Whether it’s a friend who can’t quit smoking, a colleague afflicted with alcoholism, or a relative abusing prescription drugs, we all know someone who suffers from some form of addiction—we may even have an addiction ourselves. By some estimates, roughly one in four Americans might be considered addicts. On the other hand, many of us use substances such as alcohol recreationally, without suffering the physical or psychological symptoms of addiction. So what is the difference between drug use, abuse, and clinical addiction? What causes addictions? What happens when your brain is on drugs, and why do addicts behave the way they do?12 Lectures 1. Addiction 101 2. The Psychology and Neuroscience of Reward 3. How Addiction Hijacks the Brain 4. Genetics: Born to Be an Addict? 5. Your Brain on Drugs 6. Why We Crave Coffee and Cigarettes 7. Alcohol: Social Lubricant or Drug of Abuse? 8. The Science of Marijuana 9. Stimulants: From Cocaine to Ritalin 10. The Science of Poppies, Pleasure, and Pain 11. The Gambler's Brain 12. Junk Food, Porn, Video Games: Addictions?Listening Length: 6 hours and 23 minutes

    Our Inheritance 2. Mendel and Genes 3. Genes and Chromosomes 4. The Search for the GeneDNA 5. DNA Structure and Replication 6. DNA Expression in Proteins 7. Genes, Enzymes, and Metabolism 8. From DNA to Protein 9. Genomes 10. Manipulating GenesRecombinant DNA 11. Isolating Genes and DNA 12. BiotechnologyGenetic Engineering 13. Biotechnology and the Environment 14. Manipulating DNA by PCR and Other Methods 15. DNA in IdentificationForensics 16. DNA and Evolution 17. DNA and Human Evolution 18. Molecular MedicineGenetic Screening 19. Molecular MedicineThe Immune System 20. Molecular MedicineCancer 21. Molecular MedicineGene Therapy 22. Molecular MedicineCloning and Stem Cells 23. Genetics and Agriculture 24. Biotechnology and Agriculture

    (B) Scientific knowledge is always provisional and tells us nothing that is universal, necessary, or certain about the world. Welcome to the science wars—a long-running battle over the status of scientific knowledge that began in ancient Greece, raged furiously among scientists, social scientists, and humanists during the 1990s, and has re-emerged in today's conflict between science and religion over issues such as evolution.Professor Steven L. Goldman, whose Teaching Company course on Science in the 20th Century was praised by customers as "a scholarly achievement of the highest order" and "excellent in every way," leads you on a quest for the nature of scientific reasoning in this intellectually pathbreaking lecture series, Science Wars: What Scientists Know and How They Know It.Those who have taken Professor Goldman's previous course, which is an intensive survey of the revolution in scientific knowledge from 1900 to 2000, may have wondered: if what counts as scientific knowledge can transform so dramatically within only 100 years, what exactly is scientific knowledge? Science Wars addresses this surprisingly difficult question.Five Centuries of the Science WarsIn 24 half-hour lectures, Science Wars explores the history of competing conceptions of scientific knowledge and their implications for science and society from the onset of the Scientific Revolution in the 1600s to the present. It may seem that the accelerating pace of discoveries, inventions, and unexpected insights into nature during this period guarantees the secure foundations of scientific inquiry, but that is far from true. Consider these cases:The scientific method: In the 1600s the English philosopher Francis Bacon defined the scientific method in its classic form: the use of inductive reasoning to draw conclusions from an exhaustive body of facts. But "no scientist has ever been a strict Baconian," says Professor Goldman. "If you followed that, you would get nowhere."A "heated" debate: Around 1800 the dispute over the nature of heat was resolved in favor of the theory that heat is motion and not a substance given off during burning. But then the French mathematical physicist Joseph Fourier wrote a set of equations that accurately described how heat behaves regardless of what it "really" is, which, Fourier contended, was not a scientific question at all.Paradigm shifts: The publication in 1962 of Thomas Kuhn's The Structure of Scientific Revolutions precipitated a radical change in attitudes toward scientific knowledge, prompted by Kuhn's insight that science is not an entirely rational enterprise, and that its well-established theories (or paradigms) are overturned in a revolutionary, nonlogical process.Postmodern putdown: The postmodern attack on science as a privileged mode of inquiry made some headway in the late 20th century. But the credibility of the movement wilted in 1996, when a postmodern journal unwittingly published a spoof by physicist Alan Sokal, purporting to prove that physical theory was socially constructed. Sokal then exposed his piece as a parody.In the penultimate lecture of the course, Professor Goldman considers intelligent design—the argument that evolution can't account for the immense complexity of life and that a master designer must be at work. He approaches this topical debate by asking: What are the minimum criteria that define a hypothesis as scientific, and does intelligent design qualify? Having already covered five centuries of the science wars in the previous lectures, you will analyze this controversy with a set of tools that allows you to see the issues in a sharp, new light.What Is Reality?"Fasten your seatbelts," says Professor Goldman at the outset of Lecture 21—an advisory that applies equally to the whole course, which covers an astonishing array of ideas and thinkers. Throughout, Professor Goldman never loses his narrative thread, which begins 2,400 years ago with Plato's allegorical battle between "the gods" and "the earth giants"—between those for whom knowledge is universal, necessary, and certain; and those for whom it cannot be so and is based wholly on experience.The problem of what constitutes scientific knowledge can be illustrated with one of the most famous and widely accepted scientific theories of all time, Nicolaus Copernicus's heliostatic (stationary sun) theory of the solar system, which has undergone continual change since it was first proposed in 1543: Copernicus called for the planets to move in uniform circular motion around the sun, slightly displaced from the center. Using observations by Tycho Brahe, Johannes Kepler revised the Copernican model, discarding the ancient dogma of circular motion, which did not fit the data. Instead, he guessed that the planets in fact move in elliptical orbits. In his influential work endorsing the Copernican theory, Galileo ignored Kepler's corrections and opted for circular motion. Notoriously, the Catholic Church condemned Galileo for heresy. But the church was actually correct that he had no basis for claiming the heliocentric theory was true, rather than simply an interpretation of experience. Galileo's picture of space was superseded by Newton's and later by Einstein's, which also will doubtless be revised. Even something as basic as the elliptical motion of the planets is a vast oversimplification. There are no closed curves in space, since the solar system is moving around the center of the galaxy; the galaxy is moving within the local cluster; and the local cluster is also moving. Although we still call the conventional picture of the solar system Copernican astronomy, there is effectively no resemblance between astronomy today and Copernicus's 1543 theory of the heavens. The same is also true of other theories, such as the atomic theory of matter. All scientific theories are in a state of ceaseless revision, which raises the question of what reality "really" is. As the contemporary philosopher of science Mary Hesse has pointed out, the lesson of the history of science seems to be that the theories we currently hold to be true are as likely to be overturned as the theories they replaced!Sharpen Your Understanding of What Science IsThe uncertainty about the status of scientific knowledge and about the objectivity of the scientific enterprise led to a broad assault on science in the late 20th century by sociologists, philosophers, and historians, many connected with the postmodern movement. The lectures covering this attack and the ensuing counterattack by scientists are some of the most thrilling in the course and involve a number of figures whom Professor Goldman knows personally.Of one of the firebrands in this conflict, the late Viennese philosopher of science Paul Feyerabend, Professor Goldman says, "I myself took a seminar with Feyerabend when he was teaching at Berkeley in the early 1960s. … Feyerabend was not really off the wall, although he was often depicted that way. … He too recognized, as everyone must, that after all, science does work and science is knowledge of a sort. It's just not the absolute knowledge that scientists and philosophers have historically claimed that it is."By the time you reach the end of this course, you will understand exactly what science is, and you will be enlightened about a fascinating problem that perhaps you didn't even know existed. "There have been a raft of popular books about what scientists know," says Professor Goldman, "but to the best of my knowledge, there is not a single one of these popular books that focuses centrally on the question of how scientists know what they know."This course serves as that book.Course Lecture Titles1. Knowledge and Truth Are Age-Old Problems 2. Competing Visions of the Scientific Method 3. Galileo, the Catholic Church, and Truth 4. Isaac Newtons Theory of the Universe 5. Science vs. Philosophy in the 17th Century 6. Locke, Hume, and the Path to Skepticism 7. Kant Restores Certainty 8. Science, Society, and the Age of Reason 9. Science Comes of Age in the 19th Century 10. Theories Need Not Explain 11. Knowledge as a Product of the Active Mind 12. Trading Reality for Experience 13. Scientific Truth in the Early 20th Century 14. Two New Theories of Scientific Knowledge 15. Einstein and Bohr Redefine Reality 16. Truth, Ideology, and Thought Collectives 17. Kuhn's Revolutionary Image of Science 18. Challenging Mainstream Science from Within 19. Objectivity Under Attack 20. Scientific Knowledge as Social Construct 21. New Definitions of Objectivity 22. Science Wars of the Late 20th Century 23. Intelligent Design and the Scope of Science 24. Truth, History, and Citizenship12 Audio CDs(24 lectures, 30 minutes/lecture)

    His language and culture - those of Elizabethan England - are greatly different from our own, and his poetry, thick with metaphorical imagery and double meanings, can be hard to penetrate.Yet the keys to understanding Shakespeare are written into the plays themselves. If you can learn to recognize the playwright's own clues, you'll become able to engage meaningfully with his language, to follow the plot structures and themes that drive his plays, and to track the development of his characters.Over the course of 24 lectures, this innovative and penetrating exploration of Shakespeare's plays reveals how to enter Shakespeare's dramatic world, how to grasp what's happening in any of his plays, and how to enjoy them fully both on the page and the stage.Under Professor Conner's expert guidance, shaped by decades of studying and performing Shakespeare, you learn more than 40 interpretive tools, drawn from the texts themselves, that give you direct insight into the plays. These guiding principles allow you to follow the narratives of the plays as they unfold, with a clear understanding of how the plays function and fit together.The professor also reveals fascinating details of Shakespeare's era, which shed further light on the plays and the way his contemporary audiences perceived them.This course builds the skills that allow you to reach your own understanding of the plays - to deeply comprehend Shakespeare's transcendent poetic language, the spellbinding world of his great characters and stories, and his revelatory reflections on human experience.Disclaimer: Please note that this recording may include references to supplemental texts or print references that are not essential to the program and not supplied with your purchase.©2013 The Teaching Company, LLC (P)2013 The Great Courses

    415 is taught by Kathleen M. Higgins and Robert Solomon.Part 1 (6 CDs with 54 page booklet)andPart 2 (6 CDs with 48 page booklet)

    As generous patrons to the likes of Botticelli and Michelangelo, the ruling Medici embodied the progressive humanist spirit of the age, and in Lorenzo the Magnificent they possessed a diplomat capable of guarding the militarily weak city in a climate of constantly shifting allegiances between the major Italian powers.However, in the form of Savonarola, an unprepossessing provincial monk, Lorenzo found his nemesis. Filled with Old Testament fury and prophecies of doom, Savonarola's sermons reverberated among a disenfranchised population, who preferred medieval Biblical certainties to the philosophical interrogations and intoxicating surface glitter of the Renaissance. Savonarola's aim was to establish a 'City of God' for his followers, a new kind of democratic state, the likes of which the world had never seen before.The battle which this provoked would be a fight to the death, a series of sensational events - invasions, trials by fire, the 'Bonfire of the Vanities', terrible executions and mysterious deaths - featuring a cast of the most important and charismatic Renaissance figures.This famous struggle has often been portrayed as a simple clash of wills between a benign ruler and religious fanatic, between secular pluralism and repressive extremism. However, in an exhilaratingly rich and deeply researched story, Paul Strathern reveals the paradoxes, self-doubts and political compromises which made the battle for the soul of the Renaissance city one of the most complex and important moments in Western history.

    It repays us many times over to be good economists. Economic issues are active in our lives every day. However, when the subject of economics comes up in conversation or on the news, we can find ourselves longing for a more sophisticated understanding of the fundamentals of economics.36 lectures | 30 minutes each.

    Though he never wrote down his thoughts, he had a brilliant pupil in Plato, who immortalized his teacher's legacy in 35 timeless dialogues that laid the philosophical basis for Western civilization.Professor Michael Sugrue of Princeton University brings the Socratic quest for truth alive in these lectures, which discuss ideas that are as vital today as they were 25 centuries ago. Ideas about truth, justice, love, beauty, courage, and wisdom. Ideas that can change lives and reveal the world in new ways to the true student.Professor Sugrue reveals the inner structure, action, and meaning of 17 of Plato's greatest dialogues, making this course an indispensable companion for anyone interested in philosophy in general or Platonic thought in particular.

    It has become so central to the way we communicate and live, however, that it often seems as if writing has always existed.But the question remains: Who invented writing, and why?In these 24 fascinating lectures, you'll trace the remarkable saga of the invention and evolution of "visible speech," from its earliest origins to its future in the digital age. Your guide is an accomplished professor and epigrapher who whisks you around the globe to explore how an array of sophisticated writing systems developed, then were adopted and adapted by surrounding cultures.Along the way, you'll visit the great early civilizations of Egypt, Mesopotamia, China, Japan, and the Americas, and you'll see how deciphering ancient scripts is a little like cracking secret codes - only far more difficult.You'll be spellbound as you hear accounts of the breathtaking moments when the decipherment of ancient scripts broke centuries of silence. And you'll marvel at fascinating objects once shrouded in mystery, including the iconic Rosetta stone.Writing and Civilization offers the chance to not only discover the history of ancient writing systems, but also the rare opportunity to actually hear those scripts read aloud and to learn the meaning of their messages hidden in plain sight.Please note a guidebook is included with the audiobook.

    This makes economic history - the study of how civilizations structured their environments to provide food, shelter, and material goods - a vital lens through which to think about how we arrived at our present, globalized moment.Designed to fill a long-empty gap in how we think about modern history, these 48 lectures are a comprehensive journey through more than 600 years of economic history, from the medieval world to the 21st century. Aimed at the layperson with only a cursory understanding of the field, An Economic History of the World since 1400 reveals how economics has influenced (and been influenced by) historical events and trends, including the Black Death, the Age of Exploration, the Industrial Revolution, the European colonization of Africa, the collapse of the Soviet Union, and the birth of personal computing. Professor Harreld has crafted a riveting, centuries-long story of power, glory, and ideology that reveals how, in step with history, economic ideas emerged, evolved, and thrived or died.Along the way, you'll strengthen your understanding of a range of economic concepts, philosophies, trends, treaties, and organizations, including the mercantile system, Adam Smith's The Wealth of Nations, Marxist economics, African independence movements, and the formation of economic organizations including the European Union. You'll also consider provocative questions about the intersection of history and economics. What did the economies of Roosevelt's America and Hitler's Germany have in common? What does history tell us about how nations should dictate economic policy? Can we say that free trade is truly free?Marvel at just how much we still have to learn about the economic forces that have dictated our past - and that will dictate our future.Listening Length: 24 hours and 29 minutes

    Its principles can be found in our Bill of Rights and in the Constitution. But what was this strange document that dwells on tax relief and greater fishing rights, and how did it gain legendary status?Dan Jones takes us back to 1215, the turbulent year when the Magna Carta was just a peace treaty between England’s King John and a group of self-interested, violent barons who were tired of his high taxes and endless foreign wars. The treaty would fail within two months of its confirmation. But this important document marked the first time a king was forced to obey his own laws. Jones’s 1215 follows the story of the Magna Carta’s creation, its failure, and the war that subsequently engulfed England and is book that will appeal to fans of microhistories of pivotal years like 1066, 1491, and especially 1776—when American patriots, inspired by that long-ago defiance, dared to pick up arms against another English king.

    Distinguished historian and author of The Middle Ages Johannes Fried presents a new biographical study of the legendary Frankish king and emperor, illuminating the life and reign of a ruler who shaped Europe’s destiny in ways few figures, before or since, have equaled.Living in an age of faith, Charlemagne was above all a Christian king, Fried says. He made his court in Aix-la-Chapelle the center of a religious and intellectual renaissance, enlisting the Anglo-Saxon scholar Alcuin of York to be his personal tutor, and insisting that monks be literate and versed in rhetoric and logic. He erected a magnificent cathedral in his capital, decorating it lavishly while also dutifully attending Mass every morning and evening. And to an extent greater than any ruler before him, Charlemagne enhanced the papacy’s influence, becoming the first king to enact the legal principle that the pope was beyond the reach of temporal justice—a decision with fateful consequences for European politics for centuries afterward.Though devout, Charlemagne was not saintly. He was a warrior-king, intimately familiar with violence and bloodshed. And he enjoyed worldly pleasures, including physical love. Though there are aspects of his personality we can never know with certainty, Fried paints a compelling portrait of a ruler, a time, and a kingdom that deepens our understanding of the man often called “the father of Europe.”

    From the rising and setting of the sun to the cycles of nature, the thought processes in our brains, and the biorhythms in our day, nothing so pervades our existence and yet is so difficult to explain. Time seems to be woven into the very fabric of the universe. But why? Consider these contrasting views of time: A movie of a person diving into a pool has an obvious arrow of time. When the movie is played backward, everyone recognizes that it shows an event that would never occur in the real world. But zoom in on any part of this scene at the atomic scale and the movie can be run backward or forward and be indistinguishable. Either way, the particle interactions are consistent with the laws of physics. Why does one movie have an arrow of time moving in only one direction and the other does not? Surprisingly, the search for an answer leads through some of the most pioneering fields of physics, including thermodynamics, relativity, quantum theory, and cosmology. The key concept is called "entropy," which is related to the second law of thermodynamics, considered by many scientists to be the most secure law in all of physics. But that's only the beginning, since the quest for the ultimate theory of time draws on such exciting ideas as black holes, cosmic inflation, and dark energy, before closing in on a momentous question that until recently was considered unanswerable: What happened before the big bang? In 24 riveting half-hour lectures, Mysteries of Modern Physics: Time takes you on a mind-expanding journey through the past, present, and future, guided by Professor Sean Carroll, noted author and Senior Research Associate in Physics at the California Institute of Technology.

    The nature of myth and its importance to ancient Greece in terms of storytelling, music, poetry, religion, cults, rituals, theatre, and literature are viewed through works ranging from Homer's Illiad and Odyssey to the writings of Sophocles and Aeschylus. These lectures are an entertaining guide to Greek mythology and a fascinating look into the culture and time that produced these eternal tales.

    In this meditation on Aristotle's Nicomachean Ethics, an award-winning teacher shows you the clarity and ethical wisdom of one of humanity's greatest minds.Often called "the philosopher of common sense," Aristotle offers an exquisitely balanced account of many ethical questions.Professor Koterski's aim is to provide you with a clear and thoughtful introduction to Aristotle as a moral philosopher. And he suggests ways in which this thinker from so long ago still speaks to the deep concerns of our own or any age.After absorbing some important background information designed to introduce you to Aristotle's career and general approach to the various fields of knowledge, you turn to the 10 books (today we would call them chapters) of this brief but towering work.