But I was getting there. I wanted the world to know that all of this pain I had been feeling…that it was related to my vagina. Thus, Vagina Problems was born. It was a cutesy name. It was my way of taking this pain and saying, “Whatever. I’m here. I have it. It sucks. Let’s talk about it.”In April 2014, Deputy Editorial Director at BuzzFeed Lara Parker opened up to the world in an article on the website: she suffers from endometriosis. And beyond that? She let the whole world know that she wasn’t having any sex, as sex was excruciatingly painful. Less than a year before, she received not only the diagnosis of endometriosis, but also a diagnosis of pelvic floor dysfunction, vulvodynia, vaginismus, and vulvar vestibulitis. Combined, these debilitating conditions have wreaked havoc on her life, causing excruciating pain throughout her body since she was fourteen years old. These are her Vagina Problems. It was five years before Lara learned what was happening to her body. Five years of doctors insisting she just had “bad period cramps,” or implying her pain was psychological. Shamed and stigmatized, Lara fought back against a medical community biased against women and discovered that the ignorance of many doctors about women’s anatomy was damaging more than just her own life. One in ten women have endometriosis and it takes an average of seven years before they receive an accurate diagnosis—or any relief from this incurable illness’ chronic pain. With candid revelations about her vaginal physical therapy, dating as a straight woman without penetrative sex, coping with painful seizures while at the office, diet and wardrobe malfunctions when your vagina hurts all the time, and the depression and anxiety of feeling unloved, Lara tackles it all in Vagina Problems: Endometriosis, Painful Sex, and Other Taboo Topics with courage, wit, love, and a determination to live her best life."

    Then he disappeared, eluding capture by multiple police forces and some of the best detectives in the area.Three decades later, Michelle McNamara, a true crime journalist who created the popular website TrueCrimeDiary.com, was determined to find the violent psychopath she called "the Golden State Killer." Michelle pored over police reports, interviewed victims, and embedded herself in the online communities that were as obsessed with the case as she was.At the time of the crimes, the Golden State Killer was between the ages of eighteen and thirty, Caucasian, and athletic—capable of vaulting tall fences. He always wore a mask. After choosing a victim—he favored suburban couples—he often entered their home when no one was there, studying family pictures, mastering the layout. He attacked while they slept, using a flashlight to awaken and blind them. Though they could not recognize him, his victims recalled his voice: a guttural whisper through clenched teeth, abrupt and threatening.I’ll Be Gone in the Dark—the masterpiece McNamara was writing at the time of her sudden death—offers an atmospheric snapshot of a moment in American history and a chilling account of a criminal mastermind and the wreckage he left behind. It is also a portrait of a woman’s obsession and her unflagging pursuit of the truth. Framed by an introduction by Gillian Flynn and an afterword by her husband, Patton Oswalt, the book was completed by Michelle’s lead researcher and a close colleague. Utterly original and compelling, it is destined to become a true crime classic—and may at last unmask the Golden State Killer.

    Leslie Jamison deftly excavates the stories we tell about addiction--both her own and others'--and examines what we want these stories to do, and what happens when they fail us.All the while, she offers a fascinating look at the larger history of the recovery movement, and at the literary and artistic geniuses whose lives and works were shaped by alcoholism and substance dependence, including John Berryman, Jean Rhys, Raymond Carver, Billie Holiday, David Foster Wallace, and Denis Johnson, as well as brilliant figures lost to obscurity but newly illuminated here.For the power of her striking language and the sharpness of her piercing observations, Jamison has been compared to such iconic writers as Joan Didion and Susan Sontag. Yet her utterly singular voice also offers something new. With enormous empathy and wisdom, Jamison has given us nothing less than the story of addiction and recovery in America writ large, a definitive and revelatory account that will resonate for years to come.

    In What We Don't Talk About When We Talk About Fat, Aubrey Gordon unearths the cultural attitudes and social systems that have led to people being denied basic needs because they are fat and calls for social justice movements to be inclusive of plus-sized people's experiences. Unlike the recent wave of memoirs and quasi self-help books that encourage readers to love and accept themselves, Gordon pushes the discussion further towards authentic fat activism, which includes ending legal weight discrimination, giving equal access to health care for large people, increased access to public spaces, and ending anti-fat violence. As she argues, I did not come to body positivity for self-esteem. I came to it for social justice.By sharing her experiences as well as those of others--from smaller fat to very fat people--she concludes that to be fat in our society is to be seen as an undeniable failure, unlovable, unforgivable, and morally condemnable. Fatness is an open invitation for others to express disgust, fear, and insidious concern. To be fat is to be denied humanity and empathy. Studies show that fat survivors of sexual assault are less likely to be believed and less likely than their thin counterparts to report various crimes; 27% of very fat women and 13% of very fat men attempt suicide; over 50% of doctors describe their fat patients as awkward, unattractive, ugly and noncompliant; and in 48 states, it's legal--even routine--to deny employment because of an applicant's size.Advancing fat justice and changing prejudicial structures and attitudes will require work from all people. What We Don't Talk About When We Talk About Fat is a crucial tool to create a tectonic shift in the way we see, talk about, and treat our bodies, fat and thin alike.

    In addition to offering a clear-eyed explanation of the root causes of this insidious and entrenched bias and laying out its effects, she suggests concrete steps we can take to cure it.

    When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    These include her "transformation from Pippi Longstocking-esque tomboy to are-you-a-lesbian-or-what tom man," attempting to find watchable porn, and identifying the difference between being called "ma'am" and "miss" ("Miss" sounds like you weigh ninety-nine pounds).Raw, relatable, and consistently hilarious, YOU'LL GROW OUT OF IT is a one-of-a-kind book by a singular and irresistible comic voice.

    Beginning with the above questions, she began informally researching every affliction that she encountered in humans to learn whether it happened with animals, too. And usually, it did: dinosaurs suffered from brain cancer, koalas can catch chlamydia, reindeer seek narcotic escape in hallucinogenic mushrooms, stallions self-mutilate, and gorillas experience clinical depression. Natterson-Horowitz and science writer Kathryn Bowers have dubbed this pan-species approach to medicine zoobiquity. Here, they present a revelatory understanding of what animals can teach us about the human body and mind, exploring how animal and human commonality can be used to diagnose, treat, and heal patients of all species.

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    By all appearances, she had mastered being a grown-up. But beneath that veneer of success, she was a chronically anxious, self-medicating mess. No one knew that her road to adulthood had been paved with depression, anxiety, and shame, owing in large part to her minimally parented upbringing. She realized she’d hit rock bottom when she drunk-dialed her therapist pleading for help.Buy Yourself the F*cking Lilies is the story of Tara’s path to re-parenting herself and becoming a “ninja of self-love.” Through simple, daily rituals, Tara transformed her mind, body, and relationships, and shows how to:• fake gratitude until you actually feel gratitude• excavate your emotional wounds and heal them with kindness• identify your self-limiting beliefs, kick them to the curb, and start living a life you choose• silence your inner frenemy and shield yourself from self-criticism• carve out time each morning to start your day empowered, inspired, and ready to rule• create a life you truly, totally f*cking LOVEThis is the book Tara wished someone had given her and it is the book many of us desperately need: a candid, hysterical, addictively readable, practical guide to growing up (no matter where you are in life) and learning to love yourself in a non-throw-up-in-your-mouth-it’s-so-cheesy way.

    From Sarajevo under siege in 1993 to clandestine hospitals in rebel-held eastern Aleppo, he has carried out lifesaving operations in the most challenging conditions, and with none of the resources of a major metropolitan hospital. He is now widely acknowledged as the most experienced trauma surgeon in the world.War Doctor is his extraordinary story, encompassing his surgeries in nearly every major conflict zone since the end of the Cold War, as well as his struggles to return to a “normal” life and routine after each trip. Culminating in his recent trips to war-torn Syria—and the untold story of his efforts to help secure a humanitarian corridor out of besieged Aleppo to evacuate some 50,000 people—War Doctor is a blend of medical memoir, personal journey, and nonfiction thriller that provides unforgettable, at times raw, insight into the human toll of war.

    From New England aquarium tanks to the reefs of French Polynesia and the Gulf of Mexico, she has befriended octopuses with strikingly different personalities—gentle Athena, assertive Octavia, curious Kali, and joyful Karma. Each creature shows her cleverness in myriad ways: escaping enclosures like an orangutan; jetting water to bounce balls; and endlessly tricking companions with multiple “sleights of hand” to get food.Scientists have only recently accepted the intelligence of dogs, birds, and chimpanzees but now are watching octopuses solve problems and are trying to decipher the meaning of the animal’s color-changing techniques. With her “joyful passion for these intelligent and fascinating creatures” (Library Journal Editors’ Spring Pick), Montgomery chronicles the growing appreciation of this mollusk as she tells a unique love story. By turns funny, entertaining, touching, and profound, The Soul of an Octopus reveals what octopuses can teach us about the meeting of two very different minds.

    These essays, which found a well-deserved home within the pages of Reader's Digest as the column "My Planet," detail the inner workings of hypochondriacs, hoarders, and compulsive cheapskates. (Did we mention neurotic interior designers and professional list-makers?) For Roach, humor is hidden in the most unlikely places, which means that nothing is off limits. Whether she is dwelling on her age or talking about the pros and cons of a bedroom night light -- "A married couple can best be defined as a unit of people whose sleep habits are carefully engineered to keep each other awake" -- Roach finds a lesson, a slice of sarcasm, or a dash of something special that makes each day comical and absolutely priceless.In keeping with our mission -- curating the best reads in the land -- Reader's Digest editors neatly packaged these timeless (and hilarious) Roach essays together for the first time. Whether you read this cover-to-cover or during spare moments over morning coffee, flip to a page in this volume and try not to smile.