To its adherents, it is an elegant statement about learning from experience. To its opponents, it is subjectivity run amok.In the first-ever account of Bayes' rule for general readers, Sharon Bertsch McGrayne explores this controversial theorem and the human obsessions surrounding it. She traces its discovery by an amateur mathematician in the 1740s through its development into roughly its modern form by French scientist Pierre Simon Laplace. She reveals why respected statisticians rendered it professionally taboo for 150 years—at the same time that practitioners relied on it to solve crises involving great uncertainty and scanty information (Alan Turing's role in breaking Germany's Enigma code during World War II), and explains how the advent of off-the-shelf computer technology in the 1980s proved to be a game-changer. Today, Bayes' rule is used everywhere from DNA de-coding to Homeland Security.Drawing on primary source material and interviews with statisticians and other scientists, The Theory That Would Not Die is the riveting account of how a seemingly simple theorem ignited one of the greatest controversies of all time.

    But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.Cullen's murderous career in the world's most trusted profession spanned sixteen years and nine hospitals across New Jersey and Pennsylvania. When, in March of 2006, Charles Cullen was marched from his final sentencing in an Allentown, Pennsylvania, courthouse into a waiting police van, it seemed certain that the chilling secrets of his life, career, and capture would disappear with him. Now, in a riveting piece of investigative journalism nearly ten years in the making, journalist Charles Graeber presents the whole story for the first time. Based on hundreds of pages of previously unseen police records, interviews, wire-tap recordings and videotapes, as well as exclusive jailhouse conversations with Cullen himself and the confidential informant who helped bring him down, THE GOOD NURSE weaves an urgent, terrifying tale of murder, friendship, and betrayal.Graeber's portrait of Cullen depicts a surprisingly intelligent and complicated young man whose promising career was overwhelmed by his compulsion to kill, and whose shy demeanor masked a twisted interior life hidden even to his family and friends. Were it not for the hardboiled, unrelenting work of two former Newark homicide detectives racing to put together the pieces of Cullen's professional past, and a fellow nurse willing to put everything at risk, including her job and the safety of her children, there's no telling how many more lives could have been lost.In the tradition of In Cold Blood, THE GOOD NURSE does more than chronicle Cullen's deadly career and the breathless efforts to stop him; it paints an incredibly vivid portrait of madness and offers a penetrating look inside America's medical system. Harrowing and irresistibly paced, this book will make you look at medicine, hospitals, and the people who work in them, in an entirely different way.

    And before there were fish in the sea, there were cephalopods - the ancestors of modern squid and Earth’s first truly substantial animals. Cephalopods became the first creatures to rise from the seafloor, essentially inventing the act of swimming. With dozens of tentacles and formidable shells, they presided over an undersea empire for millions of years. But when fish evolved jaws, the ocean’s former top predator became its most delicious snack. Cephalopods had to step up their game. Many species streamlined their shells and added defensive spines, but these enhancements only provided a brief advantage. Some cephalopods then abandoned the shell entirely, which opened the gates to a flood of evolutionary innovations: masterful camouflage, fin-supplemented jet propulsion, perhaps even dolphin-like intelligence. Squid Empire is an epic adventure spanning hundreds of millions of years, from the marine life of the primordial ocean to the calamari on tonight’s menu. Anyone who enjoys the undersea world—along with all those obsessed with things prehistoric—will be interested in the sometimes enormous, often bizarre creatures that ruled the seas long before the first dinosaurs.

    Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door.So what, exactly, is your immune system?Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body.Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defenses, how viruses work, and what goes on in your wounds when you cut yourself.Enlivened by engaging graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

    In this gripping account, David Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge and asks the terrifying question: What might the next big one be?

    In The Anatomy of Violence, Raine dissects the criminal mind with a fascinating, readable, and far-reaching scientific journey into the body of evidence that reveals the brain to be a key culprit in crime causation.  Raine documents from genetic research that the seeds of sin are sown early in life, giving rise to abnormal physiological functioning that cultivates crime. Drawing on classical case studies of well-known killers in history—including Richard Speck, Ted Kaczynski, and Henry Lee Lucas—Raine illustrates how impairments to brain areas controlling our ability to experience fear, make good decisions, and feel guilt predispose us to violence. He contends that killers can actually be coldhearted: something as simple as a low resting heart rate can give rise to violence. But arguing that biology is not destiny, he also sketches out provocative new biosocial treatment approaches that can change the brain and prevent violence.  Finally, Raine tackles the thorny legal and ethical dilemmas posed by his research, visualizing a futuristic brave new world where our increasing ability to identify violent offenders early in life might shape crime-prevention policies, for good and bad. Will we sacrifice our notions of privacy and civil rights to identify children as potential killers in the hopes of helping both offenders and victims? How should we punish individuals with little to no control over their violent behavior? And should parenting require a license? The Anatomy of Violence offers a revolutionary appraisal of our understanding of criminal offending, while also raising provocative questions that challenge our core human values of free will, responsibility, and punishment.From the Hardcover edition.

    Just about everyone has at least heard of Albert Einstein's formulation of 1905, which came into the world as something of an afterthought. But far fewer can explain his insightful linkage of energy to mass. David Bodanis offers an easily grasped gloss on the equation. Mass, he writes, "is simply the ultimate type of condensed or concentrated energy," whereas energy "is what billows out as an alternate form of mass under the right circumstances." Just what those circumstances are occupies much of Bodanis's book, which pays homage to Einstein and, just as important, to predecessors such as Maxwell, Faraday, and Lavoisier, who are not as well known as Einstein today. Balancing writerly energy and scholarly weight, Bodanis offers a primer in modern physics and cosmology, explaining that the universe today is an expression of mass that will, in some vastly distant future, one day slide back to the energy side of the equation, replacing the "dominion of matter" with "a great stillness"--a vision that is at once lovely and profoundly frightening. Without sliding into easy psychobiography, Bodanis explores other circumstances as well; namely, Einstein's background and character, which combined with a sterling intelligence to afford him an idiosyncratic view of the way things work--a view that would change the world. --Gregory McNamee

    Even before he won the Nobel Prize in 1965, his unorthodox and spellbinding lectures on physics secured his reputation amongst students and seekers around the world. It was his outsized love for life, however, that earned him the status of an American cultural icon - here was an extraordinary intellect devoted to the proposition that the thrill of discovery was matched only by the joy of communicating it to others." In this career-spanning collection of letters, many published here for the first time, we are able to see this side of Feynman like never before. Perfectly Reasonable Deviations from the Beaten Track covers a dazzling array of topics and themes, scientific developments and personal histories. With missives to and from scientific luminaries, as well as letters to and from fans, family, students, crackpots, as well as everyday people eager for Feynman's wisdom and counsel, the result is a de facto guide to life, and eloquent testimony to the human quest for knowledge at all levels.Published in the UK as Don't You Have Time to Think?

    The Survivors Club: The Secrets and Science that Could Save Your Life

    There are deep connections between stars and atoms, between the cosmos and the microworld. Just six numbers, imprinted in the "big bang," determine the essential features of our entire physical world. Moreover, cosmic evolution is astonishingly sensitive to the values of these numbers. If any one of them were "untuned," there could be no stars and no life. This realization offers a radically new perspective on our universe, our place in it, and the nature of physical laws.

    Here is a delightfully entertaining and enlightening look at the unique sex lives of humans.

    According to this false-yet-familiar story, the divisions between men and women are in nature alone and not part of culture. Drawing on evolutionary science, psychology, neuroscience, endocrinology, and philosophy, Testosterone Rex disproves this ingrained myth and calls for a more equal society based on both sexes’ full human potential.

    With an exhaustive knowledge of popular culture and an almost effortless ability to spin brilliant prose out of unlikely subject matter, Klosterman attacks the entire spectrum of postmodern America: reality TV, Internet porn, Pamela Anderson, literary Jesus freaks, and the real difference between apples and oranges (of which there is none). And don't even get him started on his love life and the whole Harry-Met-Sally situation. Whether deconstructing Saved by the Bell episodes or the artistic legacy of Billy Joel, the symbolic importance of The Empire Strikes Back or the Celtics/Lakers rivalry, Chuck will make you think, he'll make you laugh, and he'll drive you insane -- usually all at once. Sex, Drugs, and Cocoa Puffs is ostensibly about art, entertainment, infotainment, sports, politics, and kittens, but -- really -- it's about us. All of us. As Klosterman realizes late at night, in the moment before he falls asleep, "In and of itself, nothing really matters. What matters is that nothing is ever 'in and of itself.'" Read to believe.

    The fantastic journey began in 1977, before the first episode of Cosmos aired. The mission was planned as a grand tour beyond the moon; beyond Mars, Jupiter, and Saturn; and maybe even into interstellar space. The fact that it actually happened makes this humanity's greatest space mission.In The Interstellar Age, award-winning planetary scientist Jim Bell reveals what drove and continues to drive the members of this extraordinary team, including Ed Stone, Voyager's chief scientist and the one-time head of NASA's Jet Propulsion Lab; Charley Kohlhase, an orbital dynamics engineer who helped to design many of the critical slingshot maneuvers around planets that enabled the Voyagers to travel so far; and the geologist whose Earth-bound experience would prove of little help in interpreting the strange new landscapes revealed in the Voyagers' astoundingly clear images of moons and planets.Speeding through space at a mind-bending eleven miles a second, Voyager 1 is now beyond our solar system's planets. It carries with it artifacts of human civilization. By the time Voyager passes its first star in about 40,000 years, the gold record on the spacecraft, containing various music and images including Chuck Berry's "Johnny B. Goode," will still be playable.

    These megastorms will likely become more intense as the planet continues to warm, yet we too often treat them as local disasters and TV spectacles, unaware of how far-ranging their impact can be. As best-selling historian Eric Jay Dolin contends, we must look to our nation’s past if we hope to comprehend the consequences of the hurricanes of the future.With A Furious Sky, Dolin has created a vivid, sprawling account of our encounters with hurricanes, from the nameless storms that threatened Columbus’s New World voyages to the destruction wrought in Puerto Rico by Hurricane Maria. Weaving a story of shipwrecks and devastated cities, of heroism and folly, Dolin introduces a rich cast of unlikely heroes, such as Benito Vines, a nineteenth-century Jesuit priest whose innovative methods for predicting hurricanes saved countless lives, and puts us in the middle of the most devastating storms of the past, none worse than the Galveston Hurricane of 1900, which killed at least 6,000 people, the highest toll of any natural disaster in American history.Dolin draws on a vast array of sources as he melds American history, as it is usually told, with the history of hurricanes, showing how these tempests frequently helped determine the nation’s course. Hurricanes, it turns out, prevented Spain from expanding its holdings in North America beyond Florida in the late 1500s, and they also played a key role in shifting the tide of the American Revolution against the British in the final stages of the conflict. As he moves through the centuries, following the rise of the United States despite the chaos caused by hurricanes, Dolin traces the corresponding development of hurricane science, from important discoveries made by Benjamin Franklin to the breakthroughs spurred by the necessities of the World War II and the Cold War.Yet after centuries of study and despite remarkable leaps in scientific knowledge and technological prowess, there are still limits on our ability to predict exactly when and where hurricanes will strike, and we remain terribly vulnerable to the greatest storms on earth. A Furious Sky is, ultimately, a story of a changing climate, and it forces us to reckon with the reality that as bad as the past has been, the future will probably be worse, unless we drastically reimagine our relationship with the planet.103 black-and-white illustrations; 8 pages of color illustrations