That her mother died of the disease, that her own chance of inheriting it was fifty-fifty, that her sister and father directed much of the extraordinary biomedical research to find the gene and a cure, make Wexler's story both astonishingly intimate and scientifically compelling.Alice Wexler's graceful and eloquent account goes beyond the specifics of Huntington's disease to explore the dynamics of family secrets, of living at risk, and the drama and limits of biomedical research. Mapping Fate will be a touchstone for anyone with questions about genetic illness and the possibilities and perils of genetic testing.

    Bernie Schein was his best friend from the time they met in a high-school pickup basketball game in Beaufort, South Carolina, until Conroy’s death in 2016. Both were popular athletes but also outsiders as a Jew and a Catholic military brat in the small-town Bible-Belt South, and they bonded. Wise ass and smart aleck, loudmouths both, they shared an ebullient sense of humor and romanticism, were mesmerized by the highbrow and reveled in the low, and would sacrifice entire evenings and afternoons to endless conversation. As young teachers in the Beaufort area and later in Atlanta, they were activists in the civil rights struggle and against institutional racism and bigotry. Bernie knew intimately the private family story of the Conroys and his friend’s difficult relationship with his Marine Corps colonel father that Pat would draw on repeatedly in his fiction. A love letter and homage, and a way to share the Pat he knew, this book collects Bernie’s cherished memories about the gregarious, welcoming, larger-than-life man who remained his best friend, even during the years they didn’t speak. It offers a trove of insights and anecdotes that will be treasured by Pat Conroy’s many devoted fans.

    Night Falls Fast is tragically timely: suicide has become one of the most common killers of Americans between the ages of fifteen and forty-five.An internationally acknowledged authority on depressive illnesses, Dr. Jamison has also known suicide firsthand: after years of struggling with manic-depression, she tried at age twenty-eight to kill herself. Weaving together a historical and scientific exploration of the subject with personal essays on individual suicides, she brings not only her remarkable compassion and literary skill but also all of her knowledge and research to bear on this devastating problem. This is a book that helps us to understand the suicidal mind, to recognize and come to the aid of those at risk, and to comprehend the profound effects on those left behind. It is critical reading for parents, educators, and anyone wanting to understand this tragic epidemic.

    

    Their extraordinary meeting and the two years they spent in one another’s company serves as the basis for an investigation into the nature of human identity, belief, and delusion that is poignant, amusing, and at times disturbing. Displaying the sympathy and subtlety of a gifted novelist, Rokeach draws us into the lives of three troubled and profoundly different men who find themselves “confronted with the ultimate contradiction conceivable for human beings: more than one person claiming the same identity.”

    While psychedelics of all sorts are demonized in America today, the visionary compounds found in plants are the spiritual sacraments of tribal cultures around the world. From the iboga of the Bwiti in Gabon, to the Mazatecs of Mexico, these plants are sacred because they awaken the mind to other levels of awareness--to a holographic vision of the universe.Breaking Open the Head is a passionate, multilayered, and sometimes rashly personal inquiry into this deep division. On one level, Daniel Pinchbeck tells the story of the encounters between the modern consciousness of the West and these sacramental substances, including such thinkers as Allen Ginsberg, Antonin Artaud, Walter Benjamin, and Terence McKenna, and a new underground of present-day ethnobotanists, chemists, psychonauts, and philosophers. It is also a scrupulous recording of the author's wide-ranging investigation with these outlaw compounds, including a thirty-hour tribal initiation in West Africa; an all-night encounter with the master shamans of the South American rain forest; and a report from a psychedelic utopia in the Black Rock Desert that is the Burning Man Festival.Breaking Open the Head is brave participatory journalism at its best, a vivid account of psychic and intellectual experiences that opened doors in the wall of Western rationalism and completed Daniel Pinchbeck's personal transformation from a jaded Manhattan journalist to shamanic initiate and grateful citizen of the cosmos.

    The case would become one of the most famous in modern medicine—and a total failure. As Nature Made Him tells the extraordinary story of David Reimer, who, when finally informed of his medical history, made the decision to live as a male. A macabre tale of medical arrogance, it is first and foremost a human drama of one man's—and one family's—amazing survival in the face of terrible odds.

    This book will equally deepen the awareness of clinicians and enlighten the lay reader. It is a gift to both.' Donald M. Berwick, MD, MPPIn this highly articulate, down-to-earth, generous book, Dr David Galler tells stories of life and death from his position as Intensive Care specialist at Middlemore Hospital. Written lyrically and warmly, these stories are based on real life events describing the everyday dilemmas and challenges that doctors and patients commonly face.It aims to explain and demystify much of the work doctors do, cast light on the workings of the medical establishment and how medicine operates, in the hope that it will encourage patients to seek to be better informed and play a greater role in the decisions that will affect them and their loved ones.It speaks to the resilience of individuals and families and their extraordinary generosity and dignity under the most extreme pressure. This book is about realistic optimism and is a celebration of life.It is also a very personal story about David Galler's life, his family and about his own slow coming of age as a doctor, from the sadness and helplessness he felt about his father's death to at last feeling that he was of some use to his most important patient, his mother.

    It is a poignant observation about the relationship between Mira, her sister, and their mentally ill mother. Before she was struck with schizophrenia at the age of nineteen, beautiful piano protégé Norma Herr had been the most vibrant personality in the room. She loved her daughters and did her best to raise them well, but as her mental state deteriorated, Norma spoke less about Chopin and more about Nazis and her fear that her daughters would be kidnapped, murdered, or raped. When the girls left for college, the harassment escalated--Norma called them obsessively, appeared at their apartments or jobs, threatened to kill herself if they did not return home. After a traumatic encounter, Mira and her sister were left with no choice but to change their names and sever all contact with Norma in order to stay safe. But while Mira pursued her career as an artist--exploring the ancient romance of Florence, the eerie mysticism of northern Norway, and the raw desert of Israel--the haunting memories of her mother were never far away. Then one day, Mira’s life changed forever after a debilitating car accident. As she struggled to recover from a traumatic brain injury, she was confronted with a need to recontextualize her life--she had to relearn how to paint, read, and interact with the outside world. In her search for a way back to her lost self, Mira reached out to the homeless shelter where she believed her mother was living and discovered that Norma was dying. Mira and her sister traveled to Cleveland, where they shared an extraordinary reconciliation with their mother that none of them had thought possible. At the hospital, Mira discovered a set of keys that opened a storage unit Norma had been keeping for seventeen years. Filled with family photos, childhood toys, and ephemera from Norma’s life, the storage unit brought back a flood of previous memories that Mira had thought were lost to her forever. The Memory Palace is a breathtaking literary memoir about the complex meaning of love, truth, and the capacity for forgiveness among family. Through stunning prose and original art created by the author in tandem with the text, The Memory Palace explores the connections between mother and daughter that cannot be broken no matter how much exists--or is lost--between them.

    Burroughs is bound to be a trial. After all, the man who frequented lesbian dives and had a fascination with firearms couldn't possibly make that great of a father. Perhaps inevitably, William Jr. (called Billy) referred to himself as "cursed from birth" and in the book of the same name editor David Ohle collects parts of Billy's third and unfinished novel Prakriti Junction, his last journals and poems, and correspondence and conversations to recreate this tortured life. Endowed with the sufferings — but not the patience — of Job, Billy's life was often characterized by tragedy and frustration, although there were also pockets of success and levity. More than just the memoir of a casualty of the Beat Generation, Cursed From Birth provides rare insight in Billy's father, as well as his scene, friends, and times. It also provides an all-too-familiar story of familial difficulties that anyone with difficult parents can understand and appreciate.

    The competition for training fellowship spots is intense. Hundreds of applicants from all over the world compete to be accepted into the Cardiovascular Disease Training Fellowship at Johns Hopkins. Only nine are chosen each year. This is the story of one of those fellows. In Alpha Docs, Daniel Muñoz, M.D., recounts his transformation from wide-eyed young medical student to caring, empathetic professional—providing a rare inside look into the day-to-day operations of one of the world’s most prestigious medical institutions. The training is arduous and often unforgiving, as Muñoz and his colleagues are schooled by a staff of brilliant and demanding physicians. How they learn the art and science of untangling cardiac mysteries, how they live up to the standards of an iconic institution, how they survive the pressures and relentlessly push themselves to reach the top ranks of American medicine, supplies the beating heart of this gripping narrative. Readers accompany Muñoz as he interacts with his mentors, diagnoses and treats patients, counsels worried family members, and struggles to stay awake for days and nights on end. Lives are saved—and sometimes lost. But the rewards are immediate and the incentives powerful. As Muñoz confides after helping to rescue one man from the throes of a heart attack: “I knew where I wanted to be: not watching but doing, on the side of the glass where I can help shape a patient’s fate. I would be a cardiologist.” A unique yet universal story about striving to be the best in a high-risk, high-impact field, Alpha Docs provides fresh perspective on the state of America’s healthcare system as it captures all the fulfillment and frustrations of life as a doctor in the twenty-first century.Praise for Alpha Docs“From the book’s beginning, Dr. Daniel Muñoz captivates readers with [the] life-changing story that decided his future. . . . Thoroughly allows readers to understand how cardiologists are made. Highly recommended.”—Medical Library Association “In simple, compelling prose, Alpha Docs captures the reader’s attention with gripping case histories, the astonishing breadth and complexity of top-notch medical training, and often wry, sometimes pointed character sketches of the attending physicians.”—Hopkins Medicine magazine “An insider’s view of the high-stakes world of cardiology, Alpha Docs offers a vivid and fast-paced exploration of the cauldron that creates doctors in the twenty-first century.”—Danielle Ofri, M.D., Ph.D., author of What Doctors Feel“[A] heartfelt medical-education memoir . . . a successful portrayal of just how hard it is, intellectually, emotionally, and physically, to train as a physician specialist.”—Booklist “This engaging book will interest those considering a career in medicine as well as readers who want to learn more about cardiology.

    From Zoroastrian sky burials to wish-granting Bolivian skulls, she investigates the world’s funerary customs and expands our sense of what it means to treat the dead with dignity. Her account questions the rituals of the American funeral industry—especially chemical embalming—and suggests that the most effective traditions are those that allow mourners to personally attend to the body of the deceased. Exquisitely illustrated by artist Landis Blair, From Here to Eternity is an adventure into the morbid unknown, a fascinating tour through the unique ways people everywhere confront mortality.

    It was inside, inside my head, where all had become so wretchedly different. I had the night before been incontrovertibly a man of stable mood, of calm, of good cheer and unforced bonhomie. Now I had become changed, with dreadful suddenness, into another being altogether.”Simon Winchester has never shied away from big, even enormous, topics—as evidenced by his bestselling biography of the Atlantic Ocean, his account of the Krakatoa volcanic eruption, and his wildly popular “The Professor and the Madman,” about the making of the Oxford English Dictionary. In his Byliner Original “The Man with the Electrified Brain,” he takes on arguably his most daunting subject yet: his own flirtation with madness, and one of nature’s greatest and most enduring mysteries, the human brain. As a geology student in his second year at Oxford, Winchester was known as a young man of even temper and keen intellect, until one June morning when he woke to find himself “changed with dreadful suddenness into another being altogether,” his normal life “slumped into chasm” and “folded in the dirt.” For a period of nine days, he lived in immobilizing fear. Everyday items—familiar paintings, a pile of books, his own robe hanging from a hook—became objects of horror; the world lost color, purpose, all sense and safety. When the episode finally passed, he returned to normal, presuming that what had happened to him was a fluke. It wasn’t. The episode repeated itself at unpredictable and dangerous intervals for four years—always lasting for nine days—and very nearly caused the author’s death while he was on an expedition in the Arctic. What was wrong with him? Where could he find help? Would he spend the rest of his life anticipating the return of these mental blackouts? With the urgency of a whodunit, Winchester describes the coming and going of these terrifying dissociative states and the chance encounter that led to the controversial treatment of electroconvulsive therapy, which may or may not have cured him once and for all. Written by a consummate storyteller, “The Man with the Electrified Brain” locates that finest of lines between sanity and insanity and is Winchester’s most riveting and deeply personal work yet.

    At first I tried to deny my condition (trying to treat a tumor with hot baths and ice packs). Eventually, I decided I would learn as much about my illness as possible while trying to keep my emotions on hold.What followed was an experience that finally forced me to deal with issues about my body that I had tried to ignore for decades. Along the way I dealt with a physician who gave me ridiculous advice and acquaintances who asked unbelievable questions. But I was also fortunate to be surrounded by people who supported me and doctors who helped me through the process.

    With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.