By 1988 she was living at home but was brain dead after a tragic cycle of misunderstanding, over-medication, and culture clash: "What the doctors viewed as clinical efficiency the Hmong viewed as frosty arrogance." The Spirit Catches You and You Fall Down is a tragedy of Shakespearean dimensions, written with the deepest of human feeling. Sherwin Nuland said of the account, "There are no villains in Fadiman's tale, just as there are no heroes. People are presented as she saw them, in their humility and their frailty—and their nobility.

    It may be the start of a scientific experiment that could alter the human race forever--and reveal a shocking truth about our future.Experience the groundbreaking novel that will change everything you think you know about pandemics--and how to survive one.“Reads like a superior collaboration between Dan Brown and Michael Crichton.”—The GuardianNow an Amazon Charts and Wall Street Journal bestseller.A hundred miles north of Alaska, a US Coast Guard vessel discovers a sunken submarine at the bottom of the Arctic Ocean. It has no national identification and doesn’t match the records of any known vessel. Deep within, researchers find evidence of a scientific experiment that will rewrite our basic understanding of the human race.In Atlanta, Dr. Peyton Shaw is awakened by the phone call she has dreaded for years. As the CDC’s leading epidemiologist, she’s among the first responders to outbreaks around the world. It’s a lonely and dangerous job, but it’s her life—and she’s good at it. This time, she may have met her match.In Kenya, an Ebola-like pathogen has infected two Americans. One lies at death’s door. With the clock ticking, Peyton assembles her team and joins personnel from the Kenyan Ministry of Health and the WHO. What they find in the remote village is beyond their worst fears. As she traces the origin of the pathogen, Peyton begins to believe that there is more to this outbreak—that it may be merely the opening act in a conspiracy with far reaching consequences.In Berlin, Desmond Hughes awakens in a hotel room with no memory of how he got there or who he is. On the floor, he finds a dead security guard from an international pharmaceutical company. His only clue leads him to Peyton Shaw—a woman who seems to know him, but refuses to tell him how. With the police searching the city for him, Desmond desperately tries to piece together what happened to him. To his shock and horror, he learns that he may be involved in causing the outbreak—and could hold the only key to stopping it.As the pathogen spreads around the world, Peyton and Desmond race to unravel the conspiracy behind the pandemic—and uncover secrets some want to keep buried. With time running out, they face an unimaginable decision.Buy now and begin the journey (or read for free in Kindle Unlimited).Selected Praise and Published Reviews“I finished the book fast because I just couldn’t wait...”—WIRED GeekDad on Departure“Riddle makes an effort to keep the focus on how his characters react to each other (including to their future selves) rather than to the technological marvels that reshaped their world.”—Publisher’s Weekly on Departure“Well-constructed and tightly-wound as a fine Swiss watch—Departure has non-stop action, an engaging plot and, of course, wheels within wheels.”—Diana Gabaldon, #1 New York Times bestselling author of Outlander on Departure About Pandemic

    Deep in the mist-shrouded forests of the Pacific Northwest is a small mill town called Commonwealth, conceived as a haven for workers weary of exploitation. For Philip Worthy, the adopted son of the town's founder, it is a haven in another sense-as the first place in his life he's had a loving family to call his own. And yet, the ideals that define this outpost are being threatened from all sides. A world war is raging, and with the fear of spies rampant, the loyalty of all Americans is coming under scrutiny. Meanwhile, another shadow has fallen across the region in the form of a deadly illness striking down vast swaths of surrounding communities. When Commonwealth votes to quarantine itself against contagion, guards are posted at the single road leading in and out of town, and Philip Worthy is among them. He will be unlucky enough to be on duty when a cold, hungry, tired-and apparently ill-soldier presents himself at the town's doorstep begging for sanctuary. The encounter that ensues, and the shots that are fired, will have deafening reverberations throughout Commonwealth, escalating until every human value-love, patriotism, community, family, friendship-not to mention the town's very survival, is imperiled. Inspired by a little-known historical footnote regarding towns that quarantined themselves during the 1918 epidemic, "The Last Town on Earth" is a remarkably moving and accomplished debut.

    The popularity of murder mystery books, TV series, and even board games shows that there is an appetite for death, and the more unusual or macabre the method, the better. With gunshots or stabbings the cause of death is obvious, but poisons are inherently more mysterious. How are some compounds so deadly in such tiny amounts?Agatha Christie used poison to kill her characters more often than any other crime fiction writer. The poison was a central part of the novel, and her choice of deadly substances was far from random; the chemical and physiological characteristics of each poison provide vital clues to the discovery of the murderer. Christie demonstrated her extensive chemical knowledge (much of it gleaned by working in a pharmacy during both world wars) in many of her novels, but this is rarely appreciated by the reader.Written by former research chemist Kathryn Harkup, each chapter takes a different novel and investigates the poison used by the murderer. Fact- and fun-packed, A is for Arsenic looks at why certain chemicals kill, how they interact with the body, and the feasibility of obtaining, administering, and detecting these poisons, both when Christie was writing and today.

    Jonathan B. Tucker traces the history of the smallpox virus from its first recorded outbreak around 3700 B.C. through its use as the first biological warfare agent in human history, and draws some decisively important lessons for the future. In a timely debate, Tucker addresses the ever-growing concerns about the proliferation of the deadly smallpox virus and its use by terrorist organizations. Explaining how the eradication of the disease in the late 1970s encouraged military research and production of the virus, he exposes the failure of the Russian government to secure its remaining cold-war stockpiles, and evaluates the past and present measures undertaken by the United States to counter the existing dangers of a smallpox attack. Ultimately, he passionately argues for the strengthening of the existing legal ban on the development and possession of biological weapons. Impeccably researched, Scourge is as arresting as it is indispensable, and as William Beatty in Booklist raves, Tucker has a sense of ... history that helps him make the story of smallpox as disease and ... weapon fascinating and frightening. Scourge has been acclaimed as a concise, suspenseful and scientifically accurate narrative. -- The New York Times Book Review Tucker's fascinating, revealing book affords the reader a sobering look at this new type of warfare.... -- Chris Patsilelis, Houston Chronicle -- [Tucker] reports the debate evenhandedly and with telling detail. -- David Brown, The Washington Post Book World

    government. You have to remember because Harvard doesn't let you forget.1969: the height of counterculture and the year universities would seek to curb the unruly spectacle of student protest; the winter that Harvard University would begin the tumultuous process of merging with Radcliffe, its all-female sister school; and the year that Jane Britton, an ambitious twenty-three-year-old graduate student in Harvard's Anthropology Department and daughter of Radcliffe Vice President J. Boyd Britton, would be found bludgeoned to death in her Cambridge, Massachusetts apartment.   Forty years later, Becky Cooper a curious undergrad, will hear the first whispers of the story. In the first telling the body was nameless. The story was this: a Harvard student had had an affair with her professor, and the professor had murdered her in the Peabody Museum of Archaeology and Ethnology because she'd threatened to talk about the affair. Though the rumor proves false, the story that unfolds, one that Cooper will follow for ten years, is even more complex: a tale of gender inequality in academia, a 'cowboy culture' among empowered male elites, the silencing effect of institutions, and our compulsion to rewrite the stories of female victims. We Keep the Dead Close is a memoir of mirrors, misogyny, and murder. It is at once a rumination on the violence and oppression that rules our revered institutions, a ghost story reflecting one young woman's past onto another's present, and a love story for a girl who was lost to history.

    By allowing women to control their fertility, the birth control pill has revolutionized women's lives. Women are going to college, graduating, and entering the workforce in greater numbers than ever before, and there's good reason to believe that the birth control pill has a lot to do with this. But there's a lot more to the pill than meets the eye.Although women go on the pill for a small handful of targeted effects (pregnancy prevention and clearer skin, yay!), sex hormones can't work that way. Sex hormones impact the activities of billions of cells in the body at once, many of which are in the brain. There, they play a role in influencing attraction, sexual motivation, stress, hunger, eating patterns, emotion regulation, friendships, aggression, mood, learning, and more. This means that being on the birth control pill makes women a different version of themselves than when they are off of it. And this is a big deal. For instance, women on the pill have a dampened cortisol spike in response to stress. While this might sound great (no stress!), it can have negative implications for learning, memory, and mood. Additionally, because the pill influences who women are attracted to, being on the pill may inadvertently influence who women choose as partners, which can have important implications for their relationships once they go off it. Sometimes these changes are for the better . . . but other times, they're for the worse. By changing what women's brains do, the pill also has the ability to have cascading effects on everything and everyone that a woman encounters. This means that the reach of the pill extends far beyond women's own bodies, having a major impact on society and the world.This paradigm-shattering book provides an even-handed, science-based understanding of who women are, both on and off the pill. It will change the way that women think about their hormones and how they view themselves. It also serves as a rallying cry for women to demand more information from science about how their bodies and brains work and to advocate for better research. This book will help women make more informed decisions about their health, whether they're on the pill or off of it.

    Forty-five million called him emperor, and he commanded a nation that was the richest, most cultured, and advanced on earth. No army could stand against his impeccably trained, brilliantly led forces, and his continued sweep across Europe seemed inevitable. Early that year, bolstered by his successes, Napoleon turned his attentions toward Moscow, helming the largest invasion in human history. Surely, Tsar Alexander’s outnumbered troops would crumble against this mighty force. But another powerful and ancient enemy awaited Napoleon’s men in the Russian steppes. Virulent and swift, this microscopic foe would bring the emperor to his knees. Even as the Russians retreated before him in disarray, Napoleon found his army disappearing, his frantic doctors powerless to explain what had struck down a hundred thousand soldiers. The emperor’s vaunted military brilliance suddenly seemed useless, and when the Russians put their own occupied capital to the torch, the campaign became a desperate race through the frozen landscape as troops continued to die by the thousands. Through it all, with tragic heroism, Napoleon’s disease-ravaged, freezing, starving men somehow rallied, again and again, to cries of “Vive l’Empereur!”Yet Talty’s sweeping tale takes us far beyond the doomed heroics and bloody clashes of the battlefield. The Illustrious Dead delves deep into the origins of the pathogen that finally ended the mighty emperor’s dreams of world conquest and exposes this “war plague’s” hidden role throughout history. A tale of two unstoppable forces meeting on the road to Moscow in an epic clash of killer microbe and peerless army, The Illustrious Dead is a historical whodunit in which a million lives hang in the balance.

    But it’s also messy, fallible, and about 50,000 years out of date. We cling to superstitions, remember faces but not names, miss things sitting right in front of us, and lie awake at night while our brains endlessly replay our greatest fears. Idiot Brain is for anyone who has ever wondered why their brain appears to be sabotaging their life—and what on earth it is really up to.A Library Journal Science Bestseller and a Finalist for the Goodreads Choice Award in Science Technology.

    Mankind's battle to stay alive and healthy for as long as possible is our oldest, most universal struggle. With his characteristic wit and vastly informed historical scope, Roy Porter examines the war fought between disease and doctors on the battleground of the flesh from ancient times to the present. He explores the many ingenious ways in which we have attempted to overcome disease through the ages: the changing role of doctors, from ancient healers, apothecaries, and blood-letters to today's professionals; the array of drugs, from Ayurvedic remedies to the launch of Viagra; the advances in surgery, from amputations performed by barbers without anesthetic to today's sophisticated transplants; and the transformation of hospitals from Christian places of convalescence to modern medical powerhouses. Cleverly illustrated with historic line drawings, the chronic ailments of humanity provide vivid anecdotes for Porter's enlightening story of medicine's efforts to prevail over a formidable and ever-changing adversary.

    If your anxiety about global warming is dominated by fears of sea-level rise, you are barely scratching the surface of what terrors are possible. In California, wildfires now rage year-round, destroying thousands of homes. Across the US, "500-year" storms pummel communities month after month, and floods displace tens of millions annually.This is only a preview of the changes to come. And they are coming fast. Without a revolution in how billions of humans conduct their lives, parts of the Earth could become close to uninhabitable, and other parts horrifically inhospitable, as soon as the end of this century.In his travelogue of our near future, David Wallace-Wells brings into stark relief the climate troubles that await--food shortages, refugee emergencies, and other crises that will reshape the globe. But the world will be remade by warming in more profound ways as well, transforming our politics, our culture, our relationship to technology, and our sense of history. It will be all-encompassing, shaping and distorting nearly every aspect of human life as it is lived today.Like An Inconvenient Truth and Silent Spring before it, The Uninhabitable Earth is both a meditation on the devastation we have brought upon ourselves and an impassioned call to action. For just as the world was brought to the brink of catastrophe within the span of a lifetime, the responsibility to avoid it now belongs to a single generation.

    Seven months later, after joining a party of emigrants led by George Donner, they reached the Sierra Nevada Mountains as the first heavy snows of the season closed the pass ahead of them. In early December, starving and desperate, Sarah and fourteen others set out for California on snowshoes and, over the next thirty-two days, endured almost unfathomable hardships and horrors. In this gripping narrative, Daniel James Brown sheds new light on one of the most infamous events in American history. Following every painful footstep of Sarah's journey with the Donner Party, Brown produces a tale both spellbinding and richly informative.

    From Sarajevo under siege in 1993 to clandestine hospitals in rebel-held eastern Aleppo, he has carried out lifesaving operations in the most challenging conditions, and with none of the resources of a major metropolitan hospital. He is now widely acknowledged as the most experienced trauma surgeon in the world.War Doctor is his extraordinary story, encompassing his surgeries in nearly every major conflict zone since the end of the Cold War, as well as his struggles to return to a “normal” life and routine after each trip. Culminating in his recent trips to war-torn Syria—and the untold story of his efforts to help secure a humanitarian corridor out of besieged Aleppo to evacuate some 50,000 people—War Doctor is a blend of medical memoir, personal journey, and nonfiction thriller that provides unforgettable, at times raw, insight into the human toll of war.

    Join renowned neuroscientist David Eagleman for a journey into the questions at the mysterious heart of our existence. What is reality? Who are “you”? How do you make decisions? Why does your brain need other people? How is technology poised to change what it means to be human?  In the course of his investigations, Eagleman guides us through the world of extreme sports, criminal justice, facial expressions, genocide, brain surgery, gut feelings, robotics, and the search for immortality.  Strap in for a whistle-stop tour into the inner cosmos. In the infinitely dense tangle of billions of brain cells and their trillions of connections, something emerges that you might not have expected to see in there: you.

    In his grey suit and tie, he looked like any other Soviet citizen. The bag alone was mildly conspicuous, printed with the red logo of Safeway, the British supermarket.The man was a spy for MI6. A senior KGB officer, for more than a decade he had supplied his British spymasters with a stream of priceless secrets from deep within the Soviet intelligence machine. No spy had done more to damage the KGB. The Safeway bag was a signal: to activate his escape plan to be smuggled out of Soviet Russia. So began one of the boldest and most extraordinary episodes in the history of spying. Ben Macintyre reveals a tale of espionage, betrayal and raw courage that changed the course of the Cold War forever...