In Missing Microbes, Dr. Martin Blaser invites us into the wilds of the human microbiome where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now, this invisible eden is being irrevocably damaged by some of our most revered medical advances—antibiotics—threatening the extinction of our irreplaceable microbes with terrible health consequences. Taking us into both the lab and deep into the fields where these troubling effects can be witnessed firsthand, Blaser not only provides cutting edge evidence for the adverse effects of antibiotics, he tells us what we can do to avoid even more catastrophic health problems in the future. http://us.macmillan.com/missingmicrob...

    1 begins one of the most remarkable works of history ever fashioned. All the great battles are here, of course, from Bull Run through Shiloh, the Seven Days Battles, and Antietam, but so are the smaller ones: Ball's Bluff, Fort Donelson, Pea Ridge, Island Ten, New Orleans, and Monitor versus Merrimac. The word "narrative" is the key to this extraordinary book's incandescence and its truth. The story is told entirely from the point of view of the people involved in it. One learns not only what was happening on all fronts but also how the author discovered it during his years of exhaustive research. This first volume in Shelby Foote's comprehensive history is a must-listen for anyone interested in one of the bloodiest wars in America's history.

    In a matter of months, a city designed to produce this dangerous material arose from the desert of eastern Washington State. Plutonium powered the bomb that dropped on Nagasaki on August 9, 1945 (a target selected in almost arbitrary fashion). And the work of Glenn Seaborg, Enrico Fermi, and hundreds of thousands of others—the physicists, engineers, laborers, and support staff of the Hanford Nuclear Facility—would remain the basis of the entire US nuclear arsenal during the Cold War and into the present.With his characteristic blend of scientific clarity and human stories, Steve Olson offers this dramatic story of human achievement—and hubris—to a new generation.

    . . alive and fascinating and provocative on every page."—Oliver Sacks, M.D.Porter's charting of the history of medicine affords readers the opportunity as never before to assess its culture and science and its costs and benefits to humankind. "A splendid and thoroughly engrossing book."--"L.A. Times." of illustrations.

    In the middle of building an atomic bomb, the leaders of the Manhattan Project were alarmed to learn that Nazi Germany was far outpacing the Allies in nuclear weapons research. Hitler, with just a few pounds of uranium, would have the capability to reverse the entire D-Day operation and conquer Europe. So they assembled a rough and motley crew of geniuses - dubbed the Alsos Mission - and sent them careening into Axis territory to spy on, sabotage, and even assassinate members of Nazi Germany's feared Uranium Club.

    But power is not merely shifting and dispersing. It is also decaying. Those in power today are more constrained in what they can do with it and more at risk of losing it than ever before. In The End of Power, award-winning columnist and former Foreign Policy editor Moisés Naím illuminates the struggle between once-dominant megaplayers and the new micropowers challenging them in every field of human endeavor. Drawing on provocative, original research, Naím shows how the antiestablishment drive of micropowers can topple tyrants, dislodge monopolies, and open remarkable new opportunities, but it can also lead to chaos and paralysis. Naím deftly covers the seismic changes underway in business, religion, education, within families, and in all matters of war and peace. Examples abound in all walks of life: In 1977, eighty-nine countries were ruled by autocrats while today more than half the world's population lives in democracies. CEO's are more constrained and have shorter tenures than their predecessors. Modern tools of war, cheaper and more accessible, make it possible for groups like Hezbollah to afford their own drones. In the second half of 2010, the top ten hedge funds earned more than the world's largest six banks combined. Those in power retain it by erecting powerful barriers to keep challengers at bay. Today, insurgent forces dismantle those barriers more quickly and easily than ever, only to find that they themselves become vulnerable in the process. Accessible and captivating, Naím offers a revolutionary look at the inevitable end of power—and how it will change your world.

    The stewards of Earth, these organisms transformed the chemistry of our planet to make it habitable for plants, animals, and us. Life's Engines takes readers deep into the microscopic world to explore how these marvelous creatures made life on Earth possible--and how human life today would cease to exist without them.Paul Falkowski looks "under the hood" of microbes to find the engines of life, the actual working parts that do the biochemical heavy lifting for every living organism on Earth. With insight and humor, he explains how these miniature engines are built--and how they have been appropriated by and assembled like Lego sets within every creature that walks, swims, or flies. Falkowski shows how evolution works to maintain this core machinery of life, and how we and other animals are veritable conglomerations of microbes.A vibrantly entertaining book about the microbes that support our very existence, Life's Engines will inspire wonder about these elegantly complex nanomachines that have driven life since its origin. It also issues a timely warning about the dangers of tinkering with that machinery to make it more "efficient" at meeting the ever-growing demands of humans in the coming century.

    In this remarkable and intimate account, author G. J. Meyer draws on exhaustive research to bring to life the story of how the Great War reduced Europe’s mightiest empires to rubble, killed twenty million people, and cracked the foundations of the world we live in today.

    In The Viral Storm, award-winning biologist Nathan Wolfe tells the story of how viruses and human beings have evolved side by side through history; how deadly viruses like HIV, swine flu, and bird flu almost wiped us out in the past; and why modern life has made our species vulnerable to the threat of a global pandemic.Wolfe's research missions to the jungles of Africa and the rain forests of Borneo have earned him the nickname "the Indiana Jones of virus hunters," and here Wolfe takes readers along on his groundbreaking and often dangerous research trips—to reveal the surprising origins of the most deadly diseases and to explain the role that viruses have played in human evolution.In a world where each new outbreak seems worse than the one before, Wolfe points the way forward, as new technologies are brought to bear in the most remote areas of the world to neutralize these viruses and even harness their power for the good of humanity. His provocative vision of the future will change the way we think about viruses, and perhaps remove a potential threat to humanity's survival.

    Most Iraqis were barred from entering the Emerald City for fear they would blow it up. Drawing on hundreds of interviews and internal documents, Chandrasekaran tells the story of the people and ideas that inhabited the Green Zone during the occupation, from the imperial viceroy L. Paul Bremer III to the fleet of twentysomethings hired to implement the idea that Americans could build a Jeffersonian democracy in an embattled Middle Eastern country. In the vacuum of postwar planning, Bremer ignores what Iraqis tell him they want or need and instead pursues irrelevant neoconservative solutions—a flat tax, a sell-off of Iraqi government assets, and an end to food rationing. His underlings spend their days drawing up pie-in-the-sky policies, among them a new traffic code and a law protecting microchip designs, instead of rebuilding looted buildings and restoring electricity production. His almost comic initiatives anger the locals and help fuel the insurgency. Chandrasekaran details Bernard Kerik’s ludicrous attempt to train the Iraqi police and brings to light lesser known but typical travesties: the case of the twenty-four-year-old who had never worked in finance put in charge of reestablishing Baghdad’s stock exchange; a contractor with no previous experience paid millions to guard a closed airport; a State Department employee forced to bribe Americans to enlist their help in preventing Iraqi weapons scientists from defecting to Iran; Americans willing to serve in Iraq screened by White House officials for their views on Roe v. Wade; people with prior expertise in the Middle East excluded in favor of lesser-qualified Republican Party loyalists. Finally, he describes Bremer’s ignominious departure in 2004, fleeing secretly in a helicopter two days ahead of schedule. This is a startling portrait of an Oz-like place where a vital aspect of our government’s folly in Iraq played out. It is a book certain to be talked about for years to come.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    In his classic The Age of Spiritual Machines, he argued that computers would soon rival the full range of human intelligence at its best. Now he examines the next step in this inexorable evolutionary process: the union of human and machine, in which the knowledge and skills embedded in our brains will be combined with the vastly greater capacity, speed, and knowledge-sharing ability of our creations.

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    Navy, and a crazy billionaire spent six years and nearly a billion dollars to steal the nuclear-armed Soviet submarine K-129 after it had sunk to the bottom of the Pacific Ocean; all while the Russians were watching.In the early hours of February 25, 1968, a Russian submarine armed with three nuclear ballistic missiles set sail from its base in Siberia on a routine combat patrol to Hawaii. It never arrived. As the Soviet Navy searched in vain for the lost vessel, a top-secret American operation using sophisticated deep-sea spy equipment found it—wrecked on the sea floor at a depth of 16,800 feet, far beyond the capabilities of any salvage that existed. But the potential intelligence assets onboard the ship—the nuclear warheads, battle orders, and cryptological machines—justified going to extreme lengths to find a way to raise the submarine.So began Project Azorian, a top-secret mission that took six years, cost an estimated $800 million, and would become the largest and most daring covert operation in CIA history. After the U.S. Navy declared retrieving the sub “impossible,” the mission fell to the CIA's burgeoning Directorate of Science and Technology, the little-known division responsible for the legendary U-2 and SR-71 Blackbird spy planes. Working with Global Marine Systems, the country's foremost maker of exotic, deep-sea drill ships, the CIA commissioned the most expensive ship ever built and told the world that it belonged to the reclusive billionaire Howard Hughes, who would use the mammoth vessel to mine rare minerals from the ocean floor. In reality, a complex network of spies, scientists, and politicians attempted a project even crazier than Hughes’s reputation: raising the sub directly under the watchful eyes of the Russians. The Taking of K-129 is a riveting, almost unbelievable true-life tale of military history, engineering genius, and high-stakes spy-craft set during the height of the Cold War, when nuclear annihilation was a constant fear, and the opportunity to gain even the slightest advantage over your enemy was worth massive risk.