huge resurgence of popularity, her 1995 memoir makes a comeback too. Here We Go Again is a behind-the-scenes look at Betty's career from her start on radio to her first show, Hollywood on Television, to several iterations of The Betty White Show and much, much more. Packed with wonderful anecdotes about famous personalities and friendships, stories of Betty's off-screen life, and the comedienne's trademark humor, this deliciously entertaining book will give readers an entrée into Betty's fascinating life, confirming yet again why we can't get enough of this funny lady.

    After seven brutally unhappy years as a nun, she left her order to pursue English literature at Oxford. But convent life had profoundly altered her, and coping with the outside world and her expiring faith proved to be excruciating. Her deep solitude and a terrifying illness–diagnosed only years later as epilepsy–marked her forever as an outsider. In her own mind she was a complete failure: as a nun, as an academic, and as a normal woman capable of intimacy. Her future seemed very much in question until she stumbled into comparative theology. What she found, in learning, thinking, and writing about other religions, was the ecstasy and transcendence she had never felt as a nun. Gripping, revelatory, and inspirational, The Spiral Staircase is an extraordinary account of an astonishing spiritual journey.