By examining fossils and DNA, Shubin shows us that our hands actually resemble fish fins, our head is organized like that of a long-extinct jawless fish, and major parts of our genome look and function like those of worms and bacteria.Shubin makes us see ourselves and our world in a completely new light. Your Inner Fish is science writing at its finest-enlightening, accessible, and told with irresistible enthusiasm.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    But in the modern world, the breast is changing. Breasts are getting bigger, arriving earlier, and attracting newfangled chemicals. Increasingly, the odds are stacked against us in the struggle with breast cancer, even among men. What makes breasts so mercurial—and so vulnerable?In this informative and highly entertaining account, intrepid science reporter Florence Williams sets out to uncover the latest scientific findings from the fields of anthropology, biology, and medicine. Her investigation follows the life cycle of the breast from puberty to pregnancy to menopause, taking her from a plastic surgeon’s office where she learns about the importance of cup size in Texas to the laboratory where she discovers the presence of environmental toxins in her own breast milk. The result is a fascinating exploration of where breasts came from, where they have ended up, and what we can do to save them.

    But AIDS is just one of the many emerging viruses for which we have, as yet, no cure. Even the old plagues – TB, cholera, bubonic plague – are making a comeback, resistant now to our drugs.Frank Ryan, a leading authority on disease, describes the groundbreaking research of the world’s leading experts in the field to show both where these viruses come from and why they prove to be so lethal, and advances a radical new biological theory for the origins and behaviour of plague viruses. Full of vivid despatches from the front line of research and medicine, 'Virus X' is terrifying and essential reading for anyone interested in the effects of plague viruses on human evolution.“Extremely well written…Frank Ryan has the page-turning and spine-chilling ability of a good novelist”MATT RIDLEY, 'Sunday Telegraph'“Compelling and frightening…the plot could not be bettered”MICHAEL SMITH, 'Scotsman'“Ryan is very good at making technical matters comprehensible to the lay reader but more impressive still is the way he conveys the intellectual excitement and elation of scientific discovery”ANTHONY DANIELS, 'Literary Review'“Ryan takes us through the drama of discovery and challenges the notion that certain questions are too appalling to contemplate”DAVID BRADLEY, 'New Scientist'“Dr Ryan writes well in a difficult technical field, weaving the technicalities of scientific history, medicine, molecular biology and evolution into the human narratives…very readable and disturbing”JOHN R.G. TURNER, 'New York Times'

    Beginning with a dramatic account of the SARS pandemic at the start of the 21st century, Dorothy Crawford takes us back in time to follow the interlinked history of microbes and humanity, offering an up-to-date look at ancient plagues and epidemics, and identifying key changes in the way humans have lived--such as our move from hunter-gatherer to farmer to city-dweller--which made us ever more vulnerable to microbe attack. Showing that how we live our lives today--with increased crowding and air travel--puts us once again at risk, Crawford asks whether we might ever conquer microbes completely. Among the possible answers, one thing becomes clear: that for generations to come, our deadly companions will continue to influence our lives. New in Paperback

    An exhilarating account of Sapolsky’s twenty-one-year study of a troop of rambunctious baboons in Kenya, A Primate’s Memoir interweaves serious scientific observations with wry commentary about the challenges and pleasures of living in the wilds of the Serengeti — for man and beast alike. Over two decades, Sapolsky survives culinary atrocities, gunpoint encounters, and a surreal kidnapping, while witnessing the encroachment of the tourist mentality on the farthest vestiges of unspoiled Africa. As he conducts unprecedented physiological research on wild primates, he becomes evermore enamored of his subjects — unique and compelling characters in their own right — and he returns to them summer after summer, until tragedy finally prevents him.By turns hilarious and poignant, A Primate’s Memoir is a magnum opus from one of our foremost science writers.

    In three successive waves, from 1918 to 1919, influenza killed more than 50 million people. German soldiers termed it Blitzkatarrh, British soldiers referred to it as Flanders Grippe, but world-wide, the pandemic gained the notorious title of “Spanish Flu." Nowhere on earth escaped: the United States recorded 550,000 deaths (five times its total military fatalities in the war), while European deaths totaled more than two million.Amid the war, some governments suppressed news of the outbreak. Even as entire battalions were decimated, with both the Allies and the Germans suffering massive casualties, the details of many servicemen’s deaths were hidden to protect public morale. Meanwhile, civilian families were being struck down in their homes. Philadelphia ran out of gravediggers and coffins, and mass burial trenches had to be excavated with steam shovels. Spanish flu conjured up the specter of the Black Death of 1348 and the great plague of 1665, while the medical profession, shattered after five terrible years of conflict, lacked the resources to contain and defeat this new enemy. Through primary and archival sources, historian Catharine Arnold gives readers the first truly global account of this terrible epidemic.

    But we should--even those of us who take care of our business in pristine, sanitary conditions. For it's not only in developing countries that human waste is a major public health threat: population growth is taxing even the most advanced sewage systems, and the disease spread by waste kills more people worldwide every year than any other single cause of death. Even in America, 1.95 million people have no access to an indoor toilet. Yet the subject remains unmentionable."The Big Necessity "takes aim at the taboo, revealing everything that matters about how people do--and don't--deal with their own waste. Moving from the deep underground sewers of Paris, London, and New York--an infrastructure disaster waiting to happen--to an Indian slum where ten toilets are shared by 60,000 people, Rose George stops along the way to explore the potential saviors: China's five million biogas digesters, which produce energy from waste; the heroes of third world sanitation movements; the inventor of the humble Car Loo; and the U.S. Army's personal lasers used by soldiers to zap their feces in the field.With razor-sharp wit and crusading urgency, mixing levity with gravity, Rose George has turned the subject we like to avoid into a cause with the most serious of consequences.

    In The Woman with a Worm in Her Head, Dr. Pamela Nagami reveals-through real-life cases-the sobering facts about some of the world's most horrific diseases: the warning signs, the consequences, treatments, and most compellingly, what it feels like to make medical and ethical decisions that can mean the difference between life and death.Unfailingly precise, calmly instructive, and absolutely engrossing, The Woman with the Worm in Her Head offers both useful information and enjoyable reading.

    In Wicked Plants, Stewart takes on over two hundred of Mother Nature’s most appalling creations. It’s an A to Z of plants that kill, maim, intoxicate, and otherwise offend. You’ll learn which plants to avoid (like exploding shrubs), which plants make themselves exceedingly unwelcome (like the vine that ate the South), and which ones have been killing for centuries (like the weed that killed Abraham Lincoln's mother). Menacing botanical illustrations and splendidly ghastly drawings create a fascinating portrait of the evildoers that may be lurking in your own backyard. Drawing on history, medicine, science, and legend, this compendium of bloodcurdling botany will entertain, alarm, and enlighten even the most intrepid gardeners and nature lovers.

    Sixty-six million years ago, the Earth’s most fearsome creatures vanished. Today they remain one of our planet’s great mysteries. Now The Rise and Fall of the Dinosaurs reveals their extraordinary, 200-million-year-long story as never before.In this captivating narrative (enlivened with more than seventy original illustrations and photographs), Steve Brusatte, a young American paleontologist who has emerged as one of the foremost stars of the field—naming fifteen new species and leading groundbreaking scientific studies and fieldwork—masterfully tells the complete, surprising, and new history of the dinosaurs, drawing on cutting-edge science to dramatically bring to life their lost world and illuminate their enigmatic origins, spectacular flourishing, astonishing diversity, cataclysmic extinction, and startling living legacy. Captivating and revelatory, The Rise and Fall of the Dinosaurs is a book for the ages.Brusatte traces the evolution of dinosaurs from their inauspicious start as small shadow dwellers—themselves the beneficiaries of a mass extinction caused by volcanic eruptions at the beginning of the Triassic period—into the dominant array of species every wide-eyed child memorizes today, T. rex, Triceratops, Brontosaurus, and more. This gifted scientist and writer re-creates the dinosaurs’ peak during the Jurassic and Cretaceous, when thousands of species thrived, and winged and feathered dinosaurs, the prehistoric ancestors of modern birds, emerged. The story continues to the end of the Cretaceous period, when a giant asteroid or comet struck the planet and nearly every dinosaur species (but not all) died out, in the most extraordinary extinction event in earth’s history, one full of lessons for today as we confront a “sixth extinction.”Brusatte also recalls compelling stories from his globe-trotting expeditions during one of the most exciting eras in dinosaur research—which he calls “a new golden age of discovery”—and offers thrilling accounts of some of the remarkable findings he and his colleagues have made, including primitive human-sized tyrannosaurs; monstrous carnivores even larger than T. rex; and paradigm-shifting feathered raptors from China.An electrifying scientific history that unearths the dinosaurs’ epic saga, The Rise and Fall of the Dinosaurs will be a definitive and treasured account for decades to come.

    From biblical plagues, to the AIDS crisis, to supergerms of the future, this updated and revised edition of the original covers the whole gamut of diseases that have threatened humanity since its origins.It also includes a new chapter on the history of bioterrorism and the deplorable role it has played and is likely to play in the phenomenal diversity of diseases.

    She finds that you cannot immunize your child, or yourself, from the world.In this bold, fascinating book, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. As she hears more and more fears about vaccines, Biss researches what they mean for her own child, her immediate community, America, and the world, both historically and in the present moment. She extends a conversation with other mothers to meditations on Voltaire's Candide, Bram Stoker's Dracula, Rachel Carson's Silent Spring, Susan Sontag's AIDS and Its Metaphors, and beyond.On Immunity is a moving account of how we are all interconnected-our bodies and our fates.