The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.In Pandemics: What Everyone Needs to Know�, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know� series.What Everyone Needs to Know� is a registered trademark of Oxford University Press.

    . . when it comes to the legacy of this country's war on drugs, we should all share his outrage." --The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy lifeDr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a colleague, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism.Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars.Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

    

    But what should we change and how do we do it? Annabel Streets and Susan Saunders spent their 30s climbing the career ladder, having children and caring for elderly parents - all at the same time. By their 40s, they were exhausted, stressed, sleeping too little and rushing too much. They began to ask whether the prolonged ill health and dementia suffered by their parents was their inevitable future too - could they do anything to avoid requiring their own children to care for them in old age? Thus began THE AGE-WELL PROJECT. With incredible tenacity, Annabel and Susan read 50,000 scientific research papers on all aspects of ageing to find what advice cutting-edge research can offer us on how to ensure the longer lives we're living are healthy and happy. Putting their findings into practice, they found that the lifestyle changes they made were having incredible benefits on their health and wellbeing now - as well as for the future. Told with empathy and humour, in THE AGE-WELL PROJECT Annabel and Susan share the 50 key lessons they learned, the meals they cooked and the experts' tips they uncovered to make the second half of your life the best half of your life - happy, healthy and disease-free. Author BiographyAnnabel was a founder member of an award-winning marketing company, advising the chief executives of companies such as Sony, Reuters and the Financial Times. After four children, and at breaking point, she sold her company. Following a stint studying photography and producing a community cook book, she changed tack and wrote an award-winning novel The Joyce Girl which sold in 14 countries and was selected for the 2017 Berlin Film Festival. Since then she has written regularly for a range of titles including the Daily Telegraph, Psychologies, The Author, the Guardian, The Irish Times, Elle, Australian

    But we should--even those of us who take care of our business in pristine, sanitary conditions. For it's not only in developing countries that human waste is a major public health threat: population growth is taxing even the most advanced sewage systems, and the disease spread by waste kills more people worldwide every year than any other single cause of death. Even in America, 1.95 million people have no access to an indoor toilet. Yet the subject remains unmentionable."The Big Necessity "takes aim at the taboo, revealing everything that matters about how people do--and don't--deal with their own waste. Moving from the deep underground sewers of Paris, London, and New York--an infrastructure disaster waiting to happen--to an Indian slum where ten toilets are shared by 60,000 people, Rose George stops along the way to explore the potential saviors: China's five million biogas digesters, which produce energy from waste; the heroes of third world sanitation movements; the inventor of the humble Car Loo; and the U.S. Army's personal lasers used by soldiers to zap their feces in the field.With razor-sharp wit and crusading urgency, mixing levity with gravity, Rose George has turned the subject we like to avoid into a cause with the most serious of consequences.

    Too bad. Because medicine isn't an industry, it's practically witchcraft. Despite the growth of big pharma, HMOs, and hospital chains, medicine remains the isolated work of individual doctors—and the system is going broke fast.So why is Andy Kessler—the man who told you outrageous stories of Wall Street analysts gone bad in Wall Street Meat and tales from inside a hedge fund in Running Money—poking around medicine for the next big wave of technology?It's because he smells change coming. Heart attacks, strokes, and cancer are a huge chunk of medical spending, yet there's surprisingly little effort to detect disease before it's life threatening. How lame is that—especially since the technology exists today to create computer-generated maps of your heart and colon?Because it's too expensive—for now. But Silicon Valley has turned computing, telecom, finance, music, and media upside down by taking expensive new technologies and making them ridiculously cheap. So why not the $1.8 trillion health care business, where the easiest way to save money is to stop folks from getting sick in the first place?Join Kessler's bizarre search for the next big breakthrough as he tries to keep from passing out while following cardiologists around, cracks jokes while reading mammograms, and watches twitching mice get injected with radioactive probes. Looking for a breakthrough, Kessler even selflessly pokes, scans, and prods himself.CT scans of your heart will identify problems before you have a heart attack or stroke; a nanochip will search your blood for cancer cells--five years before they grow uncontrollably and kill you; and baby boomers can breathe a little easier because it's all starting to happen now.Your doctor can't be certain what's going on inside your body, but technology will. Embedding the knowledge of doctors in silicon will bring a breakout technology to health care, and we will soon see an end of medicine as we know it.

    It's become more expensive, more exclusive, and effectively off-limits to huge swaths of the potential sports-loving population. Youth registration numbers are stagnant; efforts to appeal to new Canadians are often grim at best; the game, increasingly, does not resemble the country of which it's for so long been an integral part. These signs worried Sean Fitz-Gerald. As a lifelong hockey fan and father of a young mixed-race son falling headlong in love with the game, he wanted to get to the roots of these issues. His entry point: a season with the Peterborough Petes, a storied OHL team far from its former glory in a once-emblematic Canadian city that is finding itself on the wrong side of the country's changing demographics. Fitz-Gerald profiles the players, coaches and front office staff, a mix of world-class talents with NHL aspirations and Peterborough natives happy with more modest dreams. Through their experiences, their widely varied motivations and expectations, we get a rich, colourful understanding of who ends up playing hockey in Canada and why. Fitz-Gerald interweaves the action of the season with portraits of public figures who've shaped and been shaped by the game: authors who captured its spirit, politicians who exploited it, and broadcasters who try to embody and sell it. He finds his way into community meetings full of angry season ticket holders, as well as into sterile boardrooms full of the sport's institutional brain trust, unable to break away from the inertia of tradition and hopelessly at war with itself. Before the Lights Go Out is a moving, funny, yet unsettling picture of a sport at a crossroads. Fitz-Gerald's warm but rigorous journalistic approach reads, in the end, like a letter to a troubled friend: it's not too late to save hockey in this country, but who has the will to do it?

    Organized conceptually around the major fields of medical endeavour - anatomy, physiology, pathology, pharmacology, surgery, obstetrics, psychiatry, pediatrics, and family medicine - this book is an accessible overview of medical history as a vibrant component of social, intellectual, and cultural history, and as a research discipline in its own right.Each chapter begins in antiquity and ends in the twentieth century. Throughout, Duffin shows that alternative interpretations can be found for most elements of our past and that topics of interest can go well beyond 'great men' and 'great discoveries' to include ideas, diseases, patients, institutions, and great mistakes. This approach does not mean that the 'great men' (and women) are neglected; rather they appear in context. Medical disasters such as chloramphenicol and thalidomide, are covered along with the triumphs, and examples from Canada's past, largely ignored in other medical histories, are included. A chapter on methodology, suggestions for further reading with special attention to Canadian sources, and a careful index make it possible to research a specific event or historical debate, or to satisfy a more general curiosity.By presenting the material in a structure that resonates with the broad outlines of medical training, and by focusing on the questions asked most often, this text is a relevant guide for students to the history of the profession they are about to embrace, and for those who would teach them, be they physicians or historians. Duffin's clear and entertaining prose and the many illustrations will help to demystify medicine for general readers and for students in other domains, such as history, philosophy, and sociology.

    In the majority of cases individuals diagnosed as "brain dead" are the source of the organs without which transplants could not take place. In this compelling and provocative examination, Margaret Lock traces the discourse over the past thirty years that contributed to the locating of a new criterion of death in the brain, and its routinization in clinical practice in North America. She compares this situation with that in Japan where, despite the availability of the necessary technology and expertise, brain death was legally recognized only in 1997, and then under limited and contested circumstances. Twice Dead explores the cultural, historical, political, and clinical reasons for the ready acceptance of the new criterion of death in North America and its rejection, until recently, in Japan, with the result that organ transplantation has been severely restricted in that country. This incisive and timely discussion demonstrates that death is not self-evident, that the space between life and death is historically and culturally constructed, fluid, multiple, and open to dispute. In addition to an analysis of that professional literature on and popular representations of the subject, Lock draws on extensive interviews conducted over ten years with physicians working in intensive care units, transplant surgeons, organ recipients, donor families, members of the general public in both Japan and North America, and political activists in Japan opposed to the recognition of brain death. By showing that death can never be understood merely as a biological event, and that cultural, medical, legal, and political dimensions are inevitably implicated in the invention of brain death, Twice Dead confronts one of the most troubling questions of our era.

    There was atime when this revered organization ranked among the lowest in the country in this area. Within ten years, however, it had climbed to among the highest and has emerged as the thought leader in the space.How did Cleveland Clinic turn itself around so effectively and so quickly?More important, how can you do the same with your organization?In gripping, visceral, on-the ground fashion, Service Fanatics reveals the strategies and tactics the Clinic applied to become one of today's leading patient-experience healthcare organizations--methods that seamlessly translate to any business seeking to improveits customer experience. This strategic guide covers:How the Clinic's leaders redefined the concept of patient experience and developed a strategy to improve itCritical lessons learned regarding organization, recruitment, training, and measuring service excellenceWays in which the Clinic aligned its entire workforce around its Patients First strategyHow leaders improved the critical element of physician communicationRather than view patients simply as sick people who need treatment, Cleveland Clinic sees them also as important stakeholders in the organization's success. Patients are customers--who desire, pay for, and deserve the best possible care and experience during what is often a challenging time in their lives.Featuring customer service case studies, as well as invaluable insight from C-level executives at top corporations in various industries, Service Fanatics provides actionable lessons for any manager and business leader beyond healthcare.Whether you run a healthcare institution, nonprofit, or for-profit business, Service Fanatics will help you create the kind of customer experience that promises to transform your organization into an industry powerhouse.

    Covid by Numbers is comprehensive yet concise, impeccably clear and always humane' Tim HarfordHow many people have died because of COVID-19? Which countries have been hit hardest by the virus? What are the benefits and harms of different vaccines? How does COVID-19 compare to the Spanish flu? How have the lockdown measures affected the economy, mental health and crime?This year we have been bombarded by statistics - seven day rolling averages, rates of infection, excess deaths. Never have numbers been more central to our national conversation, and never has it been more important that we think about them clearly. In the media and in their Observer column, Professor Sir David Spiegelhalter and RSS Statistical Ambassador Anthony Masters have interpreted these statistics, offering a vital public service by giving us the tools we need to make sense of the virus for ourselves and holding the government to account.In Covid by Numbers, they crunch the data on a year like no other, exposing the leading misconceptions about the virus and the vaccine, and answering our essential questions. This timely, concise and approachable book offers a rare depth of insight into one of the greatest upheavals in history, and a trustworthy guide to these most uncertain of times.

    Mao Zedong threw his country into a frenzy with the Great Leap Forward, an attempt to catch up and overtake Britain in less than 15 years. The experiment ended in the greatest catastrophe the country had ever known, destroying tens of millions of lives. Access to Communist Party archives has long been denied to all but the most loyal historians, but now a new law has opened up thousands of central and provincial documents that fundamentally change the way one can study the Maoist era. Frank Dikotter's astonishing, riveting and magnificently detailed book chronicles an era in Chinese history much speculated about but never before fully documented. Dikotter shows that instead of lifting the country among the world's superpowers and proving the power of communism, as Mao imagined, in reality the Great Leap Forward was a giant - and disastrous -- step in the opposite direction. He demonstrates, as nobody has before, that under this initiative the country became the site not only of one of the most deadly mass killings of human history (at least 45 million people were worked, starved or beaten to death) but also the greatest demolition of real estate - and catastrophe for the natural environment - in human history, as up to a third of all housing was turned to rubble and the land savaged in the maniacal pursuit of steel and other industrial accomplishments. Piecing together both the vicious machinations in the corridors of power and the everyday experiences of ordinary people, Dikotter at last gives voice to the dead and disenfranchised. Exhaustively researched and brilliantly written, this magisterial, groundbreaking account definitively recasts the history of the People's Republic of China.

    He threw himself into the study of medicine and excelled—winning a Rhodes Scholarship, earning two advanced degrees, and landing a tenure-track position at Columbia University. At 30, he became the youngest city health official in America, tasked with rebuilding Detroit's health department after years of austerity policies.    But El-Sayed found himself disillusioned. He could heal the sick—even build healthier and safer communities—but that wouldn’t address the social and economic conditions causing illness in the first place. So he left health for politics, running for Governor of Michigan and earning the support of progressive champions like Congresswoman Alexandria Ocasio-Cortez-Cortez and Senator Bernie Sanders.    In Healing Politics, El-Sayed traces the life of a young idealist, weaving together powerful personal stories and fascinating forays into history and science. Marrying his unique perspective with the science of epidemiology, El-Sayed diagnoses an underlying epidemic afflicting our country, an epidemic of insecurity. And to heal the rifts this epidemic has created, he lays out a new direction for the progressive movement. This is a bold, personal, and compellingly original book from a prominent young leader.

    As was the case with Gore's first movie (An Inconvenient Truth), the movie is bursting with bad science, bad policy and some outright falsehoods. The storm events Gore addresses occur naturally, and there is little or no evidence they are being made worse from human activities: sea level is rising at the same rate it was before humans started burning fossil fuels; in Miami Beach the natural rise is magnified because buildings and streets were constructed on reclaimed swampland that has been sinking; the 9/11 memorial was not flooded by sea level rise from melting ice sheets, but a storm surge at high tide, which would have happened anyway and was not predicted by Gore in his first movie, as he claims; the Greenland ice sheet undergoes melt every summer, which was large in 2012 but then unusually weak in 2017; glaciers advance and retreat naturally, as evidenced by 1,000 to 2,000 year old tree stumps being uncovered in Alaska; rain gauge measurements reveal the conflict in Syria was not caused by reduced rainfall hurting farming there, and in fact the Middle East is greening from increasing CO2 in the atmosphere; agricultural yields in China have been rising, not falling as claimed by Gore. The renewable energy sources touted by Gore (wind and solar), while a laudable goal for our future, are currently very expensive: their federal subsidies per kilowatt-hour of energy produced are huge compared to coal, natural gas, and nuclear power. These costs are hidden from the public in increased federal and state tax rates. Gore is correct that "it is right to save humanity", but what we might need saving from the most are bad decisions that reduce prosperity and hurt the poor.

    Soon Gen Xers will be the only cohort of Americans who remember life as it was lived before the arrival of the Internet. They are, as Hennessey dubs them, “the last adult generation,” the sole remaining link to a time when childhood was still a bit dangerous but produced adults who were naturally resilient. More than a decade into the social media revolution, the American public is waking up to the idea that the tech sector’s intentions might not be as pure as advertised. The mountains of money being made off our browsing habits and purchase histories are used to fund ever-more extravagant and utopian projects that, by their very natures, will corrode the foundations of free society, leaving us all helpless and digitally enslaved to an elite crew of ultra-sophisticated tech geniuses. But it’s not too late to turn the tide. There’s still time for Gen X to write its own future. A spirited defense of free speech, eye contact, and the virtues of patience, Zero Hour for Gen X is a cultural history of the last 35 years, an analysis of the current social and historical moment, and a generational call to arms.