Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    Roosevelt, Winston Churchill, and the capitalist West.            At the Big Three conferences of World War II, Stalin persuasively played the role of a great world leader. Even astute observers like George F. Kennan concluded that the United States and Great Britain should view Stalin as a modern-day tsarist-like figure whose primary concerns lay in international strategy and power politics, not in ideology. Now Robert Gellately uses recently uncovered documents to make clear that, in fact, the dictator was an unwavering revolutionary merely biding his time, determined as ever to establish Communist regimes across Europe and beyond, and that his actions during these years (and the poorly calculated Western responses) set in motion what would eventually become the Cold War. Gellately takes us behind the scenes. We see the dictator disguising his political ambitions and prioritizing the future of Communism, even as he pursued the war against Hitler. Along the way, the ascetic dictator’s Machiavellian moves and bouts of irrationality kept the Western leaders on their toes, in a world that became more dangerous and divided year by year.               Exciting, deeply engaging, and shrewdly perceptive, Stalin’s Curse is an unprecedented revelation of the sinister machinations of the Soviet dictator.

    Striking humanity in waves, the cycle of plagues set the tempo of civilizational growth and decline, since common response to the threat was exclusion—quarantining the sick or keeping them out. But the unprecedented hygiene and medical revolutions of the past two centuries have allowed humanity to free itself from the hold of epidemic cycles—resulting in an urbanized, globalized, and unimaginably wealthy world. However, our development has lately become precarious. Climate and population fluctuations and aspects of our prosperity such as global trade have left us more vulnerable than ever to newly emerging plagues. Greater global cooperation toward sustainable health is urgently required—such as the international efforts to harvest a Covid-19 vaccine—with millions of lives and trillions of dollars at stake. Written as colorful history, The Plague Cycle reveals the relationship between civilization, globalization, prosperity, and infectious disease over the past five millennia. It harnesses history, economics, and public health, and charts humanity’s remarkable progress, providing a fascinating and timely look at the cyclical nature of infectious disease.

    But as costs levitate, that argument becomes more difficult to make. Today, we spend twice as much as Japan on health care—yet few would argue that our health care system is twice as good.Instead, startling new evidence suggests that one out of every three of our health care dollars is squandered on unnecessary or redundant tests; unproven, sometimes unwanted procedures; and overpriced drugs and devices that, too often, are no better than the less expensive products they have replaced.How did this happen? In Money-Driven Medicine, Maggie Mahar takes the reader behind the scenes of a $2 trillion industry to witness how billions of dollars are wasted in a Hobbesian marketplace that pits the industry's players against each other. In remarkably candid interviews, doctors, hospital administrators, patients, health care economists, corporate executives, and Wall Street analysts describe a war of "all against all" that can turn physicians, hospitals, insurers, drugmakers, and device makers into blood rivals. Rather than collaborating, doctors and hospitals compete. Rather than sharing knowledge, drugmakers and device makers divide value. Rather than thinking about long-term collective goals, the imperatives of an impatient marketplace force health care providers to focus on short-term fiscal imperatives. And so investments in untested bleeding-edge medical technologies crowd out investments in information technology that might, in the long run, not only reduce errors but contain costs.In theory, free market competition should tame health care inflation. In fact, Mahar demonstrates, when it comes to medicine, the traditional laws of supply and demand do not apply. Normally, when supply expands, prices fall. But in the health care industry, as the number and variety of drugs, devices, and treatments multiplies, demand rises to absorb the excess, and prices climb. Meanwhile, the perverse incentives of a fee-for-service system reward health care providers for doing more, not less.In this superbly written book, Mahar shows why doctors must take responsibility for the future of our health care industry. Today, she observes, "physicians have been stripped of their standing as professionals: Insurers address them as vendors ('Dear Health Care Provider'), drugmakers and device makers see them as customers (someone you might take to lunch or a strip club), while . . . consumers (aka patients) are encouraged to see their doctors as overpaid retailers. . . . Before patients can reclaim their rightful place as the center—and indeed as the raison d'être—of our health care system," Mahar suggests, "we must once again empower doctors . . . to practice patient-centered medicine—based not on corporate imperatives, doctors' druthers, or even patients' demands," but on the best scientific research available.

    But just as vodka is central to the lives of many Russians, it is also central to understanding Russian history and politics.In Vodka Politics, Mark Lawrence Schrad argues that debilitating societal alcoholism is not hard-wired into Russians' genetic code, but rather their autocratic political system, which has long wielded vodka as a tool of statecraft. Through a series of historical investigations stretching from Ivanthe Terrible through Vladimir Putin, Vodka Politics presents the secret history of the Russian state itself-a history that is drenched in liquor. Scrutinizing (rather than dismissing) the role of alcohol in Russian politics yields a more nuanced understanding of Russian history itself: from palaceintrigues under the tsars to the drunken antics of Soviet and post-Soviet leadership, vodka is there in abundance.Beyond vivid anecdotes, Schrad scours original documents and archival evidence to answer provocative historical questions. How have Russia's rulers used alcohol to solidify their autocratic rule? What role did alcohol play in tsarist coups? Was Nicholas II's ill-fated prohibition a catalyst for theBolshevik Revolution? Could the Soviet Union have become a world power without liquor? How did vodka politics contribute to the collapse of both communism and public health in the 1990s? How can the Kremlin overcome vodka's hurdles to produce greater social well-being, prosperity, and democracy intothe future?Viewing Russian history through the bottom of the vodka bottle helps us to understand why the liquor question remains important to Russian high politics even today-almost a century after the issue had been put to bed in most every other modern state. Indeed, recognizing and confronting vodka'sdevastating political legacies may be the greatest political challenge for this generation of Russia's leadership, as well as the next.

    The author argues that though this most ambitious of social engineering projects was promoted as a way to lift people out of poverty and even to save the planet, it became a means to plan other people's families.

    . . meticulously researched and packed with documentary evidence (Publishers Weekly), Sonia Shah's riveting journalistic account shines a much-needed spotlight on a disturbing new global trend. Drawing on years of original research and reporting in Africa and Asia, Shah examines how the multinational pharmaceutical industry, in its quest to develop lucrative drugs, has begun exporting its clinical research trials to the developing world, where ethical oversight is minimal and desperate patients abound. As the New England Journal of Medicine notes, it is critical that those engaged in drug development, clinical research and its oversight, research ethics, and policy know about these stories, which tell of an impossible choice being faced by many of the world's poorest patients--be experimented upon or die for lack of medicine.

    Instead Chagnon discovered a remarkably violent society. Men who killed others had the most wives and offspring, their violence possibly giving them an evolutionary advantage. The prime reasons for violence, Chagnon found, were to avenge deaths and, if possible, abduct women. When Chagnon began publishing his observations, some cultural anthropologists who could not accept an evolutionary basis for human behavior refused to believe them. Chagnon became perhaps the most famous American anthropologist since Margaret Mead—and the most controversial. He was attacked in a scathing popular book, whose central allegation that he helped start a measles epidemic among the Yanomamö was quickly disproven, and the American Anthropological Association condemned him, only to rescind its condemnation after a vote by the membership. Throughout his career Chagnon insisted on an evidence-based scientific approach to anthropology, even as his professional association dithered over whether it really is a scientific organization. In Noble Savages, Chagnon describes his seminal fieldwork—during which he lived among the Yanomamö, was threatened by tyrannical headmen, and experienced an uncomfortably close encounter with a jaguar—taking readers inside Yanomamö villages to glimpse the kind of life our distant ancestors may have lived thousands of years ago. And he forcefully indicts his discipline of cultural anthropology, accusing it of having traded its scientific mission for political activism. This book, like Chagnon’s research, raises fundamental questions about human nature itself.

    Featuring a wide array of distinguished voices, including Peter Kramer, Kay Redfield Jamison, Robert Coles, Lauren Slater, Sandeep Jauhar, and Perri Klass, these original stories create a vivid mural of the medical world and provide invaluable insight for both doctors in training and longtime physicians. Becoming a Doctor portrays the broad arc of a doctor’s life, from a medical student’s uneasy first encounter with a cadaver and her realization that the experience’s redemption will lie ahead in the lives saved, to a resident’s reliance on dance during her grueling year in an inner-city hospital, and a veteran doctor’s profound ruminations on what it means to really listen to a patient’s story.

    These kids often have violent outbursts, steal, engage in outlandish lying, play with feces, and hoard food. They are broken children who too often break even the most loving of caregivers. Many parents of these children feel utterly isolated as family, friends, and professionals minimize their struggles. Reactive Attachment Disorder (RAD) - The Essential Guide for Parents is written by a parent who is in the trenches with you. Keri has lived the journey of raising a son with RAD and has navigated the mental health system for over a decade. This is the resource you’ve been waiting for – you won’t find platitudes or false hopes. What you will find is essential information, practical suggestions, and resource recommendations to provide a way forward. If you desperately need help navigating the difficult RAD journey with your child, this book is for you.

    It is hard to find a photo of Humphrey Bogart or Lauren Bacall without a cigarette. No product has been so heavily promoted or has become so deeply entrenched in American consciousness.And no product has received such sustained scientific scrutiny. The development of new medical knowledge demonstrating the dire harms of smoking ultimately shaped the evolution of evidence-based medicine. In response, the tobacco industry engineered a campaign of scientific disinformation seeking to delay, disrupt, and suppress these studies. Using a massive archive of previously secret documents, historian Allan Brandt shows how the industry pioneered these campaigns, particularly using special interest lobbying and largesse to elude regulation.But even as the cultural dominance of the cigarette has waned and consumption has fallen dramatically in the U.S., Big Tobacco remains securely positioned to expand into new global markets. The implications for the future are vast: 100 million people died of smoking-related diseases in the 20th century; in the next 100 years, we expect 1 billion deaths worldwide.

    In 1919, Spanish flu killed over 50 million people, more than died in both world wars combined. In 1950, an estimated 50 million people caught smallpox worldwide, of whom 10 million died. In 1980, before measles vaccine was widely used, an estimated 2.6 million children died of measles every year. Today we are hostage to a new pandemic disease -the seemingly unstoppable COVID-19.Less than 100 years ago, losing a child to an infection like diphtheria or polio was a dreaded but almost inevitable sorrow faced by all parents, from the richest to the poorest. Today, these killer diseases are almost never seen in industrialised countries, thanks to the development of vaccines. Immunisation has given modern parents peace of mind their ancestors could not imagine.The history of vaccination is rich with trial, error, sabotage and success. It encompasses the tragedy of lives lost, the drama of competition and discovery, the culpability of botched testing, and the triumph of effective, lifelong immunity. Yet with the eradication in the first world of some of humanity's deadliest foes, complacency in some quarters has set in. COVID-19 has us again racing for a vaccine. The story of past achievements and failures helps us keep the race - and the hope - in perspective.This is a book for everyone who wants to understand our past - and cares about our future.PRAISE'Anyone who has doubts about the life-saving miracle of vaccination should read this' Steven Carroll, Sydney Morning Herald'An entertaining and engaging work that is sure to delight general readers' Australian Book Review'The ideal handbook for pregnant women, parents, travellers, childcare and aged-care workers, GPs and anyone with an interest in public health' The Australian'Isaacs explores the understanding of immunity as it develops from the fifth century BC to the present day and thrills us with the progressive successes of each of the 14 vaccines which a child routinely receives today ... The work is authoritative, beguiling, amusing, instructive and inspirational. It deserves a wide readership, including infectious disease experts, other health professionals and, most assuredly, a diversity of lay people' Sir Gustav Nossal, immunologist and director of The Walter and Eliza Institute of Medical Research, Melbourne, 1965-1996'A rollicking story of human endeavour, error, misinformation, success and failure ... and more than a glimpse of why we need to continue to research, evaluate, educate and fund vaccines to prevent disease' Fiona Stanley, Distinguished Research Professor, University of Western Australia'Effortlessly accessible, Defeating the Ministers of Death brilliantly reveals the people behind the most important public health intervention in history' Professor Andrew J Pollard, Department of Paediatrics, University of Oxford'This book is an unflinching look at the triumphs and inevitable tragedies in the war against infectious diseases. Nonfiction is at its best when it reads like fiction. And David Isaacs has written a page turner' Paul A. Offit, MD, author of Bad Advice: Or Why Celebrities, Politicians, and Activists Aren't Your Best Source of Health Information

    In this pocket version of his bestselling Life Without Diabetes, Professor Roy Taylor offers a brilliantly concise explanation of what happens to us when we get type 2 and how we can escape it.Taylor's research has demonstrated that type 2 is caused by just one factor - too much internal fat in the liver and pancreas - and that to reverse it you need to strip this harmful internal fat out with rapid weight loss.In simple, accessible language, Taylor takes you through the three steps of his clinically proven Newcastle weight loss plan and shows how to incorporate the programme into your life.Complete with FAQs and inspirational tips from his trial participants, this is an essential read for anyone who has been given a diagnosis of type 2 diabetes or pre-diabetes and wants to understand their condition and transform their outcomes.

    r/K Theory examines how all populations tend to adopt one of two psychologies as a means of adapting their behavior to the presence or absence of environmental resources. The two strategies, termed r and K, each correlate perfectly with the psychologies underlying Liberalism and Conservatism.One strategy, named the r-strategy, imbues those who are programmed with it to be averse to all peer on peer competition, embrace promiscuity, embrace single parenting, and support early onset sexual activity in youth. Obviously, this mirrors the Liberal philosophy's aversion to individual Darwinian competitions such as capitalism and self defense with firearms, as well as group competitions such as war. Likewise, Liberalism is tolerant of promiscuity, tolerant of single parenting, and more prone to support early sex education for children and the sexualization of cultural influences. Designed to exploit a plethora of resources, one will often find this r-type strategy embodied within prey species, where predation has lowered the population's numbers, and thereby increased the resources available to it's individuals.The other strategy, termed the K-strategy, imbues those who pursue it with a fierce competitiveness, as well as tendencies towards abstinence until monogamy, two-parent parenting, and delaying sexual activity until later in life. Obviously, this mirrors Conservatism's acceptance of all sorts of competitive social schemes, from free market capitalism, to war, to individuals owning and carrying private weapons for self defense. Conservatives also tend to favor abstinence until monogamy, two parent parenting with an emphasis upon "family values," and children being shielded from any sexualized stimuli until later in life. This strategy is found most commonly in species which lack predation, and whose population's have grown to the point individuals must compete with each other for the limited environmental resources that they are rapidly running out of.Meticulously substantiated with the latest research in fields from neurobiology to human behavioral ecology, this work offers an unprecedented view into not just what governs our political battles, but why these battles have arisen within our species in the first place. From showing how these two strategies adapt in other more complex species in nature, to examining what genetic and neurostructural mechanisms may produce these divergences between individuals, to showing what this theory indicates our future may hold, this work is the most thorough analysis to date of just why we have two political ideologies, why they will never agree, and why we will tend to become even more partisan in the future.

    Your brain can't function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together.Sekeres, who writes regularly for the Well section of the New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family's wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimacy of the conversations Sekeres has with his patients, and watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it--describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia.The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.