As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    In 1474, when most women were almost powerless, twenty-three-year-old Isabella defied a hostile brother and mercurial husband to seize control of Castile and León.Her subsequent feats were legendary. She ended a twenty-four-generation struggle between Muslims and Christians, forcing Moorish invaders back over the Mediterranean Sea. She laid the foundation for a unified Spain. She sponsored Columbus's trip to the Indies and negotiated Spanish control over much of the New World with the help of Rodrigo Borgia, the infamous Pope Alexander VI. She also annihilated all who stood against her by establishing a bloody religious Inquisition that would darken Spain's reputation for centuries.Whether saintly or satanic, no female leader has done more to shape our modern world, where millions of people in two hemispheres speak Spanish and practice Catholicism. Yet history has all but forgotten Isabella's influence, due to hundreds of years of misreporting that often attributed her accomplishments to Ferdinand, the bold and philandering husband she adored.Using new scholarship, Downey's luminous biography tells the story of this brilliant, fervent, forgotten woman, the faith that propelled her through life, and the land of ancient conflicts and intrigue she brought under her command.

    It includes tales of living on her own at 14 (and how laundry may have saved her life), getting stuck in a gas station overhang on a cross country road trip, saying goodbye to her father in a way only he could have understood, and many more adventures and lessons that have led her to the successful, happy, and healthy place she is today.

    Until one day they all flood back in horrible detail.When television producers approached Alan Cumming to appear on a popular celebrity genealogy show, he hoped to solve the mystery of his maternal grandfather's disappearance that had long cast a shadow over his family. But this was not the only mystery laid before Alan.Alan grew up in the grip of a man who held his family hostage, someone who meted out violence with a frightening ease, who waged a silent war with himself that sometimes spilled over onto everyone around him. That man was Alex Cumming, Alan's father, whom Alan had not seen or spoken to for more than a decade when he reconnected just before filming for Who Do You Think You Are? began. He had a secret he had to share, one that would shock his son to his very core and set into motion a journey that would change Alan's life forever.With ribald humor, wit, and incredible insight, Alan seamlessly moves back and forth in time, integrating stories from his childhood in Scotland and his experiences today as the celebrated actor of film, television, and stage. At times suspenseful, at times deeply moving, but always incredibly brave and honest, Not My Father's Son is a powerful story of embracing the best aspects of the past and triumphantly pushing the darkness aside.

    Blake Gopnik's definitive biography digs deep into the contradictions and radical genius that led Andy Warhol to revolutionise our cultural world.Based on years of archival research and on interviews with hundreds of Warhol's surviving friends, lovers and enemies, Warhol traces the artist's path from his origins as the impoverished son of Eastern European immigrants in 1930s Pittsburgh, through his early success as a commercial illustrator and his groundbreaking pivot into fine art, to the society portraiture and popular celebrity of the '70s and '80s, as he reflected and responded to the changing dynamics of commerce and culture.Warhol sought out all the most glamorous figures of his times - Susan Sontag, Mick Jagger, the Barons de Rothschild - despite being burdened with an almost crippling shyness. Behind the public glitter of the artist's Factory, with its superstars, drag queens and socialites, there was a man who lived with his mother for much of his life and guarded the privacy of his home. He overcame the vicious homophobia of his youth to become a symbol of gay achievement, while always seeking the pleasures of traditional romance and coupledom. (Warhol explodes the myth of his asexuality.)Filled with new insights into the artist's work and personality, Warhol asks: Was he a joke or a genius, a radical or a social climber? As Warhol himself would have answered: Yes.

    When they began living together, she was 25; he was 58. Three years later, they married, but within a year and a half, she left him, amidst reports of loud arguments and spanking episodes. Their divorce, finalized in 1968, was a major news splash even in that pre-TMZ, pre-internet era. Grant died in 1986, but Cannon has continued to wrestle with the details, the rights, and the wrongs of their relationship. Dear Cary is a memoir that celebrates and scrutinizes the great love of her life.

    Described by one reviewer as “like getting stabbed in the head,” the $6 million film earned a grand total of $1,800 at the box office and closed after two weeks. Now in its tenth anniversary year, The Room is an international phenomenon to rival The Rocky Horror Picture Show. Thousands of fans wait in line for hours to attend screenings complete with costumes, audience rituals, merchandising, and thousands of plastic spoons.Readers need not have seen The Room to appreciate its costar Greg Sestero’s account of how Tommy Wiseau defied every law of artistry, business, and interpersonal relationships to achieve the dream only he could love. While it does unravel mysteries for fans, The Disaster Artist is more than just an hilarious story about cinematic hubris: It is ultimately a surprisingly inspiring tour de force that reads like a page-turning novel, an open-hearted portrait of a supremely enigmatic man who will capture your heart.

    The author of 'The Life and Times of the Thunderbolt Kid' isn't, after all, a Shakespeare scholar, a playwright, or even a biographer. Reading 'Shakespeare The World As Stage', however, one gets the sense that this eclectic Iowan is exactly the type of person the Bard himself would have selected for the task. The man who gave us 'The Mother Tongue' and 'A Walk in the Woods' approaches Shakespeare with the same freedom of spirit and curiosity that made those books such reader favorites. A refreshing take on an elusive literary master.

    Now, in Nomad, Hirsi Ali tells of coming to America to build a new life, an ocean away from the death threats made to her by European Islamists, the strife she witnessed, and the inner conflict she suffered. It is the story of her physical journey to freedom and, more crucially, her emotional journey to freedom—her transition from a tribal mind-set that restricts women’s every thought and action to a life as a free and equal citizen in an open society. Through stories of the challenges she has faced, she shows the difficulty of reconciling the contradictions of Islam with Western values. In these pages Hirsi Ali recounts the many turns her life took after she broke with her family, and how she struggled to throw off restrictive superstitions and misconceptions that initially hobbled her ability to assimilate into Western society. She writes movingly of her reconciliation, on his deathbed, with her devout father, who had disowned her when she renounced Islam after 9/11, as well as with her mother and cousins in Somalia and in Europe. Nomad is a portrait of a family torn apart by the clash of civilizations. But it is also a touching, uplifting, and often funny account of one woman’s discovery of today’s America. While Hirsi Ali loves much of what she encounters, she fears we are repeating the European mistake of underestimating radical Islam. She calls on key institutions of the West—including universities, the feminist movement, and the Christian churches—to enact specific, innovative remedies that would help other Muslim immigrants to overcome the challenges she has experienced and to resist the fatal allure of fundamentalism and terrorism. This is Hirsi Ali’s intellectual coming-of-age, a memoir that conveys her philosophy as well as her experiences, and that also conveys an urgent message and mission—to inform the West of the extent of the threat from Islam, both from outside and from within our open societies. A celebration of free speech and democracy, Nomad is an important contribution to the history of ideas, but above all a rousing call to action.

    Not long after her arrival, however, tragedy strikes, and Fanny and her brood repair to a quiet artists' colony in France where she can recuperate. There she meets Robert Louis Stevenson, ten years her junior, who is instantly smitten with the earthy, independent and opinionated belle Americaine.A woman ahead of her time, Fanny does not immediately take to the young lawyer who longs to devote his life to literature, and who would eventually write such classics as Treasure Island and The Strange Case of Dr. Jekyll and Mr. Hyde. In time, though, she succumbs to Stevenson's charms. The two begin a fierce love affair, marked by intense joy and harrowing darkness, which spans decades as they travel the world for the sake of his health. Eventually they settled in Samoa, where Robert Louis Stevenson is buried underneath the epitaph: Under the wide and starry sky,Dig the grave and let me lie.Glad did I live and gladly die,And I laid me down with a will. This be the verse you grave for me:Here he lies where he longed to be;Home is the sailor, home from sea,And the hunter home from the hill.(Requiem, Robert Louis Stevenson)

    But in this extraordinary autobiography, Shania reveals that she is so much more. She is Eilleen Twain, one of five children born into poverty in rural Canada, where her family often didn't have enough food to send her to school with lunch. She's the teenage girl who helped her mother and young siblings escape to a battered woman's shelter to put an end to the domestic violence in her family home. And she's the courageous twenty-two-year-old who sacrificed to keep her younger siblings together after her parents were tragically killed in a car accident.Shania Twain's life has evolved from a series of pivotal moments, and in unflinching, heartbreaking prose, Shania spares no details as she takes us through the events that have made her who she is. She recounts her difficult childhood, her parents' sudden death and its painful aftermath, her dramatic rise to stardom, her devastating betrayal by a trusted friend, and her joyful marriage to the love of her life. From these moments, she offers profound, moving insights into families, personal tragedies, making sense of one's life, and the process of healing. Shania Twain is a singular, remarkable woman who has faced enormous odds and downfalls, and her extraordinary story will provide wisdom, inspiration, and hope for almost anyone.

    Today Ron Ball and I are romantically involved, it read, but I fear I have placed myself at risk in a variety of ways. Based on his criminal past, writing this out just seems like the smart thing to do. If I am missing or dead this obviously has not protected me... That same spring Janine Latus was struggling to leave her marriage -- a marriage to a handsome and successful man. A marriage others emulated. A marriage in which she felt she could do nothing right and everything wrong. A marriage in which she felt afraid, controlled, inadequate, and trapped. Ten weeks later, Janine Latus had left her marriage. She was on a business trip to the East Coast, savoring her freedom, attending a work conference, when she received a call from her sister Jane asking if she'd heard from Amy. Immediately, Janine's blood ran cold. Amy was missing. Helicopters went up and search dogs went out. Coworkers and neighbors and family members plastered missing posters with Amy's picture across the county. It took more than two weeks to find Amy's body, wrapped in a tarpaulin and buried at a building site. It took nearly two years before her killer, her former boyfriend Ron Ball, was sentenced for her murder. Amy died in silent fear and pain. Haunted by this, Janine Latus turned her journalistic eye inward. How, she wondered, did two seemingly well-adjusted, successful women end up in strings of physically or emotionally abusive relationships with men? If I Am Missing or Dead is a heart-wrenching journey of discovery as Janine Latus traces the roots of her own -- and her sister's -- victimization with unflinching candor. This beautifully written memoir will move readers from the first to the last page. At once a confession, a call to break the cycle of abuse, and a deeply felt love letter to her baby sister, Amy Lynne Latus, If I Am Missing or Dead is an unforgettable read.

    After she suffers a brief but serious illness at the age of ninety-one, they resolve to change their relationship by beginning a year-long conversation unlike any they had ever had before. The result is a correspondence of surprising honesty and depth in which they discuss their lives, the things that matter to them, and what they still want to learn about each other.Both a son’s love letter to his mother and an unconventional mom’s life lessons for her grown son, The Rainbow Comes and Goes offers a rare window into their close relationship and fascinating life stories, including their tragedies and triumphs. In these often humorous and moving exchanges, they share their most private thoughts and the hard-earned truths they’ve learned along the way. In their words their distinctive personalities shine through—Anderson’s journalistic outlook on the world is a sharp contrast to his mother’s idealism and unwavering optimism.An appealing memoir with inspirational advice, The Rainbow Comes and Goes is a beautiful and affectionate celebration of the universal bond between a parent and a child, and a thoughtful reflection on life, reminding us of the precious insight that remains to be shared, no matter our age.

    But through the fog of glamour and gossip, how well do we really know the world’s most famous monarch? Drawing on numerous interviews and never-before-revealed documents, acclaimed biographer Sally Bedell Smith pulls back the curtain to show in intimate detail the public and private lives of Queen Elizabeth II, who has led her country and Commonwealth through the wars and upheavals of the last sixty years with unparalleled composure, intelligence, and grace. In Elizabeth the Queen, we meet the young girl who suddenly becomes “heiress presumptive” when her uncle abdicates the throne. We meet the thirteen-year-old Lilibet as she falls in love with a young navy cadet named Philip and becomes determined to marry him, even though her parents prefer wealthier English aristocrats. We see the teenage Lilibet repairing army trucks during World War II and standing with Winston Churchill on the balcony of Buckingham Palace on V-E Day. We see the young Queen struggling to balance the demands of her job with her role as the mother of two young children. Sally Bedell Smith brings us inside the palace doors and into the Queen’s daily routines—the “red boxes” of documents she reviews each day, the weekly meetings she has had with twelve prime ministers, her physically demanding tours abroad, and the constant scrutiny of the press—as well as her personal relationships: with Prince Philip, her husband of sixty-four years and the love of her life; her children and their often-disastrous marriages; her grandchildren and friends.

    Aligned with the resurgence of feminism in pop culture, Broad Strokes offers an entertaining corrective to that omission. Art historian Bridget Quinn delves into the lives and careers of 15 brilliant female artists in text that's smart, feisty, educational, and an enjoyable read. Replete with beautiful reproductions of the artists' works and contemporary portraits of each artist by renowned illustrator Lisa Congdon, this is art history from 1600 to the present day for the modern art lover, reader, and feminist.