But it’s hardly surprising considering how long it’s had to hone its skills. Forty-thousand years ago, our ancestors set off from the cradle of civilization on their journey towards populating the planet. Tuberculosis hitched a lift and came with us, and it’s been there ever since; waiting, watching, and learning. The organism responsible, Mycobacterium tuberculosis, has had plenty of time to adapt to its chosen habitat--human lungs--and has learned through natural selection to be an almost perfect pathogen. Using our own immune cells as a Trojan Horse to aid its spread, it’s come up with clever ways to avoid being killed by antibiotics. But patience has been its biggest lesson--it can enter into a latent state when times are tough, only to come back to life when a host’s immune system is compromised. Today, more than one million people die of the disease every year and around one-third of the world’s population are believed to be infected. That’s more than two billion people. Throw in the compounding problems of drug resistance, the HIV epidemic, and poverty, and it’s clear that tuberculosis remains one of the most serious problems in world medicine. Catching Breath follows the history of TB through the ages, from its time as an infection of hunter-gatherers to the first human villages, which set it up with everything it needed to become the monstrous disease it is today, through to the perils of industrialization and urbanization. It goes on to look at the latest research in fighting the disease, with stories of modern scientific research, interviews with doctors on the TB frontline, and the personal experiences of those affected by the disease.

    Smallpox. Incurable and horrifying Ebola-related fevers. For two decades, while a fearful world prepared for nuclear winter, an elite team of Russian bioweaponeers began to till a new killing field: a bleak tract sown with powerful seeds of mass destruction—by doctors who had committed themselves to creating a biological Armageddon. Biohazard is the never-before-told story of Russia’s darkest, deadliest, and most closely guarded Cold War secret.   No one knows more about Russia’s astounding experiments with biowarfare than Ken Alibek. Now the mastermind behind Russia’s germ warfare effort reveals two decades of shocking breakthroughs . . . how Moscow’s leading scientists actually reengineered hazardous microbes to make them even more virulent . . . the secrets behind the discovery of an invisible, untraceable new class of biological agents just right for use in political assassinations . . . the startling story behind Russia’s attempt to turn a sample of the AIDS virus into the ultimate bioweapon. And in a chilling work of real-world intrigue, Biohazard offers us all a rare glimpse into a shadowy scientific underworld where doctors manufacture mass destruction, where witnesses to errors are silenced forever, and where ground zero is closer than we ever dared believe.

    In bold contrast to the predominant Freudian school of thought, Becker tackles the problem of the vital lie -- man's refusal to acknowledge his own mortality. In doing so, he sheds new light on the nature of humanity and issues a call to life and its living that still resonates more than twenty years after its writing.

    When he emerged three years later, the summation of his efforts only hinted at what he'd experienced in one of the most dangerous regions on earth. Armed with an astonishing collection of zoological specimens, Du Chaillu leapt from the physical challenges of the jungle straight into the center of the biggest issues of the time--the evolution debate, racial discourse, the growth of Christian fundamentalism--and helped push each to unprecedented intensities. He experienced instant celebrity, but with that fame came whispers--about his past, his credibility, and his very identity--which would haunt the young man. Grand in scope, immediate in detail, and propulsively readable, Between Man and Beast brilliantly combines Du Chaillu's personal journey with the epic tale of a world hovering on the sharp edge of transformation.

    The Regency (1811–1820) began when the profligate Prince of Wales—the future king George IV—replaced his insane father, George III, as Britain’s ruler.Around the regent surged a society steeped in contrasts: evangelicalism and hedonism, elegance and brutality, exuberance and despair. The arts flourished at this time with a showcase of extraordinary writers and painters such as Jane Austen, Lord Byron, the Shelleys, John Constable, and J. M. W. Turner. Science burgeoned during this decade, too, giving us the steam locomotive and the blueprint for the modern computer.Yet the dark side of the era was visible in poverty, slavery, pornography, opium, and the gothic imaginings that birthed the novel Frankenstein. With the British military in foreign lands, fighting the Napoleonic Wars in Europe and the War of 1812 in the United States, the desire for empire and an expanding colonial enterprise gained unstoppable momentum. Exploring these crosscurrents, Robert Morrison illuminates the profound ways this period shaped and indelibly marked the modern world.

    This eerie chronology ventures right to the borderlines of science and sheds light into the darkness. Here, topics as wide ranging as the Maya death gods, golems, and séances sit side by side with entries on zombies and quantum immortality. With the turn of every page, readers will encounter beautiful artwork, along with unexpected insights about death and what may lie beyond.

    Taking a thematic rather than strictly chronological approach, W.F. Bynum, explores the key turning points in the history of Western medicine-such as the first surgical procedures, the advent of hospitals, the introduction of anesthesia, X-Rays, vaccinations, and many other innovations, as well as the rise of experimental medicine. The book also explores Western medicine's encounters with Chinese and Indian medicine, as well as nontraditional treatments such as homeopathy, chiropractic, and other alternative medicines. Covering a vast amount of information, this Very Short Introduction sheds new light on medicine's past, while at the same time engaging with contemporary issues, discoveries, and controversies, such as the spiraling costs of health care, lack of health insurance for millions, breakthrough treatments, and much more. For readers who wish to understand the how we have arrived at our current state of medical practice and knowledge, this book is essential reading.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Now comes a gripping account of the doctors and scientists fighting to protect us, an urgent wake-up call about the future of emerging viruses—from the #1 bestselling author of The Hot Zone, soon to be a National Geographic original miniseries.This time, Ebola started with a two-year-old child who likely had contact with a wild creature and whose entire family quickly fell ill and died. The ensuing global drama activated health professionals in North America, Europe, and Africa in a desperate race against time to contain the viral wildfire. By the end—as the virus mutated into its deadliest form, and spread farther and faster than ever before—30,000 people would be infected, and the dead would be spread across eight countries on three continents.In this taut and suspenseful medical drama, Richard Preston deeply chronicles the outbreak, in which we saw for the first time the specter of Ebola jumping continents, crossing the Atlantic, and infecting people in America. Rich in characters and conflict—physical, emotional, and ethical—Crisis in the Red Zone is an immersion in one of the great public health calamities of our time.Preston writes of doctors and nurses in the field putting their own lives on the line, of government bureaucrats and NGO administrators moving, often fitfully, to try to contain the outbreak, and of pharmaceutical companies racing to develop drugs to combat the virus. He also explores the charged ethical dilemma over who should and did receive the rare doses of an experimental treatment when they became available at the peak of the disaster. Crisis in the Red Zone makes clear that the outbreak of 2013–2014 is a harbinger of further, more severe outbreaks, and of emerging viruses heretofore unimagined—in any country, on any continent. In our ever more interconnected world, with roads and towns cut deep into the jungles of equatorial Africa, viruses both familiar and undiscovered are being unleashed into more densely populated areas than ever before.The more we discover about the virosphere, the more we realize its deadly potential. Crisis in the Red Zone is an exquisitely timely book, a stark warning of viral outbreaks to come.

    We then follow white settlement west, learning how, in the 1720s, seventy-five years before Edward Jenner’s experiments with smallpox vaccine, a Boston doctor learned from an African slave how to vaccinate against the disease; how, in 1809, a backwoods Kentucky doctor performed the first successful abdominal surgery; how, around 1820, a Missouri doctor realized quinine could prevent as well as cure malaria and made a fortune from the resulting pills he invented.Using diaries, journals, newspapers, letters, advertisements, medical records, and pharmacological writings, Dary gives us firsthand accounts of Indian cures; the ingenious self-healings of mountain men; home remedies settlers carried across the plains; an early “HMO” formed by Wyoming ranchers and cowboys to provide themselves with medical care; the indispensable role of country doctors and midwives; the fortunes made from patent medicines and quack cures; the contributions of army medicine; Chinese herbalists; the formation of the American Medical Association; the first black doctors; the first women doctors; and finally the early-twentieth-century shift to a formal scientific approach to medicine that by the postwar period had for the most part eliminated the trial-and-error practical methods that were at the center of frontier medicine.A wonderful—often entertaining—overview of the complexity, energy, and inventiveness of the ways in which our forebears were doctored and how our medical system came into being.

     A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments. Around the globe, 16 million people are alive today thanks to their efforts. Not since the publication of Randy Shilts's classic And the Band Played On has a book measured the AIDS plague in such brutally human, intimate, and soaring terms. In dramatic fashion, we witness the founding of ACT UP and TAG (Treatment Action Group), and the rise of an underground drug market in opposition to the prohibitively expensive (and sometimes toxic) AZT. We watch as these activists learn to become their own researchers, lobbyists, drug smugglers, and clinicians, establishing their own newspapers, research journals, and laboratories, and as they go on to force reform in the nation s disease-fighting agencies. With his unparalleled access to this community David France illuminates the lives of extraordinary characters, including the closeted Wall Street trader-turned-activist, the high school dropout who found purpose battling pharmaceutical giants in New York, the South African physician who helped establish the first officially recognized buyers club at the height of the epidemic, and the public relations executive fighting to save his own life for the sake of his young daughter. Expansive yet richly detailed, this is an insider's account of a pivotal moment in the history of American civil rights. Powerful, heart-wrenching, and finally exhilarating, How to Survive a Plague is destined to become an essential part of the literature of AIDS.

    Ebola. "Killer microbes." All around us the alarms are going off, warning of the danger of new, deadly diseases. And yet, as Nancy Tomes reminds us in her absorbing book, this is really nothing new. A remarkable work of medical and cultural history, The Gospel of Germs takes us back to the first great "germ panic" in American history, which peaked in the early 1900s, to explore the origins of our modern disease consciousness.Little more than a hundred years ago, ordinary Americans had no idea that many deadly ailments were the work of microorganisms, let alone that their own behavior spread such diseases. The Gospel of Germs shows how the revolutionary findings of late nineteenth-century bacteriology made their way from the laboratory to the lavatory and kitchen, with public health reformers spreading the word and women taking up the battle on the domestic front. Drawing on a wealth of advice books, patent applications, advertisements, and oral histories, Tomes traces the new awareness of the microbe as it radiated outward from middle-class homes into the world of American business and crossed the lines of class, gender, ethnicity, and race.Just as we take some of the weapons in this germ war for granted--fixtures as familiar as the white porcelain toilet, the window screen, the refrigerator, and the vacuum cleaner--so we rarely think of the drastic measures deployed against disease in the dangerous old days before antibiotics. But, as Tomes notes, many of the hygiene rules first popularized in those days remain the foundation of infectious disease control today. Her work offers a timely look into the history of our long-standing obsession with germs, its impact on twentieth-century culture and society, and its troubling new relevance to our own lives.

    This groundbreaking book, winner of the 1974 Sorokin Award of the American Sociological Association, helped define for an entire generation of anthropologists what their field is ultimately about.

    In The Anatomy of Violence, Raine dissects the criminal mind with a fascinating, readable, and far-reaching scientific journey into the body of evidence that reveals the brain to be a key culprit in crime causation.  Raine documents from genetic research that the seeds of sin are sown early in life, giving rise to abnormal physiological functioning that cultivates crime. Drawing on classical case studies of well-known killers in history—including Richard Speck, Ted Kaczynski, and Henry Lee Lucas—Raine illustrates how impairments to brain areas controlling our ability to experience fear, make good decisions, and feel guilt predispose us to violence. He contends that killers can actually be coldhearted: something as simple as a low resting heart rate can give rise to violence. But arguing that biology is not destiny, he also sketches out provocative new biosocial treatment approaches that can change the brain and prevent violence.  Finally, Raine tackles the thorny legal and ethical dilemmas posed by his research, visualizing a futuristic brave new world where our increasing ability to identify violent offenders early in life might shape crime-prevention policies, for good and bad. Will we sacrifice our notions of privacy and civil rights to identify children as potential killers in the hopes of helping both offenders and victims? How should we punish individuals with little to no control over their violent behavior? And should parenting require a license? The Anatomy of Violence offers a revolutionary appraisal of our understanding of criminal offending, while also raising provocative questions that challenge our core human values of free will, responsibility, and punishment.From the Hardcover edition.