Chaotic politics. Billionaire entrepreneurs. Award-winning journalist Brendan Borrell brings the defining story of our times alive through compulsively readable, first-time reporting on the players leading the fight against a vicious virus. The First Shots, soon to be the subject of an HBO limited series with superstar director and producer Adam McKay (Succession, Vice, The Big Short), draws on exclusive, high-level access to weave together the intense vaccine-race conflicts among hard-driving, heroic scientists and the epic rivalries among Washington power players that shaped 18 months of fear, resolve, and triumph. From infectious disease expert Michael Callahan, an American doctor secretly on the ground in Wuhan in January 2020 to gauge the terrifying ravages of Disease X; to Robert (Dr. Bob) Kadlec, one of Operation Warp Speed’s architects, whose audacious plans for the American people run straight into the buzz saw of the Trump White House factions; to Stéphane Bancel of upstart Moderna Therapeutics going toe-to-toe with pharma behemoth Pfizer, The First Shots lays bare, in a way we have not seen, the full stunning story behind the medical science “moon shot” of our lifetimes.

    Applying the same objective criteria to legal and illegal substances, an argument is made that legality is not a clear measure for harm. Tackling a variety of questions, such as Which is more harmful—Ecstasy or alcohol? Can addiction be cured? and Does the "War on Drugs" have serious unintended effects that can hurt children?, this analysis equips readers with the ability to make educated decisions regarding drugs both personally and in their communities. Broadening the scope of the discussion, a framework is explored for formulating national drug policies that will minimize a myriad of harms—social, medical, criminal, financial, and environmental.

    Serotonin is the "contentment" neurotransmitter that tells our brains we don't need any more; yet its deficiency leads to depression. Ideally, both are in optimal supply. Yet dopamine evolved to overwhelm serotonin--because our ancestors were more likely to survive if they were constantly motivated--with the result that constant desire can chemically destroy our ability to feel happiness, while sending us down the slippery slope to addiction. In the last forty years, government legislation and subsidies have promoted ever-available temptation (sugar, drugs, social media, porn) combined with constant stress (work, home, money, Internet), with the end result of an unprecedented epidemic of addiction, anxiety, depression, and chronic disease. And with the advent of neuromarketing, corporate America has successfully imprisoned us in an endless loop of desire and consumption from which there is no obvious escape.With his customary wit and incisiveness, Lustig not only reveals the science that drives these states of mind, he points his finger directly at the corporations that helped create this mess, and the government actors who facilitated it, and he offers solutions we can all use in the pursuit of happiness, even in the face of overwhelming opposition. Always fearless and provocative, Lustig marshals a call to action, with seminal implications for our health, our well-being, and our culture.

    How did Bernie Sanders make it out of the backwoods of Vermont – where he lived for a time in a ramshackle off-road “sugar shack” with no electricity, and where he never got more than 6 percent of the vote in a string of doomed, fringe far-left campaigns in the 1970s – to become a leading contender in the 2016 race for the White House? And perhaps more importantly for author Will Bunch, how did this gruff and sometimes didactic gray-haired political survivor make it out of the 1960s and ‘70s to become the last torch-bearer of the youthful idealism of that nearly lost “Age of Aquarius” – The One who didn’t drop out, sell out…or simply give up? In the fall of 2015, Bunch – with the voices of the late Hunter S. Thompson and the other iconic “New Journalists” of that lost era ringing in his ears – set out on a road trip that took him from the battlefields of northern Virginia to the salty air of backwater Boston to the neon sky of the Las Vegas Strip, all to get to the bottom of “The Bern Identity.” He follows the long strange trip of Bernie Sanders – a kid from a cramped Brooklyn flat who couldn’t tell a lie in school, who mourned the migration of his beloved Dodgers and was shaken up by “Death of a Salesman,” who became a campus radical, a dreamer of revolutions, and then almost disappeared before his improbable election of mayor of Burlington in 1981. Sanders’ remarkable bio is interspersed with the tale of the true believers who packed hockey rinks and concrete convention floors in crowds of 20,000 or more, who tweeted incessantly and posted memes of Sanders flying in coach class, and who exploded with excitement at their hero’s call for a “political revolution” to raise the beleaguered middle class. In a time of rampant cynicism about American politics, “The Bern Identity” turns into something most unlikely – a love story, between the long-distance runner who never gave up his fantasy of real social change, and the dreamers and the radicals and the formerly hopeless who were waiting for him at the finish line.THE AUTHOR Will Bunch is senior writer for the Philadelphia Daily News – where he writes the popular political blog Attytood – and also shared the 1992 Pulitzer Prize for spot news reporting in 1992 when he was at New York Newsday. He is the author of two other Kindle Singles: October 1, 2011: The Battle of the Brooklyn Bridge, about the Occupy Wall Street movement, and Give It To Steve!, about the 1948 Philadelphia Eagles winning the NFL title during a raging blizzard. His full-length books include The Backlash: Right-Wing Radicals, High-Def Hucksters and Paranoid Politics in the Age of Obama, and Tear Down This Myth: The Right-Wing Distortion of the Reagan Legacy. His articles have also appeared in the New York Times Magazine, The Washington Post, Mother Jones, The Los Angeles Times, American Prospect, American Journalism Review, and elsewhere. He lives in the Philadelphia suburbs with his family.

    By 1988 she was living at home but was brain dead after a tragic cycle of misunderstanding, over-medication, and culture clash: "What the doctors viewed as clinical efficiency the Hmong viewed as frosty arrogance." The Spirit Catches You and You Fall Down is a tragedy of Shakespearean dimensions, written with the deepest of human feeling. Sherwin Nuland said of the account, "There are no villains in Fadiman's tale, just as there are no heroes. People are presented as she saw them, in their humility and their frailty—and their nobility.

    With swashbuckling wit and fierce honesty, she dishes on herself and her colleagues as they try to prod reluctant governments to fund HIV prevention for the people who need it most—drug injectors, gay men, sex workers, and johns.Pisani chats with flamboyant Indonesian transsexuals about their boob jobs and watches Chinese streetwalkers turn away clients because their SUVs aren't nice enough. With verve and clarity, she shows the general reader how her profession really works; how easy it is to draw wrong conclusions from "objective" data; and, shockingly, how much money is spent so very badly. "Exhibit A": the 45 billion taxpayer dollars the Bush administration is committing to international AIDS programs.

    Rana Awdish never imagined that an emergency trip to the hospital would result in hemorrhaging nearly all of her blood volume and losing her unborn first child. But after her first visit, Dr. Awdish spent months fighting for her life, enduring consecutive major surgeries and experiencing multiple overlapping organ failures. At each step of the recovery process, Awdish was faced with something even more unexpected: repeated cavalier behavior from her fellow physicians—indifference following human loss, disregard for anguish and suffering, and an exacting emotional distance.Hauntingly perceptive and beautifully written, In Shock allows the reader to transform alongside Awidsh and watch what she discovers in our carefully-cultivated, yet often misguided, standard of care. Awdish comes to understand the fatal flaws in her profession and in her own past actions as a physician while achieving, through unflinching presence, a crystalline vision of a new and better possibility for us all.As Dr. Awdish finds herself up against the same self-protective partitions she was trained to construct as a medical student and physician, she artfully illuminates the dysfunction of disconnection. Shatteringly personal, and yet wholly universal, she offers a brave road map for anyone navigating illness while presenting physicians with a new paradigm and rationale for embracing the emotional bond between doctor and patient.

    Each tale is true and borders on the unbelievable. It’s no wonder that throughout the years the column has become an unofficial textbook for medical students, interns, doctors, and anyone interested in human illness and staying healthy. Now, physician and “Vital Signs” editor Robert Norman has compiled the very best of the series into an intriguing and suspenseful collection for fans and new readers alike. A young woman carries a baby that wasn’t her own—and wasn’t even a human; Aretha Franklin gives a physician the insight needed to save a life; a modern gynecologist faces an ancient disease. These cases and more, representing a wide variety of unique medical anomalies and life-or-death situations, bring readers to the front lines of the medical fray.Fans of hit medical dramas such as House MD will savor the opportunity to read of the real-life cases that puzzled doctors, the gripping detective work that ensued, and the completely unexpected, often life-saving diagnoses. Discover Magazine’s Vital Signs is a glimpse into the exciting work of real medical professionals, told from their perspective, and revealing that anything can happen in medicine. Readers will never look at a “routine check-up” the same again.

    Drawing on momentous (yet dimly remembered) historical epidemics, contemporary analyses, and cutting-edge research from a range of scientific disciplines, bestselling author, physician, sociologist, and public health expert Nicholas A. Christakis explores what it means to live in a time of plague—an experience that is paradoxically uncommon to the vast majority of humans who are alive, yet deeply fundamental to our species.Unleashing new divisions in our society as well as opportunities for cooperation, this 21st-century pandemic has upended our lives in ways that will test, but not vanquish, our already frayed collective culture. Featuring new, provocative arguments and vivid examples ranging across medicine, history, sociology, epidemiology, data science, and genetics, Apollo's Arrow envisions what happens when the great force of a deadly germ meets the enduring reality of our evolved social nature.

    But in this groundbreaking book, prize-winning historian Edith Sheffer exposes that Asperger was not only involved in the racial policies of Hitler’s Third Reich, he was complicit in the murder of children.As the Nazi regime slaughtered millions across Europe during World War Two, it sorted people according to race, religion, behavior, and physical condition for either treatment or elimination. Nazi psychiatrists targeted children with different kinds of minds—especially those thought to lack social skills—claiming the Reich had no place for them. Asperger and his colleagues endeavored to mold certain "autistic" children into productive citizens, while transferring others they deemed untreatable to Spiegelgrund, one of the Reich’s deadliest child-killing centers.In the first comprehensive history of the links between autism and Nazism, Sheffer uncovers how a diagnosis common today emerged from the atrocities of the Third Reich. With vivid storytelling and wide-ranging research, Asperger’s Children will move readers to rethink how societies assess, label, and treat those diagnosed with disabilities.

    In 1895 her great-great aunt, Pauline Gross, a seamstress in Ann Arbor, Michigan, confided to a pathology professor at the local university that she expected to die young, like so many others in her family. Rather than dismiss her fears, the pathologist chose to enlist Pauline in the careful tracking of those in her family tree who had died of cancer. Pauline's premonition proved true--she died at 46--but because of her efforts, her family (who the pathologist dubbed 'Family G') would become the longest and most detailed cancer genealogy ever studied in the world. A century after Pauline's confession, researchers would identify the genetic mutation responsible for the family's woes. Now known as Lynch syndrome, the genetic condition predisposes its carriers to several types of cancer, including colorectal, endometrial, ovarian and pancreatic. In 2001, as a young mother with two sons and a keen interest in survival, Ami McKay was among the first to be tested for Lynch syndrome. She had a feeling she'd test positive: her mother's side of the family was riddled with early deaths and her own mother was being treated for the disease. When the test proved her fears true, she began living in "an unsettling state between wellness and cancer," and she's been there ever since. Intimate, candid, and probing, her genetic memoir tells a fascinating story, teasing out the many ways to live with the hand you are dealt.

    After barely surviving the agony of smallpox themselves, they flouted eighteenth-century medicine by borrowing folk knowledge from African slaves and Eastern women in frantic bids to protect their children. From their heroic struggles stems the modern science of immunology as well as the vaccinations that remain our only hope should the disease ever be unleashed again.Jennifer Lee Carrell transports readers back to the early eighteenth century to tell the tales of Lady Mary Wortley Montagu and Dr. Zabdiel Boylston, two iconoclastic figures who helped save London and Boston from the deadliest disease mankind has known.

    We are most familiar with the viruses that give us colds or the flu, but viruses also cause a vast range of other diseases, including one disorder that makes people sprout branch-like growths as if they were trees. Viruses have been a part of our lives for so long, in fact, that we are actually part virus: the human genome contains more DNA from viruses than our own genes. Meanwhile, scientists are discovering viruses everywhere they look: in the soil, in the ocean, even in caves miles underground.This fascinating book explores the hidden world of viruses—a world that we all inhabit. Here Carl Zimmer, popular science writer and author of Discover magazine’s award-winning blog The Loom, presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate for years to come. In this eye-opening tour of the frontiers of biology, where scientists are expanding our understanding of life as we know it, we learn that some treatments for the common cold do more harm than good; that the world’s oceans are home to an astonishing number of viruses; and that the evolution of HIV is now in overdrive, spawning more mutated strains than we care to imagine.The New York Times Book Review calls Carl Zimmer “as fine a science essayist as we have.” A Planet of Viruses is sure to please his many fans and further enhance his reputation as one of America’s most respected and admired science journalists.

    You’ll be there as Dr. Kristine Guleserian, noted pediatric cardiothoracic surgeon, fixes the tiny hearts of the tiniest children. Follow the young boy who gets a new heart and then, three weeks later, joins Dr. Guleserian on the mound at Fenway Park to throw out the first pitch at a World Series game. Discover the years of training Dr. G went through to become the highly respected surgeon she is today. See how her warmth, humor, intelligence and dedication provide a shining example of what is good about the American health care system. To get a closer look than this, you’d have to scrub in.

    Two scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.