Turn to any page, and you'll find essential point-of-care guidance on all the major conditions seen in clinical medicine. Completely updated to reflect all the major advances and new clinical developments, the new edition of the Manual is the most indispensable yet. It continues to focus on diagnosis and therapy with an emphasis on patient care and offers authoritative, high-yield coverage of: Etiology and epidemiology Clinically relevant pathophysiology Signs & Symptoms o Differential Diagnosis Physical and Laboratory Findings Therapeutics o Practice GuidelinesNEW FEATURESFull-color presentation for the first time!Full-color images of clinical conditions encountered in dermatology, cardiology, and eye diseases New chapters on end-of-life care, congenital heart disease in the adult patient, non-invasive cardiac examination, and metabolic syndromeLook for these other great Harrison's titles:Harrison's Principles of Internal Medicine, 17eHarrison's Online available through Accessmedicine.com

    He was dubbed "the Iceman," and his discovery—along with the realization that he was actually 5,000 years old—set off a whirlwind of political, scientific, and media activity that made him an overnight sensation. In this remarkable and dramatic book, Brenda Fowler takes readers through the bizarre odyssey that began in the Stone Age and continued for years after the Iceman was unearthed.

    Rochman takes an authoritative look at the latest hot-button issues in the world of pre- and postnatal testing and tells the stories of women and men struggling to understand the variety of tests and grappling with their results—revelations that are sometimes joyous, sometimes heartbreaking, and often profound.Propelled by human narratives and meticulously reported, The Gene Machine introduces us to scientists working to unlock the secrets of the human genome; gene counselors and spiritual advisers helping parents manage this complex new reality; and, of course, parents themselves, including the author, who glimpse the genetic futures of their children. The Gene Machine is both a scientific road map and a meditation on our power to shape the future, one that gets to the very core of what it means to be human.

    The text covers the neuroanatomy that medical and other healthcare students need, with expanded coverage of neurophysiology and inclusion of clinical content providing real-life application of neuroanatomy and neurophysiologic concepts to clinical neurologic disorders. Its readability and enhanced full-color illustrations make it a favorite among both students and faculty.Provides a single-author approach for a more consistent, readable text.Contains summary statement headings to help you find what you're looking for within the text.Provides an outline introducing each chapter to help students organize and stay focused as they learn.Includes appealing four-color, computerized three-dimensional images of the brain and brain structures fully integrated with the text.Complements an Electronic Image Bank that is also available separately.Includes more coverage of neurobiology and neurophysiology.Gives more clinical content, including many images depicting neurologic disorders.Features an expanded section on higher cortical function.Features an expanded section on learning and memory.Contains a new chapter on the development, maintenance, and repair of neural connections-an explosive area of research in neuroscience.Supplies a glossary of key terms.Replaces many of the older figures with new, computer-generated illustrations.

    Access full-color pathology photos and illustrations, health history, examination steps for each body system, normal versus abnormal findings, lifespan and cross-cultural considerations, related nursing diagnoses, and summary checklists anytime you need them with this convenient clinical tool.Convenient, color-coded design helps you easily locate the information you need.More than 160 full-color illustrations clearly demonstrate important anatomy and physiology concepts, examination steps, and normal and abnormal findings.Age-specific developmental competencies highlight important considerations for pediatric, pregnant, and aging patients.Cultural competency icons alert you to relevant cultural distinctions you may encounter in the clinical setting.Abnormal findings tables provide fast access to key information on many frequently encountered conditions.Spanish-language translation chart helps you ensure accurate, effective examinations of Spanish-speaking patients.Bedside Assessment of the Hospitalized Patient chapter outlines the pertinent assessment steps specific to this patient population.New abnormal findings photos help you recognize and distinguish between abnormal conditions.Additional new full-color examination technique photos clarify exam steps for eyes, nose, mouth, throat, thorax, heart, neck, peripheral vascular, and pediatric exams. Updated evidence-based practice guidelines throughout the guide reflect the most current research and assessment practices.

    The first abnormal psychology book to present a thoroughly integrated multicultural perspective--based on the authors' view that cross-cultural comparisons can greatly enhance the understanding of disorders--the text provides extensive coverage and integration of multicultural models, explanations, and concepts. The book also helps you gain an understanding of abnormal behavior as scientific and clinical endeavors, while providing insight into the tools that mental health professionals use to study and treat disorders.

    The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published.This commemorative edition, honoring the memory of the author who died in 2011, contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin. It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA.

    It explores the critical concepts while also examining why they are relevant. The core content is presented within the framework of predicting products, proposing mechanisms, and solving synthesis problems. Readers will fine-tune the key skills involved in solving those types of problems with the help of interactive, step-by-step instructions and problems.

    In Europe: A Natural History, world-renowned scientist, explorer, and conservationist Tim Flannery applies the eloquent interdisciplinary approach he used in his ecological histories of Australia and North America to the story of Europe. He begins 100 million years ago, when the continents of Asia, North America, and Africa interacted to create an island archipelago that would later become the Europe we know today. It was on these ancient tropical lands that the first distinctly European organisms evolved. Flannery teaches us about Europe's midwife toad, which has endured since the continent's beginning, while elephants, crocodiles, and giant sharks have come and gone. He explores the monumental changes wrought by the devastating comet strike and shows how rapid atmospheric shifts transformed the European archipelago into a single landmass during the Eocene.As the story moves through millions of years of evolutionary history, Flannery eventually turns to our own species, describing the immense impact humans had on the continent's flora and fauna--within 30,000 years of our arrival in Europe, the woolly rhino, the cave bear, and the giant elk, among others, would disappear completely. The story continues right up to the present, as Flannery describes Europe's leading role in wildlife restoration, and then looks ahead to ponder the continent's future: with advancements in gene editing technology, European scientists are working to recreate some of the continent's lost creatures, such as the great ox of Europe's primeval forests and even the woolly mammoth.Written with Flannery's characteristic combination of elegant prose and scientific expertise, Europe: A Natural History narrates the dramatic natural history and dynamic evolution of one of the most influential places on Earth.

    Weschler thoroughly explains the empowering Fertility Awareness Method, which in only a couple minutes a day allows a woman to:-Enjoy highly effective, scientifically proven birth control without chemicals or devices-Maximize her chances of conception or expedite fertility treatment by identifying impediments to conception-Increase the likelihood of choosing the gender of her baby-Gain control of her sexual and gynecological health

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    In this highly actionable guide, he shares the food, mindset, exercise, and sleep strategies that have had the biggest positive impact on his diabetes – and hopefully yours too! Bright Spots & Landmines is filled with hundreds of effective diabetes tips, questions, and shortcuts, including what to eat to minimize blood sugar swings; helpful strategies to feel less stressed, guilty, and burned out; and simple ways to improve exercise and sleep. Along the way, Adam argues that the usual focus on problems and mistakes in diabetes (Landmines) misses the bigger opportunity: Bright Spots. By identifying what’s working and finding ways to do those things more often, we can all live healthier, happier, and more hopeful lives. Whether you are newly diagnosed or have had type 1 or type 2 diabetes for over 50 years, this book delivers on its promise: practical diabetes advice that works immediately.

    Gravity is a compilation of Q&A posts from Mark Rippetoe s StrengthMill forum. Edited for brevity, efficiency, clarity, accuracy, and taste (in a loose sense, sorry), Mean Ol' Mr. Gravity adds to the information available in Starting Strength: Basic Barbell Training and Practical Programming for Strength Training by tailoring it to the individual through his responses to questions posed by actual humans regarding their own training. It preserves the coarseness, humor, and candor that have become Rip s trademark style. A Question. Goombahboy: Hey Rip, why would you make a book out of a bunch of posts that are already available on the web? What could you possibly have been thinking? Mark Rippetoe: An excellent question. I have no idea, other than the fact that a book like this makes an excellent bathroom companion. The reading-kind of companion. Information and humor in small, easily managed chunks. Conveniently digestible pieces, as it were. Well, you know what I mean. Bozo1988: Yeah, what were you thinking? I mean, I know there s a lot of information here, I know that all of the really stupid stuff that would waste my time while reading it online has been removed, and that the videos posted on the board don t load very fast in a book format anyway, but why a book? Mark Rippetoe: Look, just read the damn thing, okay? You ll be fine.

    one of the most important and readable works on the human past published in recent years."Winner of the Pulitzer Prize and a national bestseller: the global account of the rise of civilization that is also a stunning refutation of ideas of human development based on race.In this "artful, informative, and delightful" (William H. McNeill, New York Review of Books) book, Jared Diamond convincingly argues that geographical and environmental factors shaped the modern world. Societies that had a head start in food production advanced beyond the hunter-gatherer stage, and then developed writing, technology, government, and organized religion—as well as nasty germs and potent weapons of war—and adventured on sea and land to conquer and decimate preliterate cultures. A major advance in our understanding of human societies, Guns, Germs, and Steel chronicles the way that the modern world came to be and stunningly dismantles racially based theories of human history.Winner of the Pulitzer Prize, the Phi Beta Kappa Award in Science, the Rhone-Poulenc Prize, and the Commonwealth Club of California's Gold Medal

    As you read this, we are engineering the next stage of human evolution. Through advances in genetic, robotic, information and nanotechnologies, we are altering our minds, our memories, our metabolisms, our personalities, our progeny - and perhaps our very souls.Taking us behind the scenes with today's foremost researchers and pioneers, Garreau reveals that the super powers of our comic-book heroes already exist, or are in development in hospitals, labs, and research facilities around the country -- from the revved up reflexes and speed of Spider-Man and Superman, to the enhanced mental acuity and memory capabilities of an advanced species. Over the next fifteen years, Garreau makes clear, these enhancements will become part of our everyday lives. Where will they lead us? To heaven - where technology's promise to make us smarter, vanquish illness and extend our lives is the answer to our prayers? Or will they lead us, as some argue, to hell - where unrestrained technology brings about the ultimate destruction of our entire species? With the help and insights of the gifted thinkers and scientists who are making what has previously been thought of as science fiction a reality, Garreau explores how these developments, in our lifetime, will affect everything from the way we date to the way we work, from how we think and act to how we fall in love. It is a book about what our world is becoming today, not fifty years out. As Garreau cautions, it is only by anticipating the future that we can hope to shape it.