As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    The disintegration of this group, a process that has been slowly occurring now for more than forty years, has been reported with growing frequency and alarm, but has never before been written about as searingly from the inside. J. D. Vance tells the true story of what a social, regional, and class decline feels like when you were born with it hung around your neck.The Vance family story begins hopefully in postwar America. J. D.’s grandparents were “dirt poor and in love,” and moved north from Kentucky’s Appalachia region to Ohio in the hopes of escaping the dreadful poverty around them. They raised a middle-class family, and eventually one of their grandchildren would graduate from Yale Law School, a conventional marker of success in achieving generational upward mobility. But as the family saga of Hillbilly Elegy plays out, we learn that J.D.'s grandparents, aunt, uncle, sister, and, most of all, his mother struggled profoundly with the demands of their new middle-class life, never fully escaping the legacy of abuse, alcoholism, poverty, and trauma so characteristic of their part of America. With piercing honesty, Vance shows how he himself still carries around the demons of his chaotic family history.A deeply moving memoir, with its share of humor and vividly colorful figures, Hillbilly Elegy is the story of how upward mobility really feels. And it is an urgent and troubling meditation on the loss of the American dream for a large segment of this country.

    In his comic, coming-of-age memoir, he takes us back to the Obama years – and charts a path forward in the age of TrumpMore than any other presidency, Barack Obama’s eight years in the White House were defined by young people – twenty-somethings who didn’t have much experience in politics (or anything else, for that matter), yet suddenly found themselves in the most high-stakes office building on earth. David Litt was one of those twenty-somethings. After graduating from college in 2008, he went straight to the Obama campaign. In 2011, he became one of the youngest White House speechwriters in history. Until leaving the White House in 2016, he wrote on topics from healthcare to climate change to criminal justice reform. As President Obama’s go-to comedy writer, he also took the lead on the White House Correspondents’ Dinner, the so-called “State of the Union of jokes.”Now, in this refreshingly honest memoir, Litt brings us inside Obamaworld. With a humorists’ eye for detail, he describes what it’s like to accidentally trigger an international incident or nearly set a president’s hair aflame. He answers questions you never knew you had: Which White House men’s room is the classiest? What do you do when the commander in chief gets your name wrong? Where should you never, under any circumstances, change clothes on Air Force One? With nearly a decade of stories to tell, Litt makes clear that politics is completely, hopelessly absurd.   But it’s also important. For all the moments of chaos, frustration, and yes, disillusionment, Litt remains a believer in the words that first drew him to the Obama campaign: “People who love this country can change it.” In telling his own story, Litt sheds fresh light on his former boss’s legacy. And he argues that, despite the current political climate, the politics championed by Barack Obama will outlive the presidency of Donald Trump.Full of hilarious stories and told in a truly original voice, Thanks, Obama is an exciting debut about what it means – personally, professionally, and politically – to grow up.

    Its mission was to know the world. When it did not succeed, it set out to change the world. Its failures have handed us, in the words of President Eisenhower, “a legacy of ashes.”Now Pulitzer Prize–winning author Tim Weiner offers the first definitive history of the CIA—and everything is on the record. LEGACY OF ASHES is based on more than 50,000 documents, primarily from the archives of the CIA itself, and hundreds of interviews with CIA veterans, including ten Directors of Central Intelligence. It takes the CIA from its creation after World War II, through its battles in the cold war and the war on terror, to its near-collapse after September 11th, 2001.Tim Weiner’s past work on the CIA and American intelligence was hailed as “impressively reported” and “immensely entertaining” in The New York Times.The Wall Street Journal called it “truly extraordinary . . . the best book ever written on a case of espionage.” Here is the hidden history of the CIA: why eleven presidents and three generations of CIA officers have been unable to understand the world; why nearly every CIA director has left the agency in worse shape than he found it; and how these failures have profoundly jeopardized our national security.

     Liliane Bettencourt is the world s richest woman and the eleventh wealthiest person on the planet, as of 2016. But at ninety-four, she s embroiled in an incredible controversy that has dominated the headlines and ensnared a former president of France in the controversy. Why? Thanks to an artist and photographer named Francois-Marie Banier, who was given hundreds of millions of dollars by Liliane. Liliane s daughter, Francoise, considers Banier a con man and filed a lawsuit against him, but Banier has a far different story to tell. It s all become Europe s biggest scandal in years, uncovering a shadowy corporate history, buried World War II secrets, illicit political payoffs, and much more. Written by Tom Sancton, aVanity Faircontributor and formerTimecorrespondent currently living in France, The Bettencourt Affairis part courtroom drama; part upstairs-downstairs tale; part business narrative of a glamorous global company with past Nazi connections; and part character-driven story of a complex, fascinating family and the intruder who nearly tore it apart."

    T. Anderson delivers an account of the Siege of Leningrad and the role played by Russian composer Shostakovich and his Leningrad Symphony.In September 1941, Adolf Hitler’s Wehrmacht surrounded Leningrad in what was to become one of the longest and most destructive sieges in Western history—almost three years of bombardment and starvation that culminated in the harsh winter of 1943–1944. More than a million citizens perished. Survivors recall corpses littering the frozen streets, their relatives having neither the means nor the strength to bury them. Residents burned books, furniture, and floorboards to keep warm; they ate family pets and—eventually—one another to stay alive. Trapped between the Nazi invading force and the Soviet government itself was composer Dmitri Shostakovich, who would write a symphony that roused, rallied, eulogized, and commemorated his fellow citizens—the Leningrad Symphony, which came to occupy a surprising place of prominence in the eventual Allied victory.This is the true story of a city under siege: the triumph of bravery and defiance in the face of terrifying odds. It is also a look at the power—and layered meaning—of music in beleaguered lives.

    But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.Cullen's murderous career in the world's most trusted profession spanned sixteen years and nine hospitals across New Jersey and Pennsylvania. When, in March of 2006, Charles Cullen was marched from his final sentencing in an Allentown, Pennsylvania, courthouse into a waiting police van, it seemed certain that the chilling secrets of his life, career, and capture would disappear with him. Now, in a riveting piece of investigative journalism nearly ten years in the making, journalist Charles Graeber presents the whole story for the first time. Based on hundreds of pages of previously unseen police records, interviews, wire-tap recordings and videotapes, as well as exclusive jailhouse conversations with Cullen himself and the confidential informant who helped bring him down, THE GOOD NURSE weaves an urgent, terrifying tale of murder, friendship, and betrayal.Graeber's portrait of Cullen depicts a surprisingly intelligent and complicated young man whose promising career was overwhelmed by his compulsion to kill, and whose shy demeanor masked a twisted interior life hidden even to his family and friends. Were it not for the hardboiled, unrelenting work of two former Newark homicide detectives racing to put together the pieces of Cullen's professional past, and a fellow nurse willing to put everything at risk, including her job and the safety of her children, there's no telling how many more lives could have been lost.In the tradition of In Cold Blood, THE GOOD NURSE does more than chronicle Cullen's deadly career and the breathless efforts to stop him; it paints an incredibly vivid portrait of madness and offers a penetrating look inside America's medical system. Harrowing and irresistibly paced, this book will make you look at medicine, hospitals, and the people who work in them, in an entirely different way.

    In her adolescence, she was a religious radical, melting her brother’s boy band cassettes in the oven because music was haram: forbidden by Islamic law. But what a difference an education can make. By her twenties she was a computer security engineer, one of few women working in a desert compound that resembled suburban America. That’s when the Saudi kingdom’s contradictions became too much to bear: she was labeled a slut for chatting with male colleagues, her teenage brother chaperoned her on a business trip, and while she kept a car in her garage, she was forbidden from driving down city streets behind the wheel.Daring to Drive is the fiercely intimate memoir of an accidental activist, a powerfully vivid story of a young Muslim woman who stood up to a kingdom of men—and won. Writing on the cusp of history, Manal offers a rare glimpse into the lives of women in Saudi Arabia today. Her memoir is a remarkable celebration of resilience in the face of tyranny, the extraordinary power of education and female solidarity, and the difficulties, absurdities, and joys of making your voice heard.

    Adam Neumann, an immigrant determined to make his fortune in the United States, landed on the idea of repurposing surplus New York office space for the burgeoning freelance class. Over the course of ten years, WeWork attracted billions of dollars from some of the most sought-after investors in the world, while spending it to build a global real estate empire that he insisted was much more than that: an organization that aspired to nothing less than "elevating the world's consciousness."Moving between New York real estate, Silicon Valley venture capital, and the very specific force field of spirituality and ambition erected by Adam Neumann himself, Billion Dollar Loser lays bare the internal drama inside WeWork. Based on more than two hundred interviews, this book chronicles the breakneck speed at which WeWork’s CEO built and grew his company along with Neumann’s relationship to a world of investors, including Masayoshi Son of Softbank, who fueled its chaotic expansion into everything from apartment buildings to elementary schools.Culminating in a day-by-day account of the five weeks leading up to WeWork’s botched IPO and Neumann’s dramatic ouster, Wiedeman exposes the story of the company’s desperate attempt to secure the funding it needed in the final moments of a decade defined by excess. Billion Dollar Loser is the first book to indelibly capture the highly leveraged, all-blue-sky world of American business in President Trump’s first term, and also offers a sober reckoning with its fallout as a new era begins.

    Over the course of minutes, they would kill twelve students and a teacher and wound twenty-four others before taking their own lives.   For the last sixteen years, Sue Klebold, Dylan’s mother, has lived with the indescribable grief and shame of that day. How could her child, the promising young man she had loved and raised, be responsible for such horror? And how, as his mother, had she not known something was wrong? Were there subtle signs she had missed? What, if anything, could she have done differently?   These are questions that Klebold has grappled with every day since the Columbine tragedy. In A Mother’s Reckoning, she chronicles with unflinching honesty her journey as a mother trying to come to terms with the incomprehensible. In the hope that the insights and understanding she has gained may help other families recognize when a child is in distress, she tells her story in full, drawing upon her personal journals, the videos and writings that Dylan left behind, and on countless interviews with mental health experts.   Filled with hard-won wisdom and compassion, A Mother’s Reckoning is a powerful and haunting book that sheds light on one of the most pressing issues of our time. And with fresh wounds from the recent Newtown and Charleston shootings, never has the need for understanding been more urgent.  All author profits from the book will be donated to research and to charitable organizations focusing on mental health issues.

    When Papa Pilgrim appeared in the Alaska frontier outpost of McCarthy with his wife and fifteen children in tow, his new neighbors had little idea of the trouble to come. The Pilgrim Family presented themselves as a shining example of the homespun Christian ideal, with their proud piety and beautiful old-timey music, but their true story ran dark and deep. Within weeks, Papa had bulldozed a road through the mountains to the new family home at an abandoned copper mine, sparking a tense confrontation with the National Park Service and forcing his ghost town neighbors to take sides in an ever-more volatile battle over where a citizen’s rights end and the government’s power begins. In Pilgrim’s Wilderness, veteran Alaska journalist Tom Kizzia unfolds the remarkable, at times harrowing, story of a charismatic spinner of American myths who was not what he seemed, the townspeople caught in his thrall, and the family he brought to the brink of ruin. As Kizzia discovered, Papa Pilgrim was in fact the son of a rich Texas family with ties to Hoover’s FBI and strange, oblique connections to the Kennedy assassination and the movie stars of Easy Rider. And as his fight with the government in Alaska grew more intense, the turmoil in his brood made it increasingly difficult to tell whether his children were messianic followers or hostages in desperate need of rescue. In this powerful piece of Americana, written with uncommon grace and high drama, Kizzia uses his unparalleled access to capture an era-defining clash between environmentalists and pioneers ignited by a mesmerizing sociopath who held a town and a family captive

    The young women profiled in this book fought a fearsome war against brutal men in impossible circumstances--and proved in the process what girls and women can accomplish when given the chance to lead. Brilliantly researched and respectfully reported, this book is a lesson in heroism, sacrifice, and the real meaning of sisterhood. I am so grateful that this story has been told." --Elizabeth Gilbert, author of Big Magic and Eat, Pray, Love"Absolutely fascinating and brilliantly written, The Daughters of Kobani is a must-read for anyone who wants to understand both the nobility and the brutality of war. This is one of the most compelling stories in modern warfare." --Admiral William H. McRaven, author of Make Your BedIn 2014, northeastern Syria might have been the last place you would expect to find a revolution centered on women's rights. But that year, an all-female militia faced off against ISIS in a little town few had ever heard of: Kobani. By then, the Islamic State had swept across vast swaths of the country, taking town after town and spreading terror as the civil war burned all around it. From that unlikely showdown in Kobani emerged a fighting force that would wage war against ISIS across northern Syria alongside the United States. In the process, these women would spread their own political vision, determined to make women's equality a reality by fighting--house by house, street by street, city by city--the men who bought and sold women.Based on years of on-the-ground reporting, The Daughters of Kobani is the unforgettable story of the women of the Kurdish militia that improbably became part of the world's best hope for stopping ISIS in Syria. Drawing from hundreds of hours of interviews, bestselling author Gayle Tzemach Lemmon introduces us to the women fighting on the front lines, determined to not only extinguish the terror of ISIS but also prove that women could lead in war and must enjoy equal rights come the peace. In helping to cement the territorial defeat of ISIS, whose savagery toward women astounded the world, these women played a central role in neutralizing the threat the group posed worldwide. In the process they earned the respect--and significant military support--of U.S. Special Operations Forces.Rigorously reported and powerfully told, The Daughters of Kobani shines a light on a group of women intent on not only defeating the Islamic State on the battlefield but also changing women's lives in their corner of the Middle East and beyond.

    Both Nick and his character, Ron Swanson, are known for their humor and patriotism in equal measure.After the great success of his autobiography, Paddle Your Own Canoe, Offerman now focuses on the lives of those who inspired him. From George Washington to Willie Nelson, he describes twenty-one heroic figures and why they inspire in him such great meaning. He combines both serious history with light-hearted humor—comparing, say, Benjamin Franklin’s abstinence from daytime drinking to his own sage refusal to join his construction crew in getting plastered on the way to work. The subject matter also allows Offerman to expound upon his favorite topics, which readers love to hear—areas such as religion, politics, woodworking and handcrafting, agriculture, creativity, philosophy, fashion, and, of course, meat.

    Today, they lead to Beijing.'When The Silk Roads was published in 2015, it became an instant classic. A major reassessment of world history, it compelled us to look at the past from a different perspective. The New Silk Roads brings this story up to date, addressing the present and future of a world that is changing dramatically.Following the Silk Roads eastwards, from Europe through to China, by way of Russia and the Middle East, The New Silk Roads provides a timely reminder that we live in a world that is profoundly interconnected. In an age of Brexit and Trump, the themes of isolation and fragmentation permeating the Western world stand in sharp contrast to events along the Silk Roads since 2015, where ties have been strengthened and mutual cooperation established.With brilliant insight, Peter Frankopan takes a fresh look at the network of relationships being formed along the length and breadth of the Silk Roads today, assessing the global reverberations of these continual shifts in the centre of power - all too often absent from headlines in the West. This important - and ultimately hopeful - book asks us to reassess who we are and where we are in the world, illuminating the themes on which all our lives and livelihood depend.

    From Senator Al Franken - #1 bestselling author and beloved SNL alum - comes the story of an award-winning comedian who decided to run for office and then discovered why award-winning comedians tend not to do that.This is a book about an unlikely campaign that had an even more improbable ending: the closest outcome in history and an unprecedented eight-month recount saga, which is pretty funny in retrospect.It's a book about what happens when the nation's foremost progressive satirist gets a chance to serve in the United States Senate and, defying the low expectations of the pundit class, actually turns out to be good at it.It's a book about our deeply polarized, frequently depressing, occasionally inspiring political culture, written from inside the belly of the beast.In this candid personal memoir, the honorable gentleman from Minnesota takes his army of loyal fans along with him from Saturday Night Live to the campaign trail, inside the halls of Congress, and behind the scenes of some of the most dramatic and/or hilarious moments of his new career in politics.Has Al Franken become a true Giant of the Senate? Franken asks readers to decide for themselves.