In 1967, Dr. D.A. Henderson became director of a worldwide campaign to eliminate this disease from the face of the earth.This spellbinding book is Dr. Henderson’s personal story of how he led the World Health Organization’s campaign to eradicate smallpox—the only disease in history to have been deliberately eliminated. Some have called this feat "the greatest scientific and humanitarian achievement of the past century."In a lively, engrossing narrative, Dr. Henderson makes it clear that the gargantuan international effort involved more than straightforward mass vaccination. He and his staff had to cope with civil wars, floods, impassable roads, and refugees as well as formidable bureaucratic and cultural obstacles, shortages of local health personnel and meager budgets. Countries across the world joined in the effort; the United States and the Soviet Union worked together through the darkest cold war days; and professionals from more than 70 nations served as WHO field staff. On October 26, 1976, the last case of smallpox occurred. The disease that annually had killed two million people or more had been vanquished–and in just over ten years.The story did not end there. Dr. Henderson recounts in vivid detail the continuing struggle over whether to destroy the remaining virus in the two laboratories still that held it. Then came the startling discovery that the Soviet Union had been experimenting with smallpox virus as a biological weapon and producing it in large quantities. The threat of its possible use by a rogue nation or a terrorist has had to be taken seriously and Dr. Henderson has been a central figure in plans for coping with it.New methods for mass smallpox vaccination were so successful that he sought to expand the program of smallpox immunization to include polio, measles, whooping cough, diphtheria, and tetanus vaccines. That program now reaches more than four out of five children in the world and is eradicating poliomyelitis.This unique book is to be treasured—a personal and true story that proves that through cooperation and perseverance the most daunting of obstacles can be overcome.

    Yet the term itself did not exist before the emergence of the HIV/AIDS epidemic in the 1980s. How did this idea so swiftly come to exert such a strong grip on the scientific, media, and popular consciousness? In Patient Zero, Richard A. McKay interprets a wealth of archival sources and interviews to demonstrate how this seemingly new concept drew upon centuries-old ideas—and fears—about contagion and social disorder. McKay presents a carefully documented and sensitively written account of the life of Gaétan Dugas, a gay man whose skin cancer diagnosis in 1980 took on very different meanings as the HIV/AIDS epidemic developed—and who received widespread posthumous infamy when he was incorrectly identified as patient zero of the North American outbreak. McKay shows how investigators from the US Centers for Disease Control inadvertently created the term amid their early research into the emerging health crisis; how an ambitious journalist dramatically amplified the idea in his determination to reframe national debates about AIDS; and how many individuals grappled with the notion of patient zero—adopting, challenging and redirecting its powerful meanings—as they tried to make sense of and respond to the first fifteen years of an unfolding epidemic. With important insights for our interconnected age, Patient Zero untangles the complex process by which individuals and groups create meaning and allocate blame when faced with new disease threats. What McKay gives us here is myth-smashing revisionist history at its best.

    

    

    It has been used to expose injustice, improve health outcomes, and topple governments. But it has also been used to discriminate, police, and surveil. This potential for good, on the one hand, and harm, on the other, makes it essential to ask: Data science by whom? Data science for whom? Data science with whose interests in mind? The narratives around big data and data science are overwhelmingly white, male, and techno-heroic. In Data Feminism, Catherine D'Ignazio and Lauren Klein present a new way of thinking about data science and data ethics—one that is informed by intersectional feminist thought.Illustrating data feminism in action, D'Ignazio and Klein show how challenges to the male/female binary can help challenge other hierarchical (and empirically wrong) classification systems. They explain how, for example, an understanding of emotion can expand our ideas about effective data visualization, and how the concept of invisible labor can expose the significant human efforts required by our automated systems. And they show why the data never, ever “speak for themselves.”Data Feminism offers strategies for data scientists seeking to learn how feminism can help them work toward justice, and for feminists who want to focus their efforts on the growing field of data science. But Data Feminism is about much more than gender. It is about power, about who has it and who doesn't, and about how those differentials of power can be challenged and changed.

    Yet around the world, in rich countries and poor ones, it is quietly poisoning us.  Air pollution prematurely kills seven million people every year, including more than one hundred thousand Americans. It is strongly linked to strokes, heart attacks, many kinds of cancer, dementia, and premature birth, among other ailments. In Choked, Beth Gardiner travels the world to tell the story of this modern-day plague, taking readers from the halls of power in Washington and the diesel-fogged London streets she walks with her daughter to Poland’s coal heartland and India’s gasping capital. In a gripping narrative that’s alive with powerful voices and personalities, she exposes the political decisions and economic forces that have kept so many of us breathing dirty air. This is a moving, up-close look at the human toll, where we meet the scientists who have transformed our understanding of pollution’s effects on the body and the ordinary people fighting for a cleaner future. In the United States, air is far cleaner than it once was. But progress has failed to keep up with the science, which tells us that even today’s lower pollution levels are doing real damage. And as the Trump administration rips up the regulations that have brought us where we are, decades of gains are now at risk. Elsewhere, the problem is far worse, and choking nations like China are scrambling to replicate the achievements of an American agency—the EPA—that until recently was the envy of the world. Clean air feels like a birthright. But it can disappear in a puff of smoke if the rules that protect it are unraveled. At home and around the world, it’s never been more important to understand how progress happened and what dangers might still be in store. Choked shows us that we hold the power to build a cleaner, healthier future: one in which breathing, life’s most basic function, no longer carries a hidden danger.

    The consequences of this gathering may be enormous. In this new ebook, experts Patrick J. Michaels and Paul C. Knappenberger assess the issues sure to drive the debate before, during, and after the Paris meeting.

    Now, in her unsparing and illuminating account of this global disease, she describes how international health experts, governments, and ordinary Africans have struggled to understand the rapid and devastating spread of the disease in Africa, and traces the changes wrought by new medical developments and emerging political realities. It is an account of scientific discovery and intrigue with implications far beyond the fight against one tragic disease. The AIDS epidemic is partly a consequence of the rapid transition of African societies from an agrarian past to an impoverished present. Millions of African people have yet to find a place in an increasingly globalized world, and their poverty and social dislocation have generated an earthquake in gender relations that deeply affects the spread of HIV. But Epstein argues that there are solutions to this crisis, and some of the most effective ones may be simpler than many people assume. Written with conviction, knowledge, and insight, Why Don't They Listen? will change how we think about the worst health crisis of the past century, and our strategies for improving global public health.

    For more than a decade, well-known consultant and business professor Wayne Winston has been teaching corporate clients and MBA students the most effective ways to use Microsoft Excel for data analysis, modeling, and decision making. Now this award-winning educator shares the best of his classroom experience in this practical, business-focused guide. Each chapter advances your data analysis and modeling expertise using real-world examples and learn-by-doing exercises. You also get all the book’s problem-and-solution files on CD—for all the practice you need to solve complex problems and work smarter with Excel.Learn how to solve real business problems with Excel!Create best, worst, and most-likely scenarios for sales Calculate how long it would take to recoup a project’s startup costs Plan personal finances, such as computing loan terms or saving for retirement Estimate a product’s demand curve Simulate stock performance over a year Determine which product mix will yield the greatest profits Interpret the effects of price and advertising on sales Assign a dollar value to customer loyalty Manage inventory and order quantities with precision Create customer service queues with short wait times Estimate the probabilities of equipment failure Model business uncertainties Get new perspectives on data with PivotTable dynamic views Help predict quarterly revenue, outcomes of sporting events, presidential elections, and more! On the CD:Practice files for all the book’s exercises Solutions for problem sets Fully searchable eBook A Note Regarding the CD or DVDThe print version of this book ships with a CD or DVD. For those customers purchasing one of the digital formats in which this book is available, we are pleased to offer the CD/DVD content as a free download via O'Reilly Media's Digital Distribution services. To download this content, please visit O'Reilly's web site, search for the title of this book to find its catalog page, and click on the link below the cover image (Examples, Companion Content, or Practice Files). Note that while we provide as much of the media content as we are able via free download, we are sometimes limited by licensing restrictions. Please direct any questions or concerns to booktech@oreilly.com.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    This provocative book exposes pervasive myths about women’s hormones and shows how flawed, obsolete research and sexism have combined to keep women “in their place.”Although the idea that women become raving lunatics when their hormones fluctuate is firmly entrenched in American culture—images of hormone-crazed women are prominent on TV and in movies, books, and magazines—a thorough examination of the evidence overwhelmingly tells us otherwise. This book will confront the pervasive myth that women are at the mercy of their reproductive hormones, and illustrate how the perpetuation of this stereotype harms women.Scientific evidence shows that the majority of women do not experience major mental or physical symptoms linked to their hormones. Rather, much of women’s supposed “irrationality” can be attributed to environmental factors and the cultural and social realities of being a woman in the Western world.With a thorough exploration of women’s hormonal lives, from the initiation of menstruation through menopause, The Hormone Myth will help you reject the negative stereotype of the hormone-crazed woman and gain an appreciation for the natural changes that occur over time.

    Yet, David Wootton argues, from the fifth century BC until the 1930s, doctors actually did more harm than good. In this controversial new account of the history of medicine, he asks just how much good it has done us over the years, and how much harm it continues to do today.

    

    This is a disturbing, well-researched wake-up call for improving the current system of drug supply and manufacturing.Several decades ago, penicillin, vitamin C, and many other prescription and over-the-counter products were manufactured in the United States. But with the rise of globalization, antibiotics, antidepressants, birth control pills, blood pressure medicines, cancer drugs, among many others are made in China and sold in the United States. China's biggest impact on the US drug supply is making essential ingredients for thousands of medicines found in American homes and used in hospital intensive care units and operating rooms. The authors convincingly argue that there are at least two major problems with this scenario. First, it is inherently risky for the United States to become dependent on any one country as a source for vital medicines, especially given the uncertainties of geopolitics. For example, if an altercation in the South China Sea causes military personnel to be wounded, doctors may rely upon medicines with essential ingredients made by the adversary. Second, lapses in safety standards and quality control in Chinese manufacturing are a risk. Citing the concerns of FDA officials and insiders within the pharmaceutical industry, the authors document incidents of illness and death caused by contaminated medications that prompted reform. This probing book examines the implications of our reliance on China on the quality and availability of vital medicines.

    In this book you will see how commonly performed operations can be found to be useless or even harmful when properly evaluated. That these claims come from an experienced, practicing orthopedic surgeon who performs many of these operations himself, makes the unsettling argument particularly compelling. Of course no surgeon is recommending invasive surgery in bad faith, but Ian Harris argues that the evidence for the success for many common operations, including knee arthroscopies, back fusion or cardiac stenting, become current accepted practice without full examination of the evidence.