For centuries, the power of zero savored of the demonic; once harnessed, it became the most important tool in mathematics. Zero follows this number from its birth as an Eastern philosophical concept to its struggle for acceptance in Europe and its apotheosis as the mystery of the black hole. Today, zero lies at the heart of one of the biggest scientific controversies of all time, the quest for the theory of everything. Elegant, witty, and enlightening, Zero is a compelling look at the strangest number in the universe and one of the greatest paradoxes of human thought.

    In Taylor's groundbreaking investigation, he discusses vampirism, cannibalism, near-death experiences, and modern-day human sacrifice.

    Charles Pellegrino’s scientific authority and close relationship with the A-bomb’s survivors make his account the most gripping and authoritative ever written.** At the narrative’s core are eyewitness accounts of those who experienced the atomic explosions firsthand—the Japanese civilians on the ground and the American flyers in the air. Thirty people are known to have fled Hiroshima for Nagasaki—where they arrived just in time to survive the second bomb. One of them, Tsutomu Yamaguchi, is the only person who experienced the full effects of the cataclysm at ground zero both times. The second time, the blast effects were diverted around the stairwell in which Yamaguchi had been standing, placing him and a few others in a shock coccoon that offered protection, while the entire building disappeared around them.Pellegrino weaves spellbinding stories together within an illustrated narrative that challenges the “official report,” showing exactly what happened in Hiroshima and Nagasaki—and why. **As of Mar 2010, the publisher is discontinuing publication of the book due to issues with its veracity. "Publisher Henry Holt and Company, said that author Charles Pellegrino "was not able to answer" concerns about "The Last Train from Hiroshima," including whether two men mentioned in the book actually existed...Doubts were first raised about the book a week ago after Pellegrino acknowledged that one of his interview subjects had falsely claimed to be on one of the planes accompanying the Enola Gay, from which an atom bomb was dropped by the United States on Hiroshima in 1945. Holt had initially promised to send a corrected edition.But further doubts about the book emerged. The publisher was unable to determine the existence of a Father Mattias (the first name is not given) who supposedly lived in Hiroshima at the time of the bombing, and John MacQuitty, identified as a Jesuit scholar presiding over Mattias' funeral.Pellegrino's own background was also questioned. He sometimes refers to himself as Dr. Pellegrino, and his Web site lists him as receiving a Ph.D. in 1982 from Victoria University of Wellington, New Zealand. But in response to a query from the AP, the school said it had no proof that Pellegrino had such a degree."

    And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization.From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again.Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

    But in eagerly pursuing what would a century later become known as the "American dream," this optimistic-yet-motley crew of emigrants was met with a chilling nightmare; in the following months, their jingoistic excitement would be replaced by desperate cries for help that would fall silent in the deadly snow-covered mountains of the Sierra Nevada.We know these early pioneers as the Donner Party, a name that has elicited horror since the late 1840s. Now, celebrated historian Michael Wallis—beloved for his myth-busting portraits of legendary American figures—continues his life’s work of parsing fact from fiction to tell the true story of one of the most embroidered sagas in Western history.Wallis begins the story in 1846, a momentous "year of decision" for the nation, when incredible territorial strides were being made in Texas, New Mexico, and California. Against this dramatic backdrop, an unlikely band of travelers appeared, stratified in age, wealth, education and ethnicity. At the forefront were the Donners: brothers George and Jacob, true sons of the soil determined to tame the wild land of California; and the Reeds, headed by adventurous, business-savvy patriarch James. In total, the Donner-Reed group would reach eighty-seven men, women, and children, and though personal motives varied—bachelors thirsting for adventure, parents wanting greater futures for their children—everyone was linked by the same unwavering belief that California was theirs for the taking.Skeptical of previous accounts of how the group ended up in peril, Wallis has spent years retracing its ill-fated journey, uncovering hundreds of new documents that illuminate how a combination of greed, backbiting, and recklessness led the group to become hopelessly snowbound at the infamous Donner Pass in present-day California. Climaxing with the grim stories of how the party’s paltry rations soon gave way to unimaginable hunger, Wallis not only details the cannibalism that has in perpetuity haunted their legacy but also the heroic rescue parties that managed to reach the stranded, only to discover that just forty-eight had survived the ordeal.An unflinching and historically invaluable account of the darkest side of Manifest Destiny, The Best Land Under Heaven offers a brilliant, revisionist examination of one of America's most calamitous and sensationalized catastrophes.

    It was an act that forced the permanent evacuation of a city, killed thousands and crippled the Soviet Union. The event spawned decades of conflicting, exaggerated and inaccurate stories. This book, the result of five years of research, presents an accessible but comprehensive account of what really happened. From the desperate fight to prevent a burning reactor core from irradiating eastern Europe, to the self-sacrifice of the heroic men who entered fields of radiation so strong that machines wouldn’t work, to the surprising truth about the legendary ‘Chernobyl divers’, all the way through to the USSR’s final show-trial. The historical narrative is interwoven with a story of the author’s own spontaneous journey to Ukraine’s still-abandoned city of Pripyat and the wider Chernobyl Zone. Complete with over 45 pages of photographs of modern-day Pripyat and technical diagrams of the power station, Chernobyl 01:23:40 is a fascinating new account of the world’s worst nuclear disaster.

    They came from Fleet Street, Knightsbridge, Wolverhampton, Sweden and Wales. They wrote ballads, ran coffee houses, lived on country estates, they breathed ink-dust from printing presses and escaped people-traffickers. What they had in common was the year of their murders: 1888. The person responsible was never identified, but the character created by the press to fill that gap has become far more famous than any of these five women.For more than a century, newspapers have been keen to tell us that ‘the Ripper’ preyed on prostitutes. Not only is this untrue, as historian Hallie Rubenhold has discovered, it has prevented the real stories of these fascinating women from being told. Now, in this devastating narrative of five lives, Rubenhold finally sets the record straight, revealing a world not just of Dickens and Queen Victoria, but of poverty, homelessness and rampant misogyny. They died because they were in the wrong place at the wrong time – but their greatest misfortune was to be born a woman.

    But from the very beginning, many accounts have obscured a fascinating truth: the Massacre arose from conflicts that were as personal as they were political.     Professor Serena Zabin draws on original sources and lively stories to follow British troops as they are dispatched from Ireland to Boston in 1768 to subdue the increasingly rebellious colonists. And she reveals a forgotten world hidden in plain sight: the many regimental wives and children who accompanied these armies. We see these families jostling with Bostonians for living space, finding common cause in the search for a lost child, trading barbs and and sharing baptisms. Becoming, in other words, neighbors. When soldiers shot unarmed citizens in the street, it was these intensely human, now broken bonds that fueled what quickly became a bitterly fought American Revolution.    Serena Zabin’s The Boston Massacre delivers an indelible new slant on iconic American Revolutionary history.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    From the advent of photography in the 19th and into the 20th century, medical students, often in secrecy, took photographs of themselves with the cadavers that they dissected: their first patients. Featuring 138 of these historic photographs and illuminating essays by two experts on the subject, Dissection reveals a startling piece of American history. Sherwin Nuland, MD, said this is "a truly unique and important book [that] documents a period in medical education in a way that is matched by no other existing contribution." And Mary Roach said Dissection "is the most extraordinary book I have ever seen--the perfect coffee table book for all the households where I'd most like to be invited for coffee."

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    They include Catherine the Great, Elizabeth I, Isabella of Spain, the Rani of Jhansi, and the formidable Queen Jinga of Angola. With Boadicea as the definitive example, her female champions from other ages and civilisations make a fascinating and awesome assembly. Yet if Boadicea's apocryphal chariot has ensured her place in history, what are the myths that surround the others? And how different are the democratically elected if less regal warrior queens of recent times: Indira Gandhi and Golda Meir? This remarkable book is much more than a biographical selection. It examines how Antonia Fraser's heroines have held and wrested the reins of power from their (consistently male) adversaries.

    She takes us by her side down hospital corridors to visit the wards and meet her unforgettable patients.In the neonatal unit, premature babies fight for their lives, hovering at the very edge of survival, like tiny Emmanuel, wrapped up in a sandwich bag. On the cancer wards, the nurses administer chemotherapy and, long after the medicine stops working, something more important--which Watson learns to recognize when her own father is dying of cancer. In the pediatric intensive care unit, the nurses wash the hair of a little girl to remove the smell of smoke from the house fire. The emergency room is overcrowded as ever, with waves of alcohol and drug addicted patients as well as patients like Betty, a widow suffering chest pain, frail and alone. And the stories of the geriatric ward--Gladys and older patients like her--show the plight of the most vulnerable members of our society.

    It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research and now revised to reflect the growing danger of the avian flu, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. John M. Barry has written a new afterword for this edition that brings us up to speed on the terrible threat of the avian flu and suggest ways in which we might head off another flu pandemic.