Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

    Drawing on fieldwork in a Dutch university hospital, Annemarie Mol looks at the day-to-day diagnosis and treatment of atherosclerosis. A patient information leaflet might describe atherosclerosis as the gradual obstruction of the arteries, but in hospital practice this one medical condition appears to be many other things. From one moment, place, apparatus, specialty, or treatment, to the next, a slightly different “atherosclerosis” is being discussed, measured, observed, or stripped away. This multiplicity does not imply fragmentation; instead, the disease is made to cohere through a range of tactics including transporting forms and files, making images, holding case conferences, and conducting doctor-patient conversations.The Body Multiple juxtaposes two distinct texts. Alongside Mol’s analysis of her ethnographic material—interviews with doctors and patients and observations of medical examinations, consultations, and operations—runs a parallel text in which she reflects on the relevant literature. Mol draws on medical anthropology, sociology, feminist theory, philosophy, and science and technology studies to reframe such issues as the disease-illness distinction, subject-object relations, boundaries, difference, situatedness, and ontology. In dialogue with one another, Mol’s two texts meditate on the multiplicity of reality-in-practice.Presenting philosophical reflections on the body and medical practice through vivid storytelling, The Body Multiple will be important to those in medical anthropology, philosophy, and the social study of science, technology, and medicine.

    

    It is the secret of what makes humans special, hiding in plain sight. Agustin Fuentes argues that your child's finger painting comes essentially from the same place as creativity in hunting and gathering millions of years ago, and throughout history in making war and peace, in intimate relationships, in shaping the planet, in our communities, and in all of art, religion, and even science.It requires imagination and collaboration. Every poet has her muse; every engineer, an architect; every politician, a constituency. The manner of the collaborations varies widely, but successful collaboration is inseparable from imagination, and it brought us everything from knives and hot meals to iPhones and interstellar spacecraft.Weaving fascinating stories of our ancient ancestors' creativity, Fuentes finds the patterns that match modern behavior in humans and animals. This key quality has propelled the evolutionary development of our bodies, minds, and cultures, both for good and for bad. It's not the drive to reproduce; nor competition for mates, or resources, or power; nor our propensity for caring for one another that have separated us out from all other creatures.As Fuentes concludes, to make something lasting and useful today you need to understand the nature of your collaboration with others, what imagination can and can't accomplish, and, finally, just how completely our creativity is responsible for the world we live in. Agustin Fuentes's resounding multimillion-year perspective will inspire readers and spark all kinds of creativity.

    . . when it comes to the legacy of this country's war on drugs, we should all share his outrage." --The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy lifeDr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a colleague, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism.Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars.Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

    The twentieth century—a time of unprecedented progress—has produced a tremendous strain on the very elements that comprise life itself: This raises the key question of the twenty-first century: How much longer can this go on? With wit and erudition, Ronald Wright lays out a-convincing case that history has always provided an answer, whether we care to notice or not. From Neanderthal man to the Sumerians to the Roman Empire, A Short History of Progress dissects the cyclical nature of humanity's development and demise, the 10,000-year old experiment that we've unleashed but have yet to control. It is Wright's contention that only by understanding and ultimately breaking from the patterns of progress and disaster that humanity has repeated around the world since the Stone Age can we avoid the onset of a new Dark Age. Wright illustrates how various cultures throughout history have literally manufactured their own end by producing an overabundance of innovation and stripping bare the very elements that allowed them to initially advance. Wright's book is brilliant; a fascinating rumination on the hubris at the heart of human development and the pitfalls we still may have time to avoid.

    Evans connects the dots between coffee and its Islamic origins, the drug ephedra and Mormons, music and Stonehenge, and much more. Chapters also include step-by-step guides for re-creating prehistoric debauchery in your modern life based on Evans's firsthand fieldwork. Readers won't just learn about the beer that destroyed South America's first empire; they'll learn how to make it.

    Buried there lie answers about the origins of humankind. After a century of investigation, scientists have transformed our understanding about the beginnings of human life. But vital clues still remain hidden. In Born in Africa, Martin Meredith follows the trail of discoveries about human origins made by scientists over the last hundred years, recounting their intense rivalry, personal feuds, and fierce controversies as well as their feats of skill and endurance.The results have been momentous. Scientists have identified more than twenty species of extinct humans. They have firmly established Africa as the birthplace not only of humankind but also of modern humans. They have revealed how early technology, language ability, and artistic endeavour all originated in Africa; and they have shown how small groups of Africans spread out from Africa in an exodus sixty thousand years ago to populate the rest of the world. We have all inherited an African past.

    The meme is also one of the most important--and controversial--concepts to emerge since 'The Origin of the Species' appeared nearly 150 years ago.In 'The Meme Machine' Susan Blackmore boldly asserts: "Just as the design of our bodies can be understood only in terms of natural selection, so the design of our minds can be understood only in terms of memetic selection." Indeed, Blackmore shows that once our distant ancestors acquired the crucial ability to imitate, a second kind of natural selection began, a survival of the fittest amongst competing ideas and behaviors. Ideas and behaviors that proved most adaptive - making tools, for example, or using language--survived and flourished, replicating themselves in as many minds as possible. These memes then passed themselves on from generation to generation by helping to ensure that the genes of those who acquired them also survived and reproduced. Applying this theory to many aspects of human life, Blackmore offers brilliant explanations for why we live in cities, why we talk so much, why we can't stop thinking, why we behave altruistically, how we choose our mates, and much more.With controversial implications for our religious beliefs, our free will, our very sense of "self," 'The Meme Machine' offers a provocative theory everyone will soon be talking about.

    America's most famous anarchist.

    Now, with an astonishing new discovery, everything we thought we knew about primate origins could change. Lying inside a high-security vault, deep within the heart of one of the world's leading natural history museums, is the scientific find of a lifetime - a perfectly fossilized early primate, older than the previously most famous primate fossil, Lucy, by forty-four million years.  A secret until now, the fossil - "Ida" to the researchers who have painstakingly verified her provenance - is the most complete primate fossil ever found. Forty-seven million years old, Ida rewrites what we've assumed about the earliest primate origins. Her completeness is unparalleled - so much of what we understand about evolution comes from partial fossils and even single bones, but Ida's fossilization offers much more than that, from a haunting "skin shadow" to her stomach contents. And, remarkably, knowledge of her discovery and existence almost never saw the light of day. With exclusive access to the first scientists to study her, the award-winning science writer Colin Tudge tells the history of Ida and her place in the world. A magnificent, cutting-edge scientific detective story followed her discovery, and The Link offers a wide-ranging investigation into Ida and our earliest origins. At the same time, it opens a stunningly evocative window into our past and changes what we know about primate evolution and, ultimately, our own.

    . . . Wonderland inspires grins and well-what-d'ya-knows" —The New York Times Book Review From the New York Times-bestselling author of How We Got to Now and Where Good Ideas Come From, a look at the world-changing innovations we made while keeping ourselves entertained. This lushly illustrated history of popular entertainment takes a long-zoom approach, contending that the pursuit of novelty and wonder is a powerful driver of world-shaping technological change. Steven Johnson argues that, throughout history, the cutting edge of innovation lies wherever people are working the hardest to keep themselves and others amused.Johnson's storytelling is just as delightful as the inventions he describes, full of surprising stops along the journey from simple concepts to complex modern systems. He introduces us to the colorful innovators of leisure: the explorers, proprietors, showmen, and artists who changed the trajectory of history with their luxurious wares, exotic meals, taverns, gambling tables, and magic shows.In Wonderland, Johnson compellingly argues that observers of technological and social trends should be looking for clues in novel amusements. You'll find the future wherever people are having the most fun.

    Looking at the organisms that have made all this possible gives us a new way of understanding how we got here--and perhaps of thinking about where we're going. Instead of a history of which great scientists had which great ideas, this story of passionflowers and hawkweeds, of zebra fish and viruses, offers a bird's (or rodent's) eye view of the work that makes science possible.Mixing the celebrities of genetics, like the fruit fly, with forgotten players such as the evening primrose, the book follows the unfolding history of biological inheritance from Aristotle's search for the "universal, absolute truth of fishiness" to the apparently absurd speculations of eighteenth-century natural philosophers to the spectacular findings of our day--which may prove to be the absurdities of tomorrow.The result is a quirky, enlightening, and thoroughly engaging perspective on the history of heredity and genetics, tracing the slow, uncertain path--complete with entertaining diversions and dead ends--that led us from the ancient world's understanding of inheritance to modern genetics.

    Antonio Damasio makes clear that we descend biologically, psychologically, and even socially from a long lineage that begins with single living cells; that our minds and cultures are linked by an invisible thread to the ways and means of ancient unicellular life and other primitive life-forms; and that inherent in our very chemistry is a powerful force, a striving toward life maintenance that governs life in all its guises, including the development of genes that help regulate and transmit life. In The Strange Order of Things, Damasio gives us a new way of comprehending the world and our place in it.www.antoniodamasio.com

    Today, the majority of the world’s megacities are located in coastal zones, yet few of them are adequately prepared for the floods that will increasingly menace their shores. Instead, most continue to develop luxury waterfront condos for the elite and industrial facilities for corporations. These not only intensify carbon emissions, but also place coastal residents at greater risk when water levels rise.In Extreme Cities, Dawson offers an alarming portrait of the future of our cities, describing the efforts of Staten Island, New York, and Shishmareff, Alaska residents to relocate; Holland’s models for defending against the seas; and the development of New York City before and after Hurricane Sandy. Our best hope lies not with fortified sea walls, he argues. Rather, it lies with urban movements already fighting to remake our cities in a more just and equitable way.As much a harrowing study as a call to arms Extreme Cities is a necessary read for anyone concerned with the threat of global warming, and of the cities of the world.