But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    In The Boy Who Was Raised as a Dog, he tells their stories of trauma and transformation through the lens of science, revealing the brain's astonishing capacity for healing. Deftly combining unforgettable case histories with his own compassionate, insightful strategies for rehabilitation, Perry explains what exactly happens to the brain when a child is exposed to extreme stress-and reveals the unexpected measures that can be taken to ease a child's pain and help him grow into a healthy adult. Through the stories of children who recover-physically, mentally, and emotionally-from the most devastating circumstances, Perry shows how simple things like surroundings, affection, language, and touch can deeply impact the developing brain, for better or for worse. In this deeply informed and moving book, Bruce Perry dramatically demonstrates that only when we understand the science of the mind can we hope to heal the spirit of even the most wounded child.

    Champagne drunk. My mouth was stretched in a smile so wide, that my jaw hurt. The sky had the colours of a bruise.' When Nick Johnstone got drunk for the first time at the age of fourteen he discovered a cure for the depression and anxiety that had been humming in his head since childhood. Over the next ten years he drank to overcome shyness, to make the world bearable, to get through the days and to get through the nights. He also began to cut himself and he began to lie. Intelligent, sensitive, from a loving family, neither he nor his countless doctors, psychiatrists, counsellors and therapists could understand where his disorders came from. Then, when he was twenty-four he was admitted into hospital. Stripped of his 'cure', Nick Johnstone painfully began the process of recovery. Although love proves to be the strongest 'cure' of all, this is a story with no tidy or happy endings. Honest and gripping, by turns stark and lyrical, "A Head Full of Blue" powerfully evokes the often unfathomable psychology and behaviour that drives addiction, examining self-harm as a coping mechanism rather than a taboo. It is an unusual, moving and thought-provoking memoir.

    No one in this radical splinter sect of the Mormon Church was more powerful or terrifying than its leader Warren Jeffs—Rachel’s father.Living outside mainstream Mormonism and federal law, Jeffs arranged marriages between under-age girls and middle-aged and elderly members of his congregation. In 2006, he gained international notoriety when the FBI placed him on its Ten Most Wanted List. Though he is serving a life sentence for child sexual assault, Jeffs’ iron grip on the church remains firm, and his edicts to his followers increasingly restrictive and bizarre.In Breaking Free, Rachel blows the lid off this taciturn community made famous by John Krakauer’s bestselling Under the Banner of Heaven to offer a harrowing look at her life with Warren Jeffs, and the years of physical and emotional abuse she suffered. Sexually assaulted, compelled into an arranged polygamous marriage, locked away in "houses of hiding" as punishment for perceived transgressions, and physically separated from her children, Rachel, Jeffs’ first plural daughter by his second of more than fifty wives, eventually found the courage to leave the church in 2015. But Breaking Free is not only her story—Rachel’s experiences illuminate those of her family and the countless others who remain trapped in the strange world she left behind.A shocking and mesmerizing memoir of faith, abuse, courage, and freedom, Breaking Free is an expose of religious extremism and a beacon of hope for anyone trying to overcome personal obstacles.

    With a child’s uncluttered eye, she describes the small details—shopping in the market, men waiting for work at the dock gates, the rituals of washday, and the sights, sounds, and smells of the old East End of London. She also describes the fear—of illness, of unemployment, of the workhouse—that hung over her family and thousands like them, and her determination that her own children would never know the kind of poverty she had experienced.

    But it was only when his own son-in the throes of a manic episode-broke into a neighbor's house that he learned what happens to mentally ill people who break a law. This is the Earley family's compelling story, a troubling look at bureaucratic apathy and the countless thousands who suffer confinement instead of care, brutal conditions instead of treatment, in the "revolving doors" between hospital and jail. With mass deinstitutionalization, large numbers of state mental patients are homeless or in jail-an experience little better than the horrors of a century ago. Earley takes us directly into that experience-and into that of a father and award-winning journalist trying to fight for a better way.

    He has confronted, interviewed and researched dozens of serial killers and assassins, including Charles Manson, Richard Speck, John Wayne Gacy, and James Earl Ray - for a landmark study to understand their motives. To get inside their minds. He is Special Agent John Douglas, the model for law enforcement legend Jack Crawford in Thomas Harris's thrillers Red Dragon and The Silence of the Lambs, and the man who ushered in a new age in behavorial science and criminal profiling. Recently retired after twenty-five years of service, John Douglas can finally tell his unique and compelling story.

    

    Soon it was gone, only to be succeeded by another. And another. Strange, Karinthy thought, it had been years since Budapest had streetcars. Only then did he realize he was suffering from an auditory hallucination of extraordinary intensity. What in fact Karinthy was suffering from was a brain tumor, not cancerous but hardly benign, though it was only much later—after spells of giddiness, fainting fits, friends remarking that his handwriting had altered, and books going blank before his eyes—that he consulted a doctor and embarked on a series of examinations that would lead to brain surgery. Karinthy’s description of his descent into illness and his observations of his symptoms, thoughts, and feelings, as well as of his friends’ and doctors’ varied responses to his predicament, are exact and engrossing and entirely free of self-pity. A Journey Round My Skull is not only an extraordinary piece of medical testimony, but a powerful work of literature—one that dances brilliantly on the edge of extinction.

    What happens next is downright frightening.Surgery saves Ken’s life but improper care sends him spiraling into madness. Unable to fend for himself, his wife Beth takes charge. She does her best to save him but the unyielding stigma of mental illness hampers his recovery at every turn until he is beyond hope.Desperate to get Ken the help that he needs, Beth makes a heartbreaking decision: she brands the man she loves a “danger to himself and others” and commits him to psychiatric treatment. A police SUV then delivers him to a high-security facility where the real nightmare begins. Plagued by the pitfalls of contemporary psych wards, Ken struggles through living hell. Nevertheless, as the days stretch to weeks, he finds solace by befriending the lost and forgotten and helping patients with worse problems than his.Featured in Amazon Prime Reading and spotlighted as Great on Kindle, Detour from Normal will touch your heart in ways that you never imagined and make you question your faith in our medical and mental health systems.What readers are saying:“A massive amount of emotion rolled into a page-turner.”“An enlightening and dare I say frightening glimpse into the world of mental health care.”“This is a story you will want to share with the people you know and love.”“Scary, life-changing and inspiring!”“Powerful and gripping.”“A psychological thriller, medical mystery, and compelling drama—made all the more vivid because it actually happened.”

    Although labeled, at times, deaf, retarded, or disturbed, Donna Williams is autistic--afflicted by a baffling condition of heightened sensory perception that imprisons the sufferer in a private, almost hallucinatory universe of patterns and colors. Nobody Nowhere is Donna's story in her own words--a haunting, courageous memoir of the titanic struggles she has endured in her quest to merge "my world" with "the world."

    Linnea Smith went to Peru on an ecotourism vacation. She was so moved that she abandoned her thriving medical practice in Wisconsin to serve the Yagua Indians in the deepest part of the Amazon rainforest of Peru-alone.Taken straight from the pages of Dr. Smith’s journal, La Doctora offers readers a rare glimpse into the suspense and drama of practicing medicine in a culture far removed from the sophisticated supplies and supports of 20th-century medicine.Learn how Dr. Smith evolved from a “strange white woman” to an adopted member of the indigenous community. Her story of adventure, self-discovery and service creates inspiring testimony to one person’s power to make a lasting difference.

    But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into the story of Western medicine, how we have got it wrong as well as right in the past, and how we could start getting to grips with depression and other mental disorders much more effectively in the future.

     Whether eating, taking drugs, engaging in sex, or doing good deeds, the pursuit of pleasure is a central drive of the human animal. In The Compass of Pleasure Johns Hopkins neuroscientist David J. Linden explains how pleasure affects us at the most fundamental level: in our brain. As he did in his award-winning book, The Accidental Mind, Linden combines cutting-edge science with entertaining anecdotes to illuminate the source of the behaviors that can lead us to ecstasy but that can easily become compulsive. Why are drugs like nicotine and heroin addictive while LSD is not? Why has the search for safe appetite suppressants been such a disappointment? The Compass of Pleasure concludes with a provocative consideration of pleasure in the future, when it may be possible to activate our pleasure circuits at will and in entirely novel patterns.

    John Fitzgerald was a Canadian hero. He founded Connaught Labs, saved untold lives with his vaccines and transformed the idea of public health in Canada and the world. What so darkened his reputation that his memory has been all but erased?A sensitive, withdrawn boy is born into the gothic house of his long dead grandfather, a brilliant yet tormented pathologist of Irish blood and epic accomplishment whose memory has been mysteriously erased from public consciousness. As the boy watches his own father - also an eminent doctor - plunge into a suicidal psychosis, he intuits, as the psychiatrists do not, some unspeakable secret buried like a tumour deep in the multi-generational layers of the family unconscious. Growing into manhood, he knows in his bones that he must stalk an ancient curse before it stalks him. To set himself free, he must break the silence and put words to the page. His future lies in the past.