For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as 'junk'. But in recent years researchers have discovered that variations in this 'junk' DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself - and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

    It’s in the fibers in your hair, the timbers in your walls, the food that you eat, and the air that you breathe. It’s worth billions as a luxury and half a trillion as a necessity, but there are still mysteries yet to be solved about the element that can be both diamond and coal. Where does it come from, what does it do, and why, above all, does life need it?With poetic storytelling, earth scientist Robert Hazen leads us on a global journey through the origin and evolution of life’s most ubiquitous element. The story unfolds in four movements—Earth, Air, Fire, and Water—and transports us through 14 billion years of cosmic history.From the archives of Harvard to the cliffs of Scotland and into the preciousmetal mines of Namibia, Symphony in C is a sweeping chronicle of carbon: the most essential element on Earth.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    I watched my mother waste her life dreaming of a man who left her without a second glance. As a woman, I don’t dream, I work. I don’t fall in love, I focus. I would never let anything as frivolous as love distract me. Until I meet Simon. A gorgeous, brilliant young architect with dark eyes, a sweet smile, and a dirty, dirty mouth. He sets me on fire, and suddenly all I can do is dream…of his hands, his lips, his body. Of a heart good enough and a love strong enough to make me believe in happily ever after. But Simon has secrets that are even deeper than mine. Will our pasts destroy everything we’ve worked for? Or will we find the courage to rise to the challenge and fight for the love we share?

    She doesn't fall over herself to gain the attention of the gruff and virile stablemaster, Rufus Blackthorne. She performs her duties most diligently, hoping one day to become housekeeper of the grand ducal manor.Stranded together, anything can happen...When Vera is forced to take shelter from a storm with the big, handsome stablemaster in a cottage with just one bed, she can't deny the sparks flying between them. Nor can Blackthorne deny how much he wants to strip the prickly housemaid of her wet garments and get her into that bed.In Bed with the Stablemaster is set in the Rogue Files world and can be read as a stand-alone, but it does tie into the series. Basically, it's a very sexy love story happening "belowstairs" between a housemaid and the stablemaster... while The Virgin and the Rogue is happening upstairs.

    with life life as the prize?PLUS * seven other superb stories * four horrible puns * a trible feghoot * four original songs, with E-Z Play chords * foreword, afterwords, illustrations, and a weapons list9 • Introduction: Welcome to the Antinomy Mine • essay by Spider Robinson13 • Antinomy • (1978) • novelette by Spider Robinson48 • Afterword to "Antinomy" • essay by Spider Robinson51 • Half an Oaf • (1976) • novelette by Spider Robinson79 • Rhythms and 'Rithms • short fiction by Spider Robinson79 • Tidbit: two puns • short story by Spider Robinson80 • The Shamin' of the Shaman • short fiction by Spider Robinson81 • Too Soon We Grow Old • (1978) • short story by Spider Robinson98 • Valkyrie Ride • poem by Spider Robinson98 • Tidbit: two songs • poem by Spider Robinson102 • Feed Me Fire • poem by Spider Robinson105 • When No Man Pursueth • (1974) • novelette by Spider Robinson139 • Tidbit: afterword to "When No Man Pursueth" • essay by Spider Robinson144 • Nobody Likes to Be Lonely • (1975) • novelette by Spider Robinson186 • Tidbit: interleaf • essay by Spider Robinson188 • Satan's Children • (1979) • novella by Spider Robinson229 • Three-Time Winner • short fiction by Spider Robinson229 • Tidbit: a triple Feghoot and a cartoon • short story by Spider Robinson231 •  Cartoon: "Sorry, Mr. Griffin: he says he can't see you now." • interior artwork by Spider Robinson232 • Apogee • (1978) • short story by Spider Robinson236 • A Standing Joke • short fiction by Spider Robinson237 • The Snoopy Scientist • short fiction by Spider Robinson238 • Tidbit: two puns (includes some artwork) • short story by Spider Robinson240 • No Renewal • (1977) • short story by Spider Robinson246 • Tidbit: afterword (to "No Renewal"), an illo, and a weapons list • essay by Spider Robinson247 • Through My Eyes- illustration of Mike Callahan • essay by Spider Robinson248 • Silly Weapons Throughout History • (1980) • essay by Spider Robinson251 • Overdose • (1975) • short story by Spider Robinson262 • Perspective • poem by Spider Robinson262 • Tidbit: two more songs • poem by Spider Robinson265 • Mountain Lady • poem by Spider Robinson268 • Tin Ear • (1977) • short story by Spider Robinson277 • Tidbit: foreword to "The Magnificent Conspiracy" • essay by Spider Robinson280 • The Magnificent Conspiracy • (1977) • novelette by Spider Robinson310 • This Time Next Year • poem by Spider Robinson311 • Come to My Bedside • poem by Spider Robinson

    It has built on itself for centuries, becoming vast and increasingly specialized. Most of us are ignorant about the fundamental principles of the civilization that supports us, happily utilizing the latest—or even the most basic—technology without having the slightest idea of why it works or how it came to be. If you had to go back to absolute basics, like some sort of postcataclysmic Robinson Crusoe, would you know how to re-create an internal combustion engine, put together a microscope, get metals out of rock, accurately tell time, weave fibers into clothing, or even how to produce food for yourself? Regarded as one of the brightest young scientists of his generation, Lewis Dartnell proposes that the key to preserving civilization in an apocalyptic scenario is to provide a quickstart guide, adapted to cataclysmic circumstances. The Knowledge describes many of the modern technologies we employ, but first it explains the fundamentals upon which they are built. Every piece of technology rests on an enormous support network of other technologies, all interlinked and mutually dependent. You can’t hope to build a radio, for example, without understanding how to acquire the raw materials it requires, as well as generate the electricity needed to run it. But Dartnell doesn’t just provide specific information for starting over; he also reveals the greatest invention of them all—the phenomenal knowledge-generating machine that is the scientific method itself. This would allow survivors to learn technological advances not explicitly explored in The Knowledge as well as things we have yet to discover. The Knowledge is a brilliantly original guide to the fundamentals of science and how it built our modern world as well as a thought experiment about the very idea of scientific knowledge itself.

    It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict?In a blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores the morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function.Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom.

    From these basics, they sought to understand the essential ingredients of the world. Those who could see further, those who understood that the four were just the beginning, were the last sorcerers ? and the world's first chemists.What we now call chemistry began in the fiery cauldrons of mystics and sorcerers seeking not to make a better world through science, but rather to make themselves richer through magic formulas and con games. But among these early magicians, frauds, and con artists were a few far-seeing alchemists who, through rigorous experimentation, transformed mysticism into science.By the 18th century the building blocks of nature, the elements of which all matter is composed, were on the verge of being discovery. Initially, it was not easy to determine whether a substance really was an element. Was water just water, plain and simple? Or could it be the sum of other (unknown and maybe unknowable) parts? And if water was made up of other substances, how could it be broken down into discreet, fundamental, and measurable components?Scientific historians generally credit the great 18th century French chemist Antoine Lavoisier with addressing these fundamental questions and ultimately modernizing the field of chemistry. Through his meticulous and precise work this chaotic new field of scientific inquiry was given order. Exacting by nature, Lavoisier painstakingly set about performing experiments that would provide lasting and verifiable proofs of various chemical theories. Unfortunately, the outspoken Lavoisier eventually lost his head in the Terror, but others would follow his lead, carefully examining, measuring, and recording their findings.As the field slowly progressed, another pioneer was to emerged almost 100 years later. Dimitri Mendeleev, an eccentric genius who cut his flowing hair and beard but once a year, sought to answer the most pressing questions that remained to chemists: Why did some elements have properties that resembled those of others? Were there certain natural groups of elements? And, if so, how many, and what elements fit into them? It was Mendeleev who finally addressed all these issues when he constructed the first Periodic Table in the late 1800s.But between and after Lavoisier and Mendeleev were a host of other colorful, brilliant scientists who made their mark on the field of chemistry. Depicting the lively careers of these scientists and their contributions while carefully deconstructing the history and the science, author Richard Morris skillfully brings it all to life. Hailed by Kirkus Reviews as a clear and lively writer with a penchant for down-to-earth examples Morris's gift for explanation ? and pure entertainment ? is abundantly obvious. Taking a cue from the great chemists themselves, Morris has brewed up a potent combination of the alluringly obscure and the historically momentous, spiked with just the right dose of quirky and ribald detail to deliver a magical brew of history, science, and personalities.

    Each volume’s series editor selects notable works from hundreds of magazines, journals, and websites. A special guest editor, a leading writer in the field, then chooses the best twenty or so pieces to publish. This unique system has made the Best American series the most respected—and most popular—of its kind. The Best American Science and Nature Writing 2011 includes Atul Gawande, Jonathan Franzen, Deborah Blum, Malcolm Gladwell, Oliver Sacks, Jon Mooallem, Jon Cohen, Luke Dittrich, and others

    He shows that weight gain is driven by genetic, hormonal factors - and not overeating or 'gluttony' as is commonly the underlying suggestion - citing compelling evidence that people with the propensity to fatten easily can be helped best by a low carbohydrate high-fat diet.This groundbreaking read offers hope to anyone wishing to prevent or reverse diabetes or obesity - as well as anyone wanting to eat more healthily - and will fundamentally change our habits around food forever.

    Every time we cook, clean, take a shower, drive a car, use a solvent, such as fingernail polish remover, or perform any of the countless everyday activities that involve complex chemical reactions we're doing chemistry. You might even say that we're all participating in a grand chemistry experiment that started with the first human who mixed pigments to do a cave painting. Why do so many of us desperately resist learning chemistry when we're young? Maybe it has something to do with the way it's taught in school. Now there's a fun, easy way to learn basic chemistry. Whether you're studying chemistry in school and you're looking for a little help making sense of what's being taught in class, or you're just into learning new things for their own sake, Chemistry For Dummies gets you rolling with all the basics of matter and energy, atoms and molecules, acids and bases, and much more. In no time you'll:Understand atomic structure and function Use the Periodic Table of elements Know what happens when matter changes from one state to another Explore ionic and covalent bonding Get a handle on chemical reactions Perform simple chemistry calculations Understand acids, bases, pHs, antacids, and gases Make sense Boyle's Law, Avrogadro's Law and other key laws in chemistry Packed with examples of chemistry in action in everyday life, Chemistry For Dummies is a fascinating exploration of broad range of topics in chemistry, including:States of matter, from the macroscopic to the microscopic Understanding how the elements are arranged in the Periodic Table Nuclear chemistry, radioactivity and radioactive decay Positive and negative ions and ionic compounds Covalent bonding in covalent compounds Chemical reactions, chemical equilibrium, and electrochemistry The mole and how it's used to calculate chemical reactions Great serendipitous discoveries in chemistry Environmental chemistry Written in plain English and requiring only basic math, Chemistry For Dummies puts you on the fast track to mastering the basics of chemistry.

    Featuring the imprimatur of bestselling author and New York Times reporter Gina Kolata, one of the nation's foremost voices in science and medicine, and with contributions from Atul Gawande, Elizabeth Kolbert, and Oliver Sacks, among others, The Best American Science Writing 2007 is a compelling anthology of our most advanced, and most relevant, scientific inquiries.