The latest scientific research reveals that the balance of bacteria in an individual’s microbiome can have a profound impact on inflammation throughout the body. In those with psoriasis or autoimmune arthritis, there is often a characteristic lack of certain beneficial bacteria that normally regulate the immune system – known as “keystone” species. This is typically coupled with an overabundance of potentially harmful bacteria that further trigger the inflammatory response. The Keystone Approach calms inflammation at the source by restoring the balance of good and bad bacteria in the microbiome. Based on an in-depth analysis of the latest scientific evidence, The Keystone Approach also explains how to optimize the Mediterranean diet for the greatest reduction in inflammation, along with providing detailed guidance for choosing supplements supported by good-quality clinical trials. ---- Rebecca Fett is a science writer with a degree in molecular biotechnology and biochemistry from the University of Sydney. She previously spent ten years as a biotechnology patent litigation attorney in New York, where she specialized in analyzing the scientific and clinical evidence for immune-targeting biologic medicines

    Whether you're building the next killer app, investing in a startup, or simply curious about the technology, this practical book is essential reading.Bitcoin, the first successful decentralized digital currency, is still in its infancy and it's already spawned a multi-billion dollar global economy. This economy is open to anyone with the knowledge and passion to participate. Mastering Bitcoin provides you with the knowledge you need (passion not included).This book includes:A broad introduction to bitcoin--ideal for non-technical users, investors, and business executivesAn explanation of the technical foundations of bitcoin and cryptographic currencies for developers, engineers, and software and systems architectsDetails of the bitcoin decentralized network, peer-to-peer architecture, transaction lifecycle, and security principlesOffshoots of the bitcoin and blockchain inventions, including alternative chains, currencies, and applicationsUser stories, analogies, examples, and code snippets illustrating key technical concepts

    In the past, discoveries often had to wait for the rise of the next generation to see questions in a new light and let go of old truisms. Today, in a world that is defined by a rapid rate of change, staying on the cutting edge has as much to do with shedding outdated notions as adopting new ones. In this spirit, John Brockman, publisher of the online salon Edge.org ("the world's smartest website"—The Guardian), asked 175 of the world's most influential scientists, economists, artists, and philosophers: What scientific idea is ready for retirement?Jared Diamond explores the diverse ways that new ideas emerge * Nassim Nicholas Taleb takes down the standard deviation * Richard Thaler and novelist Ian McEwan reveal the usefulness of "bad" ideas * Steven Pinker dismantles the working theory of human behavior * Richard Dawkins renounces essentialism * Sherry Turkle reevaluates our expectations of artificial intelligence * Physicist Andrei Linde suggests that our universe and its laws may not be as unique as we think * Martin Rees explains why scientific understanding is a limitless goal * Alan Guth rethinks the origins of the universe * Sam Harris argues that our definition of science is too narrow * Nobel Prize winner Frank Wilczek disputes the division between mind and matter * Lawrence Krauss challenges the notion that the laws of physics were preordained * plus contributions from Daniel Goleman, Mihaly Csikszentmihalyi, Nicholas Carr, Rebecca Newberger Goldstein, Matt Ridley, Stewart Brand, Sean Carroll, Daniel C. Dennett, Helen Fisher, Douglas Rushkoff, Lee Smolin, Kevin Kelly, Freeman Dyson, and others.

    Now this classic book has been fully updated and revised with leading-edge practices--and hundreds of new code samples--illustrating the art and science of software construction. Capturing the body of knowledge available from research, academia, and everyday commercial practice, McConnell synthesizes the most effective techniques and must-know principles into clear, pragmatic guidance. No matter what your experience level, development environment, or project size, this book will inform and stimulate your thinking--and help you build the highest quality code. Discover the timeless techniques and strategies that help you: Design for minimum complexity and maximum creativity Reap the benefits of collaborative development Apply defensive programming techniques to reduce and flush out errors Exploit opportunities to refactor--or evolve--code, and do it safely Use construction practices that are right-weight for your project Debug problems quickly and effectively Resolve critical construction issues early and correctly Build quality into the beginning, middle, and end of your project

    Double Olympic champions, world record holders and the winners of six World Championship titles in the coxless pair, they have been at the pinnacle of their sport since they captured their first title together in 2009. The Kiwi Pair shares the story of Bond and Murray's unique partnership. Some would describe them as chalk and cheese, two contrasting personalities who nevertheless bring out the best in each other. Join them as they share the secrets to their success, their extreme training regime, the highs and lows of top level sport, and the extraordinary dedication it takes to be world-beating oarsmen. 'This is a story of dedication, and that is a story that is not told often enough.' - Sir Steve Redgrave

    The story of information begins in a time profoundly unlike our own, when every thought and utterance vanishes as soon as it is born. From the invention of scripts and alphabets to the long-misunderstood talking drums of Africa, Gleick tells the story of information technologies that changed the very nature of human consciousness. He provides portraits of the key figures contributing to the inexorable development of our modern understanding of information: Charles Babbage, the idiosyncratic inventor of the first great mechanical computer; Ada Byron, the brilliant and doomed daughter of the poet, who became the first true programmer; pivotal figures like Samuel Morse and Alan Turing; and Claude Shannon, the creator of information theory itself. And then the information age arrives. Citizens of this world become experts willy-nilly: aficionados of bits and bytes. And we sometimes feel we are drowning, swept by a deluge of signs and signals, news and images, blogs and tweets. The Information is the story of how we got here and where we are heading.

     At any given moment, somewhere in the world someone struggles with the same software design problems you have. You know you don't want to reinvent the wheel (or worse, a flat tire), so you look to Design Patterns--the lessons learned by those who've faced the same problems. With Design Patterns, you get to take advantage of the best practices and experience of others, so that you can spend your time on...something else. Something more challenging. Something more complex. Something more fun. You want to learn about the patterns that matter--why to use them, when to use them, how to use them (and when NOT to use them). But you don't just want to see how patterns look in a book, you want to know how they look "in the wild". In their native environment. In other words, in real world applications. You also want to learn how patterns are used in the Java API, and how to exploit Java's built-in pattern support in your own code. You want to learn the real OO design principles and why everything your boss told you about inheritance might be wrong (and what to do instead). You want to learn how those principles will help the next time you're up a creek without a design pattern. Most importantly, you want to learn the "secret language" of Design Patterns so that you can hold your own with your co-worker (and impress cocktail party guests) when he casually mentions his stunningly clever use of Command, Facade, Proxy, and Factory in between sips of a martini. You'll easily counter with your deep understanding of why Singleton isn't as simple as it sounds, how the Factory is so often misunderstood, or on the real relationship between Decorator, Facade and Adapter. With Head First Design Patterns, you'll avoid the embarrassment of thinking Decorator is something from the "Trading Spaces" show. Best of all, in a way that won't put you to sleep! We think your time is too important (and too short) to spend it struggling with academic texts. If you've read a Head First book, you know what to expect--a visually rich format designed for the way your brain works. Using the latest research in neurobiology, cognitive science, and learning theory, Head First Design Patterns will load patterns into your brain in a way that sticks. In a way that lets you put them to work immediately. In a way that makes you better at solving software design problems, and better at speaking the language of patterns with others on your team.

    Innovator. Inventor. These three words sum up Alexander Graham Bell, one of the greatest scientific men of his era. He is most famous for the invention of the telephone, a device which he predicted would transform human society. And it did. But the telephone is just one of the many innovations and inventions that Bell brought into being. Inside you will read about... - Childhood - Emigration to North America - The Bell Telephone Company - The Race to Save the President - A Rival to the Wright Brothers - Later Years and Death And much more! A man who epitomizes the word visionary, Alexander Graham Bell predicted the use of light as a medium for transmitting information and how humanity would be transformed by flight. This is his story.

    Are you gutsy enough to try it? Rouse your inner gypsy/rebel with this intimate introduction to van dwelling. It’s stocked with DIY tips and tricks for turning a vehicle into a home (on any budget) and emotional resources to gracefully sidestep the psychological pitfalls of such an unconventional lifestyle. With concrete advice and personal reflection from an experienced solo van dweller, this guide thoroughly covers the basics of everyday life in a van with a refreshing twist of self-empowerment and a whole lotta sass.Topics covered inside: -- vehicle selection-- DIY ideas for customizing your mobile abode-- ventilation-- parking tips-- showering and toilet needs-- safety for solos-- earning an income-- mental health as a van dweller...and much more!

    Pendel's attention. It is very interesting and throws many sidelights on the life of the White House. Pendel writes: "In 1861, or 1862, the Metropolitan Police was established by Congress at the Capital, and I made application for and received an appointment on the force. I made the first arrest, with the assistance of "Buck" Essex. The case was that of a fellow named Grady, one of the English Hill toughs. A roundsman said to us, "Boys, you take a walk down Seventh Street, and if you see anything going on, take a hand in it." Just as we got opposite the Patent Office, this Grady had assaulted, or rather was assaulting, a young fellow with a whip. I went up and grabbed him and put him under arrest, then took him to Squire Dunn's court and preferred charges against him. The Squire was busy writing for some time. When he got through he handed me the paper he was writing, and I was so green at the business I did not know what it was, so said: "What is this, Squire?" He replied, "Why, that is the paper of commitment for this fellow. Take him to jail." "On November 3, 1864, Sergeant John Cronin, Alfonso Dunn, Andrew Smith, and myself were ordered to report at the First Precinct, in the old City Hall, at one o'clock in the afternoon. We supposed we were to be detailed for detective work in New York City on account of the great riot then on there, especially as we were ordered to report in citizens' clothes, to conceal our revolvers, and to be sure to have them all clean and in good order. We arrived at the City Hall, and then were told where we were to go, which was to the President's Mansion, there to report to Marshal Lanham, at that time United States Marshal of the District of Columbia, and a bosom friend of Abraham Lincoln. "These were days that tried men's hearts, and women's, too. Men were falling at the front by hundreds, both in the Union and in the Confederate armies. There was weeping and mourning all over the land. Our nation was trembling with anxiety; we were all hoping that the great strife was over or soon to be. "Marshal Lanham took us upstairs and into the President's office, where we were introduced to him and to his two secretaries, Mr. Nicolay and Mr. Hay, the latter now being Secretary of State. We were then instructed to keep a sharp lookout in the different parts of the house, more particularly in the East Room and at the door of the President's office. " CONTENTS I — Under President Lincoln II — Under President Johnson III — Under President Grant IV — Under President Hayes V — Under President Garfield VI — Under President Arthur VII — Under President Cleveland VIII — Under President Harrison IX — Cleveland's Second Administration X— Under President McKinley XI — Furniture in Executive Mansion Originally published in 1902; reformatted for the Kindle; may contain an occasional imperfections; original spellings have been kept in place.

    Over 1,000 Board-style questions, with detailed rationales, cover the most essential, need-to-know concepts in physiology. Includes thorough reviews of all major body systems, with emphasis on system interaction, homeostasis, and pathophysiology.Offers a comprehensive practice exam of over 1,000 questions in USMLE format.Includes answers and explanations for every question, as well as page references to the Guyton & Hall's Textbook of Medical Physiology.Follows a parallel chapter organization to Textbook of Medical Physiology.Provides all of the essential information needed to prepare for the physiology portion of the USMLE Step 1.Dedicates a brief section to helpful hints on preparing for the USMLE exam.

    You may find it for free on the web. Purchase of the Kindle edition includes wireless delivery.

    Close to a million people—in a nation of 120 million—were forced out of their homes. Some estimates place the death toll in the thousands. The Red Cross fed nearly 700,000 refugees for months. Rising Tide is the story of this forgotten event, the greatest natural disaster this country has ever known. But it is not simply a tale of disaster. The flood transformed part of the nation and had a major cultural and political impact on the rest. Rising Tide is an American epic about science, race, honor, politics, and society. Rising Tide begins in the nineteenth century, when the first serious attempts to control the river began. The story focuses on engineers James Eads and Andrew Humphreys, who hated each other. Out of the collision of their personalities and their theories came a compromise river policy that would lead to the disaster of the 1927 flood yet would also allow the cultivation of the Yazoo-Mississippi Delta and create wealth and aristocracy, as well as a whole culture. In the end, the flood had indeed changed the face of America, leading to the most comprehensive legislation the government had ever enacted, touching the entire Mississippi valley from Pennsylvania to Montana. In its aftermath was laid the foundation for the New Deal of Franklin D. Roosevelt.

    Drawing heavily on the author's own real-world experiences, the book stresses design and analysis. Coverage is divided into two parts, the first being a general guide to techniques for the design and analysis of computer algorithms. The second is a reference section, which includes a catalog of the 75 most important algorithmic problems. By browsing this catalog, readers can quickly identify what the problem they have encountered is called, what is known about it, and how they should proceed if they need to solve it. This book is ideal for the working professional who uses algorithms on a daily basis and has need for a handy reference. This work can also readily be used in an upper-division course or as a student reference guide. THE ALGORITHM DESIGN MANUAL comes with a CD-ROM that contains: * a complete hypertext version of the full printed book. * the source code and URLs for all cited implementations. * over 30 hours of audio lectures on the design and analysis of algorithms are provided, all keyed to on-line lecture notes.

    Featuring programs and resources available throughout the U.S. and Canada"An authoritative and comprehensive overview of the benefits of energy-efficient homes." ---Kirkus ReviewsLive in a Home that Pays You Back lights the way for enjoying a home that is healthier, more comfortable, saves money, and reduces your carbon footprint. Whether you are planning to build, buy, or retrofit a home, award-winning author Anna DeSimone takes you on a virtual tour through the home of the future. A practical reference guide that can be used for years to come, this illuminating book uncovers every part and parcel of the sustainable home, with precise explanations and infographics, plus hundreds of resources for further exploration. You'll have fun exploring the world of renewable energy, such as solar photovoltaics, wind power, geothermal energy, hydro-electric power, and biomass fuels. You'll learn how "positive energy" puts money in your pocket through incentives such as net metering, net billing or renewable energy certificates--a tradeable commodity with cash value.This eye-opening book takes a look at the health benefits of living in an energy-efficient home, and includes guidance about water safety, biological pollutants and environmental toxins. Everything you need to know about energy scores, building certifications, and the home building options for net zero, net zero ready, passive homes, pre-fab, modular, log and timber, and more. Mortgage financing chapter covers down payment assistance, national energy-efficient loan programs, borrower qualification incentives, and how to roll in the cost of an energy retrofit into your mortgage.The path to zero can be taken in small steps. This book prepares you and your household to make informed decisions for implementing energy-efficient technologies according to your needs and budget. And you'll enjoy many kinds of payback, every step of the way.Book includes a directory of rebates and incentives by Canadian province and U.S. state. Available in paperback and e-book.